| Definition | Cupriavidus metallidurans CH34 chromosome, complete genome. |
|---|---|
| Accession | NC_007973 |
| Length | 3,928,089 |
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The map label for this gene is metH [H]
Identifier: 94309033
GI number: 94309033
Start: 94333
End: 97080
Strand: Direct
Name: metH [H]
Synonym: Rmet_0088
Alternate gene names: 94309033
Gene position: 94333-97080 (Clockwise)
Preceding gene: 94309032
Following gene: 94309034
Centisome position: 2.4
GC content: 64.41
Gene sequence:
>2748_bases ATGAGCCAGCAAAACCTGCCCCCGCGTCCGATGCGCCTGTCCGGTCTGGAGCCGTTTACGATCGACGACGACACGCTGTT CGTCAACGTTGGCGAGCGTACCAACGTCACCGGTTCGAAGGCATTCGCGCGCATGATCCTGAACGGCCAGTTCGACGAAG CCCTGGCGGTGGCCCGCCAGCAGGTGGAGAACGGCGCGCAGATCATCGACATCAACATGGACGAGGCGATGCTCGATTCG AAGGCGGCGATGGTGCGCTTCCTGAATCTGATCGCATCTGAGCCGGACATCGCGCGCGTGCCGATCATGATCGATTCGTC GAAGTGGGACGTGATCGAGGCGGGCCTGCGCTGTGTGCAGGGCAAGGCCGTGGTGAACTCGATCTCGCTCAAGGAAGGTG AGGAACAGTTTCGCCACCACGCCACGCAGATCCGCCGTTATGGCGCGGCCAGCGTGGTGATGGCATTCGACGAGAAGGGC CAGGCGGACACGTTCGAGCGCAAGACCGAGATCTGCAAGCGCAGCTACGACTTCCTCGTGAACGAAGTGGGCTTCCCGCC CGAGGACATCATCTTCGATCCGAACATCTTCGCGGTGGCCACCGGTATCGAGGAGCACAACAACTACGCGGTGGACTTCA TCGAAGCCACGCGCTGGATCAAGCAGAACCTGCCGTACGCCAAGGTCAGCGGCGGGGTGTCGAACGTGTCGTTCTCGTTC CGCGGCAACGACGTGGTGCGCGAGGCGATCCACACCGTGTTCCTGTACCACGCGATCGCGGCGGGCATGGACATGGGCAT CGTCAACGCCGGCCAGCTTGGCGTGTACGACCAGCTCGACCCGGAATTGCGCGAGCGCGTGGAAGACGTGGTGCTGAACC GTCGCGACGACGCCACCGATCGCCTGCTGGAGATCGCCGACCGCTTCAAGGGCGGTGGCACGAAGCGGGAAGAGAACCTG GCCTGGCGCGGCACGCCCGAGCAACCGGTGCCGGTGGGCGATCGCCTGGCGCACGCGCTGGTGCACGGCATCACCACGTT CATCGTCGAGGACACCGAGGAAGTGCGCCAGCAGATCGCGGCGCGCGGTGGCCGTCCCATCGAGGTGATCGAGGGGCCGC TGATGGATGGCATGAACATCGTCGGCGACCTGTTCGGCGCGGGCAAGATGTTCCTGCCGCAAGTGGTGAAGAGCGCCCGT GTGATGAAGCAGGCCGTGGCGCATCTGCTGCCGTTTATCGAGGAAGAAAAGCGCCTGGTGGCCGAGGCCGGCGGCGACGT GCGCGCGCGCGGCAAGATCGTGATCGCCACCGTGAAGGGCGACGTGCACGACATCGGCAAGAACATCGTGTCGGTGGTGC TCCAGTGCAACAACTTCGAAGTGGTCAACATGGGCGTGATGGTGCCGTGCAACGAGATCCTGGCGCGCGCTAAGGTCGAG GGCGCGGACATTGTCGGGCTGTCCGGCCTGATCACGCCGTCGCTCGAGGAAATGGCCTACGTTGCCTCGGAGATGCAGCG CGACGATTACTTCCGCGTGAAGAAGATTCCGCTGCTGATCGGCGGCGCCACCACATCGCGCGTGCATACCGCGGTCAAGA TCGCGCCGAACTATGAAGGCCCGGTGGTCTACGTGCCCGATGCCTCGCGCTCTGTCAGCGTGGCGTCGAACCTCTTGTCT GACGAAGGCGCGGCGAAGTATCTGGACGAGCTGAAGTCCGACTACGACCGCATTCGCACGCAGCACGCCAACAAGAAGGC CACGCCGATGGTGTCGCTGGCCCAGGCGCGCGCCAACAAGACGCCGATCGACTGGAGCGCCTATGTGCCGCCGAAGCCGA AGTTCATCGGCCGCCGCGTGTTCCGCAACTACGATCTGTCCGAACTGGCCAACTACATCGACTGGGGCCCGTTCTTCCAG ACCTGGGACCTGGCCGGCAAATTCCCGGACATCCTAAACGACGAGATCGTCGGCGAATCGGCCCGACGCGTCTTCTCGGA TGGCAAGAGCATGCTGGCTCGCCTGATCCAGGGACGCTGGCTGACGGCCAACGGCGTGATGGCGCTGCTGCCGGCCAATA CGGTCAATGACGACGACGTCGAGATTTATACCGACGAGTCGCGCAGCAAGGTCGCGCTGACCTGGAACAACCTGCGCCAG CAGAGCGAGCGTCCGGTGGTGGATGGGGTGCGTCGCCCGAACCGTTGCCTGGCTGATTTCATCGCGCCGAAGTCGAGCGG CGTGGCCGACTACATTGGCCTGTTCGCGGTCACGGCCGGGATCGGCGTGGACAAGAAGGAGGCGCAGTTCGAGGCCGACC ACGACGACTACAGCGCCATCATGCTCAAGGCGCTGGCCGATCGTCTGGCCGAGGCGTTCGCCGAATGCCTGCACGAGCGC GTGCGCAAGGATCTCTGGGGCTACGACGCCGCAGAGTCGCTGAACAATGATCAGCTCGTCGCCGAGGCGTATCGCGGTAT TCGTCCGGCACCCGGCTATCCGGCGTGCCCGGAGCACACGGTCAAGGCGCCGATGTTCGCGTTCCTCGATGCTGCCGACA TCGGCATGGGCATTACCGAGGGGCTGGCCATGACGCCGGCGGCATCGGTGAGCGGCTTCTACCTGTCGCATCCGGACTCG ACCTACTTCAGCATTGGCAAGATCGGCCAGGACCAGCTCGACGATATGGTGGCCCGTCGCGGCGAGGACCGCCTTACGCT CGAGCGCGCTCTGGCGCCGAACCTGTAG
Upstream 100 bases:
>100_bases AGCGTGGCCAACAAGACGCCACGCACCTGGCCCGGCCAGTATCGCGAAGACACCGCACAATCCGCCGCCTGAAGCCATCG TACGCAAGAGAACAGAAATC
Downstream 100 bases:
>100_bases AAGCTGTAACCAGGTGCAAGAGCCGGGATACCGCGCGCGCGTGGCATCCCGGCTTTTTCATATTTGGCGTCAGCCGTTGA TGGTTGGGGGCAGGCCCGCG
Product: methionine synthase, cobalamine dependent
Products: NA
Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]
Number of amino acids: Translated: 915; Mature: 914
Protein sequence:
