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The map label for this gene is holA [H]

Identifier: 92114466

GI number: 92114466

Start: 2636346

End: 2637404

Strand: Direct

Name: holA [H]

Synonym: Csal_2346

Alternate gene names: 92114466

Gene position: 2636346-2637404 (Clockwise)

Preceding gene: 92114465

Following gene: 92114467

Centisome position: 71.32

GC content: 68.08

Gene sequence:

>1059_bases
ATGAAAGTCTTTCCCGACAAACTGGACGACGCTCTCGGCAAGCGGCTGCACCCGGTGTACATCGTCGCCGGCGACGAGCC
GCTGATCCACATGGAAGCATGCGACGCCATCCGCGCCGCCGCGCGCCAGCGCGGCGTCGAGGAGCGCGAGGTGCTGCACG
TGGAAAACGGCTTCCAATGGGGGCGCCTGACCGAATCGGCCGCCAGCATGTCGCTGTTCGCCTCGAGCAAGCTCATCGAA
CTGCGTCTGGGCGGCCAGTCCCCGGGCCAGGAAGGCGCCAAGGCTCTCGATGCCTACGCGCGCCAGGCCAAGGACAGCGA
CGACATCCTGCTGATCAGCAGTGCGCGTCTCGACCGGCGCGCGCAGTCCAGCGCCTGGTTCAAGGCCCTGGACAAGATCG
GCGTGTTCGTGCCGGTGTGGCCGGTGGACCATCAGCGCCTGCACTTCTGGGTGCGCGATCGCGCGAGCCGCCACGGGCTC
TCCCTGGACATGGACGCGGCCCGCCTGCTCGGCGAGCGCACCGAGGGCAACCTGCTGGCCGCCGATCAGGAACTGCAGAA
GCTCGCCTTGCTCTACCCCGCCAATGCACGGCTCGACACTCAGGCCATCGCCGGTGGCGTGGAAGACAGCGCCCGATATG
ACGTCTTCACGCTGATCGACGCCTGCCTGCGCGGCGAACGCGTGCGTGTCTCGCGCATCGTCCGCGGCCTGCGTGGCGAA
GGGGTGGAGGCTCCCGTGGTGCTGTGGGCACTGACCCGCGAGCTGCGCATCTTCCTGTCGCTGGCGCAGCACCTCGACCA
GGGGCAAAGCCTCGACCACGCCTGCAAGGCGCAGCGCCCGCCGATTCCCGACAAGCGGCGGCCGCTCTATCAGCAAGCCC
TGAACCGCATGCCACTCAAGCGACTTCACAAGCTGCTGTTGTTCGCCCAGCGCCTCGATCTGGCGATCAAGGGCGCGGTA
GCGCTGCCCGTATGGGAAGGTCTCCATGACCTGGCGCTCACCCTGGCCGGCGGACGCGGTCCCCTGGCCGAGATGGCGTA
TTCCTACCGGATCGCCTAG

Upstream 100 bases:

>100_bases
ACCTGCTCTCCCAGGACGAGCTGCGCAATGAAGCGCTCGCCTCGCTCCGCCAGGAGGCGGCACGTCAACTCGTCGATCGC
CTGCGCGCCCTAGAGACACC

Downstream 100 bases:

>100_bases
CCCGAAAGACAGAGACACTCGCCGGCTGGCGAGCCCCTCGCGGAGGAAAGCAGGATGCCTTACACGATCGCGATCAAGCG
TATCTACCAAGCCGCCGAGC

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKVFPDKLDDALGKRLHPVYIVAGDEPLIHMEACDAIRAAARQRGVEEREVLHVENGFQWGRLTESAASMSLFASSKLIE
LRLGGQSPGQEGAKALDAYARQAKDSDDILLISSARLDRRAQSSAWFKALDKIGVFVPVWPVDHQRLHFWVRDRASRHGL
SLDMDAARLLGERTEGNLLAADQELQKLALLYPANARLDTQAIAGGVEDSARYDVFTLIDACLRGERVRVSRIVRGLRGE
GVEAPVVLWALTRELRIFLSLAQHLDQGQSLDHACKAQRPPIPDKRRPLYQQALNRMPLKRLHKLLLFAQRLDLAIKGAV
ALPVWEGLHDLALTLAGGRGPLAEMAYSYRIA

Sequences:

>Translated_352_residues
MKVFPDKLDDALGKRLHPVYIVAGDEPLIHMEACDAIRAAARQRGVEEREVLHVENGFQWGRLTESAASMSLFASSKLIE
LRLGGQSPGQEGAKALDAYARQAKDSDDILLISSARLDRRAQSSAWFKALDKIGVFVPVWPVDHQRLHFWVRDRASRHGL
SLDMDAARLLGERTEGNLLAADQELQKLALLYPANARLDTQAIAGGVEDSARYDVFTLIDACLRGERVRVSRIVRGLRGE
GVEAPVVLWALTRELRIFLSLAQHLDQGQSLDHACKAQRPPIPDKRRPLYQQALNRMPLKRLHKLLLFAQRLDLAIKGAV
ALPVWEGLHDLALTLAGGRGPLAEMAYSYRIA
>Mature_352_residues
MKVFPDKLDDALGKRLHPVYIVAGDEPLIHMEACDAIRAAARQRGVEEREVLHVENGFQWGRLTESAASMSLFASSKLIE
LRLGGQSPGQEGAKALDAYARQAKDSDDILLISSARLDRRAQSSAWFKALDKIGVFVPVWPVDHQRLHFWVRDRASRHGL
SLDMDAARLLGERTEGNLLAADQELQKLALLYPANARLDTQAIAGGVEDSARYDVFTLIDACLRGERVRVSRIVRGLRGE
GVEAPVVLWALTRELRIFLSLAQHLDQGQSLDHACKAQRPPIPDKRRPLYQQALNRMPLKRLHKLLLFAQRLDLAIKGAV
ALPVWEGLHDLALTLAGGRGPLAEMAYSYRIA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=347, Percent_Identity=29.971181556196, Blast_Score=125, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39174; Mature: 39174

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFPDKLDDALGKRLHPVYIVAGDEPLIHMEACDAIRAAARQRGVEEREVLHVENGFQW
CCCCCHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCHHHEEEECCCCCC
GRLTESAASMSLFASSKLIELRLGGQSPGQEGAKALDAYARQAKDSDDILLISSARLDRR
CHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHH
AQSSAWFKALDKIGVFVPVWPVDHQRLHFWVRDRASRHGLSLDMDAARLLGERTEGNLLA
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEE
ADQELQKLALLYPANARLDTQAIAGGVEDSARYDVFTLIDACLRGERVRVSRIVRGLRGE
CHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GVEAPVVLWALTRELRIFLSLAQHLDQGQSLDHACKAQRPPIPDKRRPLYQQALNRMPLK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCHH
RLHKLLLFAQRLDLAIKGAVALPVWEGLHDLALTLAGGRGPLAEMAYSYRIA
HHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MKVFPDKLDDALGKRLHPVYIVAGDEPLIHMEACDAIRAAARQRGVEEREVLHVENGFQW
CCCCCHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHCCCCHHHEEEECCCCCC
GRLTESAASMSLFASSKLIELRLGGQSPGQEGAKALDAYARQAKDSDDILLISSARLDRR
CHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHH
AQSSAWFKALDKIGVFVPVWPVDHQRLHFWVRDRASRHGLSLDMDAARLLGERTEGNLLA
HHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEE
ADQELQKLALLYPANARLDTQAIAGGVEDSARYDVFTLIDACLRGERVRVSRIVRGLRGE
CHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
GVEAPVVLWALTRELRIFLSLAQHLDQGQSLDHACKAQRPPIPDKRRPLYQQALNRMPLK
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCHH
RLHKLLLFAQRLDLAIKGAVALPVWEGLHDLALTLAGGRGPLAEMAYSYRIA
HHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]