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The map label for this gene is sufS [H]

Identifier: 92113362

GI number: 92113362

Start: 1415260

End: 1416501

Strand: Direct

Name: sufS [H]

Synonym: Csal_1236

Alternate gene names: 92113362

Gene position: 1415260-1416501 (Clockwise)

Preceding gene: 92113361

Following gene: 92113363

Centisome position: 38.28

GC content: 64.57

Gene sequence:

>1242_bases
ATGAACGCCCTTTCCGAGCCGATGCTGGACGTGGCCCGTGTCCGCCGTGACTTTCCGATTCTCGAGCGGGAAGTGCATGG
CAAGCCGCTGATCTATCTGGATAATGCTGCGACCACCCAGACGCCGTCAGCGGTCATCGAGACGCTGGATGATTATTACC
GGCGTTACAACGCCAATATTCATCGCGGGCTGCATACCCTGGCCGACGAGGCCACGGCAGCCTATGAAGGTACGCGCGAC
AAGGTTCGCGCGTGGCTGGGGGCGGCATCGAGTCGCGAAATCATCTTCACCCGGGGCACCACCGAGGCCATCAACCTGGT
CGCCAATAGCTGGGGGCGGGCCAACCTGCGTCCGGGGGACGAGATTCTGGTCTCCTTGATGGAGCACCACTCCAATATCG
TGCCCTGGCAGATGCTGGCCGAGGCACTGGATGTGACGCTCAAGGTGATCCCCGTCGATGAGCGCGGCGTGCTCGACCAG
GCGGCCTATCGTGAATTGCTGGGCGAGCGTACGCGGCTGGTGTGCGTCAATCACGTCTCCAATGCCCTGGGGACCGTCAA
TCCAGTGGCCGAGATGGCGCGTGAGGCCCATGCCCACGATGCTCTGATTCTCGTCGACGGTGCCCAGGCGGTACCGCATC
AGCGTGTCGACGTGCATGCGCTGGGTGTCGATTTCTACGCGTTCTCGGGGCACAAGATGTACGGGCCCACCGGGGTGGGC
GTGCTCTACGGCCGCGAAGCGCTGCTCGAAGCGATGCCGCCCTGGCAGGGGGGCGGCGAGATGATCAGCCGTGTGTCCTT
CGATCAGGGCACGGTATACAGCGACATACCGCACAAGTTCGAGGCGGGCACGCCGGCCATCGCCGAAGTGATCGCCCTCG
GCGCGGCACTGGACTGGGTCGCCGCCACCGGCATCGACATGATGGCGGCCTGGGAAGGGCAGCTTCTCGAGCGCGCCACG
GCCAAGTTGCGCGATGTCGAGGGGCTGCGTCTGATCGGGACGGCGCCCGACAAGGTCAGCGTGCTGTCGTTCGTGGTCGA
TGGCGTGCACGCCCAGGATATCGGCTTGCTGATCGATCAACTGGGCGTGGCCATACGTACCGGGCATCACTGCGCGCAAC
CCGTCCTGGCCAGCATGGGGCTCGAGGCAACCTGTCGCGCGTCCCTGGCGGCGTACAATACGCCCGAAGAGGTCGACGCG
TTCGTCGAGGCCCTGGAGAAAGTCATCGCCATGGTGCGCTAA

Upstream 100 bases:

>100_bases
GCCGAGCGCGTCGAGCGCGCCGTGGCCGGGAAGCTGCCCGAGCGTTTCAATCTTGCGGACCTGGTTGAGGTGTCCGACGC
CCTGCAGGAGGCCTGACATC

Downstream 100 bases:

>100_bases
CGGAGACGGCATGGATCAACTGGATAGCCTCTACAAAGGGCAGGAAATGCCCTTGCAGCGCGACGTCAACGCGATCTCGA
TCCCCTTCGGCAAGAGCGTG

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNALSEPMLDVARVRRDFPILEREVHGKPLIYLDNAATTQTPSAVIETLDDYYRRYNANIHRGLHTLADEATAAYEGTRD
KVRAWLGAASSREIIFTRGTTEAINLVANSWGRANLRPGDEILVSLMEHHSNIVPWQMLAEALDVTLKVIPVDERGVLDQ
AAYRELLGERTRLVCVNHVSNALGTVNPVAEMAREAHAHDALILVDGAQAVPHQRVDVHALGVDFYAFSGHKMYGPTGVG
VLYGREALLEAMPPWQGGGEMISRVSFDQGTVYSDIPHKFEAGTPAIAEVIALGAALDWVAATGIDMMAAWEGQLLERAT
AKLRDVEGLRLIGTAPDKVSVLSFVVDGVHAQDIGLLIDQLGVAIRTGHHCAQPVLASMGLEATCRASLAAYNTPEEVDA
FVEALEKVIAMVR

Sequences:

>Translated_413_residues
MNALSEPMLDVARVRRDFPILEREVHGKPLIYLDNAATTQTPSAVIETLDDYYRRYNANIHRGLHTLADEATAAYEGTRD
KVRAWLGAASSREIIFTRGTTEAINLVANSWGRANLRPGDEILVSLMEHHSNIVPWQMLAEALDVTLKVIPVDERGVLDQ
AAYRELLGERTRLVCVNHVSNALGTVNPVAEMAREAHAHDALILVDGAQAVPHQRVDVHALGVDFYAFSGHKMYGPTGVG
VLYGREALLEAMPPWQGGGEMISRVSFDQGTVYSDIPHKFEAGTPAIAEVIALGAALDWVAATGIDMMAAWEGQLLERAT
AKLRDVEGLRLIGTAPDKVSVLSFVVDGVHAQDIGLLIDQLGVAIRTGHHCAQPVLASMGLEATCRASLAAYNTPEEVDA
FVEALEKVIAMVR
>Mature_413_residues
MNALSEPMLDVARVRRDFPILEREVHGKPLIYLDNAATTQTPSAVIETLDDYYRRYNANIHRGLHTLADEATAAYEGTRD
KVRAWLGAASSREIIFTRGTTEAINLVANSWGRANLRPGDEILVSLMEHHSNIVPWQMLAEALDVTLKVIPVDERGVLDQ
AAYRELLGERTRLVCVNHVSNALGTVNPVAEMAREAHAHDALILVDGAQAVPHQRVDVHALGVDFYAFSGHKMYGPTGVG
VLYGREALLEAMPPWQGGGEMISRVSFDQGTVYSDIPHKFEAGTPAIAEVIALGAALDWVAATGIDMMAAWEGQLLERAT
AKLRDVEGLRLIGTAPDKVSVLSFVVDGVHAQDIGLLIDQLGVAIRTGHHCAQPVLASMGLEATCRASLAAYNTPEEVDA
FVEALEKVIAMVR

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=413, Percent_Identity=28.0871670702179, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI156713448, Length=439, Percent_Identity=26.879271070615, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1787970, Length=401, Percent_Identity=51.1221945137157, Blast_Score=430, Evalue=1e-122,
Organism=Escherichia coli, GI1789175, Length=405, Percent_Identity=42.2222222222222, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI48994898, Length=406, Percent_Identity=27.3399014778325, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=215, Percent_Identity=28.8372093023256, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI193211090, Length=373, Percent_Identity=24.3967828418231, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319831, Length=396, Percent_Identity=27.2727272727273, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI20129463, Length=410, Percent_Identity=28.0487804878049, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 44861; Mature: 44861

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALSEPMLDVARVRRDFPILEREVHGKPLIYLDNAATTQTPSAVIETLDDYYRRYNANI
CCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCHH
HRGLHTLADEATAAYEGTRDKVRAWLGAASSREIIFTRGTTEAINLVANSWGRANLRPGD
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCHH
EILVSLMEHHSNIVPWQMLAEALDVTLKVIPVDERGVLDQAAYRELLGERTRLVCVNHVS
HHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHH
NALGTVNPVAEMAREAHAHDALILVDGAQAVPHQRVDVHALGVDFYAFSGHKMYGPTGVG
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCH
VLYGREALLEAMPPWQGGGEMISRVSFDQGTVYSDIPHKFEAGTPAIAEVIALGAALDWV
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
AATGIDMMAAWEGQLLERATAKLRDVEGLRLIGTAPDKVSVLSFVVDGVHAQDIGLLIDQ
HHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHH
LGVAIRTGHHCAQPVLASMGLEATCRASLAAYNTPEEVDAFVEALEKVIAMVR
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNALSEPMLDVARVRRDFPILEREVHGKPLIYLDNAATTQTPSAVIETLDDYYRRYNANI
CCCHHHHHHHHHHHHHCCCHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHCCHH
HRGLHTLADEATAAYEGTRDKVRAWLGAASSREIIFTRGTTEAINLVANSWGRANLRPGD
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHCCCCCCCCCHH
EILVSLMEHHSNIVPWQMLAEALDVTLKVIPVDERGVLDQAAYRELLGERTRLVCVNHVS
HHHHHHHHHCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEHHHHH
NALGTVNPVAEMAREAHAHDALILVDGAQAVPHQRVDVHALGVDFYAFSGHKMYGPTGVG
HHHCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEEEEEECCCEEECCCCCH
VLYGREALLEAMPPWQGGGEMISRVSFDQGTVYSDIPHKFEAGTPAIAEVIALGAALDWV
HHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHH
AATGIDMMAAWEGQLLERATAKLRDVEGLRLIGTAPDKVSVLSFVVDGVHAQDIGLLIDQ
HHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCHHHHHHHHHH
LGVAIRTGHHCAQPVLASMGLEATCRASLAAYNTPEEVDAFVEALEKVIAMVR
HHHHHHCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11251816 [H]