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The map label for this gene is hemH [H]

Identifier: 92113025

GI number: 92113025

Start: 1009666

End: 1010652

Strand: Direct

Name: hemH [H]

Synonym: Csal_0897

Alternate gene names: 92113025

Gene position: 1009666-1010652 (Clockwise)

Preceding gene: 92113023

Following gene: 92113032

Centisome position: 27.31

GC content: 65.75

Gene sequence:

>987_bases
ATGGGGTCAGCACCCTTTGGTGTCATGCTCGTCAATCTTGGCACGCCCGAGGCCCCCACCACGTCGGCAGTACGTCGCTA
TCTGGCAGAGTTCCTGGGTGACCCGCGCGTCATCGACCTGCCGCGCGTCAAATGGTTGCCGATCCTGCACGGGATCATCC
TGCGCATACGGCCGCCGCGAGTGGCCAAGGCCTATGCTTCCGTGTGGCAGGACGAAGGCTCGCCGCTGCTCGCCATCGGG
CGTCGCCAGCAACGCGCGCTCAAGGCACGCCTGGCGGCGCGGCTGGGGACCGACATTCCCGTCGAGCTGGCGATGACCTA
CGGCAAGCCGAGCATGGAGGAGGCCGGCCTGGCGCTGCGCGATGCCGGTGTCGAGCGCATCCTGGTGTTGCCTCTGTACC
CGCAGTACTCCGCCACGACGACCGGTGCCGTCTTCGACCGTCTGGCGCGTGCCTTGTCGCCCTGCCCGCATCTGCCGGAG
CTGCGTTTCGTGCGGGATTACCACGATCATCCGGCTTACATCGAGGCACTGGCGGAAAGCATTCGCGAGCACTGGGAGAC
GCATGGCCGGCAACCACGTCTGTTGTTCTCGTACCACGGCATTCCCAAGCGCTATGCCGAGGCGGGTGATCCTTATCCGC
GTCACTGCGAGACGACCAGCCGGCTGGTCGCCGAGGCGTTGGGGCTCGAGCCCGAGGCGTGGCAGCAGACCTATCAATCG
CGCTTCGGGCGCGAGGAATGGCTCAAGCCGTATACCGACGACACGCTGAAAGCCTGGGGCGTCGAGGGGCTCGAAGGCGT
CGATGTGATCAGCCCGGCCTTCGCCGCCGACTGCCTGGAAACGCTGGAGGAACTGGAGGTGGAGAATCGCGGTTACTTCA
CCGAGGCGGGCGGCGGTGACTACCGCTACATCCCTGCGCTCAACGACCGTGCCGCGCATATCGACATGCTGGCTTCACTC
GTCGAGCAGCACACTCAAGGCTGGTAG

Upstream 100 bases:

>100_bases
CCAGATATTGTACAAATTGTCTTCATAGTATAACGCGATAAGCATAATATGCCCGTCGCTTGTTACACTGCCTGACACGG
TCTTTTATAGGAGAGGTTTC

Downstream 100 bases:

>100_bases
GTCATCGGAGCTGGCCGGCAACGCGCCCGAGCGGGTCTACCGCTCGGGCGCGTTCACGTGAGGGGTGGGTCAGGGAAGCT
TCGAATCGCCCTGCGGGGCT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MGSAPFGVMLVNLGTPEAPTTSAVRRYLAEFLGDPRVIDLPRVKWLPILHGIILRIRPPRVAKAYASVWQDEGSPLLAIG
RRQQRALKARLAARLGTDIPVELAMTYGKPSMEEAGLALRDAGVERILVLPLYPQYSATTTGAVFDRLARALSPCPHLPE
LRFVRDYHDHPAYIEALAESIREHWETHGRQPRLLFSYHGIPKRYAEAGDPYPRHCETTSRLVAEALGLEPEAWQQTYQS
RFGREEWLKPYTDDTLKAWGVEGLEGVDVISPAFAADCLETLEELEVENRGYFTEAGGGDYRYIPALNDRAAHIDMLASL
VEQHTQGW

Sequences:

>Translated_328_residues
MGSAPFGVMLVNLGTPEAPTTSAVRRYLAEFLGDPRVIDLPRVKWLPILHGIILRIRPPRVAKAYASVWQDEGSPLLAIG
RRQQRALKARLAARLGTDIPVELAMTYGKPSMEEAGLALRDAGVERILVLPLYPQYSATTTGAVFDRLARALSPCPHLPE
LRFVRDYHDHPAYIEALAESIREHWETHGRQPRLLFSYHGIPKRYAEAGDPYPRHCETTSRLVAEALGLEPEAWQQTYQS
RFGREEWLKPYTDDTLKAWGVEGLEGVDVISPAFAADCLETLEELEVENRGYFTEAGGGDYRYIPALNDRAAHIDMLASL
VEQHTQGW
>Mature_327_residues
GSAPFGVMLVNLGTPEAPTTSAVRRYLAEFLGDPRVIDLPRVKWLPILHGIILRIRPPRVAKAYASVWQDEGSPLLAIGR
RQQRALKARLAARLGTDIPVELAMTYGKPSMEEAGLALRDAGVERILVLPLYPQYSATTTGAVFDRLARALSPCPHLPEL
RFVRDYHDHPAYIEALAESIREHWETHGRQPRLLFSYHGIPKRYAEAGDPYPRHCETTSRLVAEALGLEPEAWQQTYQSR
FGREEWLKPYTDDTLKAWGVEGLEGVDVISPAFAADCLETLEELEVENRGYFTEAGGGDYRYIPALNDRAAHIDMLASLV
EQHTQGW

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=27.190332326284, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=27.190332326284, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=54.2857142857143, Blast_Score=324, Evalue=4e-90,
Organism=Saccharomyces cerevisiae, GI6324750, Length=333, Percent_Identity=24.024024024024, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864156, Length=330, Percent_Identity=26.6666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=26.1538461538462, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=30.0613496932515, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36794; Mature: 36663

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSAPFGVMLVNLGTPEAPTTSAVRRYLAEFLGDPRVIDLPRVKWLPILHGIILRIRPPR
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCH
VAKAYASVWQDEGSPLLAIGRRQQRALKARLAARLGTDIPVELAMTYGKPSMEEAGLALR
HHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCHHH
DAGVERILVLPLYPQYSATTTGAVFDRLARALSPCPHLPELRFVRDYHDHPAYIEALAES
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHH
IREHWETHGRQPRLLFSYHGIPKRYAEAGDPYPRHCETTSRLVAEALGLEPEAWQQTYQS
HHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
RFGREEWLKPYTDDTLKAWGVEGLEGVDVISPAFAADCLETLEELEVENRGYFTEAGGGD
HCCHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
YRYIPALNDRAAHIDMLASLVEQHTQGW
EEEECCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GSAPFGVMLVNLGTPEAPTTSAVRRYLAEFLGDPRVIDLPRVKWLPILHGIILRIRPPR
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCCCCH
VAKAYASVWQDEGSPLLAIGRRQQRALKARLAARLGTDIPVELAMTYGKPSMEEAGLALR
HHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHCCHHH
DAGVERILVLPLYPQYSATTTGAVFDRLARALSPCPHLPELRFVRDYHDHPAYIEALAES
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCHHHHHHHHHH
IREHWETHGRQPRLLFSYHGIPKRYAEAGDPYPRHCETTSRLVAEALGLEPEAWQQTYQS
HHHHHHHCCCCCEEEEEECCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
RFGREEWLKPYTDDTLKAWGVEGLEGVDVISPAFAADCLETLEELEVENRGYFTEAGGGD
HCCHHHHCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
YRYIPALNDRAAHIDMLASLVEQHTQGW
EEEECCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA