Click here to switch to the map view.

The map label for this gene is guaB [H]

Identifier: 93005833

GI number: 93005833

Start: 1202111

End: 1203583

Strand: Direct

Name: guaB [H]

Synonym: Pcryo_1005

Alternate gene names: 93005833

Gene position: 1202111-1203583 (Clockwise)

Preceding gene: 93005832

Following gene: 93005834

Centisome position: 39.29

GC content: 46.3

Gene sequence:

>1473_bases
ATGTTGCGAATTGTCGATGAAGCCTTAACCTTTGATGACGTTTTATTATTGCCAGCTTATTCAGAAATACTGCCAAAAGC
TGCTAATCTAACGACCCGCCTAACAAAAAGTATCACGCTAAATTTACCGCTAATTTCTGCTGCTATGGATACAGTCACTG
AGTCTGAGATGGCCATTACCATGGCACAACTTGGTGGTTTAGGTATTTTGCATAAGAGCATGGATATCGATAAGCAGGCA
ATGCAAGTGCGCCGCGTCAAGAAATTCGAAGCTGGTACTGTGGTTGATCCTATTACTGTGCATCCAGAGATGACCATCGG
TGAGTTATTAAGACTGACCCAAGACAATAATATCTCAGGCGTGCCAGTGGTTGAGAAGGGCACGGATAAAGTAGTCGGTA
TCGTTACTCATCGTGACTGGCGCTTTGAGACCAATCTATCATTGCCTGTCAGCCATATCATGACGCCAAAAGAGCAGCTC
GTCACCGTTAAAGAAGGTGAGAGCAACGAAAACATCAAAAGACTGCTACACGAGCACCGTATCGAAAAAGTTATTGTCAT
CAATGATGATTTCCGTTTGCGTGGTCTGATTACGGTCAATGACTTTGCCAAAGCTGAAAACAATCCCAATGCTTGTAAAG
ATGAGCAAGGTCGCCTGCGTGTGGGCGCAGCAGTTGGTACGGGCGCTGATACTCAAGCACGCGTTGAAGCTTTGATTGCG
GCTGACGTCGATATCATCGTTGTTGATACCGCGCATGGTCACTCAAAAGGCGTTATTGATAAAGTATCTTGGATTAAAAA
ACATTTCCCGCATGTACAAGTGATTGGCGGCAATATCGCGACAGGTGATGCTGCAAAAGCCTTACGTGATGCTGGTGCAG
ATGCCGTGAAAGTTGGTATCGGCCCAGGATCTATCTGTACCACACGTATTATCGCTGGTATCGGTGTACCGCAAATCTCT
GCAATTGATAGTGTTGCAAGCGCTTTGCAAGACAGTATTCCATTGATTGCTGATGGTGGTATTCGCTATTCAGGTGATAT
GGCAAAAGCCATTGCTGCTGGTGCATCATGCATCATGGTTGGCTCACTTATGGCAGGTACAGAAGAAGCACCGGGCGAAG
TTGAGCTATTCCAAGGTCGCTATTATAAAGCTTACCGCGGTATGGGTAGCTTGGGCGCGATGTCAGGTCAAAACGGCTCA
TCAGATCGCTACTTCCAAGATGCCAAAGACGGTGTGGAAAAATTGGTGCCAGAAGGTATCGAAGGTCGTGTACCTTATAA
AGGTCCAGTCGCTGGTATCGTCAACCAATTGGTAGGTGGCTTGCGCTCATCTATGGGTTATACCGGCTGTGCCACGATTG
AAGATATGCGCAGCAAACCACAGTTCATCAAAGTTACCTCAGCGGGTATGAAAGAATCGCATGTGCATGATGTGCAAATC
ACCAAAGAAGCACCTAACTATCGAGTCGACTAA

Upstream 100 bases:

>100_bases
TTCTGCTAGGTTTATAACCTTATGATTTTGATAGAATTTTCGTTGATTTTCTTGATGCTGTATTGCCCACCCATCAAAAT
AACCACTACTAGGGGTCTGT

Downstream 100 bases:

>100_bases
TTATATCTTTGCCGCTATAGGATGCGATGACTCGCAGCTGTACAGTGTCAAGCGACGTTAAGATACAAACAGCCAACAAT
GCCTTGTTATTGTTGGCTGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLRIVDEALTFDDVLLLPAYSEILPKAANLTTRLTKSITLNLPLISAAMDTVTESEMAITMAQLGGLGILHKSMDIDKQA
MQVRRVKKFEAGTVVDPITVHPEMTIGELLRLTQDNNISGVPVVEKGTDKVVGIVTHRDWRFETNLSLPVSHIMTPKEQL
VTVKEGESNENIKRLLHEHRIEKVIVINDDFRLRGLITVNDFAKAENNPNACKDEQGRLRVGAAVGTGADTQARVEALIA
ADVDIIVVDTAHGHSKGVIDKVSWIKKHFPHVQVIGGNIATGDAAKALRDAGADAVKVGIGPGSICTTRIIAGIGVPQIS
AIDSVASALQDSIPLIADGGIRYSGDMAKAIAAGASCIMVGSLMAGTEEAPGEVELFQGRYYKAYRGMGSLGAMSGQNGS
SDRYFQDAKDGVEKLVPEGIEGRVPYKGPVAGIVNQLVGGLRSSMGYTGCATIEDMRSKPQFIKVTSAGMKESHVHDVQI
TKEAPNYRVD

Sequences:

>Translated_490_residues
MLRIVDEALTFDDVLLLPAYSEILPKAANLTTRLTKSITLNLPLISAAMDTVTESEMAITMAQLGGLGILHKSMDIDKQA
MQVRRVKKFEAGTVVDPITVHPEMTIGELLRLTQDNNISGVPVVEKGTDKVVGIVTHRDWRFETNLSLPVSHIMTPKEQL
VTVKEGESNENIKRLLHEHRIEKVIVINDDFRLRGLITVNDFAKAENNPNACKDEQGRLRVGAAVGTGADTQARVEALIA
ADVDIIVVDTAHGHSKGVIDKVSWIKKHFPHVQVIGGNIATGDAAKALRDAGADAVKVGIGPGSICTTRIIAGIGVPQIS
AIDSVASALQDSIPLIADGGIRYSGDMAKAIAAGASCIMVGSLMAGTEEAPGEVELFQGRYYKAYRGMGSLGAMSGQNGS
SDRYFQDAKDGVEKLVPEGIEGRVPYKGPVAGIVNQLVGGLRSSMGYTGCATIEDMRSKPQFIKVTSAGMKESHVHDVQI
TKEAPNYRVD
>Mature_490_residues
MLRIVDEALTFDDVLLLPAYSEILPKAANLTTRLTKSITLNLPLISAAMDTVTESEMAITMAQLGGLGILHKSMDIDKQA
MQVRRVKKFEAGTVVDPITVHPEMTIGELLRLTQDNNISGVPVVEKGTDKVVGIVTHRDWRFETNLSLPVSHIMTPKEQL
VTVKEGESNENIKRLLHEHRIEKVIVINDDFRLRGLITVNDFAKAENNPNACKDEQGRLRVGAAVGTGADTQARVEALIA
ADVDIIVVDTAHGHSKGVIDKVSWIKKHFPHVQVIGGNIATGDAAKALRDAGADAVKVGIGPGSICTTRIIAGIGVPQIS
AIDSVASALQDSIPLIADGGIRYSGDMAKAIAAGASCIMVGSLMAGTEEAPGEVELFQGRYYKAYRGMGSLGAMSGQNGS
SDRYFQDAKDGVEKLVPEGIEGRVPYKGPVAGIVNQLVGGLRSSMGYTGCATIEDMRSKPQFIKVTSAGMKESHVHDVQI
TKEAPNYRVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=40.625, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=40.625, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=40.625, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=40.625, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI217035152, Length=474, Percent_Identity=40.7172995780591, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=39.7916666666667, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=38.3022774327122, Blast_Score=322, Evalue=4e-88,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=38.5416666666667, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI50541954, Length=276, Percent_Identity=35.5072463768116, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541952, Length=276, Percent_Identity=35.5072463768116, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541948, Length=276, Percent_Identity=35.5072463768116, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI50541956, Length=276, Percent_Identity=35.5072463768116, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI156104880, Length=265, Percent_Identity=35.0943396226415, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1788855, Length=490, Percent_Identity=60.8163265306122, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1786293, Length=224, Percent_Identity=34.375, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=475, Percent_Identity=36.8421052631579, Blast_Score=288, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=38.9021479713604, Blast_Score=275, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=35.2697095435685, Blast_Score=152, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323585, Length=488, Percent_Identity=37.7049180327869, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=36.6803278688525, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6323464, Length=488, Percent_Identity=38.3196721311475, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=35.9649122807018, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319353, Length=123, Percent_Identity=39.0243902439024, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641071, Length=482, Percent_Identity=39.8340248962656, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24641073, Length=482, Percent_Identity=39.8340248962656, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.5454545454545, Blast_Score=291, Evalue=1e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52436; Mature: 52436

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIVDEALTFDDVLLLPAYSEILPKAANLTTRLTKSITLNLPLISAAMDTVTESEMAIT
CCEEECHHCCCCCEEEECCHHHHCCHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHH
MAQLGGLGILHKSMDIDKQAMQVRRVKKFEAGTVVDPITVHPEMTIGELLRLTQDNNISG
HHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHHHHHCCCCCCC
VPVVEKGTDKVVGIVTHRDWRFETNLSLPVSHIMTPKEQLVTVKEGESNENIKRLLHEHR
CEEEECCCCCEEEEEEECCEEEECCCCCCHHHHCCCHHHEEEEECCCCCHHHHHHHHHHC
IEKVIVINDDFRLRGLITVNDFAKAENNPNACKDEQGRLRVGAAVGTGADTQARVEALIA
CCEEEEECCCCEEEEEEEECHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHEE
ADVDIIVVDTAHGHSKGVIDKVSWIKKHFPHVQVIGGNIATGDAAKALRDAGADAVKVGI
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEC
GPGSICTTRIIAGIGVPQISAIDSVASALQDSIPLIADGGIRYSGDMAKAIAAGASCIMV
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCHHHHHHHCCCHHEEH
GSLMAGTEEAPGEVELFQGRYYKAYRGMGSLGAMSGQNGSSDRYFQDAKDGVEKLVPEGI
HHHHCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EGRVPYKGPVAGIVNQLVGGLRSSMGYTGCATIEDMRSKPQFIKVTSAGMKESHVHDVQI
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEE
TKEAPNYRVD
ECCCCCCCCC
>Mature Secondary Structure
MLRIVDEALTFDDVLLLPAYSEILPKAANLTTRLTKSITLNLPLISAAMDTVTESEMAIT
CCEEECHHCCCCCEEEECCHHHHCCHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHH
MAQLGGLGILHKSMDIDKQAMQVRRVKKFEAGTVVDPITVHPEMTIGELLRLTQDNNISG
HHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCCEECCEEECCCCCHHHHHHHHCCCCCCC
VPVVEKGTDKVVGIVTHRDWRFETNLSLPVSHIMTPKEQLVTVKEGESNENIKRLLHEHR
CEEEECCCCCEEEEEEECCEEEECCCCCCHHHHCCCHHHEEEEECCCCCHHHHHHHHHHC
IEKVIVINDDFRLRGLITVNDFAKAENNPNACKDEQGRLRVGAAVGTGADTQARVEALIA
CCEEEEECCCCEEEEEEEECHHHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHEE
ADVDIIVVDTAHGHSKGVIDKVSWIKKHFPHVQVIGGNIATGDAAKALRDAGADAVKVGI
CCCEEEEEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEC
GPGSICTTRIIAGIGVPQISAIDSVASALQDSIPLIADGGIRYSGDMAKAIAAGASCIMV
CCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCEEECCHHHHHHHCCCHHEEH
GSLMAGTEEAPGEVELFQGRYYKAYRGMGSLGAMSGQNGSSDRYFQDAKDGVEKLVPEGI
HHHHCCCCCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
EGRVPYKGPVAGIVNQLVGGLRSSMGYTGCATIEDMRSKPQFIKVTSAGMKESHVHDVQI
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCEEEEE
TKEAPNYRVD
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA