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The map label for this gene is uxuB [H]

Identifier: 92115095

GI number: 92115095

Start: 3317237

End: 3318694

Strand: Direct

Name: uxuB [H]

Synonym: Csal_2979

Alternate gene names: 92115095

Gene position: 3317237-3318694 (Clockwise)

Preceding gene: 92115094

Following gene: 92115096

Centisome position: 89.74

GC content: 68.31

Gene sequence:

>1458_bases
ATGACACCGACATCGATACCCAGCGTCCATGCGCCAGCCGAGGTGGGCATCGTGCATCTCGGCCTGGGCGCCTTCCACCG
CGCCCACCAGGCGGTCTACCTGGAGCGCAACCTGGCCCGCCACGCAGGCGGCCCGTGGGGCATCGCCAGTGCCAACCTCC
GCTCCAACCGCCGCCTCGTCGAGCTGATGCGCGAACGCGGTCAGCACTATCACGTCGCCGAGTACGCCGACAGCGACACC
CTGACGCTGCGGGAAATCACGGCGATCCGCGAAACCTACTATGCCGGCCCCGACGGCGAGGACCTCGACGCCCTGCTGGA
GCGCATGAGCGAACCCGATGTACGCATCGTCACGCTGACCGTGACGGAGAAGGGCTACCACCTTGATCCAGCCGACGGAC
GACTACGGCTCGATGCCGCGCCGATTCGCCACGATATCGCCTCGCCCGCGCGGCCCTGGACCGCCCCGGGCATGCTGGTC
GAGGCGCTGGCCCGGCGCCGGGCGGCCGGTACGCCACCTTTCGCGGTACTCAGTTGCGACAACATGCCGGACAACGGCAA
GCGCGTCCATCGCGCGGCAATCGAGCTGGCGCGCCATCGCGACGAGCGGCTCGCCGAATGGATCGCCGATGCCGTCGCCT
TCCCCTGCAGCATGGTCGATCGCATCGTCCCGGCGATGAGCGACGATGCGTTCCAGCGCCTGAGCGCCCTCGGCATCGAC
GATCCGGCAGCGGTGGTCTGCGAGGCCTTCAGCCAGTGGGTGATCGAGGACGACTTCCCGCAGGGTCGCCCCGACTGGGA
GCACGACGGGGTACAGATGGTCGCCGATGTCGCGCCCTTCGAGACCATGAAGCTGCGCATGCTCAACGGCAGCCACTCGC
TGCTCGCCTATCTCGGCGCGCTGGCCGGCATCGAAACGGTGGCAGAAGCCGTCGAGCGCCCTGAATTCGTCGCTCTGCTG
CGCCGCTACATGCGGGATGAAGCCGCACCGACACTCGCCATGCCGGCCGGTATCGATCTCGAGGCCTATGCCGACCGCCT
GATCGAACGCTTCGCCAACGACAGCCTGCATCATCGCCTGCAGCAGATCGCCATGGACGGGTCCCAGAAACTGCCCCAGC
GCTGGCTCGCCGGCGCCCGAAAACAGCTCGACACCGGCGGCGAGATCGGCTGCACGGCGCTCGGCGTGGCGGCCTGGATC
CGCTATACCGCCGGCAACGACCTGGCAGGCGCGCGCCACCCGGTCGACGACCCGATGGCCGACACTTTCGCCACCCTGCA
TGCCGACCATCGCGGGAGCGAAGCGCTGATCGCCGCCTTTCTCGGTCTCGACAGCGTTTTTCCGCGCGACCTGGCCGACG
ATGCCCGCTTTTCAGCCGCAGTGCTCGAGGCCTACCGCACACTGGACGAAGGTGGCGTCGAGAGATCGCTGACCGGCCTC
GACGCACGCACACGATAG

Upstream 100 bases:

>100_bases
GCCGTTTCTGATCTGCAATCTCGTGGTGCTGCTGCTGGTCGCATACATCCCCGCCCTGTCACTCTGGCTACCCAACCTGC
TGCTCGGGGAGTGATCGTTC

Downstream 100 bases:

>100_bases
GAGACGACCATGGAACACACCTGGCGCTGGTTCGGGCCCGACGACCCGATCACCCTCGACGAGATTCGCCAGACCGGAGC
CACCGGTATCGTCACCGCCC

Product: mannitol dehydrogenase-like protein

Products: NA

Alternate protein names: Fructuronate reductase [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTPTSIPSVHAPAEVGIVHLGLGAFHRAHQAVYLERNLARHAGGPWGIASANLRSNRRLVELMRERGQHYHVAEYADSDT
LTLREITAIRETYYAGPDGEDLDALLERMSEPDVRIVTLTVTEKGYHLDPADGRLRLDAAPIRHDIASPARPWTAPGMLV
EALARRRAAGTPPFAVLSCDNMPDNGKRVHRAAIELARHRDERLAEWIADAVAFPCSMVDRIVPAMSDDAFQRLSALGID
DPAAVVCEAFSQWVIEDDFPQGRPDWEHDGVQMVADVAPFETMKLRMLNGSHSLLAYLGALAGIETVAEAVERPEFVALL
RRYMRDEAAPTLAMPAGIDLEAYADRLIERFANDSLHHRLQQIAMDGSQKLPQRWLAGARKQLDTGGEIGCTALGVAAWI
RYTAGNDLAGARHPVDDPMADTFATLHADHRGSEALIAAFLGLDSVFPRDLADDARFSAAVLEAYRTLDEGGVERSLTGL
DARTR

Sequences:

>Translated_485_residues
MTPTSIPSVHAPAEVGIVHLGLGAFHRAHQAVYLERNLARHAGGPWGIASANLRSNRRLVELMRERGQHYHVAEYADSDT
LTLREITAIRETYYAGPDGEDLDALLERMSEPDVRIVTLTVTEKGYHLDPADGRLRLDAAPIRHDIASPARPWTAPGMLV
EALARRRAAGTPPFAVLSCDNMPDNGKRVHRAAIELARHRDERLAEWIADAVAFPCSMVDRIVPAMSDDAFQRLSALGID
DPAAVVCEAFSQWVIEDDFPQGRPDWEHDGVQMVADVAPFETMKLRMLNGSHSLLAYLGALAGIETVAEAVERPEFVALL
RRYMRDEAAPTLAMPAGIDLEAYADRLIERFANDSLHHRLQQIAMDGSQKLPQRWLAGARKQLDTGGEIGCTALGVAAWI
RYTAGNDLAGARHPVDDPMADTFATLHADHRGSEALIAAFLGLDSVFPRDLADDARFSAAVLEAYRTLDEGGVERSLTGL
DARTR
>Mature_484_residues
TPTSIPSVHAPAEVGIVHLGLGAFHRAHQAVYLERNLARHAGGPWGIASANLRSNRRLVELMRERGQHYHVAEYADSDTL
TLREITAIRETYYAGPDGEDLDALLERMSEPDVRIVTLTVTEKGYHLDPADGRLRLDAAPIRHDIASPARPWTAPGMLVE
ALARRRAAGTPPFAVLSCDNMPDNGKRVHRAAIELARHRDERLAEWIADAVAFPCSMVDRIVPAMSDDAFQRLSALGIDD
PAAVVCEAFSQWVIEDDFPQGRPDWEHDGVQMVADVAPFETMKLRMLNGSHSLLAYLGALAGIETVAEAVERPEFVALLR
RYMRDEAAPTLAMPAGIDLEAYADRLIERFANDSLHHRLQQIAMDGSQKLPQRWLAGARKQLDTGGEIGCTALGVAAWIR
YTAGNDLAGARHPVDDPMADTFATLHADHRGSEALIAAFLGLDSVFPRDLADDARFSAAVLEAYRTLDEGGVERSLTGLD
ARTR

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family. UxuB subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790779, Length=482, Percent_Identity=47.7178423236515, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1788497, Length=477, Percent_Identity=47.1698113207547, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787823, Length=468, Percent_Identity=43.5897435897436, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI48994885, Length=371, Percent_Identity=26.6846361185984, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI1790028, Length=301, Percent_Identity=27.5747508305648, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324401, Length=463, Percent_Identity=38.0129589632829, Blast_Score=303, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6320765, Length=463, Percent_Identity=38.0129589632829, Blast_Score=303, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C [H]

EC number: =1.1.1.57 [H]

Molecular weight: Translated: 53201; Mature: 53069

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPTSIPSVHAPAEVGIVHLGLGAFHRAHQAVYLERNLARHAGGPWGIASANLRSNRRLV
CCCCCCCCCCCCHHHCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ELMRERGQHYHVAEYADSDTLTLREITAIRETYYAGPDGEDLDALLERMSEPDVRIVTLT
HHHHHCCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEE
VTEKGYHLDPADGRLRLDAAPIRHDIASPARPWTAPGMLVEALARRRAAGTPPFAVLSCD
EECCCCEECCCCCEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECC
NMPDNGKRVHRAAIELARHRDERLAEWIADAVAFPCSMVDRIVPAMSDDAFQRLSALGID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
DPAAVVCEAFSQWVIEDDFPQGRPDWEHDGVQMVADVAPFETMKLRMLNGSHSLLAYLGA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHEEEEEECCCHHHHHHHHH
LAGIETVAEAVERPEFVALLRRYMRDEAAPTLAMPAGIDLEAYADRLIERFANDSLHHRL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCHHHHHHH
QQIAMDGSQKLPQRWLAGARKQLDTGGEIGCTALGVAAWIRYTAGNDLAGARHPVDDPMA
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
DTFATLHADHRGSEALIAAFLGLDSVFPRDLADDARFSAAVLEAYRTLDEGGVERSLTGL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
DARTR
CCCCC
>Mature Secondary Structure 
TPTSIPSVHAPAEVGIVHLGLGAFHRAHQAVYLERNLARHAGGPWGIASANLRSNRRLV
CCCCCCCCCCCHHHCEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
ELMRERGQHYHVAEYADSDTLTLREITAIRETYYAGPDGEDLDALLERMSEPDVRIVTLT
HHHHHCCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEEE
VTEKGYHLDPADGRLRLDAAPIRHDIASPARPWTAPGMLVEALARRRAAGTPPFAVLSCD
EECCCCEECCCCCEEEECCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECC
NMPDNGKRVHRAAIELARHRDERLAEWIADAVAFPCSMVDRIVPAMSDDAFQRLSALGID
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
DPAAVVCEAFSQWVIEDDFPQGRPDWEHDGVQMVADVAPFETMKLRMLNGSHSLLAYLGA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHCCHHHEEEEEECCCHHHHHHHHH
LAGIETVAEAVERPEFVALLRRYMRDEAAPTLAMPAGIDLEAYADRLIERFANDSLHHRL
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHHHCHHHHHHH
QQIAMDGSQKLPQRWLAGARKQLDTGGEIGCTALGVAAWIRYTAGNDLAGARHPVDDPMA
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
DTFATLHADHRGSEALIAAFLGLDSVFPRDLADDARFSAAVLEAYRTLDEGGVERSLTGL
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCC
DARTR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]