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The map label for this gene is rnz [H]

Identifier: 93006544

GI number: 93006544

Start: 2129645

End: 2130766

Strand: Reverse

Name: rnz [H]

Synonym: Pcryo_1720

Alternate gene names: 93006544

Gene position: 2130766-2129645 (Counterclockwise)

Preceding gene: 93006545

Following gene: 93006542

Centisome position: 69.64

GC content: 44.65

Gene sequence:

>1122_bases
ATGCTAAAACTCACTTTTTTGGGTACCTCAGCAGGTGTGCCAACCAAGCAACGTAATGTAACGGCGCTTGCCATCGAGTG
CATCAACCCTTATAGCTCAGGGACAAATCAACAGCAAAACAAGAAATCACGGCCGTGGTTATTGATTGATTGCGGTGAAG
GTACGCAGCATCAGCTCTTACATACCAAGTTATCTTTACATCAGTTACAAGCGATTTGCATTACTCATGTGCATGGCGAC
CATTGCTATGGTTTGCCGGGGTTGTTAGCGAGTGCGGCAATGTCAGGACGTACTGCGCCGCTGATACTGCTTGCGCCAAA
AGCGATTGCCACACTGCTTGATGCTCTTATTTTGACTACCAAATTGCACTTTCCATTTGCTATTAACTTTATGGCGATAG
AAGATTTGCTATCTGAGCAAGATAGTAAAAATAAAGCTCAGGTAACTATCAGCTTAGACAATCAACATCAGCTTGAAATT
GATATCACGCCGTTATCGCATCGCGTTCCCTCTTATGGCTTTGGTATCAGCCAGACGATCAGTCATCGCCATCTTGATAA
GGACAAGCTGATAGCAGATAATATTCCAGCCAACGCGCTGTGGGGCAGACTGCAACAGGGCGAAGATGTTATGACCGAAG
ACGGTCGCAAGCTTCGTTCAACAGGTTATGTCGATAATGAGAGTCAGCGTACAAGGGTAGTGGTGGCTGGAGATAACGAT
ACGCCAGAGTGTCTTAACAATGCTATAGCTGATGCGGATTTACTCGTTCATGAAGCTACATATACTCATGAGTTATTGAA
TAAGATTCAGGCAAAAAATCCAGATTTTGATCCAATGCATAGTAGCGCGCAGTTATTGGGTCGATTTGCCCAAGACAATG
GGCTTAAAAACCTAGTTCTCACCCATTTTAGCGCCCGTTATCAGAGCTTTGACAATCCAAATAGCAGCACGCCAAATATG
GCGCATATTCGATTGGATACCGAAAGTGTTTACCAAGGTAATCTATGGCTGGCAGCAGATTTTGACCAATATCTGGTGAA
TGGAACAGCGGAAGAAGTGGGTGATGATATAGGCAGTCGCGTACAGTATTTAGGCTCTGCACGCGACCATAAAAATACAT
GA

Upstream 100 bases:

>100_bases
ATGAATGTACGGCAAATGGCGGACAGATGATTGAAGGCAAAAAAACTATGATATGTCAGTTGCCATAACAGCTCGTAATG
ATAATCAGCAGAGATAAGCG

Downstream 100 bases:

>100_bases
TATGAGTTTTTAAGACTGACTGTCTTCAGCTGCCAATTGGGTCTGTCCTATCCAATAACGACTGAACTGATACGCCACTC
GACCAGAGCGTCCACCGCGT

Product: beta-lactamase-like protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MLKLTFLGTSAGVPTKQRNVTALAIECINPYSSGTNQQQNKKSRPWLLIDCGEGTQHQLLHTKLSLHQLQAICITHVHGD
HCYGLPGLLASAAMSGRTAPLILLAPKAIATLLDALILTTKLHFPFAINFMAIEDLLSEQDSKNKAQVTISLDNQHQLEI
DITPLSHRVPSYGFGISQTISHRHLDKDKLIADNIPANALWGRLQQGEDVMTEDGRKLRSTGYVDNESQRTRVVVAGDND
TPECLNNAIADADLLVHEATYTHELLNKIQAKNPDFDPMHSSAQLLGRFAQDNGLKNLVLTHFSARYQSFDNPNSSTPNM
AHIRLDTESVYQGNLWLAADFDQYLVNGTAEEVGDDIGSRVQYLGSARDHKNT

Sequences:

>Translated_373_residues
MLKLTFLGTSAGVPTKQRNVTALAIECINPYSSGTNQQQNKKSRPWLLIDCGEGTQHQLLHTKLSLHQLQAICITHVHGD
HCYGLPGLLASAAMSGRTAPLILLAPKAIATLLDALILTTKLHFPFAINFMAIEDLLSEQDSKNKAQVTISLDNQHQLEI
DITPLSHRVPSYGFGISQTISHRHLDKDKLIADNIPANALWGRLQQGEDVMTEDGRKLRSTGYVDNESQRTRVVVAGDND
TPECLNNAIADADLLVHEATYTHELLNKIQAKNPDFDPMHSSAQLLGRFAQDNGLKNLVLTHFSARYQSFDNPNSSTPNM
AHIRLDTESVYQGNLWLAADFDQYLVNGTAEEVGDDIGSRVQYLGSARDHKNT
>Mature_373_residues
MLKLTFLGTSAGVPTKQRNVTALAIECINPYSSGTNQQQNKKSRPWLLIDCGEGTQHQLLHTKLSLHQLQAICITHVHGD
HCYGLPGLLASAAMSGRTAPLILLAPKAIATLLDALILTTKLHFPFAINFMAIEDLLSEQDSKNKAQVTISLDNQHQLEI
DITPLSHRVPSYGFGISQTISHRHLDKDKLIADNIPANALWGRLQQGEDVMTEDGRKLRSTGYVDNESQRTRVVVAGDND
TPECLNNAIADADLLVHEATYTHELLNKIQAKNPDFDPMHSSAQLLGRFAQDNGLKNLVLTHFSARYQSFDNPNSSTPNM
AHIRLDTESVYQGNLWLAADFDQYLVNGTAEEVGDDIGSRVQYLGSARDHKNT

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=378, Percent_Identity=28.3068783068783, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=32.4675324675325, Blast_Score=156, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24652403, Length=316, Percent_Identity=26.8987341772152, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 41162; Mature: 41162

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKLTFLGTSAGVPTKQRNVTALAIECINPYSSGTNQQQNKKSRPWLLIDCGEGTQHQLL
CEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCHHCCCCCCEEEEECCCCCHHHHH
HTKLSLHQLQAICITHVHGDHCYGLPGLLASAAMSGRTAPLILLAPKAIATLLDALILTT
HHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHH
KLHFPFAINFMAIEDLLSEQDSKNKAQVTISLDNQHQLEIDITPLSHRVPSYGFGISQTI
HCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCHHCCCCCCCCCHHHHH
SHRHLDKDKLIADNIPANALWGRLQQGEDVMTEDGRKLRSTGYVDNESQRTRVVVAGDND
HHHCCCCCCEEECCCCHHHHHHHHHCCCCHHHCCCCHHHHCCCCCCCCCCEEEEEECCCC
TPECLNNAIADADLLVHEATYTHELLNKIQAKNPDFDPMHSSAQLLGRFAQDNGLKNLVL
CHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
THFSARYQSFDNPNSSTPNMAHIRLDTESVYQGNLWLAADFDQYLVNGTAEEVGDDIGSR
HHHHHHHHCCCCCCCCCCCEEEEEECCHHEEECCEEEEECHHHHHHCCCHHHHHHHHHHH
VQYLGSARDHKNT
HHHHHCCCCCCCC
>Mature Secondary Structure
MLKLTFLGTSAGVPTKQRNVTALAIECINPYSSGTNQQQNKKSRPWLLIDCGEGTQHQLL
CEEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCCCCHHCCCCCCEEEEECCCCCHHHHH
HTKLSLHQLQAICITHVHGDHCYGLPGLLASAAMSGRTAPLILLAPKAIATLLDALILTT
HHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHH
KLHFPFAINFMAIEDLLSEQDSKNKAQVTISLDNQHQLEIDITPLSHRVPSYGFGISQTI
HCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEEECCHHCCCCCCCCCHHHHH
SHRHLDKDKLIADNIPANALWGRLQQGEDVMTEDGRKLRSTGYVDNESQRTRVVVAGDND
HHHCCCCCCEEECCCCHHHHHHHHHCCCCHHHCCCCHHHHCCCCCCCCCCEEEEEECCCC
TPECLNNAIADADLLVHEATYTHELLNKIQAKNPDFDPMHSSAQLLGRFAQDNGLKNLVL
CHHHHHHHHCCHHHHEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
THFSARYQSFDNPNSSTPNMAHIRLDTESVYQGNLWLAADFDQYLVNGTAEEVGDDIGSR
HHHHHHHHCCCCCCCCCCCEEEEEECCHHEEECCEEEEECHHHHHHCCCHHHHHHHHHHH
VQYLGSARDHKNT
HHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA