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The map label for this gene is cyp18 [H]

Identifier: 93005494

GI number: 93005494

Start: 786862

End: 787377

Strand: Reverse

Name: cyp18 [H]

Synonym: Pcryo_0664

Alternate gene names: 93005494

Gene position: 787377-786862 (Counterclockwise)

Preceding gene: 93005501

Following gene: 93005493

Centisome position: 25.73

GC content: 43.6

Gene sequence:

>516_bases
ATGGTAGACATGCCACCAGTAGTAGAACTTGACACCAGTATGGGTGCGATCGTTATCGAACTCAATGAAGAAAAAGCACC
AAAAACCGTTGAAAACTTTTTAAACTACGTAAAATCTGGTCATTATGATGGCACGATTTTCCATCGCATCATTGACGGCT
TTATGATTCAAGGCGGTGGAATGGACGCTGAGATGAATGAAAAAGCCACCAACAAGCCAGTAGAAAACGAAGCAGATAAC
GGTTTAAAGAACGACGCTGGCACGATTGCTATGGCGCGTACGCAAGATCCACATTCAGCGACTAGCCAATTTTTTGTCAA
CGTAAAAGACAATGACTTCTTAAACCATTCTGGCAAAAACATGCAAGGTTGGGGTTATACCGTATTTGGTAAAGTAACAA
GCGGTATGGACGTCATCGAAAAAATGCGTGGCGTCCCAACCGGTCGTTTCGGCATGCATGCTGATGTACCAAAAGAGCCA
GTGGTTATCAATTCAGCCACCATCATCACTCAGTAA

Upstream 100 bases:

>100_bases
ATAAAAAAGCCGTTAGACTAGCCATAACTTTTTATCCACCAACTTTTTATCCACCACTTAACAGCGTCATTTTAGGCGCT
GCAATAAAGAGGAATATCCT

Downstream 100 bases:

>100_bases
TCATTCTTCAATAGTTATTACTCAGTAGCGATGAATCAGTGAAAGCTTATGAGTCGTTACTGTTTAAAGTTATGAGGATA
AGGATAAATGCAAAGTTTCA

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MVDMPPVVELDTSMGAIVIELNEEKAPKTVENFLNYVKSGHYDGTIFHRIIDGFMIQGGGMDAEMNEKATNKPVENEADN
GLKNDAGTIAMARTQDPHSATSQFFVNVKDNDFLNHSGKNMQGWGYTVFGKVTSGMDVIEKMRGVPTGRFGMHADVPKEP
VVINSATIITQ

Sequences:

>Translated_171_residues
MVDMPPVVELDTSMGAIVIELNEEKAPKTVENFLNYVKSGHYDGTIFHRIIDGFMIQGGGMDAEMNEKATNKPVENEADN
GLKNDAGTIAMARTQDPHSATSQFFVNVKDNDFLNHSGKNMQGWGYTVFGKVTSGMDVIEKMRGVPTGRFGMHADVPKEP
VVINSATIITQ
>Mature_171_residues
MVDMPPVVELDTSMGAIVIELNEEKAPKTVENFLNYVKSGHYDGTIFHRIIDGFMIQGGGMDAEMNEKATNKPVENEADN
GLKNDAGTIAMARTQDPHSATSQFFVNVKDNDFLNHSGKNMQGWGYTVFGKVTSGMDVIEKMRGVPTGRFGMHADVPKEP
VVINSATIITQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=146, Percent_Identity=41.0958904109589, Blast_Score=91, Evalue=5e-19,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=33.5365853658537, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=33.5365853658537, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=33.5365853658537, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI19557636, Length=144, Percent_Identity=36.8055555555556, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI24308049, Length=165, Percent_Identity=35.7575757575758, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI5454154, Length=177, Percent_Identity=33.8983050847458, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI64276486, Length=138, Percent_Identity=36.231884057971, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI10863927, Length=158, Percent_Identity=34.1772151898734, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=61.7283950617284, Blast_Score=219, Evalue=1e-58,
Organism=Escherichia coli, GI1789763, Length=164, Percent_Identity=56.0975609756098, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17539496, Length=148, Percent_Identity=40.5405405405405, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17506311, Length=162, Percent_Identity=34.5679012345679, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=141, Percent_Identity=37.5886524822695, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=141, Percent_Identity=37.5886524822695, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=165, Percent_Identity=31.5151515151515, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=159, Percent_Identity=33.9622641509434, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539498, Length=144, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=180, Percent_Identity=30, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=34.8837209302326, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=163, Percent_Identity=34.3558282208589, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17986117, Length=169, Percent_Identity=34.3195266272189, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922376, Length=165, Percent_Identity=29.0909090909091, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922912, Length=135, Percent_Identity=36.2962962962963, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652460, Length=164, Percent_Identity=29.2682926829268, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17647301, Length=158, Percent_Identity=32.2784810126582, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136360, Length=162, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18708; Mature: 18708

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDMPPVVELDTSMGAIVIELNEEKAPKTVENFLNYVKSGHYDGTIFHRIIDGFMIQGGG
CCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCC
MDAEMNEKATNKPVENEADNGLKNDAGTIAMARTQDPHSATSQFFVNVKDNDFLNHSGKN
CCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
MQGWGYTVFGKVTSGMDVIEKMRGVPTGRFGMHADVPKEPVVINSATIITQ
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEEEEC
>Mature Secondary Structure
MVDMPPVVELDTSMGAIVIELNEEKAPKTVENFLNYVKSGHYDGTIFHRIIDGFMIQGGG
CCCCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHEEEECCC
MDAEMNEKATNKPVENEADNGLKNDAGTIAMARTQDPHSATSQFFVNVKDNDFLNHSGKN
CCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCC
MQGWGYTVFGKVTSGMDVIEKMRGVPTGRFGMHADVPKEPVVINSATIITQ
CCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]