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The map label for this gene is maeA [H]

Identifier: 93005810

GI number: 93005810

Start: 1172106

End: 1173788

Strand: Direct

Name: maeA [H]

Synonym: Pcryo_0982

Alternate gene names: 93005810

Gene position: 1172106-1173788 (Clockwise)

Preceding gene: 93005797

Following gene: 93005829

Centisome position: 38.31

GC content: 41.59

Gene sequence:

>1683_bases
ATGTTAAACCAACGTCCGTTATATATCCCCTTTGCAGGTCCTGCACTATTAGAAACCCCTTTATTGAATAAGGGCAGTGC
TTTTTCATCAGAGGAGCGCGATAGCTTTAATTTAACCGGTCTATTACCTCATAATATTGAGACGATTGAAGAGCAGTCAT
CACGTGCTTATCTTCAACTACGCTCATTTACCAGTGATATGGATAAGCATATTTATTTGCGTAATATACAAGACACTAAT
GAGACATTATTTCACCATTTGATTGAGCAGCATATTGAGGAAGTCATGCCGCTCATCTATACCCCTACGGTTGGGCAAGC
TTGTGAAAAATTCTCTCAAATTTATCGCCGTAAACGTGGTTTATTTATTTCTTATCCTGAACGTCATAAAATCGATGACA
TGTTGCAAAACGCCACCAAACAAAACGTAAAAGTTATCGTGGTCACTGATGGCGAACGTATCTTGGGCTTAGGTGACCAA
GGTATTGGCGGTATGGGAATTCCAATTGGTAAATTGGCTTTATACACCGCTTGTGGTGGTATTAGTCCAGCTTATTGCTT
ACCTATTTTGTTAGATGTCGGTACCAATAATCAGCAGTTGCTTGACGATCCTATGTATATGGGATGGAGAAATCCACGCA
TCTCTGGCGATGAGTACAATGAATTTGTAGACTTATTTATTCAGGCTGTTAAGCGTCGTTGGCCCGAGGTGTTATTGCAA
TTTGAAGATTTTGCACAGGAAAATGCGACCCCATTATTGAATAAATATCGTGATCAGCTCTGTTGCTTTAATGATGATAT
TCAAGGAACTGCTGCTGTTTCAGTCGGTACATTGATTGCAGCATGTTTAAATAAAAGCCAGAAACTTAGTCAACAAAATA
TTGCTTTCTTGGGTGCAGGATCTGCAGGCTGCGGTATCGCTGAGCACATTATTCGTCAGATGCAGCGTGAAGGGTTAACA
GAAGAGCAAGCTCGCAGACAGGTATTTATGGTTGACCGTTATGGTCTGCTAACCGATAGCATGACAGAGCTACAAAAATT
CCAAACACCGTTAGTGCAAAAAGAATCAGATATTGAACATTGGGATAAGAGTCAAAAACTTGGGTTAGCACAAGTGGTTA
AACAAGCAAGAATAACTGTCTTGTTTGGCGTAAGCGGACAAAAAGGTCTCTTTACGCAAGAGGTCGTCGAAGCTTTATGT
GCTAATACTGAACATCCTATTGTATTGCCGCTATCAAATCCAACGTCGCGTGTTGAAGCAACACCGCAAGAAGTGACCAA
CTGGAGTCGTGGTAAGGCCATTGTTGCAACGGGCAGTCCTTTTCCTAATACCACTTTTGAAGGCCAGTCTTACGAGGTTT
CGCAGTGTAATAATAGCTACATATTCCCAGGCATTGGTTTAGGTGTATTAGCAGCACGTGCGACGGGTATCAGCGATAAT
ATGCTGACGGCAGCAAGCCAAGCACTTGCAGATATCTCAGTAGAATATGAAAAAGCGCCAGGTGCCATATTGCCGCCCAT
TAAATTCATTAGAGAAATCAGTGAAAAAATAGCCTATGCAGTTGCCTTGCAAGCGATTGAAGATAAATTGGCATTACCAG
TCACGGCAGAAAACTTAGAGCGTCGATTAAAAGCTAACTTCTGGTTACCTAAATACCGCGACTATCGCCGTACTTCTTTC
TAA

Upstream 100 bases:

>100_bases
AACCATAAATTTAAATAATTTCATTTGTTTAATGAATCGATAAAAATATTTAACCCATTAACCTTGTACCACCCCATACT
TTTAATAAGAAGATTTTATC

Downstream 100 bases:

>100_bases
CGGTTAGAAAATCCGACCAAGAAGCCGAATGCTACGATTAAAAGTAGCATTCGGCTTTTTTAATGATAACAATGCTAATC
CATTAGCCGTTGACGTTTTG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 560; Mature: 560

Protein sequence:

>560_residues
MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQLRSFTSDMDKHIYLRNIQDTN
ETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRGLFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQ
GIGGMGIPIGKLALYTACGGISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQ
FEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAGSAGCGIAEHIIRQMQREGLT
EEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEHWDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALC
ANTEHPIVLPLSNPTSRVEATPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDN
MLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLERRLKANFWLPKYRDYRRTSF

Sequences:

>Translated_560_residues
MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQLRSFTSDMDKHIYLRNIQDTN
ETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRGLFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQ
GIGGMGIPIGKLALYTACGGISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQ
FEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAGSAGCGIAEHIIRQMQREGLT
EEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEHWDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALC
ANTEHPIVLPLSNPTSRVEATPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDN
MLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLERRLKANFWLPKYRDYRRTSF
>Mature_560_residues
MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQLRSFTSDMDKHIYLRNIQDTN
ETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRGLFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQ
GIGGMGIPIGKLALYTACGGISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQ
FEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAGSAGCGIAEHIIRQMQREGLT
EEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEHWDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALC
ANTEHPIVLPLSNPTSRVEATPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDN
MLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLERRLKANFWLPKYRDYRRTSF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=521, Percent_Identity=43.5700575815739, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI62420882, Length=562, Percent_Identity=39.6797153024911, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI62420880, Length=562, Percent_Identity=39.6797153024911, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI239049447, Length=562, Percent_Identity=39.6797153024911, Blast_Score=421, Evalue=1e-117,
Organism=Homo sapiens, GI4505145, Length=555, Percent_Identity=40.5405405405405, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI270265879, Length=466, Percent_Identity=42.9184549356223, Blast_Score=379, Evalue=1e-105,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=63.7992831541219, Blast_Score=729, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=546, Percent_Identity=41.7582417582418, Blast_Score=407, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322823, Length=564, Percent_Identity=42.3758865248227, Blast_Score=433, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24646386, Length=512, Percent_Identity=42.96875, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24646388, Length=512, Percent_Identity=42.96875, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281362672, Length=516, Percent_Identity=42.6356589147287, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI21356279, Length=516, Percent_Identity=42.6356589147287, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI281362674, Length=516, Percent_Identity=42.6356589147287, Blast_Score=428, Evalue=1e-120,
Organism=Drosophila melanogaster, GI78707240, Length=532, Percent_Identity=36.6541353383459, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI78707242, Length=533, Percent_Identity=36.7729831144465, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI78707238, Length=533, Percent_Identity=36.7729831144465, Blast_Score=359, Evalue=2e-99,
Organism=Drosophila melanogaster, GI281363505, Length=510, Percent_Identity=34.7058823529412, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI78707236, Length=510, Percent_Identity=34.7058823529412, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI78707232, Length=507, Percent_Identity=34.7140039447732, Blast_Score=348, Evalue=7e-96,
Organism=Drosophila melanogaster, GI281363503, Length=508, Percent_Identity=34.4488188976378, Blast_Score=346, Evalue=3e-95,
Organism=Drosophila melanogaster, GI19922384, Length=547, Percent_Identity=29.4332723948812, Blast_Score=252, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62601; Mature: 62601

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQL
CCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RSFTSDMDKHIYLRNIQDTNETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRG
HHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCC
LFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGG
CEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHCC
ISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQ
CCHHHHHHHHEECCCCCHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAG
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCEEEEECC
SAGCGIAEHIIRQMQREGLTEEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEH
CCCCCHHHHHHHHHHHCCCCHHHHHCEEEEEECCCCHHHHHHHHHHHHCHHHCCCCCHHH
WDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALCANTEHPIVLPLSNPTSRVEA
HCHHHCCCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHCCC
TPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDN
CHHHHCCCCCCCEEEECCCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHHHHHCCCCCH
MLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLE
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RRLKANFWLPKYRDYRRTSF
HHHHHCCCCCCCCCHHCCCC
>Mature Secondary Structure
MLNQRPLYIPFAGPALLETPLLNKGSAFSSEERDSFNLTGLLPHNIETIEEQSSRAYLQL
CCCCCCEEEECCCHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
RSFTSDMDKHIYLRNIQDTNETLFHHLIEQHIEEVMPLIYTPTVGQACEKFSQIYRRKRG
HHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHCC
LFISYPERHKIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACGG
CEEECCCCCCHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHCC
ISPAYCLPILLDVGTNNQQLLDDPMYMGWRNPRISGDEYNEFVDLFIQAVKRRWPEVLLQ
CCHHHHHHHHEECCCCCHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FEDFAQENATPLLNKYRDQLCCFNDDIQGTAAVSVGTLIAACLNKSQKLSQQNIAFLGAG
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHCCCCEEEEECC
SAGCGIAEHIIRQMQREGLTEEQARRQVFMVDRYGLLTDSMTELQKFQTPLVQKESDIEH
CCCCCHHHHHHHHHHHCCCCHHHHHCEEEEEECCCCHHHHHHHHHHHHCHHHCCCCCHHH
WDKSQKLGLAQVVKQARITVLFGVSGQKGLFTQEVVEALCANTEHPIVLPLSNPTSRVEA
HCHHHCCCHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHCCC
TPQEVTNWSRGKAIVATGSPFPNTTFEGQSYEVSQCNNSYIFPGIGLGVLAARATGISDN
CHHHHCCCCCCCEEEECCCCCCCCCCCCCCEECCCCCCCEECCCCHHHHHHHHHCCCCCH
MLTAASQALADISVEYEKAPGAILPPIKFIREISEKIAYAVALQAIEDKLALPVTAENLE
HHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
RRLKANFWLPKYRDYRRTSF
HHHHHCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA