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The map label for this gene is coaBC [H]

Identifier: 93006942

GI number: 93006942

Start: 2591373

End: 2592764

Strand: Reverse

Name: coaBC [H]

Synonym: Pcryo_2118

Alternate gene names: 93006942

Gene position: 2592764-2591373 (Counterclockwise)

Preceding gene: 93006946

Following gene: 93006941

Centisome position: 84.73

GC content: 47.56

Gene sequence:

>1392_bases
ATGTCAAATATCCTGCTTGCTATCACTGGCGGTATTGCCGCTTATAAATCTGCTGTATTTGCCCGTCTATTAATCAAGGC
AGGCTTTGAGGTGCGCGTCGTTATGACGTCAGGTGCACAGGCTTTTATCACTCCACTAACCCTACAAGCTTTGACGGGTA
ATGAGGTGCATATCTCGTTACTCGATGAAAAAGCGGAAGCGGGCATGGGTCATATTGAGCTTGCAAAATGGGCAGACCTT
ATGGTCATCGCGCCGGCATCTGCCAATACGTTAGCGCGGCTGGCAATGGGTATGGCAGATGATTTACTGACCACGGTCTG
TCTTGCAACGACAGCGCCAGTCATTATCGCGCCTGCGATGAATCAACAGATGTGGGCGCATCCTGCCGTTCACTTAAATG
TGCAAACCCTGCGTGATATGAATTATCAAATCATTGCGCCTGCTAGTGGTGAGCAAGCTTGTGGTGATGTGGGTGCAGGA
CGCTTACCTGAGCCTGAACAGTTATTAGAAGAAATTTTACTGTTTCAAGCAATGCAGACGACGCCTCAGTTATTGGCAGG
TAAAAGAGTCGTGATTACCGCAGGACCGACCGTTGAAGCCATTGACCCGGTGCGTTATTTGTCTAATCATTCTACGGGGA
AAATGGGTTTTGCTTTGGCGCGTGCCTGTGTTGCTGCTGGTGCAGACGTTATCTTGATTGCGGGTGGCAAAGTGGCACTG
CCGACACCGCTCAATGTCACGCGCATTGATGTGTTGTCGGCTAAAGAGATGCTGATAGCAGCCCAGCAGTGCGTGGATGG
TACGCACAGTGCGCTACAGTATGTGCCTGAAGATGAGCACGACCATTCTCACGATCACGATCATAGCCATCAACATGAAC
ATCATGGCGAGTGTGATTGCGGCGATGGTCATAACCACAGCCATGAGATTGATGATAAGGAGCATGCTCATAGCGAGAAT
CAAAATGTAATGGCGGATATCTTTATTGCCACTGCGGCGGTTGCTGATTATCGTACTGAAGAAGCGGCCCCGCAAAAAAT
CAAAAAAACCCAAGATGCCATGACGATAAGCTTGGTCAAAAATCCTGACATTTTAGCGACGATTTCGCTTGCTCATCCTG
AGTTATTTGTCGTTGGCTTTGCAGCAGAAACTCAAGATGTTGAACGTTATGCTCGTGGTAAGCTGCTTTCTAAAGATTTA
GATTTGATTGCTTGTAATGATGTCTCGCGCGCAGATATTGGTTTTGCCAGTGATGATAATGCGATGCAGGTGTTTTTCTC
TGATCGTTATAAGAGTGAAGCTGTGACACTTGAGAAGGCGAGCAAGGATAAAATAGCTGAGCAATTAGTGAGCATCATTG
GCCAGACTTTGGTGCAACGTTTGAATGGCTAA

Upstream 100 bases:

>100_bases
ACTTGCGATGAGATAAATTTAGAAAACTTTCCCTAACTTATCGCATAATTGCTACTATAAGCGCAATTTTATCTTTCAAT
TTTTTGCTGATGCCACGCTT

Downstream 100 bases:

>100_bases
TTGTATAGTCATAAGTAGCCAGCCGCGTATGATACCTTCGACAGGGAAAATATGATGGACATGGTGGGTAGCGATAGTAC
CCAGACGTTTTTACTGATTG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSNILLAITGGIAAYKSAVFARLLIKAGFEVRVVMTSGAQAFITPLTLQALTGNEVHISLLDEKAEAGMGHIELAKWADL
MVIAPASANTLARLAMGMADDLLTTVCLATTAPVIIAPAMNQQMWAHPAVHLNVQTLRDMNYQIIAPASGEQACGDVGAG
RLPEPEQLLEEILLFQAMQTTPQLLAGKRVVITAGPTVEAIDPVRYLSNHSTGKMGFALARACVAAGADVILIAGGKVAL
PTPLNVTRIDVLSAKEMLIAAQQCVDGTHSALQYVPEDEHDHSHDHDHSHQHEHHGECDCGDGHNHSHEIDDKEHAHSEN
QNVMADIFIATAAVADYRTEEAAPQKIKKTQDAMTISLVKNPDILATISLAHPELFVVGFAAETQDVERYARGKLLSKDL
DLIACNDVSRADIGFASDDNAMQVFFSDRYKSEAVTLEKASKDKIAEQLVSIIGQTLVQRLNG

Sequences:

>Translated_463_residues
MSNILLAITGGIAAYKSAVFARLLIKAGFEVRVVMTSGAQAFITPLTLQALTGNEVHISLLDEKAEAGMGHIELAKWADL
MVIAPASANTLARLAMGMADDLLTTVCLATTAPVIIAPAMNQQMWAHPAVHLNVQTLRDMNYQIIAPASGEQACGDVGAG
RLPEPEQLLEEILLFQAMQTTPQLLAGKRVVITAGPTVEAIDPVRYLSNHSTGKMGFALARACVAAGADVILIAGGKVAL
PTPLNVTRIDVLSAKEMLIAAQQCVDGTHSALQYVPEDEHDHSHDHDHSHQHEHHGECDCGDGHNHSHEIDDKEHAHSEN
QNVMADIFIATAAVADYRTEEAAPQKIKKTQDAMTISLVKNPDILATISLAHPELFVVGFAAETQDVERYARGKLLSKDL
DLIACNDVSRADIGFASDDNAMQVFFSDRYKSEAVTLEKASKDKIAEQLVSIIGQTLVQRLNG
>Mature_462_residues
SNILLAITGGIAAYKSAVFARLLIKAGFEVRVVMTSGAQAFITPLTLQALTGNEVHISLLDEKAEAGMGHIELAKWADLM
VIAPASANTLARLAMGMADDLLTTVCLATTAPVIIAPAMNQQMWAHPAVHLNVQTLRDMNYQIIAPASGEQACGDVGAGR
LPEPEQLLEEILLFQAMQTTPQLLAGKRVVITAGPTVEAIDPVRYLSNHSTGKMGFALARACVAAGADVILIAGGKVALP
TPLNVTRIDVLSAKEMLIAAQQCVDGTHSALQYVPEDEHDHSHDHDHSHQHEHHGECDCGDGHNHSHEIDDKEHAHSENQ
NVMADIFIATAAVADYRTEEAAPQKIKKTQDAMTISLVKNPDILATISLAHPELFVVGFAAETQDVERYARGKLLSKDLD
LIACNDVSRADIGFASDDNAMQVFFSDRYKSEAVTLEKASKDKIAEQLVSIIGQTLVQRLNG

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=179, Percent_Identity=33.5195530726257, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI87082301, Length=430, Percent_Identity=45.5813953488372, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17560194, Length=171, Percent_Identity=35.0877192982456, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322762, Length=190, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6322925, Length=109, Percent_Identity=31.1926605504587, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324629, Length=52, Percent_Identity=53.8461538461538, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24657262, Length=189, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 49756; Mature: 49625

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILLAITGGIAAYKSAVFARLLIKAGFEVRVVMTSGAQAFITPLTLQALTGNEVHISL
CCCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEEEECCCEEEEEE
LDEKAEAGMGHIELAKWADLMVIAPASANTLARLAMGMADDLLTTVCLATTAPVIIAPAM
ECCHHHCCCCCEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NQQMWAHPAVHLNVQTLRDMNYQIIAPASGEQACGDVGAGRLPEPEQLLEEILLFQAMQT
CCCHHCCCEEEEEHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHC
TPQLLAGKRVVITAGPTVEAIDPVRYLSNHSTGKMGFALARACVAAGADVILIAGGKVAL
CHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEC
PTPLNVTRIDVLSAKEMLIAAQQCVDGTHSALQYVPEDEHDHSHDHDHSHQHEHHGECDC
CCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDGHNHSHEIDDKEHAHSENQNVMADIFIATAAVADYRTEEAAPQKIKKTQDAMTISLVK
CCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCEEEEEEC
NPDILATISLAHPELFVVGFAAETQDVERYARGKLLSKDLDLIACNDVSRADIGFASDDN
CCCEEEEEEECCCEEEEEEECCCHHHHHHHHHCCHHCCCCCEEEECCCCCCCCCCCCCCC
AMQVFFSDRYKSEAVTLEKASKDKIAEQLVSIIGQTLVQRLNG
CEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNILLAITGGIAAYKSAVFARLLIKAGFEVRVVMTSGAQAFITPLTLQALTGNEVHISL
CCEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEEEECCCEEEEEE
LDEKAEAGMGHIELAKWADLMVIAPASANTLARLAMGMADDLLTTVCLATTAPVIIAPAM
ECCHHHCCCCCEEHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
NQQMWAHPAVHLNVQTLRDMNYQIIAPASGEQACGDVGAGRLPEPEQLLEEILLFQAMQT
CCCHHCCCEEEEEHHHHHCCCEEEEECCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHC
TPQLLAGKRVVITAGPTVEAIDPVRYLSNHSTGKMGFALARACVAAGADVILIAGGKVAL
CHHHHCCCEEEEEECCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEC
PTPLNVTRIDVLSAKEMLIAAQQCVDGTHSALQYVPEDEHDHSHDHDHSHQHEHHGECDC
CCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDGHNHSHEIDDKEHAHSENQNVMADIFIATAAVADYRTEEAAPQKIKKTQDAMTISLVK
CCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCEEEEEEC
NPDILATISLAHPELFVVGFAAETQDVERYARGKLLSKDLDLIACNDVSRADIGFASDDN
CCCEEEEEEECCCEEEEEEECCCHHHHHHHHHCCHHCCCCCEEEECCCCCCCCCCCCCCC
AMQVFFSDRYKSEAVTLEKASKDKIAEQLVSIIGQTLVQRLNG
CEEEEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]