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The map label for this gene is luxQ [H]

Identifier: 93006775

GI number: 93006775

Start: 2407127

End: 2408938

Strand: Reverse

Name: luxQ [H]

Synonym: Pcryo_1951

Alternate gene names: 93006775

Gene position: 2408938-2407127 (Counterclockwise)

Preceding gene: 93006776

Following gene: 93006773

Centisome position: 78.73

GC content: 40.45

Gene sequence:

>1812_bases
ATGGAGTCCACCTTGTCTATATCCAACGTACCAGACTTTGATTACCCTATCGCAGAAGATGACGCTGAGCGTATCAATAG
GCTCAAAAAATATCAGGTATTTAATACCAATCAAGAGTCTTCTTTTGCACGTCTGACTGAGCTTGCGAAACTGTTTTTTA
ATGTGCCGATGGTTGCGATTACTTTTATAGATGAGGAAACTCAGTACCTAAAATCTGGTATTGGTTTTGACGAGGTATGT
ACCACGACACGTAATGTGGCTATTTGTAATTATACTATATTGTCTGATAGTATTTTTGTGGTAGCTGATTTGGCAAGCGA
TGAGCGCTTCAATACATATCCATTTGTCGCTCAATGGCCTAAGATACGCTTTTATGCTGGTGCACCCATCATCACGCATG
AAGACGGTAAAAATTATCGTTTTGGCTCTTTATGTTTAATGGATATAGAGCCTCATCATGATTTCAGTGATGAAAAAGCC
AACATACTAGCCCAATTTGCGACGATGGCAGCCGACGCTTTAAAGCTACAAGAGCAGCAGCGTAATGCCAAATATGCCAA
TGAGATGAAGTCAGCGTTTTTGGCCAATATGAGTCATGAGATACGCACACCGATGAATGGTATCATCGGTATGGTTGAGA
TGCTCAGTGACACCATGCTGAGCGTTGAACAAAGAGAATATATCGAGAATATAAAAGTATCAAATGAGCATTTGCTCGCG
ATTATCAATGGTATTTTAGACTTATCAAAAGTCGAAGCCGGTAAAATGACTATCGATTCTATCCCGATGAATCTATCTAG
TCTCTGTAATGAGGTCGTTAGCTTATTTGCTATCAAAGCTCGCCAACGTGGCTTAGTTTTAGACTATCACTATACCGAGT
CACTATCGCCTTATGTTAAAGGGGATCCCGTACGTCTTAAGCAGGTCATGGTAAATTTGGTCAATAATGCGATTAAATTT
ACCCGTGAAGGCGGGCGTGTAACGATTGATGTTAAACATATGCAAGACAATCCTTGTCTAGATAATAAGGATTGCGATCA
CGCTAAAGGAAATAATGATAGTCGTTTAGATTTTGCTATTGATGATAAAAATAGCACAACGATTCATCAAGAAATGACTT
TATGTATTGAGGTTACGGATACAGGCGTCGGTATTAAGTCTGAATCATTAGAGGCGATATTTGATGCTTATGATCAAGCA
AATAAATATACTCATAGGCTTTATGGTGGTACCGGACTTGGCTTGTCTGTTTGTAAGTCTCTAGTGGAGCTAATGGGTGG
CTATATTGAAGTAGATAGCGTAGTCGGTATTGGCACAACCTTTAGAGTATTATTGCCGCTACCGTGTATTGCTGCAGAAG
ATTATGAGATATGGCAAACGGACAATGACTTTACAATAACGTTGCCGAGTGATGAGCTGGTCGGTCATATTCTGTTGGTT
GAGGATGACAGTGTGAACGCGATGATTGCCAAAAAAGCCCTTAATAATGGTGGTCATACGGTCACTCACGTCAATGACGG
GCAACAAGCTATCGAGATATTTGCTTTATATCCTGAGCGTTATGATGTGATTTTGATGGATCATCATATGCCGATTATGG
ATGGGGTACAGGCAACCATCAAACTTCACGAGCTGTATGCTCCTCAAGACTTGCCGCCTATTATTGCGTTGACTGCCAAT
GCAATGGATGGCGAGCGTAAAAAATACCTTGATGTGGGTATGCAGGATTATTGTACAAAGCCTTTCAAACAAGAGCAGCT
GAATGCGTTGGTGCAATATTGGTTGATGCATAAGCAATCATTAGAACAATAA

Upstream 100 bases:

>100_bases
GGTCGTCGTCACCTCAGTAGTTGCCATGCTTATGGTGAGTGAGGCATTACAATTATTGCTTAAGCAGGCGGCTGTTAAAC
CAAGCCTCTGATATGAATTT

Downstream 100 bases:

>100_bases
TTGGCAGTTTAATTCCACCCTTTATTATTCATGACTTATTTGCTAGCCATTAAAAAAGCTTAACCTCTCTCTCTGAGCGG
TTAAGCTTTTTTGTTCTTAC

Product: GAF sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MESTLSISNVPDFDYPIAEDDAERINRLKKYQVFNTNQESSFARLTELAKLFFNVPMVAITFIDEETQYLKSGIGFDEVC
TTTRNVAICNYTILSDSIFVVADLASDERFNTYPFVAQWPKIRFYAGAPIITHEDGKNYRFGSLCLMDIEPHHDFSDEKA
NILAQFATMAADALKLQEQQRNAKYANEMKSAFLANMSHEIRTPMNGIIGMVEMLSDTMLSVEQREYIENIKVSNEHLLA
IINGILDLSKVEAGKMTIDSIPMNLSSLCNEVVSLFAIKARQRGLVLDYHYTESLSPYVKGDPVRLKQVMVNLVNNAIKF
TREGGRVTIDVKHMQDNPCLDNKDCDHAKGNNDSRLDFAIDDKNSTTIHQEMTLCIEVTDTGVGIKSESLEAIFDAYDQA
NKYTHRLYGGTGLGLSVCKSLVELMGGYIEVDSVVGIGTTFRVLLPLPCIAAEDYEIWQTDNDFTITLPSDELVGHILLV
EDDSVNAMIAKKALNNGGHTVTHVNDGQQAIEIFALYPERYDVILMDHHMPIMDGVQATIKLHELYAPQDLPPIIALTAN
AMDGERKKYLDVGMQDYCTKPFKQEQLNALVQYWLMHKQSLEQ

Sequences:

>Translated_603_residues
MESTLSISNVPDFDYPIAEDDAERINRLKKYQVFNTNQESSFARLTELAKLFFNVPMVAITFIDEETQYLKSGIGFDEVC
TTTRNVAICNYTILSDSIFVVADLASDERFNTYPFVAQWPKIRFYAGAPIITHEDGKNYRFGSLCLMDIEPHHDFSDEKA
NILAQFATMAADALKLQEQQRNAKYANEMKSAFLANMSHEIRTPMNGIIGMVEMLSDTMLSVEQREYIENIKVSNEHLLA
IINGILDLSKVEAGKMTIDSIPMNLSSLCNEVVSLFAIKARQRGLVLDYHYTESLSPYVKGDPVRLKQVMVNLVNNAIKF
TREGGRVTIDVKHMQDNPCLDNKDCDHAKGNNDSRLDFAIDDKNSTTIHQEMTLCIEVTDTGVGIKSESLEAIFDAYDQA
NKYTHRLYGGTGLGLSVCKSLVELMGGYIEVDSVVGIGTTFRVLLPLPCIAAEDYEIWQTDNDFTITLPSDELVGHILLV
EDDSVNAMIAKKALNNGGHTVTHVNDGQQAIEIFALYPERYDVILMDHHMPIMDGVQATIKLHELYAPQDLPPIIALTAN
AMDGERKKYLDVGMQDYCTKPFKQEQLNALVQYWLMHKQSLEQ
>Mature_603_residues
MESTLSISNVPDFDYPIAEDDAERINRLKKYQVFNTNQESSFARLTELAKLFFNVPMVAITFIDEETQYLKSGIGFDEVC
TTTRNVAICNYTILSDSIFVVADLASDERFNTYPFVAQWPKIRFYAGAPIITHEDGKNYRFGSLCLMDIEPHHDFSDEKA
NILAQFATMAADALKLQEQQRNAKYANEMKSAFLANMSHEIRTPMNGIIGMVEMLSDTMLSVEQREYIENIKVSNEHLLA
IINGILDLSKVEAGKMTIDSIPMNLSSLCNEVVSLFAIKARQRGLVLDYHYTESLSPYVKGDPVRLKQVMVNLVNNAIKF
TREGGRVTIDVKHMQDNPCLDNKDCDHAKGNNDSRLDFAIDDKNSTTIHQEMTLCIEVTDTGVGIKSESLEAIFDAYDQA
NKYTHRLYGGTGLGLSVCKSLVELMGGYIEVDSVVGIGTTFRVLLPLPCIAAEDYEIWQTDNDFTITLPSDELVGHILLV
EDDSVNAMIAKKALNNGGHTVTHVNDGQQAIEIFALYPERYDVILMDHHMPIMDGVQATIKLHELYAPQDLPPIIALTAN
AMDGERKKYLDVGMQDYCTKPFKQEQLNALVQYWLMHKQSLEQ

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=468, Percent_Identity=31.4102564102564, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI1788713, Length=409, Percent_Identity=32.7628361858191, Blast_Score=179, Evalue=6e-46,
Organism=Escherichia coli, GI1789149, Length=308, Percent_Identity=35.3896103896104, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87081816, Length=449, Percent_Identity=28.0623608017817, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI145693157, Length=275, Percent_Identity=34.1818181818182, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1786912, Length=300, Percent_Identity=24, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=25.1908396946565, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322000, Length=120, Percent_Identity=40, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=44.5945945945946, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 67832; Mature: 67832

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESTLSISNVPDFDYPIAEDDAERINRLKKYQVFNTNQESSFARLTELAKLFFNVPMVAI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
TFIDEETQYLKSGIGFDEVCTTTRNVAICNYTILSDSIFVVADLASDERFNTYPFVAQWP
EEECCHHHHHHHCCCHHHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCEECCC
KIRFYAGAPIITHEDGKNYRFGSLCLMDIEPHHDFSDEKANILAQFATMAADALKLQEQQ
CEEEEECCCEEECCCCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNAKYANEMKSAFLANMSHEIRTPMNGIIGMVEMLSDTMLSVEQREYIENIKVSNEHLLA
HHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IINGILDLSKVEAGKMTIDSIPMNLSSLCNEVVSLFAIKARQRGLVLDYHYTESLSPYVK
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
GDPVRLKQVMVNLVNNAIKFTREGGRVTIDVKHMQDNPCLDNKDCDHAKGNNDSRLDFAI
CCHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
DDKNSTTIHQEMTLCIEVTDTGVGIKSESLEAIFDAYDQANKYTHRLYGGTGLGLSVCKS
ECCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVELMGGYIEVDSVVGIGTTFRVLLPLPCIAAEDYEIWQTDNDFTITLPSDELVGHILLV
HHHHHCCEEEECCEEECCHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCHHHEEEEEEE
EDDSVNAMIAKKALNNGGHTVTHVNDGQQAIEIFALYPERYDVILMDHHMPIMDGVQATI
ECCCCCHHHHHHHHCCCCCEEEEECCCHHEEEEEEECCCCEEEEEEECCCCHHHHHHHHE
KLHELYAPQDLPPIIALTANAMDGERKKYLDVGMQDYCTKPFKQEQLNALVQYWLMHKQS
EEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
LEQ
HCC
>Mature Secondary Structure
MESTLSISNVPDFDYPIAEDDAERINRLKKYQVFNTNQESSFARLTELAKLFFNVPMVAI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
TFIDEETQYLKSGIGFDEVCTTTRNVAICNYTILSDSIFVVADLASDERFNTYPFVAQWP
EEECCHHHHHHHCCCHHHHHHCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCEECCC
KIRFYAGAPIITHEDGKNYRFGSLCLMDIEPHHDFSDEKANILAQFATMAADALKLQEQQ
CEEEEECCCEEECCCCCCEEECCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RNAKYANEMKSAFLANMSHEIRTPMNGIIGMVEMLSDTMLSVEQREYIENIKVSNEHLLA
HHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IINGILDLSKVEAGKMTIDSIPMNLSSLCNEVVSLFAIKARQRGLVLDYHYTESLSPYVK
HHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
GDPVRLKQVMVNLVNNAIKFTREGGRVTIDVKHMQDNPCLDNKDCDHAKGNNDSRLDFAI
CCHHHHHHHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
DDKNSTTIHQEMTLCIEVTDTGVGIKSESLEAIFDAYDQANKYTHRLYGGTGLGLSVCKS
ECCCCCEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LVELMGGYIEVDSVVGIGTTFRVLLPLPCIAAEDYEIWQTDNDFTITLPSDELVGHILLV
HHHHHCCEEEECCEEECCHHHHHHHCCCCCCCCCCEEEECCCCEEEEECCHHHEEEEEEE
EDDSVNAMIAKKALNNGGHTVTHVNDGQQAIEIFALYPERYDVILMDHHMPIMDGVQATI
ECCCCCHHHHHHHHCCCCCEEEEECCCHHEEEEEEECCCCEEEEEEECCCCHHHHHHHHE
KLHELYAPQDLPPIIALTANAMDGERKKYLDVGMQDYCTKPFKQEQLNALVQYWLMHKQS
EEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
LEQ
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]