Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 93006548

GI number: 93006548

Start: 2133222

End: 2136008

Strand: Reverse

Name: gyrA [H]

Synonym: Pcryo_1724

Alternate gene names: 93006548

Gene position: 2136008-2133222 (Counterclockwise)

Preceding gene: 93006550

Following gene: 93006547

Centisome position: 69.81

GC content: 45.89

Gene sequence:

>2787_bases
ATGAGCGAATCGGTCAGTCCTATTGCCATTGTGGACGAATTAAAGCAGTCCTATTTGGATTATGCGATGAGCGTGATCGT
CTCGCGCGCGCTGCCTGATGTGCGTGATGGGTTCAAACCAGTACACCGCCGTGTGATGTATGCGATGCATGTATTGTCTA
ATGACTATAACAAAGCCTACAAGAAATCTGCACGTGTGGTCGGCGATGTCATTGGTAAGTATCACCCACATGGCGATAGT
GCCGTCTATGATGCCATCGTACGTATGGCACAGGATTTTAGCTTGCGTTACCCGATGGTTGATGGTCAAGGTAACTTTGG
CTCAATTGATGATGATCCTCCGGCAGCGATGCGTTATACCGAAGTGCGTATGACCAAGTTGACCCATCAAATGCTTGCTG
ACTTGGATAAAGATACCGTCGATTGGGAGGACAACTACGATGGCTCTGAGCGTATGCCAAGCGTGTTGCCTGCGCGTATT
CCTAATTTATTGATTAATGGTGCTACCGGTATTGCAGTTGGTATGGCGACCAATATGGCGCCGCATAACCTGACCGAGGT
TATTAACGCTTGCTTAGCTTATGCTGAAAATCCGCAAATATCTGCTGAAGAGCTGATGTCGCATATCTCAGGTCCTGACT
TCCCGACAGGCGGTATTATCTATGGTCGCGCCGGTATCTTAGATGCTTATCGTACTGGTAAAGGTCGCTTGCATGTACGT
GGTCGATATATTATTGAGCCGATGAGTGAGACGGGTGTCAACCGTGACCGTGAGCGTATTGTTTTCACCGAAGTGCCTTA
TCAAACCAATAAAGCCAAGCTGATTGAGCGTATTGCAGAACTTGTGCGTGACAAAAAAATCGAAGGTATTACCGAGATTC
GTGATGAGTCTGATAAAGACGGCATGCGTATCGCTATTGATTTACGTCGTGGCGAAACAGCGGAAGTGATCGTTAACAAC
TTGTTCCTGCAAACGCCCCTTGAGTCTAGCTTTAGTATCAATATGGTGGCGCTCGATAATGGTCAGCCGAAATTATTGAC
TTTGCGTCAACTGATTGCGGCATTTGTCCGCCATCGTCAAGAAGTGGTAACGCGCCGTACCATTTTTGAGCTCAATAAAG
CCCGTGTCCGTGGTCACTTATTAGAAGGTTTGACCGTTGCACTAGCGAACATTGATGAGATTATTGCGACGATTAAAGCG
TCTGCAAACCGCGGCTTAGCTCGTGAAAACTTACTGAGTAATACTTGGGGGTCAGGTAGTGTTGTAGCGATGCTAACCGC
TGCAGGCAGCCAGTCGGTACGTCCTGACTTTATCGAAGGCGAAGATCCAAAAGCGCCATTTGGTCTGATTAATAATCAAG
AAAGCTATCGCTTATCGCTTGAGCAGGTCAATGCGATTTTAGACATGCAACTACATCGTCTAACGGGTCTTGAGCAAGAT
AAATTAACTGAAGAATACCAAGACTTGTTGCGTGAAATTGCCCATTTAGAATCGATCCTTGGTGATTTTGATAAGCTAAT
GACCATTATCTCAAACGAGATGATTGAAATCCGTGATAATTTTGGTGATGAGCGTCGCACTGATATTATTGATTCGCGTA
TGGACTTTAACCGTGAAGACTTGATCCCAGAGCAAACCGTGGTAATGACGGTATCGCGTACTGGCTATGCCAAAACTCAA
CCCATTGACGACTATGTGGCGCAAAAACGTGGCGGTAAAGGCAAATCAGCGACGGCGATGAAAGAAGACGATGTGATTGA
TCATTTAATCGTGACTTCAACGCACGCAACCGTACTGTGCTTTACCGATACGGGTCGTGTCTTTAGTTTACGTGGTTTTG
AAGTGCCAATTGCCAGCCGCGGCGCCCGTGGTCGTCCACTGGTCAATCTTATTGGCTTAAATGCTGATGAAACGGTCACA
ACGATATTGCCTATCCCAAAAATCGTAGAAGAGTTATCTAGCAAAGGTGAGACATCAGCAGATGTCACACTAGATAGTGA
TGATCTATTAGACGATAGCACGCAAGCAGAGCCGCCTTTTGTATTTTTTGCAACGGCAAATGGTACAGTGAAGCGTGTCG
AGCTGAAACAGTTTGCCAATATTCGCTCGAACGGTTTGATTGCAGTTGGCTTAGAAGAAGGCGATAAATTGGTGAGCGCT
CGTATCACCAATGGTAGCCAAGAGGTCATGCTATTTGCGTCAAGTGGTAAAGCCATTCGTTTTAATGAGACGGATGCTCG
TGCGATGGGTCGTACGGCGAAAGGTGTCCGCGGTATGCGCCTGACTGCTGATGAATTTATCAAATCGTTGGTAGTGATTG
AAGATGACGTCCGCGAAATTTTAATTGCTTGTGAAAACGGCTTTGGCAAACGCACCTTTATTGATGAGTTCAACACGCAA
AATCGTGGCGGTGGCGGTGTTATCGCTATTAAAACTAGCACGCGTAATGGTGCGCTGGTTCGTGCTACCAAGGTGGACTC
TACAGACGATATTATTTTAATTTCAGACAAAGGTACTTTAGTACGTACCCCAGTTGAGCATGTAGCAAGCTCTGGTCGTA
ATACTCAAGGCGTCACGCTGATTCGTTTATCAAAAGATGAAAAACTGGTTGCTATGGCGCGTGTTGAGCACGAAGAGGGT
AACAATGAGCTGATTGATGCAATGAGAGAAGATGGAACGTTTGAAGTAAAAGGTCAAGAACAGATGGATGTTGATGCGGC
GAATAGTGATGCTACAGAGACAGACTTTGATGATACTAGTCATACAGAAACTGACACTGACGAATAA

Upstream 100 bases:

>100_bases
ACTATATTTATTATATAACGGCGCTTTGGTGCCGTTATTGTCGCCCATTATGGCTTAGATATGCCAATGCTAGAGAGTAG
ATGTGAGTGAGGGAGTGTAT

Downstream 100 bases:

>100_bases
CGCTTTTATTAGTTAGCTTTTTGGTCTATTCTTTTATTACCTTTTATAAAAAAAGCCTCTGACGTTATCGTTGGAGGCTT
TGTTTTTTTTCTGTTTTTTA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 928; Mature: 927

Protein sequence:

>928_residues
MSESVSPIAIVDELKQSYLDYAMSVIVSRALPDVRDGFKPVHRRVMYAMHVLSNDYNKAYKKSARVVGDVIGKYHPHGDS
AVYDAIVRMAQDFSLRYPMVDGQGNFGSIDDDPPAAMRYTEVRMTKLTHQMLADLDKDTVDWEDNYDGSERMPSVLPARI
PNLLINGATGIAVGMATNMAPHNLTEVINACLAYAENPQISAEELMSHISGPDFPTGGIIYGRAGILDAYRTGKGRLHVR
GRYIIEPMSETGVNRDRERIVFTEVPYQTNKAKLIERIAELVRDKKIEGITEIRDESDKDGMRIAIDLRRGETAEVIVNN
LFLQTPLESSFSINMVALDNGQPKLLTLRQLIAAFVRHRQEVVTRRTIFELNKARVRGHLLEGLTVALANIDEIIATIKA
SANRGLARENLLSNTWGSGSVVAMLTAAGSQSVRPDFIEGEDPKAPFGLINNQESYRLSLEQVNAILDMQLHRLTGLEQD
KLTEEYQDLLREIAHLESILGDFDKLMTIISNEMIEIRDNFGDERRTDIIDSRMDFNREDLIPEQTVVMTVSRTGYAKTQ
PIDDYVAQKRGGKGKSATAMKEDDVIDHLIVTSTHATVLCFTDTGRVFSLRGFEVPIASRGARGRPLVNLIGLNADETVT
TILPIPKIVEELSSKGETSADVTLDSDDLLDDSTQAEPPFVFFATANGTVKRVELKQFANIRSNGLIAVGLEEGDKLVSA
RITNGSQEVMLFASSGKAIRFNETDARAMGRTAKGVRGMRLTADEFIKSLVVIEDDVREILIACENGFGKRTFIDEFNTQ
NRGGGGVIAIKTSTRNGALVRATKVDSTDDIILISDKGTLVRTPVEHVASSGRNTQGVTLIRLSKDEKLVAMARVEHEEG
NNELIDAMREDGTFEVKGQEQMDVDAANSDATETDFDDTSHTETDTDE

Sequences:

>Translated_928_residues
MSESVSPIAIVDELKQSYLDYAMSVIVSRALPDVRDGFKPVHRRVMYAMHVLSNDYNKAYKKSARVVGDVIGKYHPHGDS
AVYDAIVRMAQDFSLRYPMVDGQGNFGSIDDDPPAAMRYTEVRMTKLTHQMLADLDKDTVDWEDNYDGSERMPSVLPARI
PNLLINGATGIAVGMATNMAPHNLTEVINACLAYAENPQISAEELMSHISGPDFPTGGIIYGRAGILDAYRTGKGRLHVR
GRYIIEPMSETGVNRDRERIVFTEVPYQTNKAKLIERIAELVRDKKIEGITEIRDESDKDGMRIAIDLRRGETAEVIVNN
LFLQTPLESSFSINMVALDNGQPKLLTLRQLIAAFVRHRQEVVTRRTIFELNKARVRGHLLEGLTVALANIDEIIATIKA
SANRGLARENLLSNTWGSGSVVAMLTAAGSQSVRPDFIEGEDPKAPFGLINNQESYRLSLEQVNAILDMQLHRLTGLEQD
KLTEEYQDLLREIAHLESILGDFDKLMTIISNEMIEIRDNFGDERRTDIIDSRMDFNREDLIPEQTVVMTVSRTGYAKTQ
PIDDYVAQKRGGKGKSATAMKEDDVIDHLIVTSTHATVLCFTDTGRVFSLRGFEVPIASRGARGRPLVNLIGLNADETVT
TILPIPKIVEELSSKGETSADVTLDSDDLLDDSTQAEPPFVFFATANGTVKRVELKQFANIRSNGLIAVGLEEGDKLVSA
RITNGSQEVMLFASSGKAIRFNETDARAMGRTAKGVRGMRLTADEFIKSLVVIEDDVREILIACENGFGKRTFIDEFNTQ
NRGGGGVIAIKTSTRNGALVRATKVDSTDDIILISDKGTLVRTPVEHVASSGRNTQGVTLIRLSKDEKLVAMARVEHEEG
NNELIDAMREDGTFEVKGQEQMDVDAANSDATETDFDDTSHTETDTDE
>Mature_927_residues
SESVSPIAIVDELKQSYLDYAMSVIVSRALPDVRDGFKPVHRRVMYAMHVLSNDYNKAYKKSARVVGDVIGKYHPHGDSA
VYDAIVRMAQDFSLRYPMVDGQGNFGSIDDDPPAAMRYTEVRMTKLTHQMLADLDKDTVDWEDNYDGSERMPSVLPARIP
NLLINGATGIAVGMATNMAPHNLTEVINACLAYAENPQISAEELMSHISGPDFPTGGIIYGRAGILDAYRTGKGRLHVRG
RYIIEPMSETGVNRDRERIVFTEVPYQTNKAKLIERIAELVRDKKIEGITEIRDESDKDGMRIAIDLRRGETAEVIVNNL
FLQTPLESSFSINMVALDNGQPKLLTLRQLIAAFVRHRQEVVTRRTIFELNKARVRGHLLEGLTVALANIDEIIATIKAS
ANRGLARENLLSNTWGSGSVVAMLTAAGSQSVRPDFIEGEDPKAPFGLINNQESYRLSLEQVNAILDMQLHRLTGLEQDK
LTEEYQDLLREIAHLESILGDFDKLMTIISNEMIEIRDNFGDERRTDIIDSRMDFNREDLIPEQTVVMTVSRTGYAKTQP
IDDYVAQKRGGKGKSATAMKEDDVIDHLIVTSTHATVLCFTDTGRVFSLRGFEVPIASRGARGRPLVNLIGLNADETVTT
ILPIPKIVEELSSKGETSADVTLDSDDLLDDSTQAEPPFVFFATANGTVKRVELKQFANIRSNGLIAVGLEEGDKLVSAR
ITNGSQEVMLFASSGKAIRFNETDARAMGRTAKGVRGMRLTADEFIKSLVVIEDDVREILIACENGFGKRTFIDEFNTQN
RGGGGVIAIKTSTRNGALVRATKVDSTDDIILISDKGTLVRTPVEHVASSGRNTQGVTLIRLSKDEKLVAMARVEHEEGN
NELIDAMREDGTFEVKGQEQMDVDAANSDATETDFDDTSHTETDTDE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1788562, Length=907, Percent_Identity=53.8037486218302, Blast_Score=972, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=651, Percent_Identity=35.0230414746544, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 102595; Mature: 102464

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVSPIAIVDELKQSYLDYAMSVIVSRALPDVRDGFKPVHRRVMYAMHVLSNDYNKAY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KKSARVVGDVIGKYHPHGDSAVYDAIVRMAQDFSLRYPMVDGQGNFGSIDDDPPAAMRYT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHHHHH
EVRMTKLTHQMLADLDKDTVDWEDNYDGSERMPSVLPARIPNLLINGATGIAVGMATNMA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHCCHHEEECCCCEEEEHCCCCC
PHNLTEVINACLAYAENPQISAEELMSHISGPDFPTGGIIYGRAGILDAYRTGKGRLHVR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCHHHHHHCCCCEEEEC
GRYIIEPMSETGVNRDRERIVFTEVPYQTNKAKLIERIAELVRDKKIEGITEIRDESDKD
CEEEECCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GMRIAIDLRRGETAEVIVNNLFLQTPLESSFSINMVALDNGQPKLLTLRQLIAAFVRHRQ
CCEEEEEECCCCHHHHHHHHHHEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
EVVTRRTIFELNKARVRGHLLEGLTVALANIDEIIATIKASANRGLARENLLSNTWGSGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
VVAMLTAAGSQSVRPDFIEGEDPKAPFGLINNQESYRLSLEQVNAILDMQLHRLTGLEQD
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCHH
KLTEEYQDLLREIAHLESILGDFDKLMTIISNEMIEIRDNFGDERRTDIIDSRMDFNRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHHHHCCCCHHH
LIPEQTVVMTVSRTGYAKTQPIDDYVAQKRGGKGKSATAMKEDDVIDHLIVTSTHATVLC
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEECCCEEEEE
FTDTGRVFSLRGFEVPIASRGARGRPLVNLIGLNADETVTTILPIPKIVEELSSKGETSA
EECCCCEEEECCEECCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCCC
DVTLDSDDLLDDSTQAEPPFVFFATANGTVKRVELKQFANIRSNGLIAVGLEEGDKLVSA
EEEECCHHCCCCCCCCCCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEECCCCEEEEE
RITNGSQEVMLFASSGKAIRFNETDARAMGRTAKGVRGMRLTADEFIKSLVVIEDDVREI
EECCCCCEEEEEECCCCEEEECCCHHHHHCCHHCCCCCCEECHHHHHHHHHHHHHHHHHH
LIACENGFGKRTFIDEFNTQNRGGGGVIAIKTSTRNGALVRATKVDSTDDIILISDKGTL
HHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCE
VRTPVEHVASSGRNTQGVTLIRLSKDEKLVAMARVEHEEGNNELIDAMREDGTFEVKGQE
EECCHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHCCCCHHHHHHHHCCCCEEECCCC
QMDVDAANSDATETDFDDTSHTETDTDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SESVSPIAIVDELKQSYLDYAMSVIVSRALPDVRDGFKPVHRRVMYAMHVLSNDYNKAY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
KKSARVVGDVIGKYHPHGDSAVYDAIVRMAQDFSLRYPMVDGQGNFGSIDDDPPAAMRYT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEECCEECCCCCCCCCCCCCCCHHHHH
EVRMTKLTHQMLADLDKDTVDWEDNYDGSERMPSVLPARIPNLLINGATGIAVGMATNMA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCHHHHHHCCHHEEECCCCEEEEHCCCCC
PHNLTEVINACLAYAENPQISAEELMSHISGPDFPTGGIIYGRAGILDAYRTGKGRLHVR
CCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEECCCCHHHHHHCCCCEEEEC
GRYIIEPMSETGVNRDRERIVFTEVPYQTNKAKLIERIAELVRDKKIEGITEIRDESDKD
CEEEECCHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
GMRIAIDLRRGETAEVIVNNLFLQTPLESSFSINMVALDNGQPKLLTLRQLIAAFVRHRQ
CCEEEEEECCCCHHHHHHHHHHEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
EVVTRRTIFELNKARVRGHLLEGLTVALANIDEIIATIKASANRGLARENLLSNTWGSGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
VVAMLTAAGSQSVRPDFIEGEDPKAPFGLINNQESYRLSLEQVNAILDMQLHRLTGLEQD
EEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHCCCCHH
KLTEEYQDLLREIAHLESILGDFDKLMTIISNEMIEIRDNFGDERRTDIIDSRMDFNRED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCCHHHHHHHHHHCCCCHHH
LIPEQTVVMTVSRTGYAKTQPIDDYVAQKRGGKGKSATAMKEDDVIDHLIVTSTHATVLC
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHEEECCCEEEEE
FTDTGRVFSLRGFEVPIASRGARGRPLVNLIGLNADETVTTILPIPKIVEELSSKGETSA
EECCCCEEEECCEECCCCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCCC
DVTLDSDDLLDDSTQAEPPFVFFATANGTVKRVELKQFANIRSNGLIAVGLEEGDKLVSA
EEEECCHHCCCCCCCCCCCEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEECCCCEEEEE
RITNGSQEVMLFASSGKAIRFNETDARAMGRTAKGVRGMRLTADEFIKSLVVIEDDVREI
EECCCCCEEEEEECCCCEEEECCCHHHHHCCHHCCCCCCEECHHHHHHHHHHHHHHHHHH
LIACENGFGKRTFIDEFNTQNRGGGGVIAIKTSTRNGALVRATKVDSTDDIILISDKGTL
HHHHCCCCCCCHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCEEEEECCCCE
VRTPVEHVASSGRNTQGVTLIRLSKDEKLVAMARVEHEEGNNELIDAMREDGTFEVKGQE
EECCHHHHHHCCCCCCCEEEEEECCCCCEEEHHHHHHCCCCHHHHHHHHCCCCEEECCCC
QMDVDAANSDATETDFDDTSHTETDTDE
CCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]