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The map label for this gene is bioA [C]

Identifier: 92113252

GI number: 92113252

Start: 1283206

End: 1284549

Strand: Direct

Name: bioA [C]

Synonym: Csal_1125

Alternate gene names: 92113252

Gene position: 1283206-1284549 (Clockwise)

Preceding gene: 92113250

Following gene: 92113253

Centisome position: 34.71

GC content: 64.29

Gene sequence:

>1344_bases
ATGTCGGATCGCGAGTTTCCCCCCATGGCGGGTTTGAGCCCGGAGCAGCTGGACGCCTACTGGATGCCGTATACCGGCAA
TCGGCAATTCAAGCGCGATCCACGCCTCATCGTGGGCGCCAAGGGCAGCTACCTTACCGATGCCCAGGGTCGCCAAGTCT
TCGATGCGCTCTCGGGGCTGTGGACCTGCGGCGCGGGGCATTGCCGCCCCGAGATCACCGAGGCGGTCAGTCGTCAGCTC
GGCGAGCTGGACTACTCGCCGGCCTTCCAGTATGGCCACCCCAAGGCCTTCGAGCTGGCCCATCGTCTGCGGGAATTGAC
GCCTCAGGGCCTCGATCACGTGTTCTTCACCGGCTCGGGCTCGGAGAGTGCCGATACCTCGCTGAAGATAGCGCGTGCCT
ACTGGCGCAAGAAGGGCAAGCCGAGCAAGACCAAGCTGATCGGACGTGCCAAGGGATATCACGGCGTCAACTTCGGCGGC
TTCAGCCTGGGGGGAATCGGTGCCAATCGCACCGTGTTCGGCCAGGGCGTGGATGCCGATCATCTGCCCCATACCCTGTT
GAAGGAAAACGCCTTCACCCAGGGCATGCCCGCGCGGGGGGCCGAGCGCGCTGACGAGTTGCTGGAGCTGATCGCGCTGC
ATGATGCCTCCAACATCGCGGCGGTGATCGTCGAGCCGCTGGCCGGCTCCGCCGGGGTGATTCCGCCGCCCAAAGGCTAT
CTCAAGCGCCTGCGCGAGATCTGCGACCAGCACGACATCCTGCTCATCTTCGACGAGGTCATCACCGGCTTCGGGCGCAT
GGGATCGATGACCGGGGCCGAGGAGTTCGGCGTGGTACCGGATCTGCTCAATGTCGCCAAGCAGTTGACCAATGGGGCGG
TGCCCATGGGCGCGGTAATCGTGCAGGGCGAGATCTATCGGACCTTCATGGAGCAGGGCGGCCCCGACTACATGCTCGAG
CTGCCCCACGGCTATACCTATTCGGGGCACCCGGTGGCCTGTGCCGCCGCCCTGGCCGCGCTGGACGTGCTCGAGAACGA
CCGCCTCATCGAGCGAGTCAAAGAAATGGCGCCGATCTTCGAAAGTGCGCTGCATTCTCTCAAGGGGACGCGCTACATCA
GCGACATCCGCAATTACGGCCTCGCCGGCGCCCTGCAGATCGAACCGTATCCCGGCGAGCCGGGGCGGCGTCCTTTCGAG
ATCGCCATGAAGTGCTGGGAAAAAGGTTTCTACGTGCGCTATGGCGGCGACACCATCCAGCTCGGCCTGCCGTTCATCGT
CGAGCGCGAGGAGATCGATCGCCTCGTCAATGGGCTGGGTGACGCCATCGGCGAACTGGAATAA

Upstream 100 bases:

>100_bases
GACTTGAACGAGATTCAGTATTTCTGGATTTAACTTATCCGCCGTCCCGCCTAGCTTTTTCGGTAGCACCATTCATCACC
GCCTATCGGCAGGAGAAGAC

Downstream 100 bases:

>100_bases
ATCAGACGACGCCTGTCGAGATGCGCGCCGGGGACAAGGCGCAGCGAGGGTCATCCGTCATGGATGACGGATGTAGCGCC
CAGGGAAGGGTCTACAGCGC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSDREFPPMAGLSPEQLDAYWMPYTGNRQFKRDPRLIVGAKGSYLTDAQGRQVFDALSGLWTCGAGHCRPEITEAVSRQL
GELDYSPAFQYGHPKAFELAHRLRELTPQGLDHVFFTGSGSESADTSLKIARAYWRKKGKPSKTKLIGRAKGYHGVNFGG
FSLGGIGANRTVFGQGVDADHLPHTLLKENAFTQGMPARGAERADELLELIALHDASNIAAVIVEPLAGSAGVIPPPKGY
LKRLREICDQHDILLIFDEVITGFGRMGSMTGAEEFGVVPDLLNVAKQLTNGAVPMGAVIVQGEIYRTFMEQGGPDYMLE
LPHGYTYSGHPVACAAALAALDVLENDRLIERVKEMAPIFESALHSLKGTRYISDIRNYGLAGALQIEPYPGEPGRRPFE
IAMKCWEKGFYVRYGGDTIQLGLPFIVEREEIDRLVNGLGDAIGELE

Sequences:

>Translated_447_residues
MSDREFPPMAGLSPEQLDAYWMPYTGNRQFKRDPRLIVGAKGSYLTDAQGRQVFDALSGLWTCGAGHCRPEITEAVSRQL
GELDYSPAFQYGHPKAFELAHRLRELTPQGLDHVFFTGSGSESADTSLKIARAYWRKKGKPSKTKLIGRAKGYHGVNFGG
FSLGGIGANRTVFGQGVDADHLPHTLLKENAFTQGMPARGAERADELLELIALHDASNIAAVIVEPLAGSAGVIPPPKGY
LKRLREICDQHDILLIFDEVITGFGRMGSMTGAEEFGVVPDLLNVAKQLTNGAVPMGAVIVQGEIYRTFMEQGGPDYMLE
LPHGYTYSGHPVACAAALAALDVLENDRLIERVKEMAPIFESALHSLKGTRYISDIRNYGLAGALQIEPYPGEPGRRPFE
IAMKCWEKGFYVRYGGDTIQLGLPFIVEREEIDRLVNGLGDAIGELE
>Mature_446_residues
SDREFPPMAGLSPEQLDAYWMPYTGNRQFKRDPRLIVGAKGSYLTDAQGRQVFDALSGLWTCGAGHCRPEITEAVSRQLG
ELDYSPAFQYGHPKAFELAHRLRELTPQGLDHVFFTGSGSESADTSLKIARAYWRKKGKPSKTKLIGRAKGYHGVNFGGF
SLGGIGANRTVFGQGVDADHLPHTLLKENAFTQGMPARGAERADELLELIALHDASNIAAVIVEPLAGSAGVIPPPKGYL
KRLREICDQHDILLIFDEVITGFGRMGSMTGAEEFGVVPDLLNVAKQLTNGAVPMGAVIVQGEIYRTFMEQGGPDYMLEL
PHGYTYSGHPVACAAALAALDVLENDRLIERVKEMAPIFESALHSLKGTRYISDIRNYGLAGALQIEPYPGEPGRRPFEI
AMKCWEKGFYVRYGGDTIQLGLPFIVEREEIDRLVNGLGDAIGELE

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=407, Percent_Identity=28.5012285012285, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI13994255, Length=446, Percent_Identity=27.3542600896861, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI37574042, Length=366, Percent_Identity=30.8743169398907, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI24119277, Length=363, Percent_Identity=27.8236914600551, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI226442705, Length=366, Percent_Identity=30.0546448087432, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI284507298, Length=319, Percent_Identity=28.5266457680251, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI226442709, Length=330, Percent_Identity=30.9090909090909, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1786991, Length=436, Percent_Identity=30.5045871559633, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.2663438256659, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI145693181, Length=315, Percent_Identity=33.3333333333333, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1788044, Length=425, Percent_Identity=29.6470588235294, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1789016, Length=407, Percent_Identity=27.2727272727273, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1787560, Length=416, Percent_Identity=26.2019230769231, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786349, Length=329, Percent_Identity=29.1793313069909, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=27.1111111111111, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=26.8115942028986, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=370, Percent_Identity=30, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144274, Length=230, Percent_Identity=31.304347826087, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=448, Percent_Identity=26.7857142857143, Blast_Score=164, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6324386, Length=437, Percent_Identity=25.858123569794, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=417, Percent_Identity=27.3381294964029, Blast_Score=132, Evalue=8e-32,
Organism=Drosophila melanogaster, GI21357415, Length=410, Percent_Identity=28.780487804878, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=28.1879194630872, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI28574759, Length=449, Percent_Identity=28.5077951002227, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356575, Length=429, Percent_Identity=27.5058275058275, Blast_Score=125, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48896; Mature: 48765

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDREFPPMAGLSPEQLDAYWMPYTGNRQFKRDPRLIVGAKGSYLTDAQGRQVFDALSGL
CCCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHH
WTCGAGHCRPEITEAVSRQLGELDYSPAFQYGHPKAFELAHRLRELTPQGLDHVFFTGSG
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
SESADTSLKIARAYWRKKGKPSKTKLIGRAKGYHGVNFGGFSLGGIGANRTVFGQGVDAD
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCCCCC
HLPHTLLKENAFTQGMPARGAERADELLELIALHDASNIAAVIVEPLAGSAGVIPPPKGY
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LKRLREICDQHDILLIFDEVITGFGRMGSMTGAEEFGVVPDLLNVAKQLTNGAVPMGAVI
HHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEE
VQGEIYRTFMEQGGPDYMLELPHGYTYSGHPVACAAALAALDVLENDRLIERVKEMAPIF
ECHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ESALHSLKGTRYISDIRNYGLAGALQIEPYPGEPGRRPFEIAMKCWEKGFYVRYGGDTIQ
HHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEE
LGLPFIVEREEIDRLVNGLGDAIGELE
ECCCCEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDREFPPMAGLSPEQLDAYWMPYTGNRQFKRDPRLIVGAKGSYLTDAQGRQVFDALSGL
CCCCCCCCCCCCHHHCCEEECCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHH
WTCGAGHCRPEITEAVSRQLGELDYSPAFQYGHPKAFELAHRLRELTPQGLDHVFFTGSG
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCC
SESADTSLKIARAYWRKKGKPSKTKLIGRAKGYHGVNFGGFSLGGIGANRTVFGQGVDAD
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCCCCC
HLPHTLLKENAFTQGMPARGAERADELLELIALHDASNIAAVIVEPLAGSAGVIPPPKGY
CCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHH
LKRLREICDQHDILLIFDEVITGFGRMGSMTGAEEFGVVPDLLNVAKQLTNGAVPMGAVI
HHHHHHHHCCCCEEEEHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCCEEE
VQGEIYRTFMEQGGPDYMLELPHGYTYSGHPVACAAALAALDVLENDRLIERVKEMAPIF
ECHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
ESALHSLKGTRYISDIRNYGLAGALQIEPYPGEPGRRPFEIAMKCWEKGFYVRYGGDTIQ
HHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCEEE
LGLPFIVEREEIDRLVNGLGDAIGELE
ECCCCEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]