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The map label for this gene is lpxC [H]

Identifier: 93006850

GI number: 93006850

Start: 2489536

End: 2490498

Strand: Reverse

Name: lpxC [H]

Synonym: Pcryo_2026

Alternate gene names: 93006850

Gene position: 2490498-2489536 (Counterclockwise)

Preceding gene: 93006851

Following gene: 93006848

Centisome position: 81.39

GC content: 38.94

Gene sequence:

>963_bases
ATGATACACTATGGCAATTGTAACAAAATATGTGAGAAGACAGTCATGAATCAACGAACCATAAAAACAGCAATTGCTGT
TACAGGTACTGGTCTTCATAGTGGTCAACCTGTTGATTTAGAATTTCATCCGCAACCAATCGATACTGGAATCGTCTTTG
AGCGTTCTGATATTACTGGCAGCACGCCAATTCCTGCCAGTGCCTTTTTGGTACAAGATACCATGATGTCATCTAATCTG
GTGTTTGGTGGTACACGTGTCGGTACGGTTGAGCACTTGCTCAGCGCGATAGCGGGACTTGGCGTTGATAATCTATTAAT
TCGTGTATCGGCATCAGAGATACCTATTATGGATGGCAGTGCTGCGCCTTTTGTAGGACTGTTATTGCAAGCAGGTTTTT
GCGAACAGGATGCTTCAAAGAAATTTATCAGGATTGTACGTACGGTACGTGTCAAAGTTGACGATAAATGGGCAGAGCTA
CGTCCTTATAATGGATTTGAGCTTAATTTCGAGATTGATTTTGATCATCCTGCGATTGATAAAAACTTTCAGCATGCCCA
ATTACAGTTTTCAACCCAAAACTTCATTGAACGGCTGAGTTCAGCACGCACTTTTGGTTTTTTACGTGATATCGAAGCCA
TGCGTCAGAACAATCTGGCATTAGGCGGTAGCATGGACAATGCGATTGTTATCGATGAAAGTAATATTTTGAATGAAGAA
GGTCTGCGTTTTAATGACGAATTTGTTCGTCATAAAATTTTAGATGCACTTGGTGATTTATATCTGATTGGATATCCTAT
TCTGGGTCGTTTTAATGCTTATAAATCCGGTCATGCTTTAAATAACTTATTGGTACGTGAGATTTTATCTGACCATAATA
ACTTTGAAATTGTAACTTTTGATGACAATGTAACATGTCCTATCGAATATTTACCTTTAAATGGTATAACTGTCGAAGGA
TGA

Upstream 100 bases:

>100_bases
GCGACTAAACAGTCACCGATAATAATGCTTCGATAAGTGTTATCAATCAAAGAGATAGGTAAATTAACGCTTTTTATCGC
TAGCGAACAGGGTTCGGGTA

Downstream 100 bases:

>100_bases
ATACAGGAATATACACGAAGTATCGAAACATTTACGCAATATTACATAAAATGGTTATAAGTAGAGTGAAATTATATTCA
TATAAGTGGATATATATTTC

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MIHYGNCNKICEKTVMNQRTIKTAIAVTGTGLHSGQPVDLEFHPQPIDTGIVFERSDITGSTPIPASAFLVQDTMMSSNL
VFGGTRVGTVEHLLSAIAGLGVDNLLIRVSASEIPIMDGSAAPFVGLLLQAGFCEQDASKKFIRIVRTVRVKVDDKWAEL
RPYNGFELNFEIDFDHPAIDKNFQHAQLQFSTQNFIERLSSARTFGFLRDIEAMRQNNLALGGSMDNAIVIDESNILNEE
GLRFNDEFVRHKILDALGDLYLIGYPILGRFNAYKSGHALNNLLVREILSDHNNFEIVTFDDNVTCPIEYLPLNGITVEG

Sequences:

>Translated_320_residues
MIHYGNCNKICEKTVMNQRTIKTAIAVTGTGLHSGQPVDLEFHPQPIDTGIVFERSDITGSTPIPASAFLVQDTMMSSNL
VFGGTRVGTVEHLLSAIAGLGVDNLLIRVSASEIPIMDGSAAPFVGLLLQAGFCEQDASKKFIRIVRTVRVKVDDKWAEL
RPYNGFELNFEIDFDHPAIDKNFQHAQLQFSTQNFIERLSSARTFGFLRDIEAMRQNNLALGGSMDNAIVIDESNILNEE
GLRFNDEFVRHKILDALGDLYLIGYPILGRFNAYKSGHALNNLLVREILSDHNNFEIVTFDDNVTCPIEYLPLNGITVEG
>Mature_320_residues
MIHYGNCNKICEKTVMNQRTIKTAIAVTGTGLHSGQPVDLEFHPQPIDTGIVFERSDITGSTPIPASAFLVQDTMMSSNL
VFGGTRVGTVEHLLSAIAGLGVDNLLIRVSASEIPIMDGSAAPFVGLLLQAGFCEQDASKKFIRIVRTVRVKVDDKWAEL
RPYNGFELNFEIDFDHPAIDKNFQHAQLQFSTQNFIERLSSARTFGFLRDIEAMRQNNLALGGSMDNAIVIDESNILNEE
GLRFNDEFVRHKILDALGDLYLIGYPILGRFNAYKSGHALNNLLVREILSDHNNFEIVTFDDNVTCPIEYLPLNGITVEG

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=297, Percent_Identity=53.1986531986532, Blast_Score=332, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 35505; Mature: 35505

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHYGNCNKICEKTVMNQRTIKTAIAVTGTGLHSGQPVDLEFHPQPIDTGIVFERSDITG
CEEECCHHHHHHHHHHCHHHHEEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCC
STPIPASAFLVQDTMMSSNLVFGGTRVGTVEHLLSAIAGLGVDNLLIRVSASEIPIMDGS
CCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCC
AAPFVGLLLQAGFCEQDASKKFIRIVRTVRVKVDDKWAELRPYNGFELNFEIDFDHPAID
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCHHHCCCCCCEEEEEEEECCCCCCC
KNFQHAQLQFSTQNFIERLSSARTFGFLRDIEAMRQNNLALGGSMDNAIVIDESNILNEE
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCC
GLRFNDEFVRHKILDALGDLYLIGYPILGRFNAYKSGHALNNLLVREILSDHNNFEIVTF
CCCCCHHHHHHHHHHHHCCEEEECCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DDNVTCPIEYLPLNGITVEG
CCCCCCCEEEEECCCEEECC
>Mature Secondary Structure
MIHYGNCNKICEKTVMNQRTIKTAIAVTGTGLHSGQPVDLEFHPQPIDTGIVFERSDITG
CEEECCHHHHHHHHHHCHHHHEEEEEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCCC
STPIPASAFLVQDTMMSSNLVFGGTRVGTVEHLLSAIAGLGVDNLLIRVSASEIPIMDGS
CCCCCCHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCC
AAPFVGLLLQAGFCEQDASKKFIRIVRTVRVKVDDKWAELRPYNGFELNFEIDFDHPAID
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEECCCHHHCCCCCCEEEEEEEECCCCCCC
KNFQHAQLQFSTQNFIERLSSARTFGFLRDIEAMRQNNLALGGSMDNAIVIDESNILNEE
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECCCCCCCC
GLRFNDEFVRHKILDALGDLYLIGYPILGRFNAYKSGHALNNLLVREILSDHNNFEIVTF
CCCCCHHHHHHHHHHHHCCEEEECCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEE
DDNVTCPIEYLPLNGITVEG
CCCCCCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA