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The map label for this gene is ubiB [C]

Identifier: 93005987

GI number: 93005987

Start: 1404577

End: 1405938

Strand: Direct

Name: ubiB [C]

Synonym: Pcryo_1159

Alternate gene names: 93005987

Gene position: 1404577-1405938 (Clockwise)

Preceding gene: 93005986

Following gene: 93005988

Centisome position: 45.9

GC content: 43.91

Gene sequence:

>1362_bases
ATGAAAATTCATCGTCCGCATTTATTAAAACATACCTTTAATGTCGTTAATCGTGTTCGTCAAACAGCAAGTGTCGCTGG
TTTATCAGCGCTTAGAGTGGCGAAGGGCGAAAAGCCTGATGCCATGCTGTTAAAAGAAACTTTTGAACAACTGGGTACGA
CTTATATCAAAATTGGGCAGTTTATTGCCAGTACGCCGTCATTATTTCCGCGCGAATATGTGCAAGCCTTTCAAAGCTGT
TTGGATCAAACCACGCCATTGTCTTATGCTTATATCGAGCAAGTATTAACAGAAGAGCTAGCTGTTAATGGACTCACACT
TGAAGAGACGTTTGCCTATATTGACTCAAAACCACTGGCTTCCGCTTCTATCGCTCAAGTCCACGCAGCGCGTTTGCATA
ATGGTGATGAAGTTGTATTAAAGGTGCAAAAACCTGGCGTCGAAACCATTATGCAGACGGATTTGGGTGTATTGCATGGC
GTGACAAAGCTGGTTGAATTGTTGATGCCTTCAATGAGATTTGCCAGCATTGCGCCGATTATTGATGAGATTCGTTTGCG
TATGCTTGCGGAGACAGACTTTATCGCTGAGGCACAAAATATTCGTGACTTTCAGCAGTTTTTGGCAGTATCAGGCAATA
CACGCGTGGTGGCACCAAAAGTCTATGAGGCGTACACTACCAAGCGTGTGTTGACCATGAGCCGCTTATACGGTGTCTCT
ATGGTAGATGAAACTTTGATGCGTCAATATTGTACTGATCCTGCCCAAGTGATGGCAGATACGCTCAATACTTGGTTTGC
AAGCCTGATGCTGTGTAATAGTTTCCATGCGGATTTGCATGCGGGTAATTTAATGCTATTAACTGATGGACGTATCGGAT
TTTTAGATTTTGGTATTGTCGGTAAATTGAAGGCTGAAAGCTGGCGCGCTTGCATGGGAATGATGCAAGCCATGCAGGAT
AATGATTATTATGCGATGGCACGCCATATGATAGATATGGAGATGACACATGGTGGTAATCAGGTTGATGTGGTGGCATT
GGGTGATGATTTGCAGCGTATGATGAAGACCATCATGGCAGAGGACAAAGCCTTTACCAGTGGTGTGCCTTTTAATACGA
AAGAGCAGGCGGATGAGCTGAATACAATGATGCTGGAGATAGTTGAGGTCGGTAAGCGTCATGGTATTCATTTTCCGCGT
GATTTTGCTTTATTGACCAAGCAGATGCTCTATTTTGACCGCTTTATGCGTACGCTTGCACCTGATATGGATATGTTTAG
TGATCAGCGCGTGCAGATGTTGGGGCAAGCAGAGAAAAATGAGCAAGAAAATCGTCCAACACTCAATGTTTCGTGGGATT
AA

Upstream 100 bases:

>100_bases
GTCCTGTCTGTAATAGCCTTTCCTAATTTTAATTAATGATTTTTTACCAATTATAATCGCCGATTCTCAAATATCCTTCT
TATGACCACAGTTGTCTTTT

Downstream 100 bases:

>100_bases
ATACTATATTCAATGCTGTTCTAATACTCGTTCATAATTGTTGTTTACTACTTTAACACAAAGGATTGTGTGCTTTTTGC
CACAAAATGGCCCTGTCATG

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MKIHRPHLLKHTFNVVNRVRQTASVAGLSALRVAKGEKPDAMLLKETFEQLGTTYIKIGQFIASTPSLFPREYVQAFQSC
LDQTTPLSYAYIEQVLTEELAVNGLTLEETFAYIDSKPLASASIAQVHAARLHNGDEVVLKVQKPGVETIMQTDLGVLHG
VTKLVELLMPSMRFASIAPIIDEIRLRMLAETDFIAEAQNIRDFQQFLAVSGNTRVVAPKVYEAYTTKRVLTMSRLYGVS
MVDETLMRQYCTDPAQVMADTLNTWFASLMLCNSFHADLHAGNLMLLTDGRIGFLDFGIVGKLKAESWRACMGMMQAMQD
NDYYAMARHMIDMEMTHGGNQVDVVALGDDLQRMMKTIMAEDKAFTSGVPFNTKEQADELNTMMLEIVEVGKRHGIHFPR
DFALLTKQMLYFDRFMRTLAPDMDMFSDQRVQMLGQAEKNEQENRPTLNVSWD

Sequences:

>Translated_453_residues
MKIHRPHLLKHTFNVVNRVRQTASVAGLSALRVAKGEKPDAMLLKETFEQLGTTYIKIGQFIASTPSLFPREYVQAFQSC
LDQTTPLSYAYIEQVLTEELAVNGLTLEETFAYIDSKPLASASIAQVHAARLHNGDEVVLKVQKPGVETIMQTDLGVLHG
VTKLVELLMPSMRFASIAPIIDEIRLRMLAETDFIAEAQNIRDFQQFLAVSGNTRVVAPKVYEAYTTKRVLTMSRLYGVS
MVDETLMRQYCTDPAQVMADTLNTWFASLMLCNSFHADLHAGNLMLLTDGRIGFLDFGIVGKLKAESWRACMGMMQAMQD
NDYYAMARHMIDMEMTHGGNQVDVVALGDDLQRMMKTIMAEDKAFTSGVPFNTKEQADELNTMMLEIVEVGKRHGIHFPR
DFALLTKQMLYFDRFMRTLAPDMDMFSDQRVQMLGQAEKNEQENRPTLNVSWD
>Mature_453_residues
MKIHRPHLLKHTFNVVNRVRQTASVAGLSALRVAKGEKPDAMLLKETFEQLGTTYIKIGQFIASTPSLFPREYVQAFQSC
LDQTTPLSYAYIEQVLTEELAVNGLTLEETFAYIDSKPLASASIAQVHAARLHNGDEVVLKVQKPGVETIMQTDLGVLHG
VTKLVELLMPSMRFASIAPIIDEIRLRMLAETDFIAEAQNIRDFQQFLAVSGNTRVVAPKVYEAYTTKRVLTMSRLYGVS
MVDETLMRQYCTDPAQVMADTLNTWFASLMLCNSFHADLHAGNLMLLTDGRIGFLDFGIVGKLKAESWRACMGMMQAMQD
NDYYAMARHMIDMEMTHGGNQVDVVALGDDLQRMMKTIMAEDKAFTSGVPFNTKEQADELNTMMLEIVEVGKRHGIHFPR
DFALLTKQMLYFDRFMRTLAPDMDMFSDQRVQMLGQAEKNEQENRPTLNVSWD

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=259, Percent_Identity=29.3436293436293, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI41393593, Length=311, Percent_Identity=27.3311897106109, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI217035081, Length=234, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI34147522, Length=275, Percent_Identity=24, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI27363457, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI2367309, Length=395, Percent_Identity=26.0759493670886, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17559152, Length=273, Percent_Identity=29.3040293040293, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI32565180, Length=257, Percent_Identity=27.6264591439689, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323282, Length=259, Percent_Identity=25.8687258687259, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=243, Percent_Identity=28.3950617283951, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6325148, Length=449, Percent_Identity=20.0445434298441, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24662575, Length=414, Percent_Identity=24.8792270531401, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI22024280, Length=255, Percent_Identity=28.2352941176471, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI18859849, Length=276, Percent_Identity=24.6376811594203, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 51169; Mature: 51169

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIHRPHLLKHTFNVVNRVRQTASVAGLSALRVAKGEKPDAMLLKETFEQLGTTYIKIGQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
FIASTPSLFPREYVQAFQSCLDQTTPLSYAYIEQVLTEELAVNGLTLEETFAYIDSKPLA
HHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
SASIAQVHAARLHNGDEVVLKVQKPGVETIMQTDLGVLHGVTKLVELLMPSMRFASIAPI
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IDEIRLRMLAETDFIAEAQNIRDFQQFLAVSGNTRVVAPKVYEAYTTKRVLTMSRLYGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
MVDETLMRQYCTDPAQVMADTLNTWFASLMLCNSFHADLHAGNLMLLTDGRIGFLDFGIV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCC
GKLKAESWRACMGMMQAMQDNDYYAMARHMIDMEMTHGGNQVDVVALGDDLQRMMKTIMA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHH
EDKAFTSGVPFNTKEQADELNTMMLEIVEVGKRHGIHFPRDFALLTKQMLYFDRFMRTLA
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PDMDMFSDQRVQMLGQAEKNEQENRPTLNVSWD
CCHHHHHHHHHHHHHHHHCCHHCCCCEEEECCC
>Mature Secondary Structure
MKIHRPHLLKHTFNVVNRVRQTASVAGLSALRVAKGEKPDAMLLKETFEQLGTTYIKIGQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHH
FIASTPSLFPREYVQAFQSCLDQTTPLSYAYIEQVLTEELAVNGLTLEETFAYIDSKPLA
HHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
SASIAQVHAARLHNGDEVVLKVQKPGVETIMQTDLGVLHGVTKLVELLMPSMRFASIAPI
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
IDEIRLRMLAETDFIAEAQNIRDFQQFLAVSGNTRVVAPKVYEAYTTKRVLTMSRLYGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
MVDETLMRQYCTDPAQVMADTLNTWFASLMLCNSFHADLHAGNLMLLTDGRIGFLDFGIV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEECCCC
GKLKAESWRACMGMMQAMQDNDYYAMARHMIDMEMTHGGNQVDVVALGDDLQRMMKTIMA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHH
EDKAFTSGVPFNTKEQADELNTMMLEIVEVGKRHGIHFPRDFALLTKQMLYFDRFMRTLA
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHC
PDMDMFSDQRVQMLGQAEKNEQENRPTLNVSWD
CCHHHHHHHHHHHHHHHHCCHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]