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The map label for this gene is trxA [H]

Identifier: 92114547

GI number: 92114547

Start: 2732501

End: 2732824

Strand: Direct

Name: trxA [H]

Synonym: Csal_2429

Alternate gene names: 92114547

Gene position: 2732501-2732824 (Clockwise)

Preceding gene: 92114545

Following gene: 92114551

Centisome position: 73.92

GC content: 60.8

Gene sequence:

>324_bases
ATGGCTAACAATGTCGATGTCACCTCCGCCAACTTCGAGCAGGAAGTCATCAACGCGGAACAGCCGGTGCTGCTCAAGTT
CTGGGCACCGTGGTGCGGCCCCTGCAAGATGATGGCTCCGGTGGTCGATGAAGTCGCCGACGAGAAAGCCGGTGGCCTCA
AGGTCGTCAGCGTCAACGTCGACGATGCTCCCGAAATCGCCGCCGAACAAGGTGTGCGCGGTGTCCCCACCGTGATGCTG
TTCAAGTCCGGTGCCAAGGTCGCCTCGCTGGTCGGCGCTCAGTCGAAGTCCCAACTGACGCAGTTCATCGACCAGAACAC
CTGA

Upstream 100 bases:

>100_bases
GTCGCCATACCGATGGGGCATTTGCCAGGGCCATGGTCAACGGCTACCATCGCCTCATCTACGCTCGCAAAAGCGCAACG
GAATACTGGAGAGATTCGTA

Downstream 100 bases:

>100_bases
TCGAGCAGCCCCCTGAACGACAGGCTGCGCAGAACTTTCATCGCCCCGCTCCCATGCGGGGCGATGTCGTTTCAGCGCTC
CGGTGTCATCAATCCACGCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MANNVDVTSANFEQEVINAEQPVLLKFWAPWCGPCKMMAPVVDEVADEKAGGLKVVSVNVDDAPEIAAEQGVRGVPTVML
FKSGAKVASLVGAQSKSQLTQFIDQNT

Sequences:

>Translated_107_residues
MANNVDVTSANFEQEVINAEQPVLLKFWAPWCGPCKMMAPVVDEVADEKAGGLKVVSVNVDDAPEIAAEQGVRGVPTVML
FKSGAKVASLVGAQSKSQLTQFIDQNT
>Mature_106_residues
ANNVDVTSANFEQEVINAEQPVLLKFWAPWCGPCKMMAPVVDEVADEKAGGLKVVSVNVDDAPEIAAEQGVRGVPTVMLF
KSGAKVASLVGAQSKSQLTQFIDQNT

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=35.7894736842105, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI42794771, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=9e-13,
Organism=Homo sapiens, GI224493972, Length=100, Percent_Identity=35, Blast_Score=69, Evalue=1e-12,
Organism=Homo sapiens, GI5031973, Length=99, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=102, Percent_Identity=48.0392156862745, Blast_Score=117, Evalue=2e-28,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=37.7358490566038, Blast_Score=89, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI212646193, Length=104, Percent_Identity=36.5384615384615, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17554386, Length=104, Percent_Identity=37.5, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17556044, Length=83, Percent_Identity=34.9397590361446, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=101, Percent_Identity=29.7029702970297, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=101, Percent_Identity=31.6831683168317, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=101, Percent_Identity=31.6831683168317, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=77, Percent_Identity=36.3636363636364, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=75, Percent_Identity=37.3333333333333, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=97, Percent_Identity=30.9278350515464, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=97, Percent_Identity=30.9278350515464, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=97, Percent_Identity=30.9278350515464, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=84, Percent_Identity=34.5238095238095, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=36.046511627907, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319806, Length=103, Percent_Identity=35.9223300970874, Blast_Score=61, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=34.6938775510204, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=31.25, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24639826, Length=97, Percent_Identity=35.0515463917526, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921434, Length=85, Percent_Identity=38.8235294117647, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=40.5405405405405, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11377; Mature: 11246

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANNVDVTSANFEQEVINAEQPVLLKFWAPWCGPCKMMAPVVDEVADEKAGGLKVVSVNV
CCCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
DDAPEIAAEQGVRGVPTVMLFKSGAKVASLVGAQSKSQLTQFIDQNT
CCCCHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ANNVDVTSANFEQEVINAEQPVLLKFWAPWCGPCKMMAPVVDEVADEKAGGLKVVSVNV
CCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
DDAPEIAAEQGVRGVPTVMLFKSGAKVASLVGAQSKSQLTQFIDQNT
CCCCHHHHHCCCCCCCEEEEEECCCHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]