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The map label for this gene is dehH2

Identifier: 94309074

GI number: 94309074

Start: 134975

End: 135874

Strand: Direct

Name: dehH2

Synonym: Rmet_0129

Alternate gene names: NA

Gene position: 134975-135874 (Clockwise)

Preceding gene: 94309067

Following gene: 94309075

Centisome position: 3.44

GC content: 67.56

Gene sequence:

>900_bases
ATGCAGAACGATGCCAGTGCGTTGCTGTTTCCCAATTTCGAGTGGTTCCGGCTGAAGGTGGACGAGGTGGAAATCGCTGG
CGTGCGTGGCGGTTCCGGCCCGCCGCTGCTGTTGCTGCACGGGTTTCCGCAAAGCCACCTGATCTGGCACAAGGTGGCCC
CGGCGCTGGCCGACCGCTTCACGGTGATTGCCACCGACCTGCGCGGATATGGCAGCAGCGGCGCGCCACCGGCCAGCCCT
GGGCACGAGGCCTACAGCAAGCGCGAGATGGCGCGGGACCAGGTGGAGGTCATGCGCCAGCTTGGTTTTTCCCGTTTCGC
GCTGTGTGCCCACGACCGTGGCGCGCGCGTGGCGCATCGGCTCTGCATCGACCACCCCGAGGCGGTCAGCCGCGCGATGC
TGCTCGATATCGCGCCGACACTGGCGATGTACGAGGCCACCAGCATGGCCTTTGCCGCCGCCTACTGGCATTGGTTCTTC
CTGATTCAGCCGGCGCCGTTCCCGGAGACCCTGATCAATGCCGAGCCCGCGTTCTTCATCGACAAGCTGCTGGGCTTGCG
CCACGCGGGCCCGAGCCCATTCGCCCCCGATGCGATGGCTGCGTATGTCGCCGCGATGCAGGAGCCGGCGCGCGTCCATG
CGATGTGCGAGGACTATCGCGCCGCCGCTACCATCGATCTGGACCACGACCGCGCCGACCGCGAGGCCGGGCGCAAGCTG
GCCATGCCTGTGCGCGTGCTATGGGGCGAACACGGCGTGGTGGCGCGCTGCTTCGAGCCGCTGGCGCTCTGGCAGGCCCT
GGGCGACGCGGTCAGCGGCGCGACGCTGCCGTGTGGCCACTATGTTCCGGAAGAGGTGCCCGAGCCGCTGCTTGAGGAAA
TGCTCGAATTCTTCCGTTAG

Upstream 100 bases:

>100_bases
GCAATTCAGTTGCACCAACAGGGTCTTCGAGACGGCGGTGCGCCGGGATTCAGCCTATGATCGGCACAAAGCGCCAGAAA
AGAGGCCCGGAGACAAAGTC

Downstream 100 bases:

>100_bases
ATAACAGTGGGTCACATTCTCACGGGTTAGCCCCTATACCTCGCAATTGTCCGGGGTTGCTAACATCCACCTCCGGCTCC
GCCTGTCGGCGGGGTTCGCT

Product: haloacetate dehalogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MQNDASALLFPNFEWFRLKVDEVEIAGVRGGSGPPLLLLHGFPQSHLIWHKVAPALADRFTVIATDLRGYGSSGAPPASP
GHEAYSKREMARDQVEVMRQLGFSRFALCAHDRGARVAHRLCIDHPEAVSRAMLLDIAPTLAMYEATSMAFAAAYWHWFF
LIQPAPFPETLINAEPAFFIDKLLGLRHAGPSPFAPDAMAAYVAAMQEPARVHAMCEDYRAAATIDLDHDRADREAGRKL
AMPVRVLWGEHGVVARCFEPLALWQALGDAVSGATLPCGHYVPEEVPEPLLEEMLEFFR

Sequences:

>Translated_299_residues
MQNDASALLFPNFEWFRLKVDEVEIAGVRGGSGPPLLLLHGFPQSHLIWHKVAPALADRFTVIATDLRGYGSSGAPPASP
GHEAYSKREMARDQVEVMRQLGFSRFALCAHDRGARVAHRLCIDHPEAVSRAMLLDIAPTLAMYEATSMAFAAAYWHWFF
LIQPAPFPETLINAEPAFFIDKLLGLRHAGPSPFAPDAMAAYVAAMQEPARVHAMCEDYRAAATIDLDHDRADREAGRKL
AMPVRVLWGEHGVVARCFEPLALWQALGDAVSGATLPCGHYVPEEVPEPLLEEMLEFFR
>Mature_299_residues
MQNDASALLFPNFEWFRLKVDEVEIAGVRGGSGPPLLLLHGFPQSHLIWHKVAPALADRFTVIATDLRGYGSSGAPPASP
GHEAYSKREMARDQVEVMRQLGFSRFALCAHDRGARVAHRLCIDHPEAVSRAMLLDIAPTLAMYEATSMAFAAAYWHWFF
LIQPAPFPETLINAEPAFFIDKLLGLRHAGPSPFAPDAMAAYVAAMQEPARVHAMCEDYRAAATIDLDHDRADREAGRKL
AMPVRVLWGEHGVVARCFEPLALWQALGDAVSGATLPCGHYVPEEVPEPLLEEMLEFFR

Specific function: Catalyzes the hydrolytic defluorination of fluoroacetate to produce glycolate. Has low activity towards chloroacetate [H]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=277, Percent_Identity=28.158844765343, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI13376164, Length=277, Percent_Identity=28.158844765343, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI218777837, Length=235, Percent_Identity=24.6808510638298, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI27597073, Length=108, Percent_Identity=36.1111111111111, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17554012, Length=291, Percent_Identity=23.0240549828179, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17562298, Length=223, Percent_Identity=23.7668161434978, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.8.1.3 [H]

Molecular weight: Translated: 33053; Mature: 33053

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNDASALLFPNFEWFRLKVDEVEIAGVRGGSGPPLLLLHGFPQSHLIWHKVAPALADRF
CCCCCCEEEECCCEEEEEEECCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
TVIATDLRGYGSSGAPPASPGHEAYSKREMARDQVEVMRQLGFSRFALCAHDRGARVAHR
HEEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCHHHHHH
LCIDHPEAVSRAMLLDIAPTLAMYEATSMAFAAAYWHWFFLIQPAPFPETLINAEPAFFI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHH
DKLLGLRHAGPSPFAPDAMAAYVAAMQEPARVHAMCEDYRAAATIDLDHDRADREAGRKL
HHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCC
AMPVRVLWGEHGVVARCFEPLALWQALGDAVSGATLPCGHYVPEEVPEPLLEEMLEFFR
CCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHC
>Mature Secondary Structure
MQNDASALLFPNFEWFRLKVDEVEIAGVRGGSGPPLLLLHGFPQSHLIWHKVAPALADRF
CCCCCCEEEECCCEEEEEEECCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHH
TVIATDLRGYGSSGAPPASPGHEAYSKREMARDQVEVMRQLGFSRFALCAHDRGARVAHR
HEEEEHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHEEHHHCCCCHHHHHH
LCIDHPEAVSRAMLLDIAPTLAMYEATSMAFAAAYWHWFFLIQPAPFPETLINAEPAFFI
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHCCCHHHHH
DKLLGLRHAGPSPFAPDAMAAYVAAMQEPARVHAMCEDYRAAATIDLDHDRADREAGRKL
HHHHHHHCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCEEEEECCCCHHHHHHCCCC
AMPVRVLWGEHGVVARCFEPLALWQALGDAVSGATLPCGHYVPEEVPEPLLEEMLEFFR
CCCHHEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA