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The map label for this gene is nrdA [H]

Identifier: 93005950

GI number: 93005950

Start: 1350026

End: 1352302

Strand: Reverse

Name: nrdA [H]

Synonym: Pcryo_1122

Alternate gene names: 93005950

Gene position: 1352302-1350026 (Counterclockwise)

Preceding gene: 93005951

Following gene: 93005949

Centisome position: 44.19

GC content: 46.64

Gene sequence:

>2277_bases
ATGACACATATCGATAAAATCCAAGTAACCAAACGTGATGGACGTTTAGAGCCTATCGAGTTAGATAAAATTCACAAGGT
TATCGAGTGGGCAGCTCACGGTTTAGATAATGTGTCGGTGTCACAAGTGGAGCTAAAATCGCACATTCAGTTTTATGAAG
GTATCAAAACTCGTGATATTCACGAAACCATCATCAAATCTGCCGCTGACCTTATCTCTGAAGATACGCCTGACTATCAG
TATTTAGCTGCGCGTTTGGCTATCTTCCATTTACGTAAAATTGCTTATAATAAATTTACCCCGCCGCACCTGTATGATCA
CGTTAAAAAACTCACTGATGCTGGAAAATACGATCAGCATATCCTAGCGGACTATAGCCGTGCTGAATTTGACGAGTTAG
AAGAGTATCTCGATCACTGGCGCGATATGAACCTTGCTTATGCTGCTGTTGAGCAAATGGCAGGTAAATACCTCGTTCAA
GATCGCGTGAGCAAAACCGTCTTTGAAAGCCCGCAGTTCTTGTACATGCTGGTTGGTATGTGCTTGTTCAGCCGTTACGA
AAAATCAGAGCGTATGAACTATGTGAAGCGTTTCTATGATGCGACTTCAGAATTCAAAATCTCACTACCAACCCCTATCA
TGTCAGGCGTACGTACGCCATCGCGCCAGTTTAGCTCGTGCGTCCTTATCGAATGTGGTGATAGCCTAGACTCTATCAAC
GCGACCACCAGCGCCATCGTACGCTACGTGTCACAGCGTGCTGGTATCGGCATCAACGCTGGTCGCATCCGTGCCCTCGG
TAGCCCTATCCGTGGCGGCGAAGCACAGCATACGGGTTGTATCCCATTCTACAAATTGTTTCAGACAGCCGTTAAATGCT
GCTCACAAGGTGGCGTCCGTGGCGGTGCTGCGACATTATTCTACCCATTATGGCATTTAGAAGTTGAGTCGCTCTTAGTA
TTGAAAAACAACCGTGGCGTCGAAGACAACCGTGTCCGTCATATGGATTATGGCGTACAGTTAAACAAAACGATGTACAC
TCGCCTAATAAAAGGTCAAGACATCTCGCTATTCTCTCCAGGTGATACCCCTGGCTTGTATGATGCTTTCTTTGAAGATC
AAGACAAGTTCGAAGAGCTATACACCAAGTACGAAAATGACCCTGCTATTCGTAGCCGTCAAATCCCAGCAGCAGACTTG
TTCAGTCTAATGATGCAAGAGCGCGCCAGTACGGGTCGTATCTATATCCAAAACGTCGATCATTGCAATACGCATAGCCC
ATTTGACGCGACGGTTGCGCCGATTCGCCAGTCAAACCTATGTATGGAAATCGCCCTACCGACGAAGCCACTGGATAATA
TCAATGACGAAGAAGGCGAAATCGCGCTTTGCACGCTATCAGCGGTCAACTTGGGTAAAGTCGAAAACGTCAGCGATATC
GAAGAACCAGCTGAGCTAATTGTCCGTGCGCTTGATGCCCTGCTTGACTATCAAGACTATCCAGTAAAAGCCGCTCAAAA
CGGCAGCATGCGTCGCCGTACGCTCGGTGTGGGCGTGATTAACTATGCTTATTACCTTGCCAAGAATGGCGTACGCTATT
CAGACGACAGCGCCATTGGTCTGACGCATCAAACCTTTGAAGCATTGCAATTTTATCTCTTGAAAGCGTCAAACAAATTG
GCAAAAGAGCAAGGCGCTTGCCCTGCGTTCAATGAGACGACGTACTCACAAGGTATCTTGCCGATTGATACGTACAAAAA
AGACTTGGATAAAATCTGCCAAGAGCCGCTACATCTCGATTGGGAAACGCTACGTGGCGAGATCACTGAGCACGGTCTAC
GCAACTCTACCCTAACCGCCTTGATGCCGTCTGAGACCTCGAGTCAGATCGCCAACGCCACTAATGGTATCGAGCCACCA
CGCGGTCTGGTCTCTATCAAAGCGTCAAAAGATGGCATCTTGAAGCAAGTCGTGCCTGAGATTAATAAGCTAAAAAATCA
GTATGAGCTACTATGGCAAATGCCAAACAATGATGGTTACCTAAAGCTGGTCGCTGTCATGCAAAAATTCGTTGATCAAA
GTATCTCTGCCAATACCAACTACGATCCTGTTCGTTATGAAGGCGGCCGTGTACCAATGAAGATATTACTAAAAGACTTG
TTAAACGCGTATAAGCTTGGCGTGAAAACTTTGTACTATCATAACACTCGTGATGGTGCGAACGATGCCCAAGCGGATAT
GGAAGATGATTGTGCGGGCGGGGCTTGTAAGATCTAG

Upstream 100 bases:

>100_bases
ATATCGCGTTATAAAGCATGATTGGCGTCCTTACACCGCGCGGCATCACTAATAAGTCATTCAGTAAATAACTATTAAGC
AATCAACTTACGAGGTCAGC

Downstream 100 bases:

>100_bases
GTTTGCAAAAGAAGCTCTTTAAATAGAATTTCTGACGGATGGCGGGTTTTGCTTATTTAGTTAAGCTCGCTATGTTCCAA
TATTGAGACTAGCAGTGAAA

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 758; Mature: 757

Protein sequence:

>758_residues
MTHIDKIQVTKRDGRLEPIELDKIHKVIEWAAHGLDNVSVSQVELKSHIQFYEGIKTRDIHETIIKSAADLISEDTPDYQ
YLAARLAIFHLRKIAYNKFTPPHLYDHVKKLTDAGKYDQHILADYSRAEFDELEEYLDHWRDMNLAYAAVEQMAGKYLVQ
DRVSKTVFESPQFLYMLVGMCLFSRYEKSERMNYVKRFYDATSEFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
ATTSAIVRYVSQRAGIGINAGRIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLV
LKNNRGVEDNRVRHMDYGVQLNKTMYTRLIKGQDISLFSPGDTPGLYDAFFEDQDKFEELYTKYENDPAIRSRQIPAADL
FSLMMQERASTGRIYIQNVDHCNTHSPFDATVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGKVENVSDI
EEPAELIVRALDALLDYQDYPVKAAQNGSMRRRTLGVGVINYAYYLAKNGVRYSDDSAIGLTHQTFEALQFYLLKASNKL
AKEQGACPAFNETTYSQGILPIDTYKKDLDKICQEPLHLDWETLRGEITEHGLRNSTLTALMPSETSSQIANATNGIEPP
RGLVSIKASKDGILKQVVPEINKLKNQYELLWQMPNNDGYLKLVAVMQKFVDQSISANTNYDPVRYEGGRVPMKILLKDL
LNAYKLGVKTLYYHNTRDGANDAQADMEDDCAGGACKI

Sequences:

>Translated_758_residues
MTHIDKIQVTKRDGRLEPIELDKIHKVIEWAAHGLDNVSVSQVELKSHIQFYEGIKTRDIHETIIKSAADLISEDTPDYQ
YLAARLAIFHLRKIAYNKFTPPHLYDHVKKLTDAGKYDQHILADYSRAEFDELEEYLDHWRDMNLAYAAVEQMAGKYLVQ
DRVSKTVFESPQFLYMLVGMCLFSRYEKSERMNYVKRFYDATSEFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
ATTSAIVRYVSQRAGIGINAGRIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLV
LKNNRGVEDNRVRHMDYGVQLNKTMYTRLIKGQDISLFSPGDTPGLYDAFFEDQDKFEELYTKYENDPAIRSRQIPAADL
FSLMMQERASTGRIYIQNVDHCNTHSPFDATVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGKVENVSDI
EEPAELIVRALDALLDYQDYPVKAAQNGSMRRRTLGVGVINYAYYLAKNGVRYSDDSAIGLTHQTFEALQFYLLKASNKL
AKEQGACPAFNETTYSQGILPIDTYKKDLDKICQEPLHLDWETLRGEITEHGLRNSTLTALMPSETSSQIANATNGIEPP
RGLVSIKASKDGILKQVVPEINKLKNQYELLWQMPNNDGYLKLVAVMQKFVDQSISANTNYDPVRYEGGRVPMKILLKDL
LNAYKLGVKTLYYHNTRDGANDAQADMEDDCAGGACKI
>Mature_757_residues
THIDKIQVTKRDGRLEPIELDKIHKVIEWAAHGLDNVSVSQVELKSHIQFYEGIKTRDIHETIIKSAADLISEDTPDYQY
LAARLAIFHLRKIAYNKFTPPHLYDHVKKLTDAGKYDQHILADYSRAEFDELEEYLDHWRDMNLAYAAVEQMAGKYLVQD
RVSKTVFESPQFLYMLVGMCLFSRYEKSERMNYVKRFYDATSEFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSINA
TTSAIVRYVSQRAGIGINAGRIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVRGGAATLFYPLWHLEVESLLVL
KNNRGVEDNRVRHMDYGVQLNKTMYTRLIKGQDISLFSPGDTPGLYDAFFEDQDKFEELYTKYENDPAIRSRQIPAADLF
SLMMQERASTGRIYIQNVDHCNTHSPFDATVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGKVENVSDIE
EPAELIVRALDALLDYQDYPVKAAQNGSMRRRTLGVGVINYAYYLAKNGVRYSDDSAIGLTHQTFEALQFYLLKASNKLA
KEQGACPAFNETTYSQGILPIDTYKKDLDKICQEPLHLDWETLRGEITEHGLRNSTLTALMPSETSSQIANATNGIEPPR
GLVSIKASKDGILKQVVPEINKLKNQYELLWQMPNNDGYLKLVAVMQKFVDQSISANTNYDPVRYEGGRVPMKILLKDLL
NAYKLGVKTLYYHNTRDGANDAQADMEDDCAGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=792, Percent_Identity=29.1666666666667, Blast_Score=248, Evalue=1e-65,
Organism=Escherichia coli, GI2367133, Length=755, Percent_Identity=75.8940397350993, Blast_Score=1221, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=720, Percent_Identity=23.1944444444444, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=791, Percent_Identity=26.9279393173198, Blast_Score=246, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6320914, Length=804, Percent_Identity=28.1094527363184, Blast_Score=249, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6322123, Length=652, Percent_Identity=29.601226993865, Blast_Score=247, Evalue=4e-66,
Organism=Drosophila melanogaster, GI17352481, Length=790, Percent_Identity=27.4683544303797, Blast_Score=255, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85455; Mature: 85324

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHIDKIQVTKRDGRLEPIELDKIHKVIEWAAHGLDNVSVSQVELKSHIQFYEGIKTRDI
CCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHH
HETIIKSAADLISEDTPDYQYLAARLAIFHLRKIAYNKFTPPHLYDHVKKLTDAGKYDQH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
ILADYSRAEFDELEEYLDHWRDMNLAYAAVEQMAGKYLVQDRVSKTVFESPQFLYMLVGM
HHHHCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CLFSRYEKSERMNYVKRFYDATSEFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHCH
ATTSAIVRYVSQRAGIGINAGRIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVR
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHLEVESLLVLKNNRGVEDNRVRHMDYGVQLNKTMYTRLIKGQDISLFSP
CCCHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCEEECHHHHHHHHCCCCEEEECC
GDTPGLYDAFFEDQDKFEELYTKYENDPAIRSRQIPAADLFSLMMQERASTGRIYIQNVD
CCCCCHHHHHHCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDATVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGKVENVSDI
CCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EEPAELIVRALDALLDYQDYPVKAAQNGSMRRRTLGVGVINYAYYLAKNGVRYSDDSAIG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LTHQTFEALQFYLLKASNKLAKEQGACPAFNETTYSQGILPIDTYKKDLDKICQEPLHLD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
WETLRGEITEHGLRNSTLTALMPSETSSQIANATNGIEPPRGLVSIKASKDGILKQVVPE
HHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
INKLKNQYELLWQMPNNDGYLKLVAVMQKFVDQSISANTNYDPVRYEGGRVPMKILLKDL
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHH
LNAYKLGVKTLYYHNTRDGANDAQADMEDDCAGGACKI
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THIDKIQVTKRDGRLEPIELDKIHKVIEWAAHGLDNVSVSQVELKSHIQFYEGIKTRDI
CCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHH
HETIIKSAADLISEDTPDYQYLAARLAIFHLRKIAYNKFTPPHLYDHVKKLTDAGKYDQH
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHH
ILADYSRAEFDELEEYLDHWRDMNLAYAAVEQMAGKYLVQDRVSKTVFESPQFLYMLVGM
HHHHCHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
CLFSRYEKSERMNYVKRFYDATSEFKISLPTPIMSGVRTPSRQFSSCVLIECGDSLDSIN
HHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCCCHHHCCEEEEEECCCCHHCH
ATTSAIVRYVSQRAGIGINAGRIRALGSPIRGGEAQHTGCIPFYKLFQTAVKCCSQGGVR
HHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGAATLFYPLWHLEVESLLVLKNNRGVEDNRVRHMDYGVQLNKTMYTRLIKGQDISLFSP
CCCHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCEEECHHHHHHHHCCCCEEEECC
GDTPGLYDAFFEDQDKFEELYTKYENDPAIRSRQIPAADLFSLMMQERASTGRIYIQNVD
CCCCCHHHHHHCCHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHCCCCCEEEEEECC
HCNTHSPFDATVAPIRQSNLCMEIALPTKPLDNINDEEGEIALCTLSAVNLGKVENVSDI
CCCCCCCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHH
EEPAELIVRALDALLDYQDYPVKAAQNGSMRRRTLGVGVINYAYYLAKNGVRYSDDSAIG
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
LTHQTFEALQFYLLKASNKLAKEQGACPAFNETTYSQGILPIDTYKKDLDKICQEPLHLD
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
WETLRGEITEHGLRNSTLTALMPSETSSQIANATNGIEPPRGLVSIKASKDGILKQVVPE
HHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHH
INKLKNQYELLWQMPNNDGYLKLVAVMQKFVDQSISANTNYDPVRYEGGRVPMKILLKDL
HHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHH
LNAYKLGVKTLYYHNTRDGANDAQADMEDDCAGGACKI
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]