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The map label for this gene is cocE [H]

Identifier: 92114469

GI number: 92114469

Start: 2639183

End: 2641255

Strand: Direct

Name: cocE [H]

Synonym: Csal_2349

Alternate gene names: 92114469

Gene position: 2639183-2641255 (Clockwise)

Preceding gene: 92114468

Following gene: 92114470

Centisome position: 71.39

GC content: 68.93

Gene sequence:

>2073_bases
ATGCATCGCCCCGTTCCGACGACAGGACGCCCCATGTTTCCGAGTGGAAGCCAACCCGATGCCCGGGAAGTGCGTGACTT
CCCGTACCCGATCGTCGAGGAACCGGCACTGTTCATTCCGCTGCCCGACGGCAGCCGACTCGCGGCACGAATGTGGCGGC
CGGCGGACGCCGAGACCCATCCCGTCCCCGCGATCATCGAGTGCATTCCCTACCGCAAGCGGGATGCCACCAGTGCCGAC
GACGAGCGCATGCACCCCTACTTCGCCGGCCACGGCTACGCCGCGCTGCGCATCGACCTGCGCGGCAGCGGTGACTCGGA
CGGCGTGCTCGAGGACGAATACCTGGCCAGCGAGCAGGACGACATCGTCGCCGCGATCGCCTGGCTCGCCGAGCAGCCCT
GGTGCAGCGGCCGCGTCGGCATGCTGGGCATTTCCTGGGGCGGCTTCAATTCGCTGCAGGTGGCCTCGCGCCAGCCGCCG
GCGCTCGGCGCGATCATCGCCGTCGGTGCCACCGTCGACCGCTATCACGACGACGTTCACTACAAGGGCGGCTGCGTGCT
CAACGAGAACTTCGGCTGGGCGGCCTCGTCGCTGTCCTTCATGTCGCGGCCGCCGGATCCCGCCTTGCGCGACGACTGGC
GCGAACTCTGGCAGCACCGGCTCACCCATCAACCCTTCGTCGCCGAGAACTGGTTCGACCACCAGACGCGCGATGCCTAC
TGGCGCCACGGCTCGGTATGCGAGGATTATTCGCGTCTGACGACGCCGACCCTGGCCGTTACCGGCTGGGCCGATGCCTA
CGTCAACTTCGTCGCCGAGATTCTCGAGCACGCGCCCTGCCCCCGGCGCGGCATCGTCGGCCCCTGGCCACACGCCTACC
CGCACCTGGCGATGCCGGGGCCGACCATCGGCTTTCTCCAGGAAGCGCTGCGCTGGTGGGATTACTGGCTGAAGGATCGC
GACACCGGCATCATGGAAGAACCGCTGTACCGCGTGTTCTGTCCGTCCTTTTCCGAGGCCGATCCGCAACGCCTCGAAGT
GCCCGGCGAATGGCTCGCCGAGACCCAGTGGCCGAGCCCGCACATCGCCTCCCGCGAGCTGGCGCTGGGCAACGGCGAAC
TGCAGGCCGCGGAAGACGGCGCCGCCCGCCCGAGGGTGGTCAGACTGCGCGCCCCGGCCGACAATGGCCTGCAATGCGGT
GAGTACATCCCCCACAGCAGCGGCCCCGAGATCGCCGGCGACCAGCGTGGCGACGACGCCCACTCGCTGACCTACGACAC
CGAGCCGCTGGCGTCCGACACGGTGATCCTGGGGCGCCCCACGCTCTCGCTGCGGGTCAGCGTCGACCAGCCGCGCGCCA
ACCTGATCGTGCGCGTGTGCGACGTCTCGCCCGAGGGCGTGTCGCAGCGCGTCTCCTACGGCGTGCTCAACCTCTGCCAC
CGCGACAGTCACGTCACGCCTTCCGAGGTGCCGTGCGATACGCCGCTCGACGTGACCGTGTCACTGAACCAGACCTGCTA
TCGCTTCATTGCCGGGCATCGGCTGCGCGTCTCGGTGACCACCGCCTACTGGCCGCTGGTCTGGCCGAGCCCTTATCCGG
TGACGCTGACCCTGCACGAGGCTGACTCGCGGCTCACGCTGCCCCAGCGGCCCCCGCACGATACGCCGCCCGTGCAGTTC
GAACCGGCGGTGTTTTCCGGACCCATGCAGCACCGGGTCGTGCGCGCGGGCGAACAGTCCCGGGACGTCACCCACTCGCT
GACCGACGGCTGGACCCGGCATGCCATCATCGACGACTTCGGCGAGATCGCCTACGACCACGGCCTGACCAACATCGCCT
CGGCGGACGAGCGCTACGCCATCCATCCCGAGGCCCCGGCCACCGCGACCATGAGCAAGAGCTGGCGCCAGGCCTTTCAG
CGCGACGACTGGCAGGTACACACCGAGACCTGGGCGGAGTTGAGTTGCGATGCCGAGTGGTTCTACCTGGAGGCGCACCT
GCAGGCCTTCGAGGGCGGCGAGCGCTTCATCGACCGGCGCTGGAAGACGCGACGCCGTCGCCGCTGGGTGTAA

Upstream 100 bases:

>100_bases
GGTCGCCAAGGATTTCCTGACCGAAAACGACCTCATGTGATCGTCCGTTTCTGCGGATTCTCCAGCCTTTCACCTCAGTC
TTTCACCTGCGGGGCGATGC

Downstream 100 bases:

>100_bases
GCCCCCAACGGGACACCACGAAGCACGACAGAAGCACGACAGCTGCTGAGGATGCCCCCGCTGGCATCAAAACGCCCGAG
GCAGTACCTCGGGCGTTTTT

Product: peptidase S15

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 690; Mature: 690

Protein sequence:

>690_residues
MHRPVPTTGRPMFPSGSQPDAREVRDFPYPIVEEPALFIPLPDGSRLAARMWRPADAETHPVPAIIECIPYRKRDATSAD
DERMHPYFAGHGYAALRIDLRGSGDSDGVLEDEYLASEQDDIVAAIAWLAEQPWCSGRVGMLGISWGGFNSLQVASRQPP
ALGAIIAVGATVDRYHDDVHYKGGCVLNENFGWAASSLSFMSRPPDPALRDDWRELWQHRLTHQPFVAENWFDHQTRDAY
WRHGSVCEDYSRLTTPTLAVTGWADAYVNFVAEILEHAPCPRRGIVGPWPHAYPHLAMPGPTIGFLQEALRWWDYWLKDR
DTGIMEEPLYRVFCPSFSEADPQRLEVPGEWLAETQWPSPHIASRELALGNGELQAAEDGAARPRVVRLRAPADNGLQCG
EYIPHSSGPEIAGDQRGDDAHSLTYDTEPLASDTVILGRPTLSLRVSVDQPRANLIVRVCDVSPEGVSQRVSYGVLNLCH
RDSHVTPSEVPCDTPLDVTVSLNQTCYRFIAGHRLRVSVTTAYWPLVWPSPYPVTLTLHEADSRLTLPQRPPHDTPPVQF
EPAVFSGPMQHRVVRAGEQSRDVTHSLTDGWTRHAIIDDFGEIAYDHGLTNIASADERYAIHPEAPATATMSKSWRQAFQ
RDDWQVHTETWAELSCDAEWFYLEAHLQAFEGGERFIDRRWKTRRRRRWV

Sequences:

>Translated_690_residues
MHRPVPTTGRPMFPSGSQPDAREVRDFPYPIVEEPALFIPLPDGSRLAARMWRPADAETHPVPAIIECIPYRKRDATSAD
DERMHPYFAGHGYAALRIDLRGSGDSDGVLEDEYLASEQDDIVAAIAWLAEQPWCSGRVGMLGISWGGFNSLQVASRQPP
ALGAIIAVGATVDRYHDDVHYKGGCVLNENFGWAASSLSFMSRPPDPALRDDWRELWQHRLTHQPFVAENWFDHQTRDAY
WRHGSVCEDYSRLTTPTLAVTGWADAYVNFVAEILEHAPCPRRGIVGPWPHAYPHLAMPGPTIGFLQEALRWWDYWLKDR
DTGIMEEPLYRVFCPSFSEADPQRLEVPGEWLAETQWPSPHIASRELALGNGELQAAEDGAARPRVVRLRAPADNGLQCG
EYIPHSSGPEIAGDQRGDDAHSLTYDTEPLASDTVILGRPTLSLRVSVDQPRANLIVRVCDVSPEGVSQRVSYGVLNLCH
RDSHVTPSEVPCDTPLDVTVSLNQTCYRFIAGHRLRVSVTTAYWPLVWPSPYPVTLTLHEADSRLTLPQRPPHDTPPVQF
EPAVFSGPMQHRVVRAGEQSRDVTHSLTDGWTRHAIIDDFGEIAYDHGLTNIASADERYAIHPEAPATATMSKSWRQAFQ
RDDWQVHTETWAELSCDAEWFYLEAHLQAFEGGERFIDRRWKTRRRRRWV
>Mature_690_residues
MHRPVPTTGRPMFPSGSQPDAREVRDFPYPIVEEPALFIPLPDGSRLAARMWRPADAETHPVPAIIECIPYRKRDATSAD
DERMHPYFAGHGYAALRIDLRGSGDSDGVLEDEYLASEQDDIVAAIAWLAEQPWCSGRVGMLGISWGGFNSLQVASRQPP
ALGAIIAVGATVDRYHDDVHYKGGCVLNENFGWAASSLSFMSRPPDPALRDDWRELWQHRLTHQPFVAENWFDHQTRDAY
WRHGSVCEDYSRLTTPTLAVTGWADAYVNFVAEILEHAPCPRRGIVGPWPHAYPHLAMPGPTIGFLQEALRWWDYWLKDR
DTGIMEEPLYRVFCPSFSEADPQRLEVPGEWLAETQWPSPHIASRELALGNGELQAAEDGAARPRVVRLRAPADNGLQCG
EYIPHSSGPEIAGDQRGDDAHSLTYDTEPLASDTVILGRPTLSLRVSVDQPRANLIVRVCDVSPEGVSQRVSYGVLNLCH
RDSHVTPSEVPCDTPLDVTVSLNQTCYRFIAGHRLRVSVTTAYWPLVWPSPYPVTLTLHEADSRLTLPQRPPHDTPPVQF
EPAVFSGPMQHRVVRAGEQSRDVTHSLTDGWTRHAIIDDFGEIAYDHGLTNIASADERYAIHPEAPATATMSKSWRQAFQ
RDDWQVHTETWAELSCDAEWFYLEAHLQAFEGGERFIDRRWKTRRRRRWV

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 77778; Mature: 77778

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRPVPTTGRPMFPSGSQPDAREVRDFPYPIVEEPALFIPLPDGSRLAARMWRPADAETH
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCC
PVPAIIECIPYRKRDATSADDERMHPYFAGHGYAALRIDLRGSGDSDGVLEDEYLASEQD
CCCHHHHHCCCCCCCCCCCCCHHCCCEECCCCEEEEEEEEECCCCCCCCCCHHHHCCCCC
DIVAAIAWLAEQPWCSGRVGMLGISWGGFNSLQVASRQPPALGAIIAVGATVDRYHDDVH
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCEEEEEECCHHHHHCCCCE
YKGGCVLNENFGWAASSLSFMSRPPDPALRDDWRELWQHRLTHQPFVAENWFDHQTRDAY
ECCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHH
WRHGSVCEDYSRLTTPTLAVTGWADAYVNFVAEILEHAPCPRRGIVGPWPHAYPHLAMPG
HCCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PTIGFLQEALRWWDYWLKDRDTGIMEEPLYRVFCPSFSEADPQRLEVPGEWLAETQWPSP
CHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCC
HIASRELALGNGELQAAEDGAARPRVVRLRAPADNGLQCGEYIPHSSGPEIAGDQRGDDA
CCCCCEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HSLTYDTEPLASDTVILGRPTLSLRVSVDQPRANLIVRVCDVSPEGVSQRVSYGVLNLCH
CEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
RDSHVTPSEVPCDTPLDVTVSLNQTCYRFIAGHRLRVSVTTAYWPLVWPSPYPVTLTLHE
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCEEEEEEEEEEEEEECCCCCCEEEEEEC
ADSRLTLPQRPPHDTPPVQFEPAVFSGPMQHRVVRAGEQSRDVTHSLTDGWTRHAIIDDF
CCCEEECCCCCCCCCCCCEECCHHHCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
GEIAYDHGLTNIASADERYAIHPEAPATATMSKSWRQAFQRDDWQVHTETWAELSCDAEW
HHHHHHCCCCHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCEE
FYLEAHLQAFEGGERFIDRRWKTRRRRRWV
EEEEEHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHRPVPTTGRPMFPSGSQPDAREVRDFPYPIVEEPALFIPLPDGSRLAARMWRPADAETH
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHCCCCCCCCC
PVPAIIECIPYRKRDATSADDERMHPYFAGHGYAALRIDLRGSGDSDGVLEDEYLASEQD
CCCHHHHHCCCCCCCCCCCCCHHCCCEECCCCEEEEEEEEECCCCCCCCCCHHHHCCCCC
DIVAAIAWLAEQPWCSGRVGMLGISWGGFNSLQVASRQPPALGAIIAVGATVDRYHDDVH
HHHHHHHHHHCCCCCCCCCEEEEEECCCCCCEEECCCCCCCCEEEEEECCHHHHHCCCCE
YKGGCVLNENFGWAASSLSFMSRPPDPALRDDWRELWQHRLTHQPFVAENWFDHQTRDAY
ECCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCHHH
WRHGSVCEDYSRLTTPTLAVTGWADAYVNFVAEILEHAPCPRRGIVGPWPHAYPHLAMPG
HCCCCHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PTIGFLQEALRWWDYWLKDRDTGIMEEPLYRVFCPSFSEADPQRLEVPGEWLAETQWPSP
CHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHCCCCCCCCCCCEEECCHHHHHCCCCCCC
HIASRELALGNGELQAAEDGAARPRVVRLRAPADNGLQCGEYIPHSSGPEIAGDQRGDDA
CCCCCEEEECCCCEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
HSLTYDTEPLASDTVILGRPTLSLRVSVDQPRANLIVRVCDVSPEGVSQRVSYGVLNLCH
CEEEECCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
RDSHVTPSEVPCDTPLDVTVSLNQTCYRFIAGHRLRVSVTTAYWPLVWPSPYPVTLTLHE
CCCCCCCCCCCCCCCCEEEEECCHHHHHHHCCCEEEEEEEEEEEEEECCCCCCEEEEEEC
ADSRLTLPQRPPHDTPPVQFEPAVFSGPMQHRVVRAGEQSRDVTHSLTDGWTRHAIIDDF
CCCEEECCCCCCCCCCCCEECCHHHCCCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
GEIAYDHGLTNIASADERYAIHPEAPATATMSKSWRQAFQRDDWQVHTETWAELSCDAEW
HHHHHHCCCCHHCCCCCCEEECCCCCCHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCEE
FYLEAHLQAFEGGERFIDRRWKTRRRRRWV
EEEEEHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]