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The map label for this gene is ilvD [H]

Identifier: 93005902

GI number: 93005902

Start: 1292894

End: 1294804

Strand: Reverse

Name: ilvD [H]

Synonym: Pcryo_1074

Alternate gene names: 93005902

Gene position: 1294804-1292894 (Counterclockwise)

Preceding gene: 93005903

Following gene: 93005901

Centisome position: 42.32

GC content: 49.35

Gene sequence:

>1911_bases
ATGGATTACAATTCAAAAACCTCTACCGGCGGTCGTAATATGGCAGGTGCTCGTGCCCTGTGGCGCGCAACTGGCATGAC
TGATGGCGACTTTGGCAAACCTATTATTGCAATTGCCAACTCTTTTACCCAGTTTGTACCCGGCCATGTGCATTTAAAAG
ATTTGGGACAAATGGTTGCACGCGAGATTGAAAAAGCGGGTGGCGTGGCAAAAGAATTTAATACCATTGCTGTTGATGAT
GGTATTGCCATGGGTCATAGCGGCATGTTGTATTCACTACCGAGTCGAGATTTGATTGCTGATTCTGTCGAGTATATGGT
CAATGCCCACTGCGCCGATGCGCTAGTATGTATTTCTAACTGCGATAAAATCACTCCGGGTATGTTGATGGCAGCCATGC
GCCTCAATATCCCCGTCGTCTTTATTTCAGGTGGCCCAATGGAAGCGGGTAAAATTATCGCCAGCACGGTCGCACACAGT
CATAATAATGATGGTAGTAGCGACGTCCATAGCACTGACAGTAAAGGTAATGCCATTCGTAAGCTTGACCTCGTTGATGC
GATGATGGACGCGGCCGATGATAGCATTAGTGATGAAGATGTCGCTGCTATTGAGGCCTCAGCGTGCCCGACTTGTGGGT
CGTGCTCTGGCATGTTCACTGCCAACTCGATGAATTGCTTGACCGAAGCATTAGGATTGGCATTACCGGGTAATGGCTCG
CTATTGGCAACCCATTCGCTACGTCGCGAGCTATTCCTAGAAGCGGGTCGTACTATCGTGTCACTAGCCAAACGTCGCTA
CGAGCAAGATGATGATTCAGTCCTACCGCGCTCTATCGCTACTAAAGCCGCGTTTGAAAATGCCATGACTTTAGACATCG
CCATGGGCGGCTCTACCAATACTATTTTGCATTTGCTTGCTGCTGCACATGAAGCCGAAGTCGACTTCAAAATGCACGAT
ATTGACCGTTTAAGTCGTGGCGTCCCTTGTTTGGCTAAAGTTGCCCCTGCTTCACAAAAGTATCATATGGAAGATGTGCA
TCGTGCTGGTGGTGTCTTTGCGCTATTGGCCGAGCTTGACCGTGCTGGTTTGCTGCATACCGATTTGCCAACTATCCATA
GTGCCACGATGAAAGAAGCGATTGATAAATGGGATATTATGAATCCTGACAATCTTGAAGCACGTGCACGCTATATTGCA
GCCCCTGGTGGCGTACGGACGACTGAGGCTTTCTCACAATCAAAAGAATGGTCAAATCTGGATGTGAACCGAGAGTCAGG
CTGTATCCGAAGTGCCCAACATGCTTATTCAACTGATGGCGGTCTTGCCGTTCTATACGGAAACATTGCTGAGCGTGGCT
GTGTGGTCAAAACTGCCGGCGTTGATGACAGCATCTTGGTTTTCACCGGACGTGCACGCATCTTTGAATCACAAGATGAT
GCAGTAGCAGCGGTGCTTGATGATCAAATCGTCGCAGGCGATGTAGTTATCATCCGTTTTGAGGGTCCAAAAGGCGGTCC
TGGTATGCAAGAGATGCTCTACCCGACGACTTATCTAAAATCTAAAGGCCTAGGCAAAGAATGTGCGCTGCTTACAGATG
GTCGCTTCTCTGGTGGGACATCAGGCTTGTCTATTGGTCATGCCAGCCCAGAAGCCGCTGAAGGCGGCGCCATTGGCCTA
GTGCAAGAAGGCGATACTATCCATATTGATATCCCAAACCGTACCATCAATATGCAGGTCAGTGATGAAGAGTTAGCTGC
TCGCCGCGAAGAAATGGAAAGTCGTGGACGTGATGCTTGGAAACCCGTTAGCCGTGAGCGTCATGTCTCTCCTGCTTTAC
GTGCCTATGCTGCAATGACCACCAGTGCCGATACGGGCGCTGTACGTGACGTCAGCCAAGTTGAACGTTAG

Upstream 100 bases:

>100_bases
ATTATTCACTAGTACTCGCCCGGTATAAAAAGCACACTATCAACATTGCAGCGGATGCTGCACATATTAATAAATCTCGC
TCATTTGTAAGGAATACCAC

Downstream 100 bases:

>100_bases
ACAATAATATTTAAGTACCCTTCTTGAACTGAATTTATTAAGCCTGCGCAATGCAGGCTTTTTTTCACCAAAAAACAACG
TATCTGTCTATTTAATCACT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MDYNSKTSTGGRNMAGARALWRATGMTDGDFGKPIIAIANSFTQFVPGHVHLKDLGQMVAREIEKAGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFISGGPMEAGKIIASTVAHS
HNNDGSSDVHSTDSKGNAIRKLDLVDAMMDAADDSISDEDVAAIEASACPTCGSCSGMFTANSMNCLTEALGLALPGNGS
LLATHSLRRELFLEAGRTIVSLAKRRYEQDDDSVLPRSIATKAAFENAMTLDIAMGGSTNTILHLLAAAHEAEVDFKMHD
IDRLSRGVPCLAKVAPASQKYHMEDVHRAGGVFALLAELDRAGLLHTDLPTIHSATMKEAIDKWDIMNPDNLEARARYIA
APGGVRTTEAFSQSKEWSNLDVNRESGCIRSAQHAYSTDGGLAVLYGNIAERGCVVKTAGVDDSILVFTGRARIFESQDD
AVAAVLDDQIVAGDVVIIRFEGPKGGPGMQEMLYPTTYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGL
VQEGDTIHIDIPNRTINMQVSDEELAARREEMESRGRDAWKPVSRERHVSPALRAYAAMTTSADTGAVRDVSQVER

Sequences:

>Translated_636_residues
MDYNSKTSTGGRNMAGARALWRATGMTDGDFGKPIIAIANSFTQFVPGHVHLKDLGQMVAREIEKAGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFISGGPMEAGKIIASTVAHS
HNNDGSSDVHSTDSKGNAIRKLDLVDAMMDAADDSISDEDVAAIEASACPTCGSCSGMFTANSMNCLTEALGLALPGNGS
LLATHSLRRELFLEAGRTIVSLAKRRYEQDDDSVLPRSIATKAAFENAMTLDIAMGGSTNTILHLLAAAHEAEVDFKMHD
IDRLSRGVPCLAKVAPASQKYHMEDVHRAGGVFALLAELDRAGLLHTDLPTIHSATMKEAIDKWDIMNPDNLEARARYIA
APGGVRTTEAFSQSKEWSNLDVNRESGCIRSAQHAYSTDGGLAVLYGNIAERGCVVKTAGVDDSILVFTGRARIFESQDD
AVAAVLDDQIVAGDVVIIRFEGPKGGPGMQEMLYPTTYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGL
VQEGDTIHIDIPNRTINMQVSDEELAARREEMESRGRDAWKPVSRERHVSPALRAYAAMTTSADTGAVRDVSQVER
>Mature_636_residues
MDYNSKTSTGGRNMAGARALWRATGMTDGDFGKPIIAIANSFTQFVPGHVHLKDLGQMVAREIEKAGGVAKEFNTIAVDD
GIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISNCDKITPGMLMAAMRLNIPVVFISGGPMEAGKIIASTVAHS
HNNDGSSDVHSTDSKGNAIRKLDLVDAMMDAADDSISDEDVAAIEASACPTCGSCSGMFTANSMNCLTEALGLALPGNGS
LLATHSLRRELFLEAGRTIVSLAKRRYEQDDDSVLPRSIATKAAFENAMTLDIAMGGSTNTILHLLAAAHEAEVDFKMHD
IDRLSRGVPCLAKVAPASQKYHMEDVHRAGGVFALLAELDRAGLLHTDLPTIHSATMKEAIDKWDIMNPDNLEARARYIA
APGGVRTTEAFSQSKEWSNLDVNRESGCIRSAQHAYSTDGGLAVLYGNIAERGCVVKTAGVDDSILVFTGRARIFESQDD
AVAAVLDDQIVAGDVVIIRFEGPKGGPGMQEMLYPTTYLKSKGLGKECALLTDGRFSGGTSGLSIGHASPEAAEGGAIGL
VQEGDTIHIDIPNRTINMQVSDEELAARREEMESRGRDAWKPVSRERHVSPALRAYAAMTTSADTGAVRDVSQVER

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=632, Percent_Identity=70.0949367088608, Blast_Score=924, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=563, Percent_Identity=30.9058614564831, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786464, Length=547, Percent_Identity=29.7989031078611, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI1788157, Length=565, Percent_Identity=28.3185840707965, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=624, Percent_Identity=36.3782051282051, Blast_Score=352, Evalue=1e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 67701; Mature: 67701

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYNSKTSTGGRNMAGARALWRATGMTDGDFGKPIIAIANSFTQFVPGHVHLKDLGQMVA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
REIEKAGGVAKEFNTIAVDDGIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISN
HHHHHHCCCHHHCCEEEECCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
CDKITPGMLMAAMRLNIPVVFISGGPMEAGKIIASTVAHSHNNDGSSDVHSTDSKGNAIR
CCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
KLDLVDAMMDAADDSISDEDVAAIEASACPTCGSCSGMFTANSMNCLTEALGLALPGNGS
HHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCC
LLATHSLRRELFLEAGRTIVSLAKRRYEQDDDSVLPRSIATKAAFENAMTLDIAMGGSTN
EEEHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
TILHLLAAAHEAEVDFKMHDIDRLSRGVPCLAKVAPASQKYHMEDVHRAGGVFALLAELD
HHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHH
RAGLLHTDLPTIHSATMKEAIDKWDIMNPDNLEARARYIAAPGGVRTTEAFSQSKEWSNL
HCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCCCC
DVNRESGCIRSAQHAYSTDGGLAVLYGNIAERGCVVKTAGVDDSILVFTGRARIFESQDD
CCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEEEECCEEEECCCCC
AVAAVLDDQIVAGDVVIIRFEGPKGGPGMQEMLYPTTYLKSKGLGKECALLTDGRFSGGT
EEEEECCCCEEECCEEEEEEECCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCC
SGLSIGHASPEAAEGGAIGLVQEGDTIHIDIPNRTINMQVSDEELAARREEMESRGRDAW
CCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCC
KPVSRERHVSPALRAYAAMTTSADTGAVRDVSQVER
CCCCCHHCCCHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MDYNSKTSTGGRNMAGARALWRATGMTDGDFGKPIIAIANSFTQFVPGHVHLKDLGQMVA
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHH
REIEKAGGVAKEFNTIAVDDGIAMGHSGMLYSLPSRDLIADSVEYMVNAHCADALVCISN
HHHHHHCCCHHHCCEEEECCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHC
CDKITPGMLMAAMRLNIPVVFISGGPMEAGKIIASTVAHSHNNDGSSDVHSTDSKGNAIR
CCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEE
KLDLVDAMMDAADDSISDEDVAAIEASACPTCGSCSGMFTANSMNCLTEALGLALPGNGS
HHHHHHHHHHHCCCCCCCCCHHEEECCCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCC
LLATHSLRRELFLEAGRTIVSLAKRRYEQDDDSVLPRSIATKAAFENAMTLDIAMGGSTN
EEEHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
TILHLLAAAHEAEVDFKMHDIDRLSRGVPCLAKVAPASQKYHMEDVHRAGGVFALLAELD
HHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHCCCHHHHHHHHH
RAGLLHTDLPTIHSATMKEAIDKWDIMNPDNLEARARYIAAPGGVRTTEAFSQSKEWSNL
HCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHEEEEECCCCCCHHHHHHHCCCCCCC
DVNRESGCIRSAQHAYSTDGGLAVLYGNIAERGCVVKTAGVDDSILVFTGRARIFESQDD
CCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCEEEECCCCCEEEEEECCEEEECCCCC
AVAAVLDDQIVAGDVVIIRFEGPKGGPGMQEMLYPTTYLKSKGLGKECALLTDGRFSGGT
EEEEECCCCEEECCEEEEEEECCCCCCCHHHHHCCHHHHHCCCCCCCEEEEECCCCCCCC
SGLSIGHASPEAAEGGAIGLVQEGDTIHIDIPNRTINMQVSDEELAARREEMESRGRDAW
CCCCCCCCCCCCCCCCEEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHHCCCCCC
KPVSRERHVSPALRAYAAMTTSADTGAVRDVSQVER
CCCCCHHCCCHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA