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The map label for this gene is folB [H]

Identifier: 93006036

GI number: 93006036

Start: 1464283

End: 1464705

Strand: Direct

Name: folB [H]

Synonym: Pcryo_1208

Alternate gene names: 93006036

Gene position: 1464283-1464705 (Clockwise)

Preceding gene: 93006035

Following gene: 93006037

Centisome position: 47.85

GC content: 42.08

Gene sequence:

>423_bases
ATGTTTCATACCCAGTCTGATGTCGTATTTGTAAAAGGCTTAAAAGTAGAGGCAGTGATTGGCGTTTATGAATGGGAGCG
CGCCATTACACAGCCGTTATTAATAGACATCGCAATGGAAACTGATATCAGTCGTGCTGCGGTGTCAGATGATGTAAACG
ATGCGCTAAATTACAAAGAAGTTTGTGATGATGTCAGTGCGTGGTGCCAAGCTATTAAGGCTCAGTTACTTGAACATCTG
GCTGGGCAAATCGCTGATAAATTGCTCGAAAAATATAGCTGCGATAAAATTTCCTTAAGTATTGCTAAGCCTACCGCTAT
TCAACAAGCAGATGCAGTTGGTGTACAAATCACCCGCTATGCCAAAGCCGCATCTAGCGTATCTACCAATCAAGCTAATA
CTAGCTTGTCTGATGATGCATAA

Upstream 100 bases:

>100_bases
AGCAGCTAAAAGCAGCACGCCTACGTGAAGAAGCATTAACGTCTAAATAAATCATCAAATTAAAATAGATAGTAAAAATA
TCATTAACAAGGATGCTTGT

Downstream 100 bases:

>100_bases
AGCCTTGGTTGATTTATTTGAATCACTGATAAGCTGCGATCCTGAAACGCTGCAAGCACAGCCTGTAAAAGCTGTGCTAC
TGGCCTTAGGTAGCAACCAT

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MFHTQSDVVFVKGLKVEAVIGVYEWERAITQPLLIDIAMETDISRAAVSDDVNDALNYKEVCDDVSAWCQAIKAQLLEHL
AGQIADKLLEKYSCDKISLSIAKPTAIQQADAVGVQITRYAKAASSVSTNQANTSLSDDA

Sequences:

>Translated_140_residues
MFHTQSDVVFVKGLKVEAVIGVYEWERAITQPLLIDIAMETDISRAAVSDDVNDALNYKEVCDDVSAWCQAIKAQLLEHL
AGQIADKLLEKYSCDKISLSIAKPTAIQQADAVGVQITRYAKAASSVSTNQANTSLSDDA
>Mature_140_residues
MFHTQSDVVFVKGLKVEAVIGVYEWERAITQPLLIDIAMETDISRAAVSDDVNDALNYKEVCDDVSAWCQAIKAQLLEHL
AGQIADKLLEKYSCDKISLSIAKPTAIQQADAVGVQITRYAKAASSVSTNQANTSLSDDA

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=113, Percent_Identity=38.0530973451327, Blast_Score=85, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 15190; Mature: 15190

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHTQSDVVFVKGLKVEAVIGVYEWERAITQPLLIDIAMETDISRAAVSDDVNDALNYKE
CCCCCCCEEEEECCEEEHHHHHHHHHHHHCCHHHEEEHHHCCCHHHHHHCCHHHHCCHHH
VCDDVSAWCQAIKAQLLEHLAGQIADKLLEKYSCDKISLSIAKPTAIQQADAVGVQITRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
AKAASSVSTNQANTSLSDDA
HHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFHTQSDVVFVKGLKVEAVIGVYEWERAITQPLLIDIAMETDISRAAVSDDVNDALNYKE
CCCCCCCEEEEECCEEEHHHHHHHHHHHHCCHHHEEEHHHCCCHHHHHHCCHHHHCCHHH
VCDDVSAWCQAIKAQLLEHLAGQIADKLLEKYSCDKISLSIAKPTAIQQADAVGVQITRY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
AKAASSVSTNQANTSLSDDA
HHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]