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The map label for this gene is ubiB [H]

Identifier: 93005516

GI number: 93005516

Start: 812944

End: 814605

Strand: Reverse

Name: ubiB [H]

Synonym: Pcryo_0686

Alternate gene names: 93005516

Gene position: 814605-812944 (Counterclockwise)

Preceding gene: 93005517

Following gene: 93005510

Centisome position: 26.62

GC content: 46.27

Gene sequence:

>1662_bases
ATGCTATTATCCCATCGCGCCCGTTTACTTGAGCTATGGCGCATTGCCGCCACCTATCGTATTGACACCCATTTTTCTGT
CGAAGAGGCGCCGCAGCTACAATCCTTGGTGCGATTAATTCGTATGCATCCTGCCGCGTGGGGGAAAAAGCATCAGCCTA
ATGCGATTAAATACGCGCTTGAAGATATGGGGACTCTATTTTTAAAGCTTGGACAATTACTCTCGACCCGCCGTGACCTC
GTGCCACCTGAGATTATTGCGCAACTTATTCAACTACAAGATAAAGTTAAATCTTTCGATTCTGATATTGCGATTGCGCA
AATCCAAGACCCTAGACACGGTCTCGGTCAATCTATTGGCTCTTTATTTGCACGTTTTGACGTCAAGCCTCTAGCTGCTG
CTTCTATTGCCCAAGTACATACCGCTGCGCTGCATGATGGGCGTGAAGTGGTGGTCAAAGTGGTTCGTCCTGATATTCGC
ACGACCATTATTACAGATTTTGAATTGCTACGAGAACTCGCCAATTGGGCATCGGCGCGTATCGAAGCAGCTCGTGCAAT
ACACATCATCGATATTGTTGAAGACTACCGTCAAGTCATGCTCAACGAGTTAGATTTGACATTAGAGGCAGACAATACAA
CGCAAATGCGTAACAACTTTTTGGGCTCGGCATTGATGTATGTGCCAGAAGTCTATGATGCCAATAAAAACGTCATGGTC
ATGGAGCGTATACAAGGCGTTCCAATCTCACAAATTGAGGTATTTGATCAATTAGGCTATGACCGTGCGGCACTGGCAGA
AAAAGGCTTAACGATATTTTTTACCCAAGTATTCCGTGATAACTTCTTCCATGCCGACATGCACCCCGGCAATGTTTTTG
TCGAGACGCCACCAGTCAATACCTTGACTGCAAATATGGCCGCCGTGGACTTAGGGCATGAGCCGCGTTATATCGGGCTT
GATTGTGCCATCATGGGCACCTTATCAAAGGACGATCAGCTTATCGTCGCGCGAATGTTATTGTCCGTGATGAATAACAA
CTTTACAGCGATGGTTGATATCGTCAGTCGAGCTGGCTGGATACCGCCAAGTGCTGATAAGCATGCATTGATGCGTGATA
TGAAACGCACTGTCGGTCCGATGTTACAAAAATCCATTAACGATATCGACTTTGCCGGTGTATTAATGCAAATATTAGAT
ATCGCCCGCCGCCATCATATGAGTATTCCACCGCAGTTGATGCTACTGCTCAAAACTTTAGTGCATGTCGAAGGACTTGG
TCGCGACTTGTATCCTAATCTTGATATCTGGTCGCTTGCCAAGCCAATCTTAAGCAGCTGGATTAAGGAGCAGCTTGATC
CGATGCGTAATTTACAACAGCTACGTCAGCAGTTGCCTGAGATTTTATTATCGACCACTGATATCCCAAGACTGCTAGAT
CAAGGGTTACAGAGCCTTGCTTCACAAGGATCACGTCAAGACAGTCAACTGCGTGAGATTCAACAAATCCGTGCCGATAT
GCTAAACGACCGTCGCCGAGATTGGTTGGCGCTGGCGGGCTTTGCTATTTTCATAGCCATTGCAACACAAGTTATCGGTT
GGCTATCACCTATTTTTTACCTCTTAGCGATTTTGGCAGTCGTGTGGCGTATCTTAGCCTAA

Upstream 100 bases:

>100_bases
CGCTATCAAAGATGAGCAAGCACGTCTAACTCATAGTAGATAATTGCCTTTTCTACAACGCCTACCTTATTTTTGACTTT
ATCTAGAGTATTTATATCTC

Downstream 100 bases:

>100_bases
ACCGTTAGTAGCTTTGACTAAAAGACTTCTGACAATAACAAGTACTTATTAAAAATAGATGGGCATAAGCATTTGGCTTG
AGCCTTCATCCACTATTTAA

Product: hypothetical protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MLLSHRARLLELWRIAATYRIDTHFSVEEAPQLQSLVRLIRMHPAAWGKKHQPNAIKYALEDMGTLFLKLGQLLSTRRDL
VPPEIIAQLIQLQDKVKSFDSDIAIAQIQDPRHGLGQSIGSLFARFDVKPLAAASIAQVHTAALHDGREVVVKVVRPDIR
TTIITDFELLRELANWASARIEAARAIHIIDIVEDYRQVMLNELDLTLEADNTTQMRNNFLGSALMYVPEVYDANKNVMV
MERIQGVPISQIEVFDQLGYDRAALAEKGLTIFFTQVFRDNFFHADMHPGNVFVETPPVNTLTANMAAVDLGHEPRYIGL
DCAIMGTLSKDDQLIVARMLLSVMNNNFTAMVDIVSRAGWIPPSADKHALMRDMKRTVGPMLQKSINDIDFAGVLMQILD
IARRHHMSIPPQLMLLLKTLVHVEGLGRDLYPNLDIWSLAKPILSSWIKEQLDPMRNLQQLRQQLPEILLSTTDIPRLLD
QGLQSLASQGSRQDSQLREIQQIRADMLNDRRRDWLALAGFAIFIAIATQVIGWLSPIFYLLAILAVVWRILA

Sequences:

>Translated_553_residues
MLLSHRARLLELWRIAATYRIDTHFSVEEAPQLQSLVRLIRMHPAAWGKKHQPNAIKYALEDMGTLFLKLGQLLSTRRDL
VPPEIIAQLIQLQDKVKSFDSDIAIAQIQDPRHGLGQSIGSLFARFDVKPLAAASIAQVHTAALHDGREVVVKVVRPDIR
TTIITDFELLRELANWASARIEAARAIHIIDIVEDYRQVMLNELDLTLEADNTTQMRNNFLGSALMYVPEVYDANKNVMV
MERIQGVPISQIEVFDQLGYDRAALAEKGLTIFFTQVFRDNFFHADMHPGNVFVETPPVNTLTANMAAVDLGHEPRYIGL
DCAIMGTLSKDDQLIVARMLLSVMNNNFTAMVDIVSRAGWIPPSADKHALMRDMKRTVGPMLQKSINDIDFAGVLMQILD
IARRHHMSIPPQLMLLLKTLVHVEGLGRDLYPNLDIWSLAKPILSSWIKEQLDPMRNLQQLRQQLPEILLSTTDIPRLLD
QGLQSLASQGSRQDSQLREIQQIRADMLNDRRRDWLALAGFAIFIAIATQVIGWLSPIFYLLAILAVVWRILA
>Mature_553_residues
MLLSHRARLLELWRIAATYRIDTHFSVEEAPQLQSLVRLIRMHPAAWGKKHQPNAIKYALEDMGTLFLKLGQLLSTRRDL
VPPEIIAQLIQLQDKVKSFDSDIAIAQIQDPRHGLGQSIGSLFARFDVKPLAAASIAQVHTAALHDGREVVVKVVRPDIR
TTIITDFELLRELANWASARIEAARAIHIIDIVEDYRQVMLNELDLTLEADNTTQMRNNFLGSALMYVPEVYDANKNVMV
MERIQGVPISQIEVFDQLGYDRAALAEKGLTIFFTQVFRDNFFHADMHPGNVFVETPPVNTLTANMAAVDLGHEPRYIGL
DCAIMGTLSKDDQLIVARMLLSVMNNNFTAMVDIVSRAGWIPPSADKHALMRDMKRTVGPMLQKSINDIDFAGVLMQILD
IARRHHMSIPPQLMLLLKTLVHVEGLGRDLYPNLDIWSLAKPILSSWIKEQLDPMRNLQQLRQQLPEILLSTTDIPRLLD
QGLQSLASQGSRQDSQLREIQQIRADMLNDRRRDWLALAGFAIFIAIATQVIGWLSPIFYLLAILAVVWRILA

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=241, Percent_Identity=30.2904564315353, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI40254938, Length=290, Percent_Identity=28.2758620689655, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI32261307, Length=337, Percent_Identity=23.1454005934718, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34147522, Length=231, Percent_Identity=28.1385281385281, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI217035081, Length=200, Percent_Identity=29, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI2367309, Length=449, Percent_Identity=39.4209354120267, Blast_Score=355, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI17559152, Length=236, Percent_Identity=28.3898305084746, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI32565180, Length=392, Percent_Identity=23.2142857142857, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=454, Percent_Identity=23.7885462555066, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=258, Percent_Identity=27.1317829457364, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI22024280, Length=296, Percent_Identity=28.0405405405405, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24662575, Length=284, Percent_Identity=27.8169014084507, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62533; Mature: 62533

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSHRARLLELWRIAATYRIDTHFSVEEAPQLQSLVRLIRMHPAAWGKKHQPNAIKYAL
CCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHH
EDMGTLFLKLGQLLSTRRDLVPPEIIAQLIQLQDKVKSFDSDIAIAQIQDPRHGLGQSIG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
SLFARFDVKPLAAASIAQVHTAALHDGREVVVKVVRPDIRTTIITDFELLRELANWASAR
HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEAARAIHIIDIVEDYRQVMLNELDLTLEADNTTQMRNNFLGSALMYVPEVYDANKNVMV
HHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEH
MERIQGVPISQIEVFDQLGYDRAALAEKGLTIFFTQVFRDNFFHADMHPGNVFVETPPVN
HHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEEEECCCCC
TLTANMAAVDLGHEPRYIGLDCAIMGTLSKDDQLIVARMLLSVMNNNFTAMVDIVSRAGW
HHHHHHHHEECCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC
IPPSADKHALMRDMKRTVGPMLQKSINDIDFAGVLMQILDIARRHHMSIPPQLMLLLKTL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VHVEGLGRDLYPNLDIWSLAKPILSSWIKEQLDPMRNLQQLRQQLPEILLSTTDIPRLLD
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QGLQSLASQGSRQDSQLREIQQIRADMLNDRRRDWLALAGFAIFIAIATQVIGWLSPIFY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAILAVVWRILA
HHHHHHHHHHHHC
>Mature Secondary Structure
MLLSHRARLLELWRIAATYRIDTHFSVEEAPQLQSLVRLIRMHPAAWGKKHQPNAIKYAL
CCCCHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHH
EDMGTLFLKLGQLLSTRRDLVPPEIIAQLIQLQDKVKSFDSDIAIAQIQDPRHGLGQSIG
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHH
SLFARFDVKPLAAASIAQVHTAALHDGREVVVKVVRPDIRTTIITDFELLRELANWASAR
HHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEAARAIHIIDIVEDYRQVMLNELDLTLEADNTTQMRNNFLGSALMYVPEVYDANKNVMV
HHHHHHHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEH
MERIQGVPISQIEVFDQLGYDRAALAEKGLTIFFTQVFRDNFFHADMHPGNVFVETPPVN
HHHHCCCCHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEEEECCCCC
TLTANMAAVDLGHEPRYIGLDCAIMGTLSKDDQLIVARMLLSVMNNNFTAMVDIVSRAGW
HHHHHHHHEECCCCCCEEEECCEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCC
IPPSADKHALMRDMKRTVGPMLQKSINDIDFAGVLMQILDIARRHHMSIPPQLMLLLKTL
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VHVEGLGRDLYPNLDIWSLAKPILSSWIKEQLDPMRNLQQLRQQLPEILLSTTDIPRLLD
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
QGLQSLASQGSRQDSQLREIQQIRADMLNDRRRDWLALAGFAIFIAIATQVIGWLSPIFY
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAILAVVWRILA
HHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA