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The map label for this gene is ispA [H]

Identifier: 93007052

GI number: 93007052

Start: 2734793

End: 2735875

Strand: Direct

Name: ispA [H]

Synonym: Pcryo_2228

Alternate gene names: 93007052

Gene position: 2734793-2735875 (Clockwise)

Preceding gene: 93007047

Following gene: 93007053

Centisome position: 89.38

GC content: 48.01

Gene sequence:

>1083_bases
ATGTGGCATAAGGAATATAATCTATCATGTTACACTAACGATATTTTTATTATTCACCTGATAGAAGGTTGGGTTATGTC
TGTTTCTTCTACGTCGAGCGTTGTTCCTATTAGCTTTATCCCTTTTAATAGCACAGAGCAGTTTCACCATGAGGTGCGCG
CGCAATTAGCCAAAGATATCGAAGTGTTATTTGATTACGCTGAGCTGCCAAGCCCGCTGCTTGACGCTTGCCGCTATGTA
ATGACAGGTACAGGGAAATTGGTACGTCCACTACTGGTTGCCAGCGCTTTTTCCAGCACTTATAGCCATAATGACACAAT
CGCCGATAAAGACAATGCCTTGGCATCTTTGTTAGAAAACGACTCAGATTATGATATGTGCCGCCGTGCAGCGTTGGCGG
TGGAGCTGCTGCATACTTATTCGCTGGTGCATGATGACTTGCCATGTATGGACGATGACGAGCTGCGCCGTGGTCAACCA
ACCGCTCATATCGTCTTTGAAGAATCGACCGCCCTGCTCGCAGGTGACGTATTACAGACGCTAGCCTTTGAAGTATTGAC
GGCGGATCTGCCAACCTTTGCGCCTTTTGATTCCGCTATCGCAAGTCAGTTATTTGCTATCTTTGCCCCGCGTGCACGGC
GCATGGTATCGGGTCAAATGCTTGATCTCAATGCTGAAGCCACTACTGGGATTTCGCAAAACGATTTAGAAGCCATTCAC
CGTGATAAAACCGGCGCATTAATTGAAGCGGCGATGTTGATGGGCGGTATCTGTGCTGGCGCGACGGCTCCGCAGCGCAT
GGCTCTACAAGAGTGTGCACAGCATATCGGTCTCGCCTTTCAGGTTCAGGACGATATTCTAGACGTAACGACCTCTACTG
ATACGCTTGGTAAACCTGCCGGCAGTGATGAAAAGTTAGACAAATCTACTTATGTAAAGTTAATGGGTGTCAATAATGCG
ACCAGCTATGCGCAATCGCTATTTGATGACGGGCGTGCAGCCATTTCTCGTGAGCTTGACGACAGCTCAGACACTGATGC
GCTGATGGCACTTATCGAATGGCTTTGGGCACGTAAGAAATAG

Upstream 100 bases:

>100_bases
TGCATTATTTCATGCCGCTTTTCATATTAAGCTTTCTGTTTTTGATCTCAAACCTTCTATTTTTAATATACAACTTTAAA
AAATACATTAGGGATTATGT

Downstream 100 bases:

>100_bases
CTAAATAAGGAATAAGCTTAGAAACAACACGCCCAATATTTTAATCATTAAAAACAGCAAAGGGTGATCAACATGGATAG
TGCCCCTACTCCGCGTATTT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MWHKEYNLSCYTNDIFIIHLIEGWVMSVSSTSSVVPISFIPFNSTEQFHHEVRAQLAKDIEVLFDYAELPSPLLDACRYV
MTGTGKLVRPLLVASAFSSTYSHNDTIADKDNALASLLENDSDYDMCRRAALAVELLHTYSLVHDDLPCMDDDELRRGQP
TAHIVFEESTALLAGDVLQTLAFEVLTADLPTFAPFDSAIASQLFAIFAPRARRMVSGQMLDLNAEATTGISQNDLEAIH
RDKTGALIEAAMLMGGICAGATAPQRMALQECAQHIGLAFQVQDDILDVTTSTDTLGKPAGSDEKLDKSTYVKLMGVNNA
TSYAQSLFDDGRAAISRELDDSSDTDALMALIEWLWARKK

Sequences:

>Translated_360_residues
MWHKEYNLSCYTNDIFIIHLIEGWVMSVSSTSSVVPISFIPFNSTEQFHHEVRAQLAKDIEVLFDYAELPSPLLDACRYV
MTGTGKLVRPLLVASAFSSTYSHNDTIADKDNALASLLENDSDYDMCRRAALAVELLHTYSLVHDDLPCMDDDELRRGQP
TAHIVFEESTALLAGDVLQTLAFEVLTADLPTFAPFDSAIASQLFAIFAPRARRMVSGQMLDLNAEATTGISQNDLEAIH
RDKTGALIEAAMLMGGICAGATAPQRMALQECAQHIGLAFQVQDDILDVTTSTDTLGKPAGSDEKLDKSTYVKLMGVNNA
TSYAQSLFDDGRAAISRELDDSSDTDALMALIEWLWARKK
>Mature_360_residues
MWHKEYNLSCYTNDIFIIHLIEGWVMSVSSTSSVVPISFIPFNSTEQFHHEVRAQLAKDIEVLFDYAELPSPLLDACRYV
MTGTGKLVRPLLVASAFSSTYSHNDTIADKDNALASLLENDSDYDMCRRAALAVELLHTYSLVHDDLPCMDDDELRRGQP
TAHIVFEESTALLAGDVLQTLAFEVLTADLPTFAPFDSAIASQLFAIFAPRARRMVSGQMLDLNAEATTGISQNDLEAIH
RDKTGALIEAAMLMGGICAGATAPQRMALQECAQHIGLAFQVQDDILDVTTSTDTLGKPAGSDEKLDKSTYVKLMGVNNA
TSYAQSLFDDGRAAISRELDDSSDTDALMALIEWLWARKK

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=285, Percent_Identity=29.1228070175439, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1786623, Length=300, Percent_Identity=42.6666666666667, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1789578, Length=244, Percent_Identity=27.8688524590164, Blast_Score=95, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17505681, Length=338, Percent_Identity=25.1479289940828, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24651612, Length=246, Percent_Identity=29.2682926829268, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 39540; Mature: 39540

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWHKEYNLSCYTNDIFIIHLIEGWVMSVSSTSSVVPISFIPFNSTEQFHHEVRAQLAKDI
CCCCCCCCEEEECCEEEEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
EVLFDYAELPSPLLDACRYVMTGTGKLVRPLLVASAFSSTYSHNDTIADKDNALASLLEN
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
DSDYDMCRRAALAVELLHTYSLVHDDLPCMDDDELRRGQPTAHIVFEESTALLAGDVLQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCHHHHHHHHHH
LAFEVLTADLPTFAPFDSAIASQLFAIFAPRARRMVSGQMLDLNAEATTGISQNDLEAIH
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCCHHHHHHHH
RDKTGALIEAAMLMGGICAGATAPQRMALQECAQHIGLAFQVQDDILDVTTSTDTLGKPA
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCC
GSDEKLDKSTYVKLMGVNNATSYAQSLFDDGRAAISRELDDSSDTDALMALIEWLWARKK
CCCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MWHKEYNLSCYTNDIFIIHLIEGWVMSVSSTSSVVPISFIPFNSTEQFHHEVRAQLAKDI
CCCCCCCCEEEECCEEEEEEHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
EVLFDYAELPSPLLDACRYVMTGTGKLVRPLLVASAFSSTYSHNDTIADKDNALASLLEN
HHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCC
DSDYDMCRRAALAVELLHTYSLVHDDLPCMDDDELRRGQPTAHIVFEESTALLAGDVLQT
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEECCCHHHHHHHHHH
LAFEVLTADLPTFAPFDSAIASQLFAIFAPRARRMVSGQMLDLNAEATTGISQNDLEAIH
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHCCCCCHHHHHHHH
RDKTGALIEAAMLMGGICAGATAPQRMALQECAQHIGLAFQVQDDILDVTTSTDTLGKPA
CCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCC
GSDEKLDKSTYVKLMGVNNATSYAQSLFDDGRAAISRELDDSSDTDALMALIEWLWARKK
CCCCCCCCCCEEEEEECCCHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]