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The map label for this gene is msrAB [H]

Identifier: 93005916

GI number: 93005916

Start: 1311241

End: 1313076

Strand: Direct

Name: msrAB [H]

Synonym: Pcryo_1088

Alternate gene names: 93005916

Gene position: 1311241-1313076 (Clockwise)

Preceding gene: 93005915

Following gene: 93005917

Centisome position: 42.85

GC content: 44.28

Gene sequence:

>1836_bases
ATGCCACATAAAAAAAACCATCATGACGCGAATAATCATAATACTAATAGTCATGAAAATAAGAACGCTAATGATTTAGC
GACAGTCTCACCGCATGCGGTGTCACATTGGTTAAAGAATATCAGTGCGTTTGGTGTCACGACGGTCTTGAGTGCCGGTA
TATTGGTAGCGTGTGGACAGATGAGTAGTGCAGAGAATAACGTCAGTAGTAGCACAAGCAAGCAAAATAGCGGGGTAAAA
AGCTCACGTGATATGTTGCCATCCGATATGCTCAAAACAATGCAAGCATTGCCGCAGTTGACTAAAGGTTTGGGCAAAAA
TGGCGCTGCTGTGATTGACCCTAATAAACCCACCTTGGTTAAGTTTTGGGCGAGCTGGTGCCCATTATGCTTAGGGACTC
TAGCAGAAACTGAAGAATGGCGCACGGATTCTAAATTTTCTGGTTTAAATGTCGTCACTGTGGCAAGTCCCGGTCATCTG
AATGAAAAAGCCGATGGCGAATTCAGCACTTGGTATGCTGGCGTGCAAGCCGATTACCCTAAGCTTCCCGTATTGATTGA
TGCCTCAGGTGAGCTGATTAATACGCTTGGCGTACAGGTTTATCCAAGCTGGGCAATACTCGATAAAAACGGTAATTTGG
TGCATTTGGTCAAAGGTAATATGTCAGCAGAGCAAGCCTATGCCCTTGCTGAGAATGCCAGTAATGATTTTGCTGAACTC
AAAGCTGGTAGTGCTAAGCCTGCAAATGTACAAACATTAGATAACAACAGTAAAATTGAGACTATTAAGCAAAATGATGG
CGTTTATTATAATGACAAAGGTAAGGCGATTAATACCCGCTCAATCTATCTAGCAGGTGGCTGTTTCTGGGGCGTAGAAG
CCTATATGGAGCGAGTCGACGGTGTCGTAGATGCTGTATCAGGTTATGCCAATGGCGACACAGTCAACCCAAGCTATGAG
CAAGTAATCCGTGGTTCAGGGCATGCCGAAGCAGTCAAAGTCACTTATGATGCTGATAAAACGGATCTTGATACGATTTT
AAAATACTATTTCCGCGTGGTTGATCCAACCAGCTTAAACAAGCAAGGTAATGATCGCGGTGTACAGTATCGTTCAGGCG
TTTATTACAGGGACAAAGCAGATAAAGCGGTAGTTGATGCTGCAATTAAGCGTGTACAAAGCCAATATAAGCAAAAGGTA
GTCGTTGAAAACAAAATATTGGACAACTTTTACTTAGCTGAGATGTATCATCAAGATTATCTAGCGAAAAATCCGAATGG
CTATTGCCATGTTGATTTAAGCCTTGCTGATGACAAGCCTGAAGACACGGCACGTACTAAGCTTGCACCAGTAACTACTG
TCGCTGAGACGTTAGATCCTAAGCGTTATGCTGGGTTTGATAAAGGCGCGCTAAAAAATACTTTGACCAAAGCGCAATAT
GATATTACTCAAGATGCAGGCACTGAGCGGGCGTTCAGTCATGAATATGATAACTTGTTTGCACCCGGTGTCTATGTCGA
TGTGGTCAGCGGTGAGCCTTTATTCTTATCAACCGATAAATATGCCTCAGGCTGCGGTTGGCCAAGTTTTACCAAGCCAA
TTGATAAGCAAGTGATTACTCAGCATGACGATACGGCATTTAATATGGTACGTACTGAGATTCGTTCACGAGTGGCGGAT
TCGCATCTGGGTCATGTGTTCCCTGATGGTCCAAAAGACCGTGGCGGTCTGCGTTATTGCATCAATGGCGGGGCATTGCA
GTTTATCCCAGTCAGTGTGATGCCTCAGTCAGGCTATGCGCCATTGGTCAAACTGGTCAAACCTGCGAAACCTTAG

Upstream 100 bases:

>100_bases
AAACCTTTACTCATTCACTTTAACTAATAGCGCAAGAAGATCATAAGCTGCCCTATAACCTTTAGCTTATGGTCGTAAGA
CTTCGTCAAAAGGATCTCTC

Downstream 100 bases:

>100_bases
TAAATAACATGGTTTAATAATTTTATAAAAAAGACGTTAAGAGTATTCTTAGCGTCTTTTTTATAGGTGATAGGCGGCTA
ATCATGTGATGAATACTGCT

Product: trifunctional thioredoxin/methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MPHKKNHHDANNHNTNSHENKNANDLATVSPHAVSHWLKNISAFGVTTVLSAGILVACGQMSSAENNVSSSTSKQNSGVK
SSRDMLPSDMLKTMQALPQLTKGLGKNGAAVIDPNKPTLVKFWASWCPLCLGTLAETEEWRTDSKFSGLNVVTVASPGHL
NEKADGEFSTWYAGVQADYPKLPVLIDASGELINTLGVQVYPSWAILDKNGNLVHLVKGNMSAEQAYALAENASNDFAEL
KAGSAKPANVQTLDNNSKIETIKQNDGVYYNDKGKAINTRSIYLAGGCFWGVEAYMERVDGVVDAVSGYANGDTVNPSYE
QVIRGSGHAEAVKVTYDADKTDLDTILKYYFRVVDPTSLNKQGNDRGVQYRSGVYYRDKADKAVVDAAIKRVQSQYKQKV
VVENKILDNFYLAEMYHQDYLAKNPNGYCHVDLSLADDKPEDTARTKLAPVTTVAETLDPKRYAGFDKGALKNTLTKAQY
DITQDAGTERAFSHEYDNLFAPGVYVDVVSGEPLFLSTDKYASGCGWPSFTKPIDKQVITQHDDTAFNMVRTEIRSRVAD
SHLGHVFPDGPKDRGGLRYCINGGALQFIPVSVMPQSGYAPLVKLVKPAKP

Sequences:

>Translated_611_residues
MPHKKNHHDANNHNTNSHENKNANDLATVSPHAVSHWLKNISAFGVTTVLSAGILVACGQMSSAENNVSSSTSKQNSGVK
SSRDMLPSDMLKTMQALPQLTKGLGKNGAAVIDPNKPTLVKFWASWCPLCLGTLAETEEWRTDSKFSGLNVVTVASPGHL
NEKADGEFSTWYAGVQADYPKLPVLIDASGELINTLGVQVYPSWAILDKNGNLVHLVKGNMSAEQAYALAENASNDFAEL
KAGSAKPANVQTLDNNSKIETIKQNDGVYYNDKGKAINTRSIYLAGGCFWGVEAYMERVDGVVDAVSGYANGDTVNPSYE
QVIRGSGHAEAVKVTYDADKTDLDTILKYYFRVVDPTSLNKQGNDRGVQYRSGVYYRDKADKAVVDAAIKRVQSQYKQKV
VVENKILDNFYLAEMYHQDYLAKNPNGYCHVDLSLADDKPEDTARTKLAPVTTVAETLDPKRYAGFDKGALKNTLTKAQY
DITQDAGTERAFSHEYDNLFAPGVYVDVVSGEPLFLSTDKYASGCGWPSFTKPIDKQVITQHDDTAFNMVRTEIRSRVAD
SHLGHVFPDGPKDRGGLRYCINGGALQFIPVSVMPQSGYAPLVKLVKPAKP
>Mature_610_residues
PHKKNHHDANNHNTNSHENKNANDLATVSPHAVSHWLKNISAFGVTTVLSAGILVACGQMSSAENNVSSSTSKQNSGVKS
SRDMLPSDMLKTMQALPQLTKGLGKNGAAVIDPNKPTLVKFWASWCPLCLGTLAETEEWRTDSKFSGLNVVTVASPGHLN
EKADGEFSTWYAGVQADYPKLPVLIDASGELINTLGVQVYPSWAILDKNGNLVHLVKGNMSAEQAYALAENASNDFAELK
AGSAKPANVQTLDNNSKIETIKQNDGVYYNDKGKAINTRSIYLAGGCFWGVEAYMERVDGVVDAVSGYANGDTVNPSYEQ
VIRGSGHAEAVKVTYDADKTDLDTILKYYFRVVDPTSLNKQGNDRGVQYRSGVYYRDKADKAVVDAAIKRVQSQYKQKVV
VENKILDNFYLAEMYHQDYLAKNPNGYCHVDLSLADDKPEDTARTKLAPVTTVAETLDPKRYAGFDKGALKNTLTKAQYD
ITQDAGTERAFSHEYDNLFAPGVYVDVVSGEPLFLSTDKYASGCGWPSFTKPIDKQVITQHDDTAFNMVRTEIRSRVADS
HLGHVFPDGPKDRGGLRYCINGGALQFIPVSVMPQSGYAPLVKLVKPAKP

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=126, Percent_Identity=46.8253968253968, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI301336162, Length=126, Percent_Identity=46.8253968253968, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI73089054, Length=126, Percent_Identity=46.8253968253968, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI37620216, Length=125, Percent_Identity=47.2, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI6912516, Length=161, Percent_Identity=37.888198757764, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=39.2156862745098, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=40.7692307692308, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI208609993, Length=151, Percent_Identity=36.4238410596026, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1788077, Length=118, Percent_Identity=44.9152542372881, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=37.8378378378378, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17553450, Length=118, Percent_Identity=38.9830508474576, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115532676, Length=118, Percent_Identity=38.9830508474576, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=156, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319816, Length=124, Percent_Identity=32.258064516129, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=44.3548387096774, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=44.3548387096774, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24645799, Length=124, Percent_Identity=44.3548387096774, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221378664, Length=124, Percent_Identity=44.3548387096774, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=41.9847328244275, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=40.7407407407407, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645801, Length=135, Percent_Identity=40.7407407407407, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 66740; Mature: 66609

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHKKNHHDANNHNTNSHENKNANDLATVSPHAVSHWLKNISAFGVTTVLSAGILVACGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
MSSAENNVSSSTSKQNSGVKSSRDMLPSDMLKTMQALPQLTKGLGKNGAAVIDPNKPTLV
CCCCCCCCCCCCCHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHH
KFWASWCPLCLGTLAETEEWRTDSKFSGLNVVTVASPGHLNEKADGEFSTWYAGVQADYP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCCC
KLPVLIDASGELINTLGVQVYPSWAILDKNGNLVHLVKGNMSAEQAYALAENASNDFAEL
CCCEEEECCCHHHHHCCCEEECCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHHH
KAGSAKPANVQTLDNNSKIETIKQNDGVYYNDKGKAINTRSIYLAGGCFWGVEAYMERVD
CCCCCCCCCEEEECCCCCEEEEECCCCEEECCCCCEEECEEEEEECCHHHHHHHHHHHHH
GVVDAVSGYANGDTVNPSYEQVIRGSGHAEAVKVTYDADKTDLDTILKYYFRVVDPTSLN
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
KQGNDRGVQYRSGVYYRDKADKAVVDAAIKRVQSQYKQKVVVENKILDNFYLAEMYHQDY
CCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKNPNGYCHVDLSLADDKPEDTARTKLAPVTTVAETLDPKRYAGFDKGALKNTLTKAQY
HHCCCCCEEEEEEEECCCCCCHHHHHCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHH
DITQDAGTERAFSHEYDNLFAPGVYVDVVSGEPLFLSTDKYASGCGWPSFTKPIDKQVIT
CCHHCCCCCHHHHCCCCCEECCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
QHDDTAFNMVRTEIRSRVADSHLGHVFPDGPKDRGGLRYCINGGALQFIPVSVMPQSGYA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEEEEEEECCCCCH
PLVKLVKPAKP
HHHHHHCCCCC
>Mature Secondary Structure 
PHKKNHHDANNHNTNSHENKNANDLATVSPHAVSHWLKNISAFGVTTVLSAGILVACGQ
CCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCHHEEECC
MSSAENNVSSSTSKQNSGVKSSRDMLPSDMLKTMQALPQLTKGLGKNGAAVIDPNKPTLV
CCCCCCCCCCCCCHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHH
KFWASWCPLCLGTLAETEEWRTDSKFSGLNVVTVASPGHLNEKADGEFSTWYAGVQADYP
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCCC
KLPVLIDASGELINTLGVQVYPSWAILDKNGNLVHLVKGNMSAEQAYALAENASNDFAEL
CCCEEEECCCHHHHHCCCEEECCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCHHHH
KAGSAKPANVQTLDNNSKIETIKQNDGVYYNDKGKAINTRSIYLAGGCFWGVEAYMERVD
CCCCCCCCCEEEECCCCCEEEEECCCCEEECCCCCEEECEEEEEECCHHHHHHHHHHHHH
GVVDAVSGYANGDTVNPSYEQVIRGSGHAEAVKVTYDADKTDLDTILKYYFRVVDPTSLN
HHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCC
KQGNDRGVQYRSGVYYRDKADKAVVDAAIKRVQSQYKQKVVVENKILDNFYLAEMYHQDY
CCCCCCCCEEECCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKNPNGYCHVDLSLADDKPEDTARTKLAPVTTVAETLDPKRYAGFDKGALKNTLTKAQY
HHCCCCCEEEEEEEECCCCCCHHHHHCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHH
DITQDAGTERAFSHEYDNLFAPGVYVDVVSGEPLFLSTDKYASGCGWPSFTKPIDKQVIT
CCHHCCCCCHHHHCCCCCEECCCEEEEEECCCEEEEECCCCCCCCCCCCCCCCHHHHHHH
QHDDTAFNMVRTEIRSRVADSHLGHVFPDGPKDRGGLRYCINGGALQFIPVSVMPQSGYA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCEEEEEEEEEECCCCCH
PLVKLVKPAKP
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]