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The map label for this gene is comA [H]

Identifier: 92113709

GI number: 92113709

Start: 1803788

End: 1806064

Strand: Direct

Name: comA [H]

Synonym: Csal_1585

Alternate gene names: 92113709

Gene position: 1803788-1806064 (Clockwise)

Preceding gene: 92113707

Following gene: 92113710

Centisome position: 48.8

GC content: 70.97

Gene sequence:

>2277_bases
ATGCGGATCGGTTGGGCGATGCCGCTGGCGTTGTCGGCCCTGGTCGGTAGCGTCTGGGGCGGGTGGGGCGTGTCGAGCGC
CGCGGGGCCGTGGGGACTGCTGTGCCTGCTGGCGGTGGCTCAGGCCCGCTGGCGCGGGCTGGCGATGCTGCTGGTGGCGG
GATGGTGTGCGCTGAATGTCGCCGTACAAGCGGCGGGCGAACTCCCCGACGGGCTGGCGCGTCAGGATGTCGCGCTCGAG
GGGCGGGTGACACAGGTGAGCCGCGATCGCGGGCTGGCCAAGCTGCGCCTCGCGGTCGAGCGCTGCGTGCCCCGGGCAGC
GGGATTGCCGCCTTGCACGCGTCTGTCACGGGTACGCCTCTCCTGGTACGACGCGCCCGCGCTGCGTGTCGGCGATCAGT
GGCGCCTGACGGCGCGCCTGCGCCCGCCGCAGGGCTTCGCCAACGGCTATGGTTTCGACTATGCCGCGTGGCTGTGGCGT
GAAGGCATCCAGGCGACGGGCTATGTGCGTGATGCCGCGTCCGCGCAGCGCCTCCAGGCGGCCCCCGCCGGCCTGCGCGA
GACGGGGCTGGCATTTCTGGAGGCACGTGCGTTGTCGCCGCTCGGCAAGCGCTGGCTGGCGGCATTGACCCTCGGCGCCG
GCGAGCGGTTGACCCAGGACGACTGGGATCTGCTCAACGCCACCGGTACCACGCATCTCATGGTGATCTCGGGGTTGCAT
GTCGGCCTGGTGACGAGCGTCGCGCTCTGGCTGCTGCGTTTCCTGGCGCGCGTCGTGACGCCGGGACGCTGGCGCCTCGC
GGCCTGGCCGTGGTGGCTGGCCGGGGCGGCGGCACTGGGGTATGCCGGCCTGGCGGGTTTCGAGCCGCCGGCCCTGCGCG
CCACGGTGATGGCGCTGCTGGGGTTGTGGGTGGCCAGCGGTCGCCATGCGCCCGGCCCCTGGCAGGCCTGGTGGCTGGCA
TTGCTGGTGGTCGTCACGGGCGATCCGTTGACGGTGTGGCAACCCGGGCTCTGGCTGTCGTTCCTGGCGGTAGGGGTGTT
GATCGCCGCCTGGCAGGGCAGGCCGGTGCCGCGCGGCGCGAGGGGATGGCTGCTCGCCCTGGTACGCTCGCAATGCCTGC
TGGCGCCCTTCATGGCGGCGGCCGTGCTGGTGGGGTTCGAGCGCTTGTCGCCGGCCGCGCCCTTGATCAACCTGGTTGCC
GTGCCGCTGGTGGGAAGCCTGATGGTACCGCTGGGGCTGGCGGGGTGGGCCCTGGCCTGGTCGCCGGGGCTGGCCATGTT
GCCCTGGCGGGCCTTCGATGCCCTGGCCCAGCTCGTCTGGCAAGGGCTCGCGTGGATGGGCGAAATCGTGCCATCGTGGT
TGCCACCGGGCGAGGAAATTCTGCCCCTGGCGTTGCTGCTGGCCGCCTGGGGGGGAGCATGGCTGATGCCGGGGCTTGCG
CGGTCCGTTCGTGTGTGGGCCTCGCTGAGCCTGATCGCTCTGGCACTGACCTGGCAGCCTTCGACGATTCCGCCGGGGCG
GGTCGTGGTCATCGTCCACGATGTGGGGCAGGGGCAACTGGTCGAACTGCGCAGTGCCACGCAACGCATGCTGTTCGATA
CGGGGCCGCGTTACGGCTCGGGGTTCGCCCCCGCCGCCACGTTGTGGCCGCCGGGGCGTCGCTTCGACGATGTCATCGTC
AGTCACAGCGATCGCGACCATGCCGGCGGCGTGGCCACGTTACGCGACATGCATCATGTCGGGCGCTGGTGGGGGCCGCC
GAACATGGCGGTGGGCGTTGCCACGCACGCCTGCCGTCAAGGCGTGGCCTGGCGGCGCGACGAGGTGAGTTACCGGTTCT
TGTCGCCGCGTTCCGGTGACTCGGCATTGAGCGACAATGATCGCTCCTGCGTGCTGAGCGTGACGGCCGGCGGGCAGCGC
TTGCTGATCATGGGAGATGCCGGCACCACCATCGAGCGTCGTCTGCTGCGAGACATCGAGCGCCCGCTGACGGTGCTGAT
CGCCGGCCACCACGGCAGCCGTACGAGTTCATCGCCGGCCTTCGTCGCGCGGGTACATCCTCGACATGTGATCTTCAGCG
CCGGCCGCGACAATGCCCATGGCCATCCTCATCCCGAGGTGGTGCGCCGTTTCCGGCGCGCCGGGAGCTGTCTGTGGAAT
ACCGCCGTCGACGGCGCGCTGCGTTTCACCCTGGGCGAGTCTCCGTTGCGCATGCGGCCCGCGCGCCCGCCCGGCGGTGT
CGAAGGGCCGTGCATTGGGGTAGAATCCGGCGATTGA

Upstream 100 bases:

>100_bases
GATTCATTATCCATACAACCCGATGCTCTCGCCATCGTTGCACGCAAGCCGGCGACGATCGATCATATATCCGTTTTTTC
TAAATTGAAGACTCGGACGG

Downstream 100 bases:

>100_bases
GCGGTCACCCCTCGTATCTCGTGTGGCATCGCTCTACATGCAGAGCCGGGCGAGCGTCGCCGATGGCCATGCATGGCGCT
CGGGACGGTGGCGAAGGGCT

Product: DNA internalization-related competence protein ComEC/Rec2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MRIGWAMPLALSALVGSVWGGWGVSSAAGPWGLLCLLAVAQARWRGLAMLLVAGWCALNVAVQAAGELPDGLARQDVALE
GRVTQVSRDRGLAKLRLAVERCVPRAAGLPPCTRLSRVRLSWYDAPALRVGDQWRLTARLRPPQGFANGYGFDYAAWLWR
EGIQATGYVRDAASAQRLQAAPAGLRETGLAFLEARALSPLGKRWLAALTLGAGERLTQDDWDLLNATGTTHLMVISGLH
VGLVTSVALWLLRFLARVVTPGRWRLAAWPWWLAGAAALGYAGLAGFEPPALRATVMALLGLWVASGRHAPGPWQAWWLA
LLVVVTGDPLTVWQPGLWLSFLAVGVLIAAWQGRPVPRGARGWLLALVRSQCLLAPFMAAAVLVGFERLSPAAPLINLVA
VPLVGSLMVPLGLAGWALAWSPGLAMLPWRAFDALAQLVWQGLAWMGEIVPSWLPPGEEILPLALLLAAWGGAWLMPGLA
RSVRVWASLSLIALALTWQPSTIPPGRVVVIVHDVGQGQLVELRSATQRMLFDTGPRYGSGFAPAATLWPPGRRFDDVIV
SHSDRDHAGGVATLRDMHHVGRWWGPPNMAVGVATHACRQGVAWRRDEVSYRFLSPRSGDSALSDNDRSCVLSVTAGGQR
LLIMGDAGTTIERRLLRDIERPLTVLIAGHHGSRTSSSPAFVARVHPRHVIFSAGRDNAHGHPHPEVVRRFRRAGSCLWN
TAVDGALRFTLGESPLRMRPARPPGGVEGPCIGVESGD

Sequences:

>Translated_758_residues
MRIGWAMPLALSALVGSVWGGWGVSSAAGPWGLLCLLAVAQARWRGLAMLLVAGWCALNVAVQAAGELPDGLARQDVALE
GRVTQVSRDRGLAKLRLAVERCVPRAAGLPPCTRLSRVRLSWYDAPALRVGDQWRLTARLRPPQGFANGYGFDYAAWLWR
EGIQATGYVRDAASAQRLQAAPAGLRETGLAFLEARALSPLGKRWLAALTLGAGERLTQDDWDLLNATGTTHLMVISGLH
VGLVTSVALWLLRFLARVVTPGRWRLAAWPWWLAGAAALGYAGLAGFEPPALRATVMALLGLWVASGRHAPGPWQAWWLA
LLVVVTGDPLTVWQPGLWLSFLAVGVLIAAWQGRPVPRGARGWLLALVRSQCLLAPFMAAAVLVGFERLSPAAPLINLVA
VPLVGSLMVPLGLAGWALAWSPGLAMLPWRAFDALAQLVWQGLAWMGEIVPSWLPPGEEILPLALLLAAWGGAWLMPGLA
RSVRVWASLSLIALALTWQPSTIPPGRVVVIVHDVGQGQLVELRSATQRMLFDTGPRYGSGFAPAATLWPPGRRFDDVIV
SHSDRDHAGGVATLRDMHHVGRWWGPPNMAVGVATHACRQGVAWRRDEVSYRFLSPRSGDSALSDNDRSCVLSVTAGGQR
LLIMGDAGTTIERRLLRDIERPLTVLIAGHHGSRTSSSPAFVARVHPRHVIFSAGRDNAHGHPHPEVVRRFRRAGSCLWN
TAVDGALRFTLGESPLRMRPARPPGGVEGPCIGVESGD
>Mature_758_residues
MRIGWAMPLALSALVGSVWGGWGVSSAAGPWGLLCLLAVAQARWRGLAMLLVAGWCALNVAVQAAGELPDGLARQDVALE
GRVTQVSRDRGLAKLRLAVERCVPRAAGLPPCTRLSRVRLSWYDAPALRVGDQWRLTARLRPPQGFANGYGFDYAAWLWR
EGIQATGYVRDAASAQRLQAAPAGLRETGLAFLEARALSPLGKRWLAALTLGAGERLTQDDWDLLNATGTTHLMVISGLH
VGLVTSVALWLLRFLARVVTPGRWRLAAWPWWLAGAAALGYAGLAGFEPPALRATVMALLGLWVASGRHAPGPWQAWWLA
LLVVVTGDPLTVWQPGLWLSFLAVGVLIAAWQGRPVPRGARGWLLALVRSQCLLAPFMAAAVLVGFERLSPAAPLINLVA
VPLVGSLMVPLGLAGWALAWSPGLAMLPWRAFDALAQLVWQGLAWMGEIVPSWLPPGEEILPLALLLAAWGGAWLMPGLA
RSVRVWASLSLIALALTWQPSTIPPGRVVVIVHDVGQGQLVELRSATQRMLFDTGPRYGSGFAPAATLWPPGRRFDDVIV
SHSDRDHAGGVATLRDMHHVGRWWGPPNMAVGVATHACRQGVAWRRDEVSYRFLSPRSGDSALSDNDRSCVLSVTAGGQR
LLIMGDAGTTIERRLLRDIERPLTVLIAGHHGSRTSSSPAFVARVHPRHVIFSAGRDNAHGHPHPEVVRRFRRAGSCLWN
TAVDGALRFTLGESPLRMRPARPPGGVEGPCIGVESGD

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=737, Percent_Identity=28.2225237449118, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 81606; Mature: 81606

Theoretical pI: Translated: 11.45; Mature: 11.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGWAMPLALSALVGSVWGGWGVSSAAGPWGLLCLLAVAQARWRGLAMLLVAGWCALNV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQAAGELPDGLARQDVALEGRVTQVSRDRGLAKLRLAVERCVPRAAGLPPCTRLSRVRL
HHHHCCCCCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEE
SWYDAPALRVGDQWRLTARLRPPQGFANGYGFDYAAWLWREGIQATGYVRDAASAQRLQA
EEECCCCEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
APAGLRETGLAFLEARALSPLGKRWLAALTLGAGERLTQDDWDLLNATGTTHLMVISGLH
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCH
VGLVTSVALWLLRFLARVVTPGRWRLAAWPWWLAGAAALGYAGLAGFEPPALRATVMALL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GLWVASGRHAPGPWQAWWLALLVVVTGDPLTVWQPGLWLSFLAVGVLIAAWQGRPVPRGA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCH
RGWLLALVRSQCLLAPFMAAAVLVGFERLSPAAPLINLVAVPLVGSLMVPLGLAGWALAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPGLAMLPWRAFDALAQLVWQGLAWMGEIVPSWLPPGEEILPLALLLAAWGGAWLMPGLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
RSVRVWASLSLIALALTWQPSTIPPGRVVVIVHDVGQGQLVELRSATQRMLFDTGPRYGS
HHHHHHHHHEEHEEEEEECCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHCCCCCCCC
GFAPAATLWPPGRRFDDVIVSHSDRDHAGGVATLRDMHHVGRWWGPPNMAVGVATHACRQ
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GVAWRRDEVSYRFLSPRSGDSALSDNDRSCVLSVTAGGQRLLIMGDAGTTIERRLLRDIE
CCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHC
RPLTVLIAGHHGSRTSSSPAFVARVHPRHVIFSAGRDNAHGHPHPEVVRRFRRAGSCLWN
CCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHH
TAVDGALRFTLGESPLRMRPARPPGGVEGPCIGVESGD
HHHCCEEEEEECCCCCCCCCCCCCCCCCCCEECCCCCC
>Mature Secondary Structure
MRIGWAMPLALSALVGSVWGGWGVSSAAGPWGLLCLLAVAQARWRGLAMLLVAGWCALNV
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVQAAGELPDGLARQDVALEGRVTQVSRDRGLAKLRLAVERCVPRAAGLPPCTRLSRVRL
HHHHCCCCCCCCCCCCEEECCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHEEE
SWYDAPALRVGDQWRLTARLRPPQGFANGYGFDYAAWLWREGIQATGYVRDAASAQRLQA
EEECCCCEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHH
APAGLRETGLAFLEARALSPLGKRWLAALTLGAGERLTQDDWDLLNATGTTHLMVISGLH
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCH
VGLVTSVALWLLRFLARVVTPGRWRLAAWPWWLAGAAALGYAGLAGFEPPALRATVMALL
HHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
GLWVASGRHAPGPWQAWWLALLVVVTGDPLTVWQPGLWLSFLAVGVLIAAWQGRPVPRGA
HHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCH
RGWLLALVRSQCLLAPFMAAAVLVGFERLSPAAPLINLVAVPLVGSLMVPLGLAGWALAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPGLAMLPWRAFDALAQLVWQGLAWMGEIVPSWLPPGEEILPLALLLAAWGGAWLMPGLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
RSVRVWASLSLIALALTWQPSTIPPGRVVVIVHDVGQGQLVELRSATQRMLFDTGPRYGS
HHHHHHHHHEEHEEEEEECCCCCCCCEEEEEEEECCCCCEEHHHHHHHHHHHCCCCCCCC
GFAPAATLWPPGRRFDDVIVSHSDRDHAGGVATLRDMHHVGRWWGPPNMAVGVATHACRQ
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GVAWRRDEVSYRFLSPRSGDSALSDNDRSCVLSVTAGGQRLLIMGDAGTTIERRLLRDIE
CCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHC
RPLTVLIAGHHGSRTSSSPAFVARVHPRHVIFSAGRDNAHGHPHPEVVRRFRRAGSCLWN
CCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHCCCHHH
TAVDGALRFTLGESPLRMRPARPPGGVEGPCIGVESGD
HHHCCEEEEEECCCCCCCCCCCCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]