>915_residues MSQQNLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDS KAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQGKAVVNSISLKEGEEQFRHHATQIRRYGAASVVMAFDEKG QADTFERKTEICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF RGNDVVREAIHTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADRFKGGGTKREENL AWRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIAARGGRPIEVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSAR VMKQAVAHLLPFIEEEKRLVAEAGGDVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVE GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASNLLS DEGAAKYLDELKSDYDRIRTQHANKKATPMVSLAQARANKTPIDWSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQ TWDLAGKFPDILNDEIVGESARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLRQ QSERPVVDGVRRPNRCLADFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRLAEAFAECLHER VRKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPEHTVKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDS TYFSIGKIGQDQLDDMVARRGEDRLTLERALAPNL
Sequences:
>Translated_915_residues MSQQNLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDS KAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQGKAVVNSISLKEGEEQFRHHATQIRRYGAASVVMAFDEKG QADTFERKTEICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF RGNDVVREAIHTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADRFKGGGTKREENL AWRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIAARGGRPIEVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSAR VMKQAVAHLLPFIEEEKRLVAEAGGDVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVE GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASNLLS DEGAAKYLDELKSDYDRIRTQHANKKATPMVSLAQARANKTPIDWSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQ TWDLAGKFPDILNDEIVGESARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLRQ QSERPVVDGVRRPNRCLADFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRLAEAFAECLHER VRKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPEHTVKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDS TYFSIGKIGQDQLDDMVARRGEDRLTLERALAPNL >Mature_914_residues SQQNLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQQVENGAQIIDINMDEAMLDSK AAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQGKAVVNSISLKEGEEQFRHHATQIRRYGAASVVMAFDEKGQ ADTFERKTEICKRSYDFLVNEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSFR GNDVVREAIHTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATDRLLEIADRFKGGGTKREENLA WRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIAARGGRPIEVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSARV MKQAVAHLLPFIEEEKRLVAEAGGDVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVEG ADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEGPVVYVPDASRSVSVASNLLSD EGAAKYLDELKSDYDRIRTQHANKKATPMVSLAQARANKTPIDWSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQT WDLAGKFPDILNDEIVGESARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLRQQ SERPVVDGVRRPNRCLADFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAIMLKALADRLAEAFAECLHERV RKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPEHTVKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDST YFSIGKIGQDQLDDMVARRGEDRLTLERALAPNL
Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]
COG id: COG1410
COG function: function code E; Methionine synthase I, cobalamin-binding domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pterin-binding domain [H]
Homologues:
Organism=Homo sapiens, GI169790923, Length=920, Percent_Identity=53.4782608695652, Blast_Score=947, Evalue=0.0, Organism=Escherichia coli, GI1790450, Length=922, Percent_Identity=61.7136659436009, Blast_Score=1099, Evalue=0.0, Organism=Caenorhabditis elegans, GI17535405, Length=927, Percent_Identity=53.3980582524272, Blast_Score=931, Evalue=0.0,
Paralogues:
None
Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006158 - InterPro: IPR011005 - InterPro: IPR003759 - InterPro: IPR011822 - InterPro: IPR000489 - InterPro: IPR003726 - InterPro: IPR004223 [H]
Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]
EC number: =2.1.1.13 [H]
Molecular weight: Translated: 100928; Mature: 100797
Theoretical pI: Translated: 4.94; Mature: 4.94
Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50972 PTERIN_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSQQNLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQ CCCCCCCCCCCEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH QVENGAQIIDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQ HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHC GKAVVNSISLKEGEEQFRHHATQIRRYGAASVVMAFDEKGQADTFERKTEICKRSYDFLV CHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH NEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF HHCCCCCHHEEECCCCEEEEECCHHCCCEEEHHHHHHHHHHHCCCCEEECCCCCEEEEEE RGNDVVREAIHTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATD CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHH RLLEIADRFKGGGTKREENLAWRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIA HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH ARGGRPIEVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEEKRLV HCCCCEEHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AEAGGDVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVE HHCCCCEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHCC GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEG CCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECEEEEECCCHHHEEEEEEECCCCCC PVVYVPDASRSVSVASNLLSDEGAAKYLDELKSDYDRIRTQHANKKATPMVSLAQARANK CEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC TPIDWSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQTWDLAGKFPDILNDEIVGES CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCHHHCHHHHCHH ARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLRQ HHHHHHCHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHH QSERPVVDGVRRPNRCLADFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAI HCCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHH MLKALADRLAEAFAECLHERVRKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPEHT HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCH VKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDSTYFSIGKIGQDQLDDMVARR HCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHC GEDRLTLERALAPNL CCCHHHHHHHCCCCC >Mature Secondary Structure SQQNLPPRPMRLSGLEPFTIDDDTLFVNVGERTNVTGSKAFARMILNGQFDEALAVARQ CCCCCCCCCCEECCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH QVENGAQIIDINMDEAMLDSKAAMVRFLNLIASEPDIARVPIMIDSSKWDVIEAGLRCVQ HHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHC GKAVVNSISLKEGEEQFRHHATQIRRYGAASVVMAFDEKGQADTFERKTEICKRSYDFLV CHHHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHH NEVGFPPEDIIFDPNIFAVATGIEEHNNYAVDFIEATRWIKQNLPYAKVSGGVSNVSFSF HHCCCCCHHEEECCCCEEEEECCHHCCCEEEHHHHHHHHHHHCCCCEEECCCCCEEEEEE RGNDVVREAIHTVFLYHAIAAGMDMGIVNAGQLGVYDQLDPELRERVEDVVLNRRDDATD CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHH RLLEIADRFKGGGTKREENLAWRGTPEQPVPVGDRLAHALVHGITTFIVEDTEEVRQQIA HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHH ARGGRPIEVIEGPLMDGMNIVGDLFGAGKMFLPQVVKSARVMKQAVAHLLPFIEEEKRLV HCCCCEEHHHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH AEAGGDVRARGKIVIATVKGDVHDIGKNIVSVVLQCNNFEVVNMGVMVPCNEILARAKVE HHCCCCEEECCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHCC GADIVGLSGLITPSLEEMAYVASEMQRDDYFRVKKIPLLIGGATTSRVHTAVKIAPNYEG CCCEECCCCCCCCCHHHHHHHHHHHCCCCCEEEEECEEEEECCCHHHEEEEEEECCCCCC PVVYVPDASRSVSVASNLLSDEGAAKYLDELKSDYDRIRTQHANKKATPMVSLAQARANK CEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC TPIDWSAYVPPKPKFIGRRVFRNYDLSELANYIDWGPFFQTWDLAGKFPDILNDEIVGES CCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCHHHCHHHHCHH ARRVFSDGKSMLARLIQGRWLTANGVMALLPANTVNDDDVEIYTDESRSKVALTWNNLRQ HHHHHHCHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEHHHHH QSERPVVDGVRRPNRCLADFIAPKSSGVADYIGLFAVTAGIGVDKKEAQFEADHDDYSAI HCCCCHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHH MLKALADRLAEAFAECLHERVRKDLWGYDAAESLNNDQLVAEAYRGIRPAPGYPACPEHT HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCH VKAPMFAFLDAADIGMGITEGLAMTPAASVSGFYLSHPDSTYFSIGKIGQDQLDDMVARR HCCHHHHHHHHHHHCCCHHCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHC GEDRLTLERALAPNL CCCHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12620739 [H]