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The map label for this gene is ggt [H]

Identifier: 92114450

GI number: 92114450

Start: 2618368

End: 2620098

Strand: Direct

Name: ggt [H]

Synonym: Csal_2329

Alternate gene names: 92114450

Gene position: 2618368-2620098 (Clockwise)

Preceding gene: 92114447

Following gene: 92114451

Centisome position: 70.83

GC content: 66.15

Gene sequence:

>1731_bases
ATGCTCCGATTCACTTCGCGCCGTGGGCCGCGTCTGGCACTCTGTGCCGTACTGGCACTCTTCGCCACCTCCGCCGGCGC
TCAGCAGGCGATTCTCGAGGGTGAGCGCTTCCATCCCCAGGAAAGCCGTCACGGCATGGCCGCCACCAGCCACTACCTTG
CCTCCCAAATCGCCCGGGATGTCATGCAGGACGGCGGCAACGCCGTGGACGCCGCGGTCACCGCCGGCTTCGCGCTGGCC
GTGACCCAGCCGCGCTCCGGCAACATCGGCGGGGGCGGCTTCATGCTGATTTCCGACGAGGACAGCGGCAAGGTGGTCGC
CATCGACTATCGCGAGAAGGCGCCAGCGGCCGCGTTCGAGACGATGTTCCAGAACGACGCGGGCGAGGCCGTCCCCGAGC
TGTCCCGCTATACCCACAATGCATCCGGGGTGCCGGGCACCGTCGCCGGCCTGGCGCTGGCACTCGACGAATATGGCACC
CTGAGCCTCGCCGAGGCCCTGGCGCCGGCGATCGACCTGGCCGAGAACGGCTTCGCGCTTCCGCAGCGCTTCGTCGAGGG
CATCGAGCAGGCCAGCGAGCGGTTCGAACAGTGGCCGGCCAGCCGGGCCAAGTTCTTCAAGCCCGACGGCAGCCGCTACC
AGGTGGGCGACACCTACCGTCAGCCGGCCCTGGCGGCCACCCTCAAGCGCATCGCCGAGCACGGGCCTCGCGAGTTCTAC
GAAGGCGAAACCGCCGAACTGATCGCCGCCGAAATGGAAAAACACGGCGGCCTCATGACCGCCGAGGACCTGGCCGATTA
CCGCCCCGCGATCCGCGAACCCGTGCATGGCACCTATCGCGGCTACGACGTGTATGCCATGAGCCCGCCCTCCAGCGGCG
GCGCGCATATCGTGCAGATGCTGAACATCCTCGAGGGCTACGACATCGGCGCCATGGGCTTCAACTCGGCACGCACCATC
CACGTCATGGCCGAGGCGATGAAACGCGCCTATGCCGATCGGGCCGAGTACCTGGGCGATACCGATTTCGTCGACGTGCC
ACTGGCCGGCATTACCTCGAAGGCCTATGCCGACGCGCTTCGCGAGCAGATCGACCTGGGCCGCGCCACCCCGAGCGACA
GCATCGCGGCGGGCGACCCGTTGCCCTACGAGTCCAACGAGACCACGCACTTCTCGATCGCCGACGACAGCGGCCTCGCC
GTTTCCAACACCTATACCATCAACTTCAGCTACGGCTCGGGCATCGTCGTCGACGGTGCGGGCTTTCTGCTCAACAACGA
AATGGACGATTTCTCCGCCAAGCCGGGCACGCCCAACGCCTATGGGCTGATCGGCGGCGAGGCCAACAAGATCGAGCCCG
AAAAACGCATGCTGTCATCGATGACACCGACCATCGTCAAGAAGGATGGCAAGAACGTTCTGGTCACCGGCAGTCCCGGC
GGCTCGCGCATCATCACCACGACCCTGCAAGTCGTCATGAACGTCATCGATCACGGCATGAACGTGCAAAGCGCCGTGAG
CGTGCCGCGCATTCATCACCAGTGGCTGCCCGACGAGATTCGCATCGAGGAAGGCATCAGCCCCGACACCATCGGCCTGC
TCGAATCCATGGGACACACGGTCTCGCAACAGGCCGCCATGGGCGCCGCGCAATCGGTGCTGATCGAAGATGGTCGCTTC
TACGGCGGGGCCGACCCGCGCCGCTCGACCTCCTCCGCCCTGGGGCTTTGA

Upstream 100 bases:

>100_bases
CGGCACGGACGCCTTGCACTTTCGGAAACCGCCTTCGATAGTAAAGAGAAACCTGAAACACGACACGACGCATCGCGCGT
CGCATTCACGAGGGCTCGAC

Downstream 100 bases:

>100_bases
GCTTGTCGCCGGCGCGCATGCCGCGCCGGCGGCCTTGAGGTCCTTCGGTCGTCCCGGCCTCGACCATGGTGCCATCGACA
GCTTCCGCGACGACTGGCAC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MLRFTSRRGPRLALCAVLALFATSAGAQQAILEGERFHPQESRHGMAATSHYLASQIARDVMQDGGNAVDAAVTAGFALA
VTQPRSGNIGGGGFMLISDEDSGKVVAIDYREKAPAAAFETMFQNDAGEAVPELSRYTHNASGVPGTVAGLALALDEYGT
LSLAEALAPAIDLAENGFALPQRFVEGIEQASERFEQWPASRAKFFKPDGSRYQVGDTYRQPALAATLKRIAEHGPREFY
EGETAELIAAEMEKHGGLMTAEDLADYRPAIREPVHGTYRGYDVYAMSPPSSGGAHIVQMLNILEGYDIGAMGFNSARTI
HVMAEAMKRAYADRAEYLGDTDFVDVPLAGITSKAYADALREQIDLGRATPSDSIAAGDPLPYESNETTHFSIADDSGLA
VSNTYTINFSYGSGIVVDGAGFLLNNEMDDFSAKPGTPNAYGLIGGEANKIEPEKRMLSSMTPTIVKKDGKNVLVTGSPG
GSRIITTTLQVVMNVIDHGMNVQSAVSVPRIHHQWLPDEIRIEEGISPDTIGLLESMGHTVSQQAAMGAAQSVLIEDGRF
YGGADPRRSTSSALGL

Sequences:

>Translated_576_residues
MLRFTSRRGPRLALCAVLALFATSAGAQQAILEGERFHPQESRHGMAATSHYLASQIARDVMQDGGNAVDAAVTAGFALA
VTQPRSGNIGGGGFMLISDEDSGKVVAIDYREKAPAAAFETMFQNDAGEAVPELSRYTHNASGVPGTVAGLALALDEYGT
LSLAEALAPAIDLAENGFALPQRFVEGIEQASERFEQWPASRAKFFKPDGSRYQVGDTYRQPALAATLKRIAEHGPREFY
EGETAELIAAEMEKHGGLMTAEDLADYRPAIREPVHGTYRGYDVYAMSPPSSGGAHIVQMLNILEGYDIGAMGFNSARTI
HVMAEAMKRAYADRAEYLGDTDFVDVPLAGITSKAYADALREQIDLGRATPSDSIAAGDPLPYESNETTHFSIADDSGLA
VSNTYTINFSYGSGIVVDGAGFLLNNEMDDFSAKPGTPNAYGLIGGEANKIEPEKRMLSSMTPTIVKKDGKNVLVTGSPG
GSRIITTTLQVVMNVIDHGMNVQSAVSVPRIHHQWLPDEIRIEEGISPDTIGLLESMGHTVSQQAAMGAAQSVLIEDGRF
YGGADPRRSTSSALGL
>Mature_576_residues
MLRFTSRRGPRLALCAVLALFATSAGAQQAILEGERFHPQESRHGMAATSHYLASQIARDVMQDGGNAVDAAVTAGFALA
VTQPRSGNIGGGGFMLISDEDSGKVVAIDYREKAPAAAFETMFQNDAGEAVPELSRYTHNASGVPGTVAGLALALDEYGT
LSLAEALAPAIDLAENGFALPQRFVEGIEQASERFEQWPASRAKFFKPDGSRYQVGDTYRQPALAATLKRIAEHGPREFY
EGETAELIAAEMEKHGGLMTAEDLADYRPAIREPVHGTYRGYDVYAMSPPSSGGAHIVQMLNILEGYDIGAMGFNSARTI
HVMAEAMKRAYADRAEYLGDTDFVDVPLAGITSKAYADALREQIDLGRATPSDSIAAGDPLPYESNETTHFSIADDSGLA
VSNTYTINFSYGSGIVVDGAGFLLNNEMDDFSAKPGTPNAYGLIGGEANKIEPEKRMLSSMTPTIVKKDGKNVLVTGSPG
GSRIITTTLQVVMNVIDHGMNVQSAVSVPRIHHQWLPDEIRIEEGISPDTIGLLESMGHTVSQQAAMGAAQSVLIEDGRF
YGGADPRRSTSSALGL

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=526, Percent_Identity=34.6007604562738, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI73915090, Length=526, Percent_Identity=34.6007604562738, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI73915096, Length=526, Percent_Identity=34.6007604562738, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI73915094, Length=526, Percent_Identity=34.6007604562738, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI113429324, Length=537, Percent_Identity=32.5884543761639, Blast_Score=226, Evalue=6e-59,
Organism=Homo sapiens, GI113429326, Length=541, Percent_Identity=31.9778188539741, Blast_Score=220, Evalue=3e-57,
Organism=Homo sapiens, GI109148539, Length=544, Percent_Identity=29.2279411764706, Blast_Score=176, Evalue=7e-44,
Organism=Homo sapiens, GI153266885, Length=554, Percent_Identity=26.8953068592058, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266901, Length=557, Percent_Identity=26.7504488330341, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI153266907, Length=554, Percent_Identity=25.2707581227437, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI30581157, Length=222, Percent_Identity=35.1351351351351, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI30581155, Length=222, Percent_Identity=35.1351351351351, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI218505805, Length=222, Percent_Identity=32.8828828828829, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI310124095, Length=222, Percent_Identity=31.0810810810811, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1789856, Length=538, Percent_Identity=54.6468401486989, Blast_Score=594, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI212646519, Length=539, Percent_Identity=32.2820037105751, Blast_Score=238, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI72000294, Length=539, Percent_Identity=32.2820037105751, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17506189, Length=544, Percent_Identity=31.9852941176471, Blast_Score=237, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI193208245, Length=564, Percent_Identity=31.3829787234043, Blast_Score=222, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI193208247, Length=564, Percent_Identity=31.3829787234043, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17542894, Length=506, Percent_Identity=33.00395256917, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17564448, Length=445, Percent_Identity=25.3932584269663, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI72001497, Length=232, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=230, Percent_Identity=25.2173913043478, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=533, Percent_Identity=28.7054409005629, Blast_Score=165, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45551474, Length=538, Percent_Identity=31.7843866171004, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI161077878, Length=538, Percent_Identity=31.7843866171004, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI161077880, Length=538, Percent_Identity=31.7843866171004, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24642670, Length=538, Percent_Identity=31.7843866171004, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24642666, Length=538, Percent_Identity=31.7843866171004, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI18859893, Length=506, Percent_Identity=32.0158102766798, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI161077496, Length=540, Percent_Identity=30.3703703703704, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI18859741, Length=508, Percent_Identity=28.9370078740157, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61406; Mature: 61406

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRFTSRRGPRLALCAVLALFATSAGAQQAILEGERFHPQESRHGMAATSHYLASQIARD
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHH
VMQDGGNAVDAAVTAGFALAVTQPRSGNIGGGGFMLISDEDSGKVVAIDYREKAPAAAFE
HHHCCCCEEHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHH
TMFQNDAGEAVPELSRYTHNASGVPGTVAGLALALDEYGTLSLAEALAPAIDLAENGFAL
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PQRFVEGIEQASERFEQWPASRAKFFKPDGSRYQVGDTYRQPALAATLKRIAEHGPREFY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHCHHHHHHHHHHHHCCCHHHH
EGETAELIAAEMEKHGGLMTAEDLADYRPAIREPVHGTYRGYDVYAMSPPSSGGAHIVQM
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHH
LNILEGYDIGAMGFNSARTIHVMAEAMKRAYADRAEYLGDTDFVDVPLAGITSKAYADAL
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
REQIDLGRATPSDSIAAGDPLPYESNETTHFSIADDSGLAVSNTYTINFSYGSGIVVDGA
HHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCCEEECCC
GFLLNNEMDDFSAKPGTPNAYGLIGGEANKIEPEKRMLSSMTPTIVKKDGKNVLVTGSPG
CEEECCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHEEECCCEEEEECCCC
GSRIITTTLQVVMNVIDHGMNVQSAVSVPRIHHQWLPDEIRIEEGISPDTIGLLESMGHT
CCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCCEECCCCCCCHHHHHHHHHCHH
VSQQAAMGAAQSVLIEDGRFYGGADPRRSTSSALGL
HHHHHHHHHHHHHEEECCCEECCCCCCCCCHHHCCC
>Mature Secondary Structure
MLRFTSRRGPRLALCAVLALFATSAGAQQAILEGERFHPQESRHGMAATSHYLASQIARD
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHHHHH
VMQDGGNAVDAAVTAGFALAVTQPRSGNIGGGGFMLISDEDSGKVVAIDYREKAPAAAFE
HHHCCCCEEHHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHH
TMFQNDAGEAVPELSRYTHNASGVPGTVAGLALALDEYGTLSLAEALAPAIDLAENGFAL
HHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PQRFVEGIEQASERFEQWPASRAKFFKPDGSRYQVGDTYRQPALAATLKRIAEHGPREFY
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCHHHCHHHHHHHHHHHHCCCHHHH
EGETAELIAAEMEKHGGLMTAEDLADYRPAIREPVHGTYRGYDVYAMSPPSSGGAHIVQM
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHH
LNILEGYDIGAMGFNSARTIHVMAEAMKRAYADRAEYLGDTDFVDVPLAGITSKAYADAL
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHH
REQIDLGRATPSDSIAAGDPLPYESNETTHFSIADDSGLAVSNTYTINFSYGSGIVVDGA
HHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEECCCCEEECCC
GFLLNNEMDDFSAKPGTPNAYGLIGGEANKIEPEKRMLSSMTPTIVKKDGKNVLVTGSPG
CEEECCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHEEECCCEEEEECCCC
GSRIITTTLQVVMNVIDHGMNVQSAVSVPRIHHQWLPDEIRIEEGISPDTIGLLESMGHT
CCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHCCCCCEECCCCCCCHHHHHHHHHCHH
VSQQAAMGAAQSVLIEDGRFYGGADPRRSTSSALGL
HHHHHHHHHHHHHEEECCCEECCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]