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The map label for this gene is purK [H]

Identifier: 92115015

GI number: 92115015

Start: 3228734

End: 3229828

Strand: Direct

Name: purK [H]

Synonym: Csal_2898

Alternate gene names: 92115015

Gene position: 3228734-3229828 (Clockwise)

Preceding gene: 92115014

Following gene: 92115024

Centisome position: 87.34

GC content: 69.5

Gene sequence:

>1095_bases
ATGCATATCGGTATCGTGGGCGGCGGCCAATTGGGCCGGATGCTGGCCCAAGCGGGGGCGCCGCTGGACATGCGCTTCAC
CTTCCTCGATCCCTCGACCCAGGCGTGCGCCGCCTCGCAGGGCGTGCACCTCTGCGCCGATTGGGACGACGAAGAAGCGC
ACCAGGCACTCATCGAAGCCAGCGACGTGATCACCTTCGAGTTCGAGAACGTCTCGACCATGGCGCTGACGCAGCTCGCC
GAGCAGCGCCCGGCCTTCCCGCCGGCCAAGGCACTGGAAACCGCGCGCGACCGTGGCGCCGAGAAATCGCTGTTCCAGTC
GCTGGACATCGCCATTGCCCCCATCGCGCTGATCGAGAGCCAGGAAGATCTGGACCGCGCGGTGGCCGAGATCGGCCTGC
CGGCGGTGCTCAAGACGCGCACCCTGGGCTACGACGGCAAGGGCCAGAAGGTGCTGCGCAGCGCCGACTACGTGCCCGGC
AGCGTCGCCGAGCTGGGTGACGTGCCCTTGATCCTGGAAGGCTTCATCGACTTCGATCATGAAGTCTCGGCCATCGCCGT
GCGCGGCCGCGACGGCGAGGTGCGGGTGTGGCCGCTGTCACGCAACGAGCACCGCCAGGGCATCCTGCATCGTGCCGAGC
CGCAGCCCGACCACCCGCTGTACGCCCGCGCCGCCGACTACGCCACCCGCGTGCTCGACGCGCTGGAGTACGTCGGGGTC
ATGGCCTTCGAGTTCTTCGTCACCCGCGACGGCGAGCTGCTCGCCAACGAAATCGCCCCCCGCGTGCACAACTCCGGGCA
CTGGAGCATCGAAGGCGCGACGACCAGCCAGTTCGAGAATCACCTGCGCGCCGTCGCCGGGCTGCCGCTGGGCGACACGA
CACGCCTCGTGCCCTGCGCCATGCTCAACATCATCGGCGCCTTCCCCGACCGCGACGCCGTGCTCAGTGTCGCCGGCGCA
CGCCTGCACGACTACGACAAGGCCCCGCGCCCCGGCCGCAAGATCGGCCATGTCACGGTTCTCGCACCCGACGAGGCCAC
CCTGGCCGAGCGCGTCGCCGCCGTCGAGGCCCTGCTGGTCAACGACCTGGGCTGA

Upstream 100 bases:

>100_bases
CGGCGATCCGCGAAGCGCTGGAAGCCTACCGCGCCGAGCAGACGCAAAAAGTGCTCGACGCGCCCGACCCTCGCCCCACC
GACTCCCAGGAGACATGAGC

Downstream 100 bases:

>100_bases
GCCCCCGCCCCGCGCCCCCCGTCGTAACGCAAGATGCCCGCCAATTGGCGGGCATCTGGTATCGGCATGGCAGCGACGCG
ATCACTCGTCGTCGGCGCTC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MHIGIVGGGQLGRMLAQAGAPLDMRFTFLDPSTQACAASQGVHLCADWDDEEAHQALIEASDVITFEFENVSTMALTQLA
EQRPAFPPAKALETARDRGAEKSLFQSLDIAIAPIALIESQEDLDRAVAEIGLPAVLKTRTLGYDGKGQKVLRSADYVPG
SVAELGDVPLILEGFIDFDHEVSAIAVRGRDGEVRVWPLSRNEHRQGILHRAEPQPDHPLYARAADYATRVLDALEYVGV
MAFEFFVTRDGELLANEIAPRVHNSGHWSIEGATTSQFENHLRAVAGLPLGDTTRLVPCAMLNIIGAFPDRDAVLSVAGA
RLHDYDKAPRPGRKIGHVTVLAPDEATLAERVAAVEALLVNDLG

Sequences:

>Translated_364_residues
MHIGIVGGGQLGRMLAQAGAPLDMRFTFLDPSTQACAASQGVHLCADWDDEEAHQALIEASDVITFEFENVSTMALTQLA
EQRPAFPPAKALETARDRGAEKSLFQSLDIAIAPIALIESQEDLDRAVAEIGLPAVLKTRTLGYDGKGQKVLRSADYVPG
SVAELGDVPLILEGFIDFDHEVSAIAVRGRDGEVRVWPLSRNEHRQGILHRAEPQPDHPLYARAADYATRVLDALEYVGV
MAFEFFVTRDGELLANEIAPRVHNSGHWSIEGATTSQFENHLRAVAGLPLGDTTRLVPCAMLNIIGAFPDRDAVLSVAGA
RLHDYDKAPRPGRKIGHVTVLAPDEATLAERVAAVEALLVNDLG
>Mature_364_residues
MHIGIVGGGQLGRMLAQAGAPLDMRFTFLDPSTQACAASQGVHLCADWDDEEAHQALIEASDVITFEFENVSTMALTQLA
EQRPAFPPAKALETARDRGAEKSLFQSLDIAIAPIALIESQEDLDRAVAEIGLPAVLKTRTLGYDGKGQKVLRSADYVPG
SVAELGDVPLILEGFIDFDHEVSAIAVRGRDGEVRVWPLSRNEHRQGILHRAEPQPDHPLYARAADYATRVLDALEYVGV
MAFEFFVTRDGELLANEIAPRVHNSGHWSIEGATTSQFENHLRAVAGLPLGDTTRLVPCAMLNIIGAFPDRDAVLSVAGA
RLHDYDKAPRPGRKIGHVTVLAPDEATLAERVAAVEALLVNDLG

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=360, Percent_Identity=38.6111111111111, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1788155, Length=315, Percent_Identity=27.9365079365079, Blast_Score=94, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=376, Percent_Identity=30.8510638297872, Blast_Score=185, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 39314; Mature: 39314

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGIVGGGQLGRMLAQAGAPLDMRFTFLDPSTQACAASQGVHLCADWDDEEAHQALIEA
CEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCEEEECCCCHHHHHHHHHH
SDVITFEFENVSTMALTQLAEQRPAFPPAKALETARDRGAEKSLFQSLDIAIAPIALIES
CCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
QEDLDRAVAEIGLPAVLKTRTLGYDGKGQKVLRSADYVPGSVAELGDVPLILEGFIDFDH
HHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHCCCCCCCHHHHCCCCEEEHHHHCCCC
EVSAIAVRGRDGEVRVWPLSRNEHRQGILHRAEPQPDHPLYARAADYATRVLDALEYVGV
CEEEEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MAFEFFVTRDGELLANEIAPRVHNSGHWSIEGATTSQFENHLRAVAGLPLGDTTRLVPCA
HHHHHEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHH
MLNIIGAFPDRDAVLSVAGARLHDYDKAPRPGRKIGHVTVLAPDEATLAERVAAVEALLV
HHHHHHCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NDLG
HCCC
>Mature Secondary Structure
MHIGIVGGGQLGRMLAQAGAPLDMRFTFLDPSTQACAASQGVHLCADWDDEEAHQALIEA
CEEEEECCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHCCCCEEEECCCCHHHHHHHHHH
SDVITFEFENVSTMALTQLAEQRPAFPPAKALETARDRGAEKSLFQSLDIAIAPIALIES
CCEEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCC
QEDLDRAVAEIGLPAVLKTRTLGYDGKGQKVLRSADYVPGSVAELGDVPLILEGFIDFDH
HHHHHHHHHHHCCCHHHHHEECCCCCCCHHHHHHCCCCCCCHHHHCCCCEEEHHHHCCCC
EVSAIAVRGRDGEVRVWPLSRNEHRQGILHRAEPQPDHPLYARAADYATRVLDALEYVGV
CEEEEEEECCCCCEEEEECCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MAFEFFVTRDGELLANEIAPRVHNSGHWSIEGATTSQFENHLRAVAGLPLGDTTRLVPCA
HHHHHEEECCCHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHH
MLNIIGAFPDRDAVLSVAGARLHDYDKAPRPGRKIGHVTVLAPDEATLAERVAAVEALLV
HHHHHHCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NDLG
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]