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The map label for this gene is merA'' [H]

Identifier: 335055594

GI number: 335055594

Start: 2533662

End: 2534519

Strand: Direct

Name: merA'' [H]

Synonym: NA

Alternate gene names: 335055594

Gene position: 2533662-2534519 (Clockwise)

Preceding gene: 94311252

Following gene: 94311254

Centisome position: 64.5

GC content: 68.41

Gene sequence:

>858_bases
TTGGTTCCTCCGTGGTGGCGGTCGAGTTGGCGCAAGCCTTCGCCCGGCGGGCAGCCAGGTCACGATCCTGGCGCGCAGCA
CGCTGTTCTTCCGAGAAGACCGGCCATCGGGGAAGCCGTAACAGACGCCTTCCGCGCCGAGGGCATCGAGGTGCTGGACC
ACACCCAGGCGAGCCACGTTGCCTATGCGGGCGGGGAATTCGTGCTCACCACCGGGCAGGGGGAAGTGCGCGCCGACAAG
CTGCTGGTCGCCACCGGTCGCGCGCCGAACACGCGCAGCCTGAACCTTGAAGCGGCAGGCGTCGAAGTCAATGCGCAGGG
AGCCATCGTCATCGACCGCGCCATGCGCACGAGCGCACCGCACATCTTTGCTGCCGGCGACTGCACCGACCAGCCGCAGT
TCGTCTATGTGGCGGCGGCGGCCGGCACGCGCGCCGCGATCAACATGACCGGCGGCGACGCGGCGCTGGACCTGACGGCG
ATGCCGGCGGTGGTGTTCACCGATCCGCAGGTGGCGACCGTGGGCTACAGCGAGGCGGAAGCGCACCACGACGGCATCGA
GACCGACAGCCGGCTGCTGACGCTCGACAACGTGCCGAGGGCGCTCGCCAACTTCGACACGCGCGGCTTCATCAAGCTGG
TGGCGGAAGCTGGCTCAGGGCGGCTGATCGGCGTACAGGCGGTCGCGCCGGAAGCGGGCGAACTGATCCAGACGGCCGCG
CTGGCGATCCGCCACCGGATGACCGTGCAGGAGCTGGCCGACCAGTTGTTCCCCTACCTGACCATGGTCGAGGGACTGAA
GCTCGCGGCGCAGACCTTCAACAAGGACGTGAAGCAACTGTCCTGTTGCGCCGGATGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:
NA

Sequences:

>Translated_285_residues
MVPPWWRSSWRKPSPGGQPGHDPGAQHAVLPRRPAIGEAVTDAFRAEGIEVLDHTQASHVAYAGGEFVLTTGQGEVRADK
LLVATGRAPNTRSLNLEAAGVEVNAQGAIVIDRAMRTSAPHIFAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTA
MPAVVFTDPQVATVGYSEAEAHHDGIETDSRLLTLDNVPRALANFDTRGFIKLVAEAGSGRLIGVQAVAPEAGELIQTAA
LAIRHRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG
>Mature_285_residues
MVPPWWRSSWRKPSPGGQPGHDPGAQHAVLPRRPAIGEAVTDAFRAEGIEVLDHTQASHVAYAGGEFVLTTGQGEVRADK
LLVATGRAPNTRSLNLEAAGVEVNAQGAIVIDRAMRTSAPHIFAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTA
MPAVVFTDPQVATVGYSEAEAHHDGIETDSRLLTLDNVPRALANFDTRGFIKLVAEAGSGRLIGVQAVAPEAGELIQTAA
LAIRHRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=209, Percent_Identity=32.5358851674641, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI50301238, Length=223, Percent_Identity=29.5964125560538, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI22035672, Length=173, Percent_Identity=34.1040462427746, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1786307, Length=204, Percent_Identity=34.8039215686275, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI87081717, Length=241, Percent_Identity=28.2157676348548, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789915, Length=231, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082354, Length=206, Percent_Identity=25.7281553398058, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32565766, Length=194, Percent_Identity=30.4123711340206, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71983429, Length=114, Percent_Identity=41.2280701754386, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71983419, Length=114, Percent_Identity=41.2280701754386, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17557007, Length=228, Percent_Identity=28.0701754385965, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=200, Percent_Identity=31.5, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6325240, Length=204, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21358499, Length=205, Percent_Identity=33.1707317073171, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17737741, Length=222, Percent_Identity=31.5315315315315, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 30040; Mature: 30040

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPPWWRSSWRKPSPGGQPGHDPGAQHAVLPRRPAIGEAVTDAFRAEGIEVLDHTQASHV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCEE
AYAGGEFVLTTGQGEVRADKLLVATGRAPNTRSLNLEAAGVEVNAQGAIVIDRAMRTSAP
EEECCCEEEECCCCCEEECEEEEEECCCCCCCEEEEEEECEEECCCCEEEEECHHHCCCC
HIFAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQVATVGYSEAE
EEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEHEECCEEEEECCCEEEECCCHHH
AHHDGIETDSRLLTLDNVPRALANFDTRGFIKLVAEAGSGRLIGVQAVAPEAGELIQTAA
HHCCCCCCCCEEEEECCCCHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHH
LAIRHRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVPPWWRSSWRKPSPGGQPGHDPGAQHAVLPRRPAIGEAVTDAFRAEGIEVLDHTQASHV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCCCEE
AYAGGEFVLTTGQGEVRADKLLVATGRAPNTRSLNLEAAGVEVNAQGAIVIDRAMRTSAP
EEECCCEEEECCCCCEEECEEEEEECCCCCCCEEEEEEECEEECCCCEEEEECHHHCCCC
HIFAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTDPQVATVGYSEAE
EEEECCCCCCCCCEEEEEECCCCEEEEEECCCCCEEEHEECCEEEEECCCEEEECCCHHH
AHHDGIETDSRLLTLDNVPRALANFDTRGFIKLVAEAGSGRLIGVQAVAPEAGELIQTAA
HHCCCCCCCCEEEEECCCCHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHHHHHHHH
LAIRHRMTVQELADQLFPYLTMVEGLKLAAQTFNKDVKQLSCCAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8302940 [H]