Click here to switch to the map view.

The map label for this gene is poxB [H]

Identifier: 92113138

GI number: 92113138

Start: 1139070

End: 1140791

Strand: Direct

Name: poxB [H]

Synonym: Csal_1010

Alternate gene names: 92113138

Gene position: 1139070-1140791 (Clockwise)

Preceding gene: 92113136

Following gene: 92113139

Centisome position: 30.81

GC content: 61.96

Gene sequence:

>1722_bases
ATGAGCAGTCACAGTAACGTGGCCGAGATCATCGTCGAGACACTGGCGGAGGCTGGCGCCAGGCGCTGTTACGGCGTCGT
CGGCGATACCATCAATCACTTCACCGATGCCATTCGACGCAGTGATGCCCTGGAATGGGTGCATGTGCGCCATGAAGAAG
TCGGCGGCTTCGCCGCGGGGGGCGAGGCCTACATGACGCGGGATCTGGCGGTATGTGCCGGTACCTGCGGCCCCGGCAGC
CTGCATTTCGTCAATGGGCTGTTCGAGGCGCATCGCAGTGGTTCGCCGGTGGTATTGATCGCCTCCCAGGTGGCCACCAA
GGATGCCGGTATCGGTTTTCCGCAGGACGTCGACCCCAGGGCCATCTATTCACAGTACAGCGTGTTCTGCGAGTCGATCG
TCAATCCCGAACAGGCACGCCGCATGACCGCGCTGGCCGCCCAGTCGGCACTGGCCAATAACGGGGTGGCGGTGCTCGTC
GTGCACGGCGATATCTTCACGCAGACACCGAGTCAGGACCTGCCGTTTCGCGCGCATCGCTTCGACCCCATCGTGCGGCC
CAATGCCGAGGAATTCGTGCCTGCCGTCAAACAGCTCAATAAGGGAGGCAAGATATCCATCTTCGCCGGATTTGGCTGTG
AGCACGCCCGCAGCGAGGTCATGGCCCTGGCGGCCAAGCTCAACGCGCCGATCGCCTGGACCTCGCGCGCCAAGGACTTC
ATCGAACCCGACAATCCCTTCGAGGTCGGCATGACCGGCGTGTTCGGTCTGGCAGGCGGTTATCATGCCGTGGCCGAATG
CGACACGCTCCTGCTGCTGGGCTGCAACTTCGCCTGGGGGCAGTTCTATCCCGAGAAGGCCACCATCATTCAGGTGGATA
TCGACCCGCAGCAGATCGGCAAGCGTCATCCGGTGGACATCGGCCTGGTCGGCAGCGTGCGTGATACCTGCCTGGCGCTG
GCCAAGATGATCGATGAACAGACCGATACCCGTTGGCTGGATAGCTGCCGCAAGCAGTACCAGAAAGCGTTGACGCATGA
TGCTCACGAGTCCCGCGACGATACGCTGATCCACCCGCAGGAGCTCACCCTGGCACTCAATGCGCATGCGCCCGACGATG
CCTTCTTCACGGCGGACGGGGGGAGCCCGATGGTCTGGATGCTGCGTCACATTCGGGCCACCGGCCGGCGTCGTACGCTT
TCCAGTCTCGTTCACGGCACCATGGCCAACGCGTATCCGCAGGCGATCGGCATTCAAAAGGCCTTTCCCGAGCGGCAAGT
CATCGCCATGTGCGGTGACGGTGGCCTGACCATGCTGATGGGAGACCTCTTAACCCTCAAGCAGGAGAAGGTGCCGCTCA
AGATCGTCGTCTACAACAACAGCTCGCTGGGCTTCGTCGAACTGGAACAGAAGGTCGAAGGTCTGCTCGACAGCTACACC
GATCTCGAGAATCCCGAATTCGACAAGCTGGCGCAGGTCATGGGTATCTGGGGCAGGCGAGTGGAGGAGTCGCACCAGCT
CGAACCCGCCATCATCGAATGGCTCGCCCATGAGGGGCCGGCACTGCTCGACGTGAAGGTCAACCGGATGGAACTCGTCA
TGCCGCCCAAGGTGGAAGCCGGACAAGTCGCCTCTACCGCGCTCTACTCCACCAAAGCCGTTCTCAACGGGCGCATGGAG
GATGTCGTCGACCTCGTCAAGAGCAACTTCTTCAAGCGCTGA

Upstream 100 bases:

>100_bases
ATCGACCTTCGTCGGGCATAGAGTGAAAGCGGGACGCCACGCGTCGACGTGGCGATCACGTTTATGCGCCTCTCGAGGGC
GCCGATGCGGAGGGAATCGC

Downstream 100 bases:

>100_bases
ACGCGTAGCCAAGTCAATGCTCACTCACGACCGGGCACCGCCAGGTGCCCGGTTTTTATGTGCTGAGCGACGATGAGGCA
CCTTCAAAGTGAGTCATTAC

Product: pyruvate dehydrogenase (cytochrome)

Products: NA

Alternate protein names: Pyruvate oxidase; POX [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MSSHSNVAEIIVETLAEAGARRCYGVVGDTINHFTDAIRRSDALEWVHVRHEEVGGFAAGGEAYMTRDLAVCAGTCGPGS
LHFVNGLFEAHRSGSPVVLIASQVATKDAGIGFPQDVDPRAIYSQYSVFCESIVNPEQARRMTALAAQSALANNGVAVLV
VHGDIFTQTPSQDLPFRAHRFDPIVRPNAEEFVPAVKQLNKGGKISIFAGFGCEHARSEVMALAAKLNAPIAWTSRAKDF
IEPDNPFEVGMTGVFGLAGGYHAVAECDTLLLLGCNFAWGQFYPEKATIIQVDIDPQQIGKRHPVDIGLVGSVRDTCLAL
AKMIDEQTDTRWLDSCRKQYQKALTHDAHESRDDTLIHPQELTLALNAHAPDDAFFTADGGSPMVWMLRHIRATGRRRTL
SSLVHGTMANAYPQAIGIQKAFPERQVIAMCGDGGLTMLMGDLLTLKQEKVPLKIVVYNNSSLGFVELEQKVEGLLDSYT
DLENPEFDKLAQVMGIWGRRVEESHQLEPAIIEWLAHEGPALLDVKVNRMELVMPPKVEAGQVASTALYSTKAVLNGRME
DVVDLVKSNFFKR

Sequences:

>Translated_573_residues
MSSHSNVAEIIVETLAEAGARRCYGVVGDTINHFTDAIRRSDALEWVHVRHEEVGGFAAGGEAYMTRDLAVCAGTCGPGS
LHFVNGLFEAHRSGSPVVLIASQVATKDAGIGFPQDVDPRAIYSQYSVFCESIVNPEQARRMTALAAQSALANNGVAVLV
VHGDIFTQTPSQDLPFRAHRFDPIVRPNAEEFVPAVKQLNKGGKISIFAGFGCEHARSEVMALAAKLNAPIAWTSRAKDF
IEPDNPFEVGMTGVFGLAGGYHAVAECDTLLLLGCNFAWGQFYPEKATIIQVDIDPQQIGKRHPVDIGLVGSVRDTCLAL
AKMIDEQTDTRWLDSCRKQYQKALTHDAHESRDDTLIHPQELTLALNAHAPDDAFFTADGGSPMVWMLRHIRATGRRRTL
SSLVHGTMANAYPQAIGIQKAFPERQVIAMCGDGGLTMLMGDLLTLKQEKVPLKIVVYNNSSLGFVELEQKVEGLLDSYT
DLENPEFDKLAQVMGIWGRRVEESHQLEPAIIEWLAHEGPALLDVKVNRMELVMPPKVEAGQVASTALYSTKAVLNGRME
DVVDLVKSNFFKR
>Mature_572_residues
SSHSNVAEIIVETLAEAGARRCYGVVGDTINHFTDAIRRSDALEWVHVRHEEVGGFAAGGEAYMTRDLAVCAGTCGPGSL
HFVNGLFEAHRSGSPVVLIASQVATKDAGIGFPQDVDPRAIYSQYSVFCESIVNPEQARRMTALAAQSALANNGVAVLVV
HGDIFTQTPSQDLPFRAHRFDPIVRPNAEEFVPAVKQLNKGGKISIFAGFGCEHARSEVMALAAKLNAPIAWTSRAKDFI
EPDNPFEVGMTGVFGLAGGYHAVAECDTLLLLGCNFAWGQFYPEKATIIQVDIDPQQIGKRHPVDIGLVGSVRDTCLALA
KMIDEQTDTRWLDSCRKQYQKALTHDAHESRDDTLIHPQELTLALNAHAPDDAFFTADGGSPMVWMLRHIRATGRRRTLS
SLVHGTMANAYPQAIGIQKAFPERQVIAMCGDGGLTMLMGDLLTLKQEKVPLKIVVYNNSSLGFVELEQKVEGLLDSYTD
LENPEFDKLAQVMGIWGRRVEESHQLEPAIIEWLAHEGPALLDVKVNRMELVMPPKVEAGQVASTALYSTKAVLNGRMED
VVDLVKSNFFKR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=559, Percent_Identity=19.8568872987478, Blast_Score=80, Evalue=7e-15,
Organism=Escherichia coli, GI1787096, Length=574, Percent_Identity=41.6376306620209, Blast_Score=469, Evalue=1e-133,
Organism=Escherichia coli, GI87081685, Length=576, Percent_Identity=24.4791666666667, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790104, Length=542, Percent_Identity=26.1992619926199, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786717, Length=561, Percent_Identity=22.8163992869875, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788716, Length=544, Percent_Identity=21.6911764705882, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17542570, Length=554, Percent_Identity=21.841155234657, Blast_Score=99, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17531299, Length=494, Percent_Identity=21.2550607287449, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17531301, Length=494, Percent_Identity=21.2550607287449, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323755, Length=564, Percent_Identity=25.177304964539, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI19922626, Length=541, Percent_Identity=22.181146025878, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.5.1 [H]

Molecular weight: Translated: 62658; Mature: 62527

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSHSNVAEIIVETLAEAGARRCYGVVGDTINHFTDAIRRSDALEWVHVRHEEVGGFAAG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEECC
GEAYMTRDLAVCAGTCGPGSLHFVNGLFEAHRSGSPVVLIASQVATKDAGIGFPQDVDPR
CHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEEEEECHHCCCCCCCCCCCCCCHH
AIYSQYSVFCESIVNPEQARRMTALAAQSALANNGVAVLVVHGDIFTQTPSQDLPFRAHR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCHHC
FDPIVRPNAEEFVPAVKQLNKGGKISIFAGFGCEHARSEVMALAAKLNAPIAWTSRAKDF
CCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCHHC
IEPDNPFEVGMTGVFGLAGGYHAVAECDTLLLLGCNFAWGQFYPEKATIIQVDIDPQQIG
CCCCCCCCCCCHHHHHHCCCCHHHHHHCEEEEEECCCHHCCCCCCCEEEEEEECCHHHHC
KRHPVDIGLVGSVRDTCLALAKMIDEQTDTRWLDSCRKQYQKALTHDAHESRDDTLIHPQ
CCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
ELTLALNAHAPDDAFFTADGGSPMVWMLRHIRATGRRRTLSSLVHGTMANAYPQAIGIQK
CEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
AFPERQVIAMCGDGGLTMLMGDLLTLKQEKVPLKIVVYNNSSLGFVELEQKVEGLLDSYT
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHH
DLENPEFDKLAQVMGIWGRRVEESHQLEPAIIEWLAHEGPALLDVKVNRMELVMPPKVEA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCEEEEECCCCCC
GQVASTALYSTKAVLNGRMEDVVDLVKSNFFKR
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSHSNVAEIIVETLAEAGARRCYGVVGDTINHFTDAIRRSDALEWVHVRHEEVGGFAAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEECC
GEAYMTRDLAVCAGTCGPGSLHFVNGLFEAHRSGSPVVLIASQVATKDAGIGFPQDVDPR
CHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCEEEEECHHCCCCCCCCCCCCCCHH
AIYSQYSVFCESIVNPEQARRMTALAAQSALANNGVAVLVVHGDIFTQTPSQDLPFRAHR
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCHHC
FDPIVRPNAEEFVPAVKQLNKGGKISIFAGFGCEHARSEVMALAAKLNAPIAWTSRAKDF
CCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCHHC
IEPDNPFEVGMTGVFGLAGGYHAVAECDTLLLLGCNFAWGQFYPEKATIIQVDIDPQQIG
CCCCCCCCCCCHHHHHHCCCCHHHHHHCEEEEEECCCHHCCCCCCCEEEEEEECCHHHHC
KRHPVDIGLVGSVRDTCLALAKMIDEQTDTRWLDSCRKQYQKALTHDAHESRDDTLIHPQ
CCCCCCEEEECHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCC
ELTLALNAHAPDDAFFTADGGSPMVWMLRHIRATGRRRTLSSLVHGTMANAYPQAIGIQK
CEEEEEECCCCCCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCHHH
AFPERQVIAMCGDGGLTMLMGDLLTLKQEKVPLKIVVYNNSSLGFVELEQKVEGLLDSYT
CCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHH
DLENPEFDKLAQVMGIWGRRVEESHQLEPAIIEWLAHEGPALLDVKVNRMELVMPPKVEA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEECCEEEEECCCCCC
GQVASTALYSTKAVLNGRMEDVVDLVKSNFFKR
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3016647; 8905232; 9278503; 2663858; 3902830; 8022274 [H]