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The map label for this gene is dut [H]

Identifier: 93005400

GI number: 93005400

Start: 678627

End: 679091

Strand: Reverse

Name: dut [H]

Synonym: Pcryo_0570

Alternate gene names: 93005400

Gene position: 679091-678627 (Counterclockwise)

Preceding gene: 93005401

Following gene: 93005399

Centisome position: 22.19

GC content: 45.16

Gene sequence:

>465_bases
ATGCAAGCTGTACAAGTTAAAGTCTTAAACCCTAAAATCACTGAAGATAAAGCGTTTTCTTTGCCTACTCGTGCCACTGA
TGGCAGCGCAGGTATTGATTTGCGCGCTTGTATTGATGAGCCTTTAACGATTAAAGCGGGTGCTACCCATTTGATTGGTA
CTGGTTTGGCGGTTTATATACAAGATCCCAACTTTGCAGGCATGATTTTACCGCGTTCAGGTCTTGGACATAAGCATGGT
ATTGTTTTGGGTAACTTGGTTGGACTTATCGATGCGGATTATCAAGGTGAGCTGATGGTCAGTATTTGGAATCGTAGCCA
GGAAGACTTTGTATTAACTCCTGCAGAACGCATGGCACAATACGTGGTTGTCCCTGTTGCCCGTCCTGAATTTGAAGTCG
TGACAGAATTTAGTGATACCAGCGCACGTGGTGCTGGTGGTTTTGGACACTCTGGTCGTCAGTAG

Upstream 100 bases:

>100_bases
TTATAAAAATAGTTGTTGTTAAGCAATTAAATTTAAAAATTAGGGCACGCCCTAAATTCATTCTGTTTATAAAACCATTA
AATCGTTAAGTGAGTGCGTT

Downstream 100 bases:

>100_bases
TCATTATCATTTGCTCTAAATTACATAGTCTAAATCGCATAACCTAAGCTGTATAAAAAACTATCAGCGATTTATTTATC
ATTCATATTTATCATGATAA

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGATHLIGTGLAVYIQDPNFAGMILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSIWNRSQEDFVLTPAERMAQYVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ

Sequences:

>Translated_154_residues
MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGATHLIGTGLAVYIQDPNFAGMILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSIWNRSQEDFVLTPAERMAQYVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ
>Mature_154_residues
MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGATHLIGTGLAVYIQDPNFAGMILPRSGLGHKHG
IVLGNLVGLIDADYQGELMVSIWNRSQEDFVLTPAERMAQYVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI4503423, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI70906441, Length=135, Percent_Identity=34.8148148148148, Blast_Score=73, Evalue=9e-14,
Organism=Escherichia coli, GI1790071, Length=154, Percent_Identity=59.0909090909091, Blast_Score=196, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71988561, Length=134, Percent_Identity=34.3283582089552, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319729, Length=152, Percent_Identity=36.1842105263158, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921126, Length=131, Percent_Identity=34.3511450381679, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583610, Length=131, Percent_Identity=34.3511450381679, Blast_Score=77, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 16476; Mature: 16476

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGATHLIGTGLAVYI
CCEEEEEEECCCCCCCCCEECCCCCCCCCCCEEEEEECCCCEEEECCCCEEECCCEEEEE
QDPNFAGMILPRSGLGHKHGIVLGNLVGLIDADYQGELMVSIWNRSQEDFVLTPAERMAQ
ECCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCEEECCHHHCCE
YVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ
EEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAVQVKVLNPKITEDKAFSLPTRATDGSAGIDLRACIDEPLTIKAGATHLIGTGLAVYI
CCEEEEEEECCCCCCCCCEECCCCCCCCCCCEEEEEECCCCEEEECCCCEEECCCEEEEE
QDPNFAGMILPRSGLGHKHGIVLGNLVGLIDADYQGELMVSIWNRSQEDFVLTPAERMAQ
ECCCCEEEEEECCCCCCCCCEEEEEEEEEECCCCCCEEEEEEECCCCCCEEECCHHHCCE
YVVVPVARPEFEVVTEFSDTSARGAGGFGHSGRQ
EEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA