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The map label for this gene is mro [H]

Identifier: 92112927

GI number: 92112927

Start: 894547

End: 895740

Strand: Direct

Name: mro [H]

Synonym: Csal_0799

Alternate gene names: 92112927

Gene position: 894547-895740 (Clockwise)

Preceding gene: 92112926

Following gene: 92112929

Centisome position: 24.2

GC content: 62.56

Gene sequence:

>1194_bases
ATGTCTCGATTTTCAGGAATTTCACGCTTGGCCATGGGGGTGGGCATGACCTGCCTCGCGCTGAGCGCGGCACAGGCGAA
CACGATGCAAACGCAGTCCCCGTCGGTGGAAAAGGAATCTTTCGGACAGTTGCCCGATGGCCGCAAGGTCGAGGCGTACC
ACCTACGCAATGGCCATGGCATTGACATGAAGGTGACCACCTATGGCGGCATCATCACCTCCCTGCGCACACCGGATGCC
GAGGGCGAGTGGGCCGATGTCGTTCTGGGGTTCGACAATTTGGCCGACTATCGCTCCGAGGCGTATCGCCAGTCCAACCC
CTATTTCGGTGCCCTGATCGGGCGCTATGGCAACCGAATCGCCGAGGGGCGCTTCACGCTCGATGGCACGACCCATGAGC
TGGCGACCAACGATGGTGCCAATCACCTGCATGGTGGGGAGCGGGGCTTCGACAAACGCCTGTGGACGGCGGCGCCTTTC
GAGAACGACAGCGAGGTGGGCGTCGAGCTGACCTATGTCAGCGAGGATGGCGAGGAAGGTTATCCCGGGCGGCTGGAAAC
CCACGTGACCTACACGCTGACCGCCGACGACGAGGTGATCATCGATTATCACGCCACGACCGACAAGGCCACGCCGGTCA
ATCTCACGCAGCACAGTTACTTCAACCTGGAGGGCGAGGGCAGCGGCTCGATCGTCGATCATCGGCTGATGCTCAATGCC
GATGCCTTCACGCCGGTGGACGACACCTTGATCCCGACCGGAGAGCTGCGCGACGTGGCGGACACGCCGTTCGACTTCCG
TGAGGCCACCCCGATCGGTGCACGCATTGGCGCGGACAATACGCAACTGGCGTACGGGCAGGGCTACGATCACAATTTCG
TGCTGATGCGTGACGCGACGGCGGAAGACGAACTGGTGCTGGCCGCCCGