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The map label for this gene is purE [H]

Identifier: 92115014

GI number: 92115014

Start: 3228225

End: 3228731

Strand: Direct

Name: purE [H]

Synonym: Csal_2897

Alternate gene names: 92115014

Gene position: 3228225-3228731 (Clockwise)

Preceding gene: 92115013

Following gene: 92115015

Centisome position: 87.33

GC content: 69.43

Gene sequence:

>507_bases
ATGAGCGCACTGGTTGGTGTCATCATGGGCTCGAAGTCCGACTGGGCGACCTTGTGCCATACCGTCGACACGCTCGAGGC
ACTCGGCATCGAGCACGAGGTCAAGGTCGTCTCGGCGCACCGCACGCCGGATCTGCTGTTCGACTACGCCGCCGGCGCTG
CCGATCGCGGCCTGGAAGTCATCATCGCCGGTGCCGGCGGTGCCGCGCATCTGCCCGGGATGGCCGCCGCCAAGACGCCC
CTGCCGGTGCTCGGGGTGCCCGTGCAGTCGAGCATGCTCAGCGGGGTCGACTCGCTGCTCTCCATCGTGCAGATGCCGGC
GGGCATTCCCACCGGCACCCTGGCCATCGGCCGAGCCGGCGCCATCAACGCCGCCCTGCTCGCCGCCGCCATGCTGGGCA
ACAAGTACCCGGCGATCCGCGAAGCGCTGGAAGCCTACCGCGCCGAGCAGACGCAAAAAGTGCTCGACGCGCCCGACCCT
CGCCCCACCGACTCCCAGGAGACATGA

Upstream 100 bases:

>100_bases
CTGAGCGAGGGCGCTGATGCTATAATGCCGCGCTTCTCGTTTCGCGCGACGCCACGACGTTGCCACAACGGCGTTGCCAC
ACACACGAAGGGGAGAAAGC

Downstream 100 bases:

>100_bases
GCATGCATATCGGTATCGTGGGCGGCGGCCAATTGGGCCGGATGCTGGCCCAAGCGGGGGCGCCGCTGGACATGCGCTTC
ACCTTCCTCGATCCCTCGAC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSALVGVIMGSKSDWATLCHTVDTLEALGIEHEVKVVSAHRTPDLLFDYAAGAADRGLEVIIAGAGGAAHLPGMAAAKTP
LPVLGVPVQSSMLSGVDSLLSIVQMPAGIPTGTLAIGRAGAINAALLAAAMLGNKYPAIREALEAYRAEQTQKVLDAPDP
RPTDSQET

Sequences:

>Translated_168_residues
MSALVGVIMGSKSDWATLCHTVDTLEALGIEHEVKVVSAHRTPDLLFDYAAGAADRGLEVIIAGAGGAAHLPGMAAAKTP
LPVLGVPVQSSMLSGVDSLLSIVQMPAGIPTGTLAIGRAGAINAALLAAAMLGNKYPAIREALEAYRAEQTQKVLDAPDP
RPTDSQET
>Mature_167_residues
SALVGVIMGSKSDWATLCHTVDTLEALGIEHEVKVVSAHRTPDLLFDYAAGAADRGLEVIIAGAGGAAHLPGMAAAKTPL
PVLGVPVQSSMLSGVDSLLSIVQMPAGIPTGTLAIGRAGAINAALLAAAMLGNKYPAIREALEAYRAEQTQKVLDAPDPR
PTDSQET

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=62.8930817610063, Blast_Score=168, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324702, Length=152, Percent_Identity=52.6315789473684, Blast_Score=148, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17177; Mature: 17046

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALVGVIMGSKSDWATLCHTVDTLEALGIEHEVKVVSAHRTPDLLFDYAAGAADRGLEV
CCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCEEE
IIAGAGGAAHLPGMAAAKTPLPVLGVPVQSSMLSGVDSLLSIVQMPAGIPTGTLAIGRAG
EEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
AINAALLAAAMLGNKYPAIREALEAYRAEQTQKVLDAPDPRPTDSQET
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SALVGVIMGSKSDWATLCHTVDTLEALGIEHEVKVVSAHRTPDLLFDYAAGAADRGLEV
CCCEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCEEE
IIAGAGGAAHLPGMAAAKTPLPVLGVPVQSSMLSGVDSLLSIVQMPAGIPTGTLAIGRAG
EEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCC
AINAALLAAAMLGNKYPAIREALEAYRAEQTQKVLDAPDPRPTDSQET
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]