| Definition | Chromohalobacter salexigens DSM 3043 chromosome, complete genome. |
|---|---|
| Accession | NC_007963 |
| Length | 3,696,649 |
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The map label for this gene is dkgB [H]
Identifier: 92113442
GI number: 92113442
Start: 1499334
End: 1500149
Strand: Direct
Name: dkgB [H]
Synonym: Csal_1316
Alternate gene names: 92113442
Gene position: 1499334-1500149 (Clockwise)
Preceding gene: 92113440
Following gene: 92113443
Centisome position: 40.56
GC content: 63.48
Gene sequence:
>816_bases ATGGCTACGCAACGCACGGTCTTGCCTCGTATCGGGCTTGGTACCTTTCGCCTCAAGGATCAGGACGTCATCGATTCCGT GACCTCGGCGCTGTCGCTGGGGTATCGGCATATCGATACCGCGCAGTTCTATGGCAACGAGCGCGCGGTAGGCGAGGCGC TCGCGCAAAGCCACGTGCCGCGCGAGGAGATCTTCTTGACCACCAAGGTATGGTGGGATCAACTGCAGCCGCAGGCATTG CTCGATAGCCTCGAGGAAAGTCGGCGACAGCTCGGGGTCGATTACGTCGATCTGGCGCTGGTGCATTGGCCTTCGCCCGA TGATGAAGTGCCGATGGCCGACTACATCGGGGCCTTGAACCAGGCCCGTGAACAGGGCCTGACGCGCGACATCGGCGTCT CCAACTTTACGGTGGCGCAGATCGATCGGGCGCTGTCGGTGCCGGGCGGCGAGCATCTGATCACCAACCAGATCGAGGTG CATCCTTACCTGGCCAACCGCAAGGTGGTGGCGCATTGTCAGGACAAGGGCCTGCAGGTGACGGGCTACATGCCGCTGGC AGTGGGCAAGGTGATGGATGATCCGGTACTCCAGGCGATCGCCGAGGCGCACGAGGCGACACCGGCTCAGATCGCGCTCG CCTGGGTGGCGGCCCGCGATATCGTGGTGATTCCGTCCTCGACGAAGCCGGCGCACCAGCAGTCCAATCTCGAGGCGATG CGGATCACGCTGAGTGCCGAGGAGATGGCTCGTATCGACGCGCTGGATCGCGGCGAGCGTATCGCCAACCCGGACTTTGC CCCCGAGTGGGACTGA
Upstream 100 bases:
>100_bases ATGGCGGGGGCCCCACGTGATCTAAACGTAAAACAGGGCGCTTAATGACTTTTTCCTGTTGTATCCAGGCGCCTTTCTCG CAGCATGACAAGGAGTCAGC
Downstream 100 bases:
>100_bases ACGCGCAAGACCGGCGCCATTGAGGACGCTTTCTGCTAGGCTTGGCGCCCCCGGTATTCTCGATACCGGGGGCGCACTGT TTGATACCTTGAACGCTGAT
Product: aldo/keto reductase
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 271; Mature: 270
Protein sequence:
>271_residues MATQRTVLPRIGLGTFRLKDQDVIDSVTSALSLGYRHIDTAQFYGNERAVGEALAQSHVPREEIFLTTKVWWDQLQPQAL LDSLEESRRQLGVDYVDLALVHWPSPDDEVPMADYIGALNQAREQGLTRDIGVSNFTVAQIDRALSVPGGEHLITNQIEV HPYLANRKVVAHCQDKGLQVTGYMPLAVGKVMDDPVLQAIAEAHEATPAQIALAWVAARDIVVIPSSTKPAHQQSNLEAM RITLSAEEMARIDALDRGERIANPDFAPEWD
Sequences:
>Translated_271_residues MATQRTVLPRIGLGTFRLKDQDVIDSVTSALSLGYRHIDTAQFYGNERAVGEALAQSHVPREEIFLTTKVWWDQLQPQAL LDSLEESRRQLGVDYVDLALVHWPSPDDEVPMADYIGALNQAREQGLTRDIGVSNFTVAQIDRALSVPGGEHLITNQIEV HPYLANRKVVAHCQDKGLQVTGYMPLAVGKVMDDPVLQAIAEAHEATPAQIALAWVAARDIVVIPSSTKPAHQQSNLEAM RITLSAEEMARIDALDRGERIANPDFAPEWD >Mature_270_residues ATQRTVLPRIGLGTFRLKDQDVIDSVTSALSLGYRHIDTAQFYGNERAVGEALAQSHVPREEIFLTTKVWWDQLQPQALL DSLEESRRQLGVDYVDLALVHWPSPDDEVPMADYIGALNQAREQGLTRDIGVSNFTVAQIDRALSVPGGEHLITNQIEVH PYLANRKVVAHCQDKGLQVTGYMPLAVGKVMDDPVLQAIAEAHEATPAQIALAWVAARDIVVIPSSTKPAHQQSNLEAMR ITLSAEEMARIDALDRGERIANPDFAPEWD
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=36.3321799307958, Blast_Score=182, Evalue=4e-46, Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=36.3321799307958, Blast_Score=182, Evalue=4e-46, Organism=Homo sapiens, GI223468663, Length=293, Percent_Identity=33.7883959044369, Blast_Score=174, Evalue=6e-44, Organism=Homo sapiens, GI5453543, Length=290, Percent_Identity=33.1034482758621, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI93277124, Length=300, Percent_Identity=31.6666666666667, Blast_Score=165, Evalue=4e-41, Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=32.7338129496403, Blast_Score=164, Evalue=7e-41, Organism=Homo sapiens, GI310109920, Length=290, Percent_Identity=32.7586206896552, Blast_Score=163, Evalue=1e-40, Organism=Homo sapiens, GI24497585, Length=296, Percent_Identity=32.0945945945946, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI291291012, Length=270, Percent_Identity=34.0740740740741, Blast_Score=162, Evalue=2e-40, Organism=Homo sapiens, GI45446745, Length=289, Percent_Identity=32.8719723183391, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI4503285, Length=289, Percent_Identity=32.8719723183391, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI24497583, Length=295, Percent_Identity=32.5423728813559, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI5174695, Length=291, Percent_Identity=32.6460481099656, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI4502049, Length=287, Percent_Identity=33.4494773519164, Blast_Score=151, Evalue=5e-37, Organism=Homo sapiens, GI300116273, Length=271, Percent_Identity=32.4723247232472, Blast_Score=139, Evalue=3e-33, Organism=Homo sapiens, GI300116271, Length=273, Percent_Identity=30.7692307692308, Blast_Score=120, Evalue=1e-27, Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=32.4675324675325, Blast_Score=96, Evalue=3e-20, Organism=Homo sapiens, GI310109926, Length=105, Percent_Identity=37.1428571428571, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI207028673, Length=105, Percent_Identity=37.1428571428571, Blast_Score=78, Evalue=8e-15, Organism=Escherichia coli, GI1786400, Length=265, Percent_Identity=52.8301886792453, Blast_Score=289, Evalue=1e-79, Organism=Escherichia coli, GI87082198, Length=265, Percent_Identity=37.7358490566038, Blast_Score=172, Evalue=2e-44, Organism=Escherichia coli, GI1788081, Length=264, Percent_Identity=32.1969696969697, Blast_Score=124, Evalue=7e-30, Organism=Escherichia coli, GI1787674, Length=277, Percent_Identity=27.0758122743682, Blast_Score=90, Evalue=2e-19, Organism=Escherichia coli, GI1788070, Length=326, Percent_Identity=26.0736196319018, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI87081735, Length=273, Percent_Identity=26.7399267399267, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI48994888, Length=284, Percent_Identity=27.112676056338, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17537075, Length=289, Percent_Identity=34.9480968858132, Blast_Score=155, Evalue=3e-38, Organism=Caenorhabditis elegans, GI17537077, Length=288, Percent_Identity=34.375, Blast_Score=153, Evalue=1e-37, Organism=Caenorhabditis elegans, GI17550248, Length=289, Percent_Identity=32.5259515570934, Blast_Score=144, Evalue=5e-35, Organism=Caenorhabditis elegans, GI17561298, Length=267, Percent_Identity=30.7116104868914, Blast_Score=144, Evalue=7e-35, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=30.5970149253731, Blast_Score=137, Evalue=6e-33, Organism=Caenorhabditis elegans, GI17566692, Length=283, Percent_Identity=31.4487632508834, Blast_Score=137, Evalue=8e-33, Organism=Caenorhabditis elegans, GI17538386, Length=266, Percent_Identity=30.4511278195489, Blast_Score=129, Evalue=2e-30, Organism=Caenorhabditis elegans, GI17552492, Length=271, Percent_Identity=26.1992619926199, Blast_Score=124, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17562292, Length=288, Percent_Identity=30.2083333333333, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17564128, Length=297, Percent_Identity=28.2828282828283, Blast_Score=122, Evalue=3e-28, Organism=Caenorhabditis elegans, GI17561300, Length=262, Percent_Identity=27.4809160305344, Blast_Score=121, Evalue=4e-28, Organism=Caenorhabditis elegans, GI17537079, Length=294, Percent_Identity=27.5510204081633, Blast_Score=118, Evalue=3e-27, Organism=Saccharomyces cerevisiae, GI6324694, Length=293, Percent_Identity=34.8122866894198, Blast_Score=169, Evalue=3e-43, Organism=Saccharomyces cerevisiae, GI6320576, Length=279, Percent_Identity=34.7670250896057, Blast_Score=160, Evalue=2e-40, Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=30.7692307692308, Blast_Score=140, Evalue=2e-34, Organism=Saccharomyces cerevisiae, GI6321896, Length=306, Percent_Identity=30.0653594771242, Blast_Score=134, Evalue=2e-32, Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=29.3515358361775, Blast_Score=113, Evalue=4e-26, Organism=Saccharomyces cerevisiae, GI6320079, Length=272, Percent_Identity=31.6176470588235, Blast_Score=110, Evalue=2e-25, Organism=Drosophila melanogaster, GI24657054, Length=283, Percent_Identity=36.7491166077738, Blast_Score=174, Evalue=7e-44, Organism=Drosophila melanogaster, GI24644950, Length=299, Percent_Identity=35.7859531772575, Blast_Score=164, Evalue=5e-41, Organism=Drosophila melanogaster, GI221378297, Length=319, Percent_Identity=33.2288401253918, Blast_Score=159, Evalue=2e-39, Organism=Drosophila melanogaster, GI24662789, Length=288, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=3e-38, Organism=Drosophila melanogaster, GI21356425, Length=287, Percent_Identity=33.7979094076655, Blast_Score=150, Evalue=8e-37, Organism=Drosophila melanogaster, GI24663317, Length=285, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=9e-37, Organism=Drosophila melanogaster, GI45553081, Length=293, Percent_Identity=32.7645051194539, Blast_Score=140, Evalue=8e-34, Organism=Drosophila melanogaster, GI20129731, Length=278, Percent_Identity=32.0143884892086, Blast_Score=134, Evalue=7e-32, Organism=Drosophila melanogaster, GI24662785, Length=286, Percent_Identity=33.5664335664336, Blast_Score=127, Evalue=1e-29, Organism=Drosophila melanogaster, GI24662781, Length=286, Percent_Identity=33.2167832167832, Blast_Score=123, Evalue=1e-28, Organism=Drosophila melanogaster, GI281366140, Length=268, Percent_Identity=32.089552238806, Blast_Score=122, Evalue=3e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 29960; Mature: 29829
Theoretical pI: Translated: 4.64; Mature: 4.64
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1 ; PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.2 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MATQRTVLPRIGLGTFRLKDQDVIDSVTSALSLGYRHIDTAQFYGNERAVGEALAQSHVP CCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCHHHCCHHHHHCCHHHHHHHHHHHCCC REEIFLTTKVWWDQLQPQALLDSLEESRRQLGVDYVDLALVHWPSPDDEVPMADYIGALN HHHEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHH QAREQGLTRDIGVSNFTVAQIDRALSVPGGEHLITNQIEVHPYLANRKVVAHCQDKGLQV HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEEEEEEEECCCEEEEEECCCCEEE TGYMPLAVGKVMDDPVLQAIAEAHEATPAQIALAWVAARDIVVIPSSTKPAHQQSNLEAM EECCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHEEECCCEEEECCCCCCCHHHCCCEEE RITLSAEEMARIDALDRGERIANPDFAPEWD EEEECHHHHHHHHHHHCCCCCCCCCCCCCCC >Mature Secondary Structure ATQRTVLPRIGLGTFRLKDQDVIDSVTSALSLGYRHIDTAQFYGNERAVGEALAQSHVP CCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHCHHHCCHHHHHCCHHHHHHHHHHHCCC REEIFLTTKVWWDQLQPQALLDSLEESRRQLGVDYVDLALVHWPSPDDEVPMADYIGALN HHHEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHH QAREQGLTRDIGVSNFTVAQIDRALSVPGGEHLITNQIEVHPYLANRKVVAHCQDKGLQV HHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEEEEEEEECCCEEEEEECCCCEEE TGYMPLAVGKVMDDPVLQAIAEAHEATPAQIALAWVAARDIVVIPSSTKPAHQQSNLEAM EECCHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHEEECCCEEEECCCCCCCHHHCCCEEE RITLSAEEMARIDALDRGERIANPDFAPEWD EEEECHHHHHHHHHHHCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796; 11108008 [H]