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The map label for this gene is frmA [H]

Identifier: 93006763

GI number: 93006763

Start: 2392626

End: 2393750

Strand: Reverse

Name: frmA [H]

Synonym: Pcryo_1939

Alternate gene names: 93006763

Gene position: 2393750-2392626 (Counterclockwise)

Preceding gene: 93006766

Following gene: 93006760

Centisome position: 78.23

GC content: 45.78

Gene sequence:

>1125_bases
ATGTCAGATAAATTTATCAAATCAAAAGCCGCCATTGCTTGGGGCCCTAATCAGCCATTATCGATTGAAGAAGTGGACGT
CATGCTACCGCGTAAAGGCGAAGTATTGGTTAAAATCATCGCTAGTGGCGTCTGCCATACCGATGCGTTTACCTTATCTG
GTGAAGACCCAGAAGGTGTATTCCCAGCTATCCTAGGTCATGAAGGTGGCGGTATCGTTGAGCAAATCGGCGAAGGCGTG
ACTAGCGTGCAAGTGGGTGACCATGTCATTCCTTTGTATACTGCAGAGTGCGGCGAATGTAAGTTCTGTACTTCAGGTAA
AACCAACTTATGCTCAGCGGTACGTGAGACCCAAGGTAAAGGCTTAATGCCAGATGGCACCACCCGTTTTTATAAAGACG
GTCAGCCAATCTACCATTATATGGGTTGCTCAACCTTTTCTGAATATACGGTATTGCCAGAGATCTCTTTAGCCAAAGTT
GACGCCAATGCACCATTAGAAAAAGTTTGCTTACTTGGTTGTGGTGTGACCACTGGTCTGGGTGCAGTCATGAATACCGC
TAAGGTTGAAGAAGGCGCGACCGTTGCGGTTTTCGGTCTTGGTGGTATTGGCTTAGCGGCTATTATCGGTGCAAAAATGG
CAAAAGCCAGTCGTATTATCGGTATTGATATTAACGAAGATAAATTTGAGCTCGCCAAAAAGCTTGGCGCAACTGATTGC
ATCAACTCTAAAGATTATGACAAGCCTATCCAAGAGGTCATCGTTGAGATGACTGATGGCGGTGTAGATTACTCATTTGA
GTGTATCGGTAATGTCGATGTTATGCGTTCAGCGCTTGAGTGCTGTCATAAAGGCTGGGGCGAGTCAGTCATCATCGGTG
TCGCTGGTGCAGGCAAAGAAATCTCAACCCGTCCATTCCAGCTAGTAACGGGTCGAGTCTGGCGTGGTTCAGCTTTTGGC
GGCGTCAAAGGTCGCACGGAATTACCCGGCTATGTCGATCGTTATATGCAAGGTGATATTCCATTAAATGACTTTATCAC
TCATACGATGCCATTAGAAAACATCAACGAAGCGTTTGATTTGATGCATAAAGGCGAGAGTATCCGTACGGTTATTCATT
TTTAA

Upstream 100 bases:

>100_bases
GTGTAAAAGATATTTGCAAATATGCTATATTATCATTAGCAGGGAAGTAATATAAAATAATCACACTATTAAAATTCAAC
CATTAAAAAGAGAGACTTTT

Downstream 100 bases:

>100_bases
CTTGTAACAGTTATAAAATTAGTACTATAGACAGAAAAAAGCCGCTCCTATAATACCTATGATAGGAGCGGCTTTTTTCT
GTCTATCTTTTAGTCCTTTT

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSDKFIKSKAAIAWGPNQPLSIEEVDVMLPRKGEVLVKIIASGVCHTDAFTLSGEDPEGVFPAILGHEGGGIVEQIGEGV
TSVQVGDHVIPLYTAECGECKFCTSGKTNLCSAVRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKV
DANAPLEKVCLLGCGVTTGLGAVMNTAKVEEGATVAVFGLGGIGLAAIIGAKMAKASRIIGIDINEDKFELAKKLGATDC
INSKDYDKPIQEVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESVIIGVAGAGKEISTRPFQLVTGRVWRGSAFG
GVKGRTELPGYVDRYMQGDIPLNDFITHTMPLENINEAFDLMHKGESIRTVIHF

Sequences:

>Translated_374_residues
MSDKFIKSKAAIAWGPNQPLSIEEVDVMLPRKGEVLVKIIASGVCHTDAFTLSGEDPEGVFPAILGHEGGGIVEQIGEGV
TSVQVGDHVIPLYTAECGECKFCTSGKTNLCSAVRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKV
DANAPLEKVCLLGCGVTTGLGAVMNTAKVEEGATVAVFGLGGIGLAAIIGAKMAKASRIIGIDINEDKFELAKKLGATDC
INSKDYDKPIQEVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESVIIGVAGAGKEISTRPFQLVTGRVWRGSAFG
GVKGRTELPGYVDRYMQGDIPLNDFITHTMPLENINEAFDLMHKGESIRTVIHF
>Mature_373_residues
SDKFIKSKAAIAWGPNQPLSIEEVDVMLPRKGEVLVKIIASGVCHTDAFTLSGEDPEGVFPAILGHEGGGIVEQIGEGVT
SVQVGDHVIPLYTAECGECKFCTSGKTNLCSAVRETQGKGLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVD
ANAPLEKVCLLGCGVTTGLGAVMNTAKVEEGATVAVFGLGGIGLAAIIGAKMAKASRIIGIDINEDKFELAKKLGATDCI
NSKDYDKPIQEVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESVIIGVAGAGKEISTRPFQLVTGRVWRGSAFGG
VKGRTELPGYVDRYMQGDIPLNDFITHTMPLENINEAFDLMHKGESIRTVIHF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=65.0537634408602, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=52.8301886792453, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=51.4824797843666, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=52.0107238605898, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=51.7333333333333, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI71743840, Length=371, Percent_Identity=50.1347708894879, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=50.1355013550135, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=49.0514905149051, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=49.3112947658402, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI156627571, Length=368, Percent_Identity=24.1847826086957, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=70.7317073170732, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI87082125, Length=369, Percent_Identity=26.2872628726287, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=26.775956284153, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790045, Length=365, Percent_Identity=27.1232876712329, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI87081918, Length=228, Percent_Identity=34.2105263157895, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788073, Length=375, Percent_Identity=25.0666666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=272, Percent_Identity=27.2058823529412, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788407, Length=239, Percent_Identity=28.0334728033473, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=364, Percent_Identity=22.8021978021978, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=373, Percent_Identity=24.9329758713137, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=59.4666666666667, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71997431, Length=377, Percent_Identity=59.1511936339523, Blast_Score=466, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=59.1836734693878, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17562876, Length=369, Percent_Identity=27.3712737127371, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562584, Length=363, Percent_Identity=27.5482093663912, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=267, Percent_Identity=29.5880149812734, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=361, Percent_Identity=27.4238227146814, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=363, Percent_Identity=26.9972451790634, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=373, Percent_Identity=60.0536193029491, Blast_Score=476, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=29.3800539083558, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=389, Percent_Identity=28.7917737789203, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=369, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=371, Percent_Identity=28.3018867924528, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=27.1978021978022, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=362, Percent_Identity=27.9005524861878, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319955, Length=362, Percent_Identity=27.9005524861878, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=229, Percent_Identity=29.2576419213974, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737895, Length=373, Percent_Identity=63.0026809651474, Blast_Score=497, Evalue=1e-141,
Organism=Drosophila melanogaster, GI17137530, Length=349, Percent_Identity=26.9340974212034, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17737897, Length=240, Percent_Identity=27.9166666666667, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39953; Mature: 39822

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKFIKSKAAIAWGPNQPLSIEEVDVMLPRKGEVLVKIIASGVCHTDAFTLSGEDPEGV
CCCCCCCCCEEEEECCCCCCCHHHEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCCC
FPAILGHEGGGIVEQIGEGVTSVQVGDHVIPLYTAECGECKFCTSGKTNLCSAVRETQGK
CCCEECCCCCCHHHHHCCCCEEEEECCEEEEEEECCCCCEEEECCCCHHHHHHHHHHCCC
GLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVDANAPLEKVCLLGCGVTTGL
CCCCCCCCCEECCCCCEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHHHHHCCHHHHH
GAVMNTAKVEEGATVAVFGLGGIGLAAIIGAKMAKASRIIGIDINEDKFELAKKLGATDC
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCC
INSKDYDKPIQEVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESVIIGVAGAGKE
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
ISTRPFQLVTGRVWRGSAFGGVKGRTELPGYVDRYMQGDIPLNDFITHTMPLENINEAFD
CCCCCEEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHH
LMHKGESIRTVIHF
HHHCCCCCEEEECC
>Mature Secondary Structure 
SDKFIKSKAAIAWGPNQPLSIEEVDVMLPRKGEVLVKIIASGVCHTDAFTLSGEDPEGV
CCCCCCCCEEEEECCCCCCCHHHEEEECCCCCHHHHHHHHCCCCCCCEEEECCCCCCCC
FPAILGHEGGGIVEQIGEGVTSVQVGDHVIPLYTAECGECKFCTSGKTNLCSAVRETQGK
CCCEECCCCCCHHHHHCCCCEEEEECCEEEEEEECCCCCEEEECCCCHHHHHHHHHHCCC
GLMPDGTTRFYKDGQPIYHYMGCSTFSEYTVLPEISLAKVDANAPLEKVCLLGCGVTTGL
CCCCCCCCCEECCCCCEEEEECCCCCCCEEECCCCEEEEECCCCCHHHHHHHHCCHHHHH
GAVMNTAKVEEGATVAVFGLGGIGLAAIIGAKMAKASRIIGIDINEDKFELAKKLGATDC
HHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCC
INSKDYDKPIQEVIVEMTDGGVDYSFECIGNVDVMRSALECCHKGWGESVIIGVAGAGKE
CCCCCCCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCCC
ISTRPFQLVTGRVWRGSAFGGVKGRTELPGYVDRYMQGDIPLNDFITHTMPLENINEAFD
CCCCCEEEEECEEECCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHH
LMHKGESIRTVIHF
HHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]