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The map label for this gene is maeB [H]

Identifier: 93005825

GI number: 93005825

Start: 1189066

End: 1191399

Strand: Reverse

Name: maeB [H]

Synonym: Pcryo_0997

Alternate gene names: 93005825

Gene position: 1191399-1189066 (Counterclockwise)

Preceding gene: 93005826

Following gene: 93005824

Centisome position: 38.94

GC content: 45.03

Gene sequence:

>2334_bases
ATGGCAATTATTATGAATGACGATATCACTTTGAATACGGACACCCCTAGTACGGAAAAAGAGCAGTTTGAACAAGCTGC
CTTACATTACCATGAGTTCCCTCGCCCTGGTAAAATCTCAGTTACTCCTATCAAGCAATTGGCAAACCAACGTGATCTGG
CGCTCGCCTATTCACCAGGCGTGGCAGTACCTTGTCTTGAGATTCAAAGAGACCCATCTCTTGCGGCAAAATATACCGCA
CGTAGCAACTTAGTTGGTGTTATTACCAATGGTACAGCGGTGTTAGGTTTGGGAAATATCGGTCCATTGGCATCAAAGCC
TGTTATGGAAGGCAAAGGGGTTCTATTCAAAAAGTTCGCTGGTATCGACGTTTTTGATATTGAAATTGCACAAAACGATC
CGGACAAATTCATTGAGGCTGTTGCTTCTTTAGAGCCTACGTTTGGTGGGATTAATTTAGAAGACATCAAAGCACCAGAG
TGTTTCAAAATCGAGCGCGAACTGCGTAAGCGTATGAACATTCCAGTATTCCATGATGACCAACATGGCACGTCAATCAT
TGTTGCGGCGGCGATGCTTAATGCATTAATCATCACGAACAAAAAAATTGAAGATATTAAAATCATTTGTTCTGGTGCCG
GTGCTGCAGCGATTTCTTGCTTGGATATCATTTGTGCCCTTGGTGTGAATAAAAACAATATCTACGTATCAGACTCACGT
GGCATTATCTCTACTACCCGTGAAAACCTTGATGAAACCAAACAGCGCTATGCTCGTGAAACCACTGCTACGACTATTGA
AGAGCTGATGGATGATGTCGACATGTTCCTAGGCTTATCTATGCCGGGTACATTGACAGAAGACATGGTTCGCCGTATGG
CAAAAGACCCTATCATCTTTGCGCTTGCTAACCCAACGCCTGAGATCATGCCAGAAATCGCCCATGCCGTCCGTCCAGAC
GTTATTATGGCAACCGGTCGCTCTGATTATCCGAACCAAGTAAACAACGCATTGTGTTTCCCTTATATCTTCCGCGGTGC
ATTAGATGTAGGCGCAACGACTGTCAACGAAGAAATGAAAATTGCATGCGTACGCGCCATTGCTGCCATGGCACATGTTG
AAGCGACGCCAATGAGCAACGTCAAAAACGTTGAAAGTACGCCAAGCTTTGGTCGTGATTACCTGATCCCAGGACCACTT
GAGCCAAACCTAATCATTGAAATCGCCTCTGCAGTCGCAAAAGCGGCTATGGATTCAGGCGTTGCAACGCTTCCTATCGC
AGATATGAAAGCCTATCGTCAGCGTCTGTCTGAGTTTGTCTATAACTCAGCGTTTGTAATGAAGCCTATTTTTGCTCGTG
CAAAAGCAGATCCAAAACGTATCGTTTACTGTGAAGGCGAAGACAGCAACGTACTATTAGCGGTACAAGTGGTCGTCGAT
GAGCAGTTGGCTTATCCAATCTTGGTCGGTCGTCCCTCAGTGATCGAAAATAACATCGCCAAGCTAGCATTACGCTTGAA
AGACGGCGTGAACATTACTATTGTCAATGTTGATGATGATCCGCGCTATAACGATTACTGGAAAGGCTACTACGAGAAAA
ACAAACGTACTGGGGTCAGTATCGAGCTTGCTCGCCGTGATGTGCGCCGCAAGACCTCTTTAATTGGTGCTCTTTTGGTT
GAAAATGGCGATGCCGATGGTATGATTTGTGGTACATTCGGTCACTATCAGCTGCATTTAAAATATGTTGGCGGAGTAAT
CAACAAAAAAGAAGGTATTAATGATTTTTATGCGATGAATGCGGTGCTTATGCAGGATCGTAATATTTTTATTGCTGATA
CCTATATCCATGAAGATCCAACGGCTGAGCAATTGGCTGAGATGACTGTATTGGCAGCTGAGCAATTGTGCCGCTTTAGC
ATTACCCCACGTGTGGCTTTGGTGTCGCATTCAAACTTCGGAACTTCTGATCGTGCCAGTGCTGTCAAAATGCGTAAAGT
ACATCAACTGCTGACCGAGATGAATGTCGATTTTGAGTTTGACGGTGAAATGCAAGGTGATGCTGCACTTGACGAACATA
TCCGTGCCAATGACTTGCCTTCGAGCAACCTTAAAGGTTCAGCAAATCTACTTATCTTGCCAACGTTAGATGCGTCGAAC
ATTGCCTTTAACCTGCTTAAGACAGCAACCGGTAGCGCGTCTATCGGTCCTATTTTGTTAGGTGCAAGCAAACCTGTACA
TATTCTAACGCCATCAGCCACAGCGCGCCGTGTGGTTAATATGACGGCACTTGCGGTCACTGAAGCTCAGGATTTAGACA
ACGAGAAACAGTAA

Upstream 100 bases:

>100_bases
CCTTTAACAATCAATGTACACTCATGATCATATTCAATGGTTATTGAGAATTAGGCATTAGTTTTTATCACCATTTAATT
TATTCCAATTTATCCTAACC

Downstream 100 bases:

>100_bases
TTGATTATGCTCTGTAAAGTGCGCAATTTACACGGTCTCTTGCATTTTTTATAGAGACCGTCTGCTATACTAAAACCAGC
CAATGCTTAAAGTATTGGCT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 777; Mature: 776

Protein sequence:

>777_residues
MAIIMNDDITLNTDTPSTEKEQFEQAALHYHEFPRPGKISVTPIKQLANQRDLALAYSPGVAVPCLEIQRDPSLAAKYTA
RSNLVGVITNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGIDVFDIEIAQNDPDKFIEAVASLEPTFGGINLEDIKAPE
CFKIERELRKRMNIPVFHDDQHGTSIIVAAAMLNALIITNKKIEDIKIICSGAGAAAISCLDIICALGVNKNNIYVSDSR
GIISTTRENLDETKQRYARETTATTIEELMDDVDMFLGLSMPGTLTEDMVRRMAKDPIIFALANPTPEIMPEIAHAVRPD
VIMATGRSDYPNQVNNALCFPYIFRGALDVGATTVNEEMKIACVRAIAAMAHVEATPMSNVKNVESTPSFGRDYLIPGPL
EPNLIIEIASAVAKAAMDSGVATLPIADMKAYRQRLSEFVYNSAFVMKPIFARAKADPKRIVYCEGEDSNVLLAVQVVVD
EQLAYPILVGRPSVIENNIAKLALRLKDGVNITIVNVDDDPRYNDYWKGYYEKNKRTGVSIELARRDVRRKTSLIGALLV
ENGDADGMICGTFGHYQLHLKYVGGVINKKEGINDFYAMNAVLMQDRNIFIADTYIHEDPTAEQLAEMTVLAAEQLCRFS
ITPRVALVSHSNFGTSDRASAVKMRKVHQLLTEMNVDFEFDGEMQGDAALDEHIRANDLPSSNLKGSANLLILPTLDASN
IAFNLLKTATGSASIGPILLGASKPVHILTPSATARRVVNMTALAVTEAQDLDNEKQ

Sequences:

>Translated_777_residues
MAIIMNDDITLNTDTPSTEKEQFEQAALHYHEFPRPGKISVTPIKQLANQRDLALAYSPGVAVPCLEIQRDPSLAAKYTA
RSNLVGVITNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGIDVFDIEIAQNDPDKFIEAVASLEPTFGGINLEDIKAPE
CFKIERELRKRMNIPVFHDDQHGTSIIVAAAMLNALIITNKKIEDIKIICSGAGAAAISCLDIICALGVNKNNIYVSDSR
GIISTTRENLDETKQRYARETTATTIEELMDDVDMFLGLSMPGTLTEDMVRRMAKDPIIFALANPTPEIMPEIAHAVRPD
VIMATGRSDYPNQVNNALCFPYIFRGALDVGATTVNEEMKIACVRAIAAMAHVEATPMSNVKNVESTPSFGRDYLIPGPL
EPNLIIEIASAVAKAAMDSGVATLPIADMKAYRQRLSEFVYNSAFVMKPIFARAKADPKRIVYCEGEDSNVLLAVQVVVD
EQLAYPILVGRPSVIENNIAKLALRLKDGVNITIVNVDDDPRYNDYWKGYYEKNKRTGVSIELARRDVRRKTSLIGALLV
ENGDADGMICGTFGHYQLHLKYVGGVINKKEGINDFYAMNAVLMQDRNIFIADTYIHEDPTAEQLAEMTVLAAEQLCRFS
ITPRVALVSHSNFGTSDRASAVKMRKVHQLLTEMNVDFEFDGEMQGDAALDEHIRANDLPSSNLKGSANLLILPTLDASN
IAFNLLKTATGSASIGPILLGASKPVHILTPSATARRVVNMTALAVTEAQDLDNEKQ
>Mature_776_residues
AIIMNDDITLNTDTPSTEKEQFEQAALHYHEFPRPGKISVTPIKQLANQRDLALAYSPGVAVPCLEIQRDPSLAAKYTAR
SNLVGVITNGTAVLGLGNIGPLASKPVMEGKGVLFKKFAGIDVFDIEIAQNDPDKFIEAVASLEPTFGGINLEDIKAPEC
FKIERELRKRMNIPVFHDDQHGTSIIVAAAMLNALIITNKKIEDIKIICSGAGAAAISCLDIICALGVNKNNIYVSDSRG
IISTTRENLDETKQRYARETTATTIEELMDDVDMFLGLSMPGTLTEDMVRRMAKDPIIFALANPTPEIMPEIAHAVRPDV
IMATGRSDYPNQVNNALCFPYIFRGALDVGATTVNEEMKIACVRAIAAMAHVEATPMSNVKNVESTPSFGRDYLIPGPLE
PNLIIEIASAVAKAAMDSGVATLPIADMKAYRQRLSEFVYNSAFVMKPIFARAKADPKRIVYCEGEDSNVLLAVQVVVDE
QLAYPILVGRPSVIENNIAKLALRLKDGVNITIVNVDDDPRYNDYWKGYYEKNKRTGVSIELARRDVRRKTSLIGALLVE
NGDADGMICGTFGHYQLHLKYVGGVINKKEGINDFYAMNAVLMQDRNIFIADTYIHEDPTAEQLAEMTVLAAEQLCRFSI
TPRVALVSHSNFGTSDRASAVKMRKVHQLLTEMNVDFEFDGEMQGDAALDEHIRANDLPSSNLKGSANLLILPTLDASNI
AFNLLKTATGSASIGPILLGASKPVHILTPSATARRVVNMTALAVTEAQDLDNEKQ

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=364, Percent_Identity=26.0989010989011, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI62420882, Length=365, Percent_Identity=26.8493150684932, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI62420880, Length=365, Percent_Identity=26.8493150684932, Blast_Score=87, Evalue=8e-17,
Organism=Homo sapiens, GI239049447, Length=365, Percent_Identity=26.8493150684932, Blast_Score=87, Evalue=8e-17,
Organism=Escherichia coli, GI1788806, Length=753, Percent_Identity=58.3001328021248, Blast_Score=905, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=342, Percent_Identity=28.9473684210526, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1788800, Length=321, Percent_Identity=26.4797507788162, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI87081919, Length=510, Percent_Identity=23.1372549019608, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=345, Percent_Identity=27.536231884058, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=323, Percent_Identity=29.4117647058824, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281362674, Length=491, Percent_Identity=25.050916496945, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281362672, Length=491, Percent_Identity=25.050916496945, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356279, Length=491, Percent_Identity=25.050916496945, Blast_Score=99, Evalue=2e-20,
Organism=Drosophila melanogaster, GI78707242, Length=343, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707238, Length=343, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI78707240, Length=343, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24646388, Length=406, Percent_Identity=26.1083743842365, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646386, Length=406, Percent_Identity=26.1083743842365, Blast_Score=81, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 84872; Mature: 84740

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIIMNDDITLNTDTPSTEKEQFEQAALHYHEFPRPGKISVTPIKQLANQRDLALAYSPG
CEEEEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCCCEEEEECCC
VAVPCLEIQRDPSLAAKYTARSNLVGVITNGTAVLGLGNIGPLASKPVMEGKGVLFKKFA
CCCEEEEECCCCCHHEEEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCC
GIDVFDIEIAQNDPDKFIEAVASLEPTFGGINLEDIKAPECFKIERELRKRMNIPVFHDD
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEECC
QHGTSIIVAAAMLNALIITNKKIEDIKIICSGAGAAAISCLDIICALGVNKNNIYVSDSR
CCCCHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCC
GIISTTRENLDETKQRYARETTATTIEELMDDVDMFLGLSMPGTLTEDMVRRMAKDPIIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEE
ALANPTPEIMPEIAHAVRPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTVNEEMK
EECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEECCHHHH
IACVRAIAAMAHVEATPMSNVKNVESTPSFGRDYLIPGPLEPNLIIEIASAVAKAAMDSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VATLPIADMKAYRQRLSEFVYNSAFVMKPIFARAKADPKRIVYCEGEDSNVLLAVQVVVD
CEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEC
EQLAYPILVGRPSVIENNIAKLALRLKDGVNITIVNVDDDPRYNDYWKGYYEKNKRTGVS
CCCCCEEEECCCHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCHHHCCHHHCCCCCCCE
IELARRDVRRKTSLIGALLVENGDADGMICGTFGHYQLHLKYVGGVINKKEGINDFYAMN
EHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCEEEEEEECCCHHCCCCCCCHHHHHH
AVLMQDRNIFIADTYIHEDPTAEQLAEMTVLAAEQLCRFSITPRVALVSHSNFGTSDRAS
EEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHH
AVKMRKVHQLLTEMNVDFEFDGEMQGDAALDEHIRANDLPSSNLKGSANLLILPTLDASN
HHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCH
IAFNLLKTATGSASIGPILLGASKPVHILTPSATARRVVNMTALAVTEAQDLDNEKQ
HHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHEEEECHHCCCCCCC
>Mature Secondary Structure 
AIIMNDDITLNTDTPSTEKEQFEQAALHYHEFPRPGKISVTPIKQLANQRDLALAYSPG
EEEEECCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEECHHHHHCCCCCEEEEECCC
VAVPCLEIQRDPSLAAKYTARSNLVGVITNGTAVLGLGNIGPLASKPVMEGKGVLFKKFA
CCCEEEEECCCCCHHEEEECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEHCC
GIDVFDIEIAQNDPDKFIEAVASLEPTFGGINLEDIKAPECFKIERELRKRMNIPVFHDD
CCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCEEECC
QHGTSIIVAAAMLNALIITNKKIEDIKIICSGAGAAAISCLDIICALGVNKNNIYVSDSR
CCCCHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCC
GIISTTRENLDETKQRYARETTATTIEELMDDVDMFLGLSMPGTLTEDMVRRMAKDPIIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEE
ALANPTPEIMPEIAHAVRPDVIMATGRSDYPNQVNNALCFPYIFRGALDVGATTVNEEMK
EECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCCEEHHHHHHHHHHCCCEECCHHHH
IACVRAIAAMAHVEATPMSNVKNVESTPSFGRDYLIPGPLEPNLIIEIASAVAKAAMDSG
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VATLPIADMKAYRQRLSEFVYNSAFVMKPIFARAKADPKRIVYCEGEDSNVLLAVQVVVD
CEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEEEEEC
EQLAYPILVGRPSVIENNIAKLALRLKDGVNITIVNVDDDPRYNDYWKGYYEKNKRTGVS
CCCCCEEEECCCHHHHHHHHHEEEEECCCCEEEEEECCCCCCCCHHHCCHHHCCCCCCCE
IELARRDVRRKTSLIGALLVENGDADGMICGTFGHYQLHLKYVGGVINKKEGINDFYAMN
EHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCEEEEEEECCCHHCCCCCCCHHHHHH
AVLMQDRNIFIADTYIHEDPTAEQLAEMTVLAAEQLCRFSITPRVALVSHSNFGTSDRAS
EEEEECCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHH
AVKMRKVHQLLTEMNVDFEFDGEMQGDAALDEHIRANDLPSSNLKGSANLLILPTLDASN
HHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCH
IAFNLLKTATGSASIGPILLGASKPVHILTPSATARRVVNMTALAVTEAQDLDNEKQ
HHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHEEEECHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]