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The map label for this gene is rhtB [C]

Identifier: 92114995

GI number: 92114995

Start: 3210556

End: 3211269

Strand: Direct

Name: rhtB [C]

Synonym: Csal_2878

Alternate gene names: 92114995

Gene position: 3210556-3211269 (Clockwise)

Preceding gene: 92114994

Following gene: 92114996

Centisome position: 86.85

GC content: 60.92

Gene sequence:

>714_bases
ATGATCCGCGTCCCATTATTCTGCAGTGGCCTGATGGCGCTGGTCATCGTGGTCATGACACAGGCGTTCCTGGGTGCGGT
TACCTCCATCGACTGGCCGCTCCTGATCGGTGCGTCCATAGTCATGGCTTTAACGCCTGGCGCCAATCAGCTCTTATCGC
TTTCCAATGGTTTCCATGTCGGTGTCGCGCCTGCCATGACGGCGGCCTGCGGACGCTTCGCAGCGTTCGCCTTGATGGTG
GTCGGTGTCGCGGTGGGGCTCGGGCATTGGCTGGCAACCTCCGCGATGTTCTTCAGCGTGCTCAAGTGGATTGGCGTGGC
GTATCTGTCATATCTCGGAGTGAGGTCATTGCTCACGGCTTGGCGACCTAAAGCGGTAAGCCCGAGCGAGGGCATCGAGA
CTGCGCAGACCTGGCCGCTGCTACGCCGGGAAGCGCTGGTCGCATTCTCCAACCCCAAGGCATATGTGCTGTTTGCGCTC
TTCCTGCCGCAGTTTTTGCATGCCGATAGCGTGTCGTTCGCACCGGCCATCATGCTGGCGGGGCTGGCTTATATCTTGAT
CGAGTTCGTTTGCGCGCTGCTCTATGCCGGCGCGGGACATCTACTCGGGCGCGGCCGCATCAGCCTGAGCCGGCAACGCT
GGCTGGATGGTATCAGCGGCTCGCTAATGGTTAGCCTGGCCGGGTGGTTGGCGTTGGCGAAACGCCAAGCTTAA

Upstream 100 bases:

>100_bases
TTTGTGCTTCGGTTGGCCGGCTGCTAAGCAGTAACGGGCCCCGACGGAATAAACGATGTCCGAGAGCCACTGACGGTTTT
CCACCAAGGAAGGAGTGACC

Downstream 100 bases:

>100_bases
GCCGGGAGATCGATGCAAGGCTAGCACTGCAGGGCAGTCATCAGGGATGACAATGATCCGACGCAATACTCGTCATACCG
ATCTACCCCGGCGTAACGCA

Product: lysine exporter protein LysE/YggA

Products: homoserine lactone [Periplasm]; Proton [Cytoplasm]; homoserine [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIRVPLFCSGLMALVIVVMTQAFLGAVTSIDWPLLIGASIVMALTPGANQLLSLSNGFHVGVAPAMTAACGRFAAFALMV
VGVAVGLGHWLATSAMFFSVLKWIGVAYLSYLGVRSLLTAWRPKAVSPSEGIETAQTWPLLRREALVAFSNPKAYVLFAL
FLPQFLHADSVSFAPAIMLAGLAYILIEFVCALLYAGAGHLLGRGRISLSRQRWLDGISGSLMVSLAGWLALAKRQA

Sequences:

>Translated_237_residues
MIRVPLFCSGLMALVIVVMTQAFLGAVTSIDWPLLIGASIVMALTPGANQLLSLSNGFHVGVAPAMTAACGRFAAFALMV
VGVAVGLGHWLATSAMFFSVLKWIGVAYLSYLGVRSLLTAWRPKAVSPSEGIETAQTWPLLRREALVAFSNPKAYVLFAL
FLPQFLHADSVSFAPAIMLAGLAYILIEFVCALLYAGAGHLLGRGRISLSRQRWLDGISGSLMVSLAGWLALAKRQA
>Mature_237_residues
MIRVPLFCSGLMALVIVVMTQAFLGAVTSIDWPLLIGASIVMALTPGANQLLSLSNGFHVGVAPAMTAACGRFAAFALMV
VGVAVGLGHWLATSAMFFSVLKWIGVAYLSYLGVRSLLTAWRPKAVSPSEGIETAQTWPLLRREALVAFSNPKAYVLFAL
FLPQFLHADSVSFAPAIMLAGLAYILIEFVCALLYAGAGHLLGRGRISLSRQRWLDGISGSLMVSLAGWLALAKRQA

Specific function: Conducts The Efflux Of Homoserine And Homoserine Lactone. [C]

COG id: COG1280

COG function: function code E; Putative threonine efflux protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the rht family [H]

Homologues:

Organism=Escherichia coli, GI48994979, Length=203, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788099, Length=139, Percent_Identity=28.0575539568345, Blast_Score=67, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004778
- InterPro:   IPR001123 [H]

Pfam domain/function: PF01810 LysE [H]

EC number: NA

Molecular weight: Translated: 25224; Mature: 25224

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVPLFCSGLMALVIVVMTQAFLGAVTSIDWPLLIGASIVMALTPGANQLLSLSNGFHV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
GVAPAMTAACGRFAAFALMVVGVAVGLGHWLATSAMFFSVLKWIGVAYLSYLGVRSLLTA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRPKAVSPSEGIETAQTWPLLRREALVAFSNPKAYVLFALFLPQFLHADSVSFAPAIMLA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GLAYILIEFVCALLYAGAGHLLGRGRISLSRQRWLDGISGSLMVSLAGWLALAKRQA
HHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRVPLFCSGLMALVIVVMTQAFLGAVTSIDWPLLIGASIVMALTPGANQLLSLSNGFHV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEE
GVAPAMTAACGRFAAFALMVVGVAVGLGHWLATSAMFFSVLKWIGVAYLSYLGVRSLLTA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WRPKAVSPSEGIETAQTWPLLRREALVAFSNPKAYVLFALFLPQFLHADSVSFAPAIMLA
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GLAYILIEFVCALLYAGAGHLLGRGRISLSRQRWLDGISGSLMVSLAGWLALAKRQA
HHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; homoserine [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + homoserine lactone [Cytoplasm] = Proton [Cytoplasm] + homoserine lactone [Periplasm] Proton [Periplasm] + homoserine [Cytoplasm] = Proton [Cytoplasm] + homoserine [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8169201; 10984043 [H]