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The map label for this gene is folE [H]

Identifier: 93006251

GI number: 93006251

Start: 1750981

End: 1751592

Strand: Direct

Name: folE [H]

Synonym: Pcryo_1425

Alternate gene names: 93006251

Gene position: 1750981-1751592 (Clockwise)

Preceding gene: 93006248

Following gene: 93006264

Centisome position: 57.22

GC content: 45.26

Gene sequence:

>612_bases
ATGGCTGCCAAACTTATGAGCAATACTGCAACAATAGCATCAGACTACCAAGAAAGCATCGAATCCTATCGCCAGCTCAT
CGCCTCAACGGGTGAGGACTTGCATCGTCCAGGACTTGAAGACACCCCAACACGTGCTGCCAAAGCATTTGCGCATTTGA
CCAAAGGCTATCATCAAAGCTTAGATGAAGTCGTTAATGACGCTTTGTTTCCATCGACCAACCGTGAGCTGGTATTGGTG
CAAAATATTGAGTTTTATTCATTGTGCGAGCACCATATGTTGCCTTTTCACGGTGTTGCGCACATTGGTTATTTACCAAA
CGGTCAAGTGTTAGGGCTGTCTAAATTTGCTCGTATCGTCGATATGTTTTCTCGTCGCTTGCAAGTTCAAGAAAATTTAA
GCGAACAAATAGCGCAGACGATTATGGATGTGACAGGTTGCCGCGGTGTAGCTGTCGTGATGGATGCCGCTCACATGTGT
ATGATGATGCGCGGTGTCAATAAGCAACACTCTACTACGCGCACAATGTCGATGTTAGGTGAGTATGTACATGACAATCA
AGCGCGCAATGAGTTTTTAGATGCTGTACCGAAGCGTAAACCTGCTTTTTAA

Upstream 100 bases:

>100_bases
TATAATCACAGCCCTCCCAGCTTGCACAATTTTTATAATAATCCTTTACAACCATTGTTTGTAACTAAGGATTTAGCGTT
AAGCTACACCCACATTTTGG

Downstream 100 bases:

>100_bases
TGTTGAAGATTAATATTACCTAGTTATAAAAAGGACGCTCATGCGTCCTTTTCTTGATTATCTTTTTAGTATTTCAAATA
TAGTTCACTGGCCATAATCC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MAAKLMSNTATIASDYQESIESYRQLIASTGEDLHRPGLEDTPTRAAKAFAHLTKGYHQSLDEVVNDALFPSTNRELVLV
QNIEFYSLCEHHMLPFHGVAHIGYLPNGQVLGLSKFARIVDMFSRRLQVQENLSEQIAQTIMDVTGCRGVAVVMDAAHMC
MMMRGVNKQHSTTRTMSMLGEYVHDNQARNEFLDAVPKRKPAF

Sequences:

>Translated_203_residues
MAAKLMSNTATIASDYQESIESYRQLIASTGEDLHRPGLEDTPTRAAKAFAHLTKGYHQSLDEVVNDALFPSTNRELVLV
QNIEFYSLCEHHMLPFHGVAHIGYLPNGQVLGLSKFARIVDMFSRRLQVQENLSEQIAQTIMDVTGCRGVAVVMDAAHMC
MMMRGVNKQHSTTRTMSMLGEYVHDNQARNEFLDAVPKRKPAF
>Mature_202_residues
AAKLMSNTATIASDYQESIESYRQLIASTGEDLHRPGLEDTPTRAAKAFAHLTKGYHQSLDEVVNDALFPSTNRELVLVQ
NIEFYSLCEHHMLPFHGVAHIGYLPNGQVLGLSKFARIVDMFSRRLQVQENLSEQIAQTIMDVTGCRGVAVVMDAAHMCM
MMRGVNKQHSTTRTMSMLGEYVHDNQARNEFLDAVPKRKPAF

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=172, Percent_Identity=52.3255813953488, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI4503949, Length=172, Percent_Identity=52.3255813953488, Blast_Score=194, Evalue=4e-50,
Organism=Homo sapiens, GI66932970, Length=146, Percent_Identity=48.6301369863014, Blast_Score=153, Evalue=1e-37,
Organism=Homo sapiens, GI66932972, Length=135, Percent_Identity=51.8518518518518, Blast_Score=152, Evalue=2e-37,
Organism=Escherichia coli, GI1788476, Length=175, Percent_Identity=36.5714285714286, Blast_Score=97, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=53.9325842696629, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6321706, Length=179, Percent_Identity=48.6033519553073, Blast_Score=185, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24656782, Length=175, Percent_Identity=53.1428571428571, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24656791, Length=175, Percent_Identity=53.1428571428571, Blast_Score=180, Evalue=5e-46,
Organism=Drosophila melanogaster, GI24656796, Length=175, Percent_Identity=53.1428571428571, Blast_Score=180, Evalue=5e-46,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22770; Mature: 22639

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKLMSNTATIASDYQESIESYRQLIASTGEDLHRPGLEDTPTRAAKAFAHLTKGYHQS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LDEVVNDALFPSTNRELVLVQNIEFYSLCEHHMLPFHGVAHIGYLPNGQVLGLSKFARIV
HHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHCCCCCCCEECHHHHHHHH
DMFSRRLQVQENLSEQIAQTIMDVTGCRGVAVVMDAAHMCMMMRGVNKQHSTTRTMSMLG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EYVHDNQARNEFLDAVPKRKPAF
HHHHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AAKLMSNTATIASDYQESIESYRQLIASTGEDLHRPGLEDTPTRAAKAFAHLTKGYHQS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
LDEVVNDALFPSTNRELVLVQNIEFYSLCEHHMLPFHGVAHIGYLPNGQVLGLSKFARIV
HHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHCCCHHHHHHHCCCCCCCEECHHHHHHHH
DMFSRRLQVQENLSEQIAQTIMDVTGCRGVAVVMDAAHMCMMMRGVNKQHSTTRTMSMLG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EYVHDNQARNEFLDAVPKRKPAF
HHHHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA