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The map label for this gene is betA [H]

Identifier: 92114576

GI number: 92114576

Start: 2764169

End: 2765833

Strand: Direct

Name: betA [H]

Synonym: Csal_2458

Alternate gene names: 92114576

Gene position: 2764169-2765833 (Clockwise)

Preceding gene: 92114575

Following gene: 92114577

Centisome position: 74.77

GC content: 68.89

Gene sequence:

>1665_bases
ATGACGACTCATCGAGATTACGATTACATCATCGTCGGGGCGGGATCGGCCGGCTGCGTGCTGGCCGACCGACTCACCGC
CGATGGCGAATCCCGGGTGTTGCTGCTCGAAGCCGGCCCCCGCGATCGCTCGTGGACCATCGACATGCCGGCCGCCATGG
GGGCGGCCATCGATGGACCACGCTTCAACTGGCACTATTGGTCGGGTCCCGAACCCTACCTCGACGGACGGCACATCGCC
ACACCACGTGGACGCACGCTGGGCGGCTCGTCGTCGATCAACGGCATGGTGTACATCCGCGGTCACGCCCGCGATTACGA
TGCCTGGGAAGATGCCGGCTCTCCCGGCTGGGGTTACCGGCACGTCTTGCCCTACTTTCGCCGCGCCGAGACCCACGAAC
TGGGCGCCGATGCCTACCACGGCGAGACGGGGCCGCTGCATGTCAGTGCCGGGCGCCCCGAGGATCCCCTGGCAAAAGCC
TTCCTGGCCGCCGGCGAAGAAGCCGGCTATGCCGCCAGCGACGACCTCAACGGCTATCGTCAGGAAGGCTTCGGCCGCGT
CGATCGCACGACGCGCGCCGGCAGGCGCTGGAGCACGGCGCGTGGCTACCTGGCGCGCGCCGAGACGCGCGACAACCTGA
CGGTCGTGACCCATGCGCTGGCGCAGCGCGTGTTGATCGGCGAGACCGGTGCCGAAGGCATCGAATATCGCCACGCCGAC
ACGCTGCACCGGGCACACGCCACCCGCGAGGTCATCCTGGCGGGCGGCGCCATCAACAGTCCCCAGTTGCTGATGCTCTC
CGGCATCGGCCCCGACGACGAACTGACCCGCTGGAGCATTCCTCGCGTGCATACGCTCGAGGGCGTGGGCCGCCGCCTCA
GCGACCACCCGGACACCGTCGTGGCATACCGCTGCCGCCGGCCGGTCTCGCATGCCCCCTGGACCCACGCTCCCCGCAAG
TGGTGGCTGGGCATGCGCTGGTTCCTCGACCGGCGCGGCCTCGCGGCGAGCAACCAGTTCGATGCCGGCGCCTTCATCCG
CTCGCGGGCAGGGGTCGAGCATCCCGACATCCAGTTGACGTTCATGTCCCTGGCCATCGCGCCCGGCACCACCGAAAGCC
TGCGCGAGCATGCGTTCCAGGTGCACATCGACTTGATGCGCCCCACGAGCATGGGCCGCCTGCGCCTCAGGAGCGCGGAC
CCCGCACAGGCGCCGGAGATCGTCTTCAACTACCTGGCCACCGAGCGCGATCGCGCCGACATGCGCGCGGCCGTGCGTCG
CGTCAGGGAACTGATCGAGCAGCCGGCTTTCGCGGCGTTGCGGGGCGAGGAAATCTCCCCCGGCGCCGACTGCCAGAGCG
ATGAGGCGCTGGATGCCTGGGCGCGCGCCACCACCGAAACCGGCTATCACGCCGCCGGCACCTGCAAGATGGGACCGGCC
GACGATCCGGAGGCCGTGGTCGACCCCGAGCTTCGCGTGCATGGCATCAGTGGTCTGCGCGTGGTCGATGCCTCGATCAT
GCCTCGCGTGGTCAGCGGCAACACCAATGCGCCGACCGTCATGATCGCCGAAAAGGCCAGCGACATGATCCTCGGCCACG
CGCCTCCGGCGCCCTCGGATGCACCCTTCTGGCTGCATGACGACTGGCAGCACCAGCAACGTTGA

Upstream 100 bases:

>100_bases
CCTGGCTCGAGGGCGTGACCACCGCGGATGGCGAGACCCGCGCGCAAGACGCCTATCAGGCCTCGCGTTGACCTTCCGCC
CTTCGCCACAGGATGCCTGC

Downstream 100 bases:

>100_bases
GGAGGACATGCCATGACCGCGACGCCATTCGAGGTCGTGATCGACAGCCACCAGCGGCTATCGAGCGCTATCTACCAGAT
CGAGTTGGTCGCCGCCGATG

Product: glucose-methanol-choline oxidoreductase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTTHRDYDYIIVGAGSAGCVLADRLTADGESRVLLLEAGPRDRSWTIDMPAAMGAAIDGPRFNWHYWSGPEPYLDGRHIA
TPRGRTLGGSSSINGMVYIRGHARDYDAWEDAGSPGWGYRHVLPYFRRAETHELGADAYHGETGPLHVSAGRPEDPLAKA
FLAAGEEAGYAASDDLNGYRQEGFGRVDRTTRAGRRWSTARGYLARAETRDNLTVVTHALAQRVLIGETGAEGIEYRHAD
TLHRAHATREVILAGGAINSPQLLMLSGIGPDDELTRWSIPRVHTLEGVGRRLSDHPDTVVAYRCRRPVSHAPWTHAPRK
WWLGMRWFLDRRGLAASNQFDAGAFIRSRAGVEHPDIQLTFMSLAIAPGTTESLREHAFQVHIDLMRPTSMGRLRLRSAD
PAQAPEIVFNYLATERDRADMRAAVRRVRELIEQPAFAALRGEEISPGADCQSDEALDAWARATTETGYHAAGTCKMGPA
DDPEAVVDPELRVHGISGLRVVDASIMPRVVSGNTNAPTVMIAEKASDMILGHAPPAPSDAPFWLHDDWQHQQR

Sequences:

>Translated_554_residues
MTTHRDYDYIIVGAGSAGCVLADRLTADGESRVLLLEAGPRDRSWTIDMPAAMGAAIDGPRFNWHYWSGPEPYLDGRHIA
TPRGRTLGGSSSINGMVYIRGHARDYDAWEDAGSPGWGYRHVLPYFRRAETHELGADAYHGETGPLHVSAGRPEDPLAKA
FLAAGEEAGYAASDDLNGYRQEGFGRVDRTTRAGRRWSTARGYLARAETRDNLTVVTHALAQRVLIGETGAEGIEYRHAD
TLHRAHATREVILAGGAINSPQLLMLSGIGPDDELTRWSIPRVHTLEGVGRRLSDHPDTVVAYRCRRPVSHAPWTHAPRK
WWLGMRWFLDRRGLAASNQFDAGAFIRSRAGVEHPDIQLTFMSLAIAPGTTESLREHAFQVHIDLMRPTSMGRLRLRSAD
PAQAPEIVFNYLATERDRADMRAAVRRVRELIEQPAFAALRGEEISPGADCQSDEALDAWARATTETGYHAAGTCKMGPA
DDPEAVVDPELRVHGISGLRVVDASIMPRVVSGNTNAPTVMIAEKASDMILGHAPPAPSDAPFWLHDDWQHQQR
>Mature_553_residues
TTHRDYDYIIVGAGSAGCVLADRLTADGESRVLLLEAGPRDRSWTIDMPAAMGAAIDGPRFNWHYWSGPEPYLDGRHIAT
PRGRTLGGSSSINGMVYIRGHARDYDAWEDAGSPGWGYRHVLPYFRRAETHELGADAYHGETGPLHVSAGRPEDPLAKAF
LAAGEEAGYAASDDLNGYRQEGFGRVDRTTRAGRRWSTARGYLARAETRDNLTVVTHALAQRVLIGETGAEGIEYRHADT
LHRAHATREVILAGGAINSPQLLMLSGIGPDDELTRWSIPRVHTLEGVGRRLSDHPDTVVAYRCRRPVSHAPWTHAPRKW
WLGMRWFLDRRGLAASNQFDAGAFIRSRAGVEHPDIQLTFMSLAIAPGTTESLREHAFQVHIDLMRPTSMGRLRLRSADP
AQAPEIVFNYLATERDRADMRAAVRRVRELIEQPAFAALRGEEISPGADCQSDEALDAWARATTETGYHAAGTCKMGPAD
DPEAVVDPELRVHGISGLRVVDASIMPRVVSGNTNAPTVMIAEKASDMILGHAPPAPSDAPFWLHDDWQHQQR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=546, Percent_Identity=50, Blast_Score=524, Evalue=1e-149,
Organism=Escherichia coli, GI1786503, Length=549, Percent_Identity=47.9052823315118, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17532301, Length=560, Percent_Identity=42.6785714285714, Blast_Score=443, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24642059, Length=565, Percent_Identity=38.0530973451327, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI17137792, Length=551, Percent_Identity=37.3865698729583, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24642048, Length=564, Percent_Identity=37.4113475177305, Blast_Score=317, Evalue=2e-86,
Organism=Drosophila melanogaster, GI24642055, Length=579, Percent_Identity=37.13298791019, Blast_Score=315, Evalue=4e-86,
Organism=Drosophila melanogaster, GI24642042, Length=570, Percent_Identity=35.9649122807018, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI45551458, Length=568, Percent_Identity=36.2676056338028, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI45549471, Length=568, Percent_Identity=36.2676056338028, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI24650267, Length=565, Percent_Identity=35.929203539823, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24642037, Length=582, Percent_Identity=35.3951890034364, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI24642051, Length=561, Percent_Identity=35.2941176470588, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI18859995, Length=562, Percent_Identity=35.9430604982206, Blast_Score=286, Evalue=3e-77,
Organism=Drosophila melanogaster, GI24642039, Length=572, Percent_Identity=35.6643356643357, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24642035, Length=569, Percent_Identity=35.3251318101933, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI18859993, Length=565, Percent_Identity=33.4513274336283, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24642057, Length=580, Percent_Identity=31.551724137931, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24645930, Length=579, Percent_Identity=29.0155440414508, Blast_Score=151, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60976; Mature: 60845

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHRDYDYIIVGAGSAGCVLADRLTADGESRVLLLEAGPRDRSWTIDMPAAMGAAIDGP
CCCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEECCHHHCCCCCCC
RFNWHYWSGPEPYLDGRHIATPRGRTLGGSSSINGMVYIRGHARDYDAWEDAGSPGWGYR
CCEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCHH
HVLPYFRRAETHELGADAYHGETGPLHVSAGRPEDPLAKAFLAAGEEAGYAASDDLNGYR
HHHHHHHHCCHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
QEGFGRVDRTTRAGRRWSTARGYLARAETRDNLTVVTHALAQRVLIGETGAEGIEYRHAD
HHCCCCHHHHHHCCCCCCHHCCCEEECCCCCCHHHHHHHHHHHHEEECCCCCCCEECCHH
TLHRAHATREVILAGGAINSPQLLMLSGIGPDDELTRWSIPRVHTLEGVGRRLSDHPDTV
HHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCE
VAYRCRRPVSHAPWTHAPRKWWLGMRWFLDRRGLAASNQFDAGAFIRSRAGVEHPDIQLT
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEE
FMSLAIAPGTTESLREHAFQVHIDLMRPTSMGRLRLRSADPAQAPEIVFNYLATERDRAD
EEEEEECCCCHHHHHHCEEEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHH
MRAAVRRVRELIEQPAFAALRGEEISPGADCQSDEALDAWARATTETGYHAAGTCKMGPA
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
DDPEAVVDPELRVHGISGLRVVDASIMPRVVSGNTNAPTVMIAEKASDMILGHAPPAPSD
CCCCCEECCCEEEECCCCEEEECHHHCCEEECCCCCCCEEEEECCCCCEEEECCCCCCCC
APFWLHDDWQHQQR
CCEEECCCHHCCCC
>Mature Secondary Structure 
TTHRDYDYIIVGAGSAGCVLADRLTADGESRVLLLEAGPRDRSWTIDMPAAMGAAIDGP
CCCCCCCEEEEECCCCCEEEEECCCCCCCCEEEEEECCCCCCCEEEECCHHHCCCCCCC
RFNWHYWSGPEPYLDGRHIATPRGRTLGGSSSINGMVYIRGHARDYDAWEDAGSPGWGYR
CCEEEECCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCHH
HVLPYFRRAETHELGADAYHGETGPLHVSAGRPEDPLAKAFLAAGEEAGYAASDDLNGYR
HHHHHHHHCCHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
QEGFGRVDRTTRAGRRWSTARGYLARAETRDNLTVVTHALAQRVLIGETGAEGIEYRHAD
HHCCCCHHHHHHCCCCCCHHCCCEEECCCCCCHHHHHHHHHHHHEEECCCCCCCEECCHH
TLHRAHATREVILAGGAINSPQLLMLSGIGPDDELTRWSIPRVHTLEGVGRRLSDHPDTV
HHHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCCE
VAYRCRRPVSHAPWTHAPRKWWLGMRWFLDRRGLAASNQFDAGAFIRSRAGVEHPDIQLT
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCEEEE
FMSLAIAPGTTESLREHAFQVHIDLMRPTSMGRLRLRSADPAQAPEIVFNYLATERDRAD
EEEEEECCCCHHHHHHCEEEEEEEEECCCCCCEEEECCCCCCCCHHHHHHHHHCCCHHHH
MRAAVRRVRELIEQPAFAALRGEEISPGADCQSDEALDAWARATTETGYHAAGTCKMGPA
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCCC
DDPEAVVDPELRVHGISGLRVVDASIMPRVVSGNTNAPTVMIAEKASDMILGHAPPAPSD
CCCCCEECCCEEEECCCCEEEECHHHCCEEECCCCCCCEEEEECCCCCEEEECCCCCCCC
APFWLHDDWQHQQR
CCEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA