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The map label for this gene is lpxK

Identifier: 93005891

GI number: 93005891

Start: 1279126

End: 1280244

Strand: Direct

Name: lpxK

Synonym: Pcryo_1063

Alternate gene names: 93005891

Gene position: 1279126-1280244 (Clockwise)

Preceding gene: 93005890

Following gene: 93005892

Centisome position: 41.8

GC content: 43.43

Gene sequence:

>1119_bases
ATGAATATTGAAACGATAATAACACGTGCATGGCAACGCAAAGCAGCTTGGCTTTGGCTACTGTTGCCAGTGAGTTGGCT
GTATGCACTGTTAATGGTACTGCGCCGCCAAGCTTATAAAGTAGGTATTCTTGCCAGTTACCGTGCGCCTATTCCAGTTA
TGGTGATTGGTAATATCACGGTGGGTGGTAGCGGAAAGACACCATTAATTATTGCTTTGGTTCGACATTTGCAGCAGCAA
GGCATTAAAGTAGGGGTTATCAGTCGCGGTTATGGCGGTGATAGTAGCCAGATGCCAGCATTGGTTACTACAGAGAGCCC
CCCTAATGTGGTCGGTGATGAGCCATGTCTCATTGTTAATACGACAGGGACAGCCATGGCCGTATCTCCTAACCGTCAGC
AAGCGATTGCTATTTTGCTAGAGGCTTATCCAGATCTACAGCTTATTATAGCTGATGATGGTTTGCAGCACTATGCGCTG
CAACGTGATATTGAATGGGTTGTGGTAGATGCGGCGCGAGGGTTTGGGAATAAACAGTTGCTACCGACAGGATTTTTACG
CGAACCCATATCACGCCTAAAGGATGCAAATGTCATTTATCATCACAAGCCAGACGCATCATCGATATACAATAAATCTG
ATCATAATACCCTTCTAACTGAGCATTTAACGATGCATTTACAACCAGATGATTTAGAACTGTTGTGGTCATCTAATAAT
CAGATAGATAATTTAGCCGTAGTAGCCATGGCACCTGAGAAAGGCAGTCAGGTACATGCGGTGAGCGGTATTGGGTATCC
TCAGCGTTTTTTTGATACTTTAAATGCGCTTGGTTTTGAAGTTATTCCGCATCCTTATCCTGACCATTATGATTTTAGTC
TGGATGAACTGTTGCAGTATGCTGACCATCCTATTATCGTGACCAGTAAAGATGCCGTGAAAATAAGAGCTTTGATAATG
CAAGCCATTATTAATCAAGCGCTGAGTGATGAGTATAAAGAGCTGGTCAGCAGATTATGGGTATTGCCAGTGACGGCAGT
ATTGTCAGACAGTTGTTACGAGAGTTTACAACAGCAATTGCAAACCTTGGACATCGATATAAGCATGAGAAAGCAATAA

Upstream 100 bases:

>100_bases
TACTAGATGGTGGTCAGATTGTTGAGCTTGGTACCCATACTCAGCTGATGCAATTGCATGGTCATTATGCGCAGATGTAT
GCGCGTGATTTTGAATAATT

Downstream 100 bases:

>100_bases
TATAGCGTTTATCATATAAAGATTTAAAAGGTTTTATAGGAACAGATTATGTCATCAGCCCTTATGCCCGTCAAAACTCA
TATCGTCATTCCTGCACGTT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MNIETIITRAWQRKAAWLWLLLPVSWLYALLMVLRRQAYKVGILASYRAPIPVMVIGNITVGGSGKTPLIIALVRHLQQQ
GIKVGVISRGYGGDSSQMPALVTTESPPNVVGDEPCLIVNTTGTAMAVSPNRQQAIAILLEAYPDLQLIIADDGLQHYAL
QRDIEWVVVDAARGFGNKQLLPTGFLREPISRLKDANVIYHHKPDASSIYNKSDHNTLLTEHLTMHLQPDDLELLWSSNN
QIDNLAVVAMAPEKGSQVHAVSGIGYPQRFFDTLNALGFEVIPHPYPDHYDFSLDELLQYADHPIIVTSKDAVKIRALIM
QAIINQALSDEYKELVSRLWVLPVTAVLSDSCYESLQQQLQTLDIDISMRKQ

Sequences:

>Translated_372_residues
MNIETIITRAWQRKAAWLWLLLPVSWLYALLMVLRRQAYKVGILASYRAPIPVMVIGNITVGGSGKTPLIIALVRHLQQQ
GIKVGVISRGYGGDSSQMPALVTTESPPNVVGDEPCLIVNTTGTAMAVSPNRQQAIAILLEAYPDLQLIIADDGLQHYAL
QRDIEWVVVDAARGFGNKQLLPTGFLREPISRLKDANVIYHHKPDASSIYNKSDHNTLLTEHLTMHLQPDDLELLWSSNN
QIDNLAVVAMAPEKGSQVHAVSGIGYPQRFFDTLNALGFEVIPHPYPDHYDFSLDELLQYADHPIIVTSKDAVKIRALIM
QAIINQALSDEYKELVSRLWVLPVTAVLSDSCYESLQQQLQTLDIDISMRKQ
>Mature_372_residues
MNIETIITRAWQRKAAWLWLLLPVSWLYALLMVLRRQAYKVGILASYRAPIPVMVIGNITVGGSGKTPLIIALVRHLQQQ
GIKVGVISRGYGGDSSQMPALVTTESPPNVVGDEPCLIVNTTGTAMAVSPNRQQAIAILLEAYPDLQLIIADDGLQHYAL
QRDIEWVVVDAARGFGNKQLLPTGFLREPISRLKDANVIYHHKPDASSIYNKSDHNTLLTEHLTMHLQPDDLELLWSSNN
QIDNLAVVAMAPEKGSQVHAVSGIGYPQRFFDTLNALGFEVIPHPYPDHYDFSLDELLQYADHPIIVTSKDAVKIRALIM
QAIINQALSDEYKELVSRLWVLPVTAVLSDSCYESLQQQLQTLDIDISMRKQ

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=368, Percent_Identity=38.5869565217391, Blast_Score=216, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_PSYCK (Q1QBV9)

Other databases:

- EMBL:   CP000323
- RefSeq:   YP_580328.1
- ProteinModelPortal:   Q1QBV9
- STRING:   Q1QBV9
- GeneID:   4035464
- GenomeReviews:   CP000323_GR
- KEGG:   pcr:Pcryo_1063
- NMPDR:   fig|335284.3.peg.476
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q1QBV9
- ProtClustDB:   PRK00652
- BioCyc:   PCRY335284:PCRYO_1063-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 41458; Mature: 41458

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIETIITRAWQRKAAWLWLLLPVSWLYALLMVLRRQAYKVGILASYRAPIPVMVIGNIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEEE
VGGSGKTPLIIALVRHLQQQGIKVGVISRGYGGDSSQMPALVTTESPPNVVGDEPCLIVN
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
TTGTAMAVSPNRQQAIAILLEAYPDLQLIIADDGLQHYALQRDIEWVVVDAARGFGNKQL
CCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCC
LPTGFLREPISRLKDANVIYHHKPDASSIYNKSDHNTLLTEHLTMHLQPDDLELLWSSNN
CCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCEEEEEEEEEEECCCCEEEEECCCC
QIDNLAVVAMAPEKGSQVHAVSGIGYPQRFFDTLNALGFEVIPHPYPDHYDFSLDELLQY
CCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHH
ADHPIIVTSKDAVKIRALIMQAIINQALSDEYKELVSRLWVLPVTAVLSDSCYESLQQQL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLDIDISMRKQ
HHCCCEEEECCC
>Mature Secondary Structure
MNIETIITRAWQRKAAWLWLLLPVSWLYALLMVLRRQAYKVGILASYRAPIPVMVIGNIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEEEEEEEE
VGGSGKTPLIIALVRHLQQQGIKVGVISRGYGGDSSQMPALVTTESPPNVVGDEPCLIVN
ECCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEEEE
TTGTAMAVSPNRQQAIAILLEAYPDLQLIIADDGLQHYALQRDIEWVVVDAARGFGNKQL
CCCCEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCEEEEEEECCCCCCCCC
LPTGFLREPISRLKDANVIYHHKPDASSIYNKSDHNTLLTEHLTMHLQPDDLELLWSSNN
CCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCEEEEEEEEEEECCCCEEEEECCCC
QIDNLAVVAMAPEKGSQVHAVSGIGYPQRFFDTLNALGFEVIPHPYPDHYDFSLDELLQY
CCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHH
ADHPIIVTSKDAVKIRALIMQAIINQALSDEYKELVSRLWVLPVTAVLSDSCYESLQQQL
CCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QTLDIDISMRKQ
HHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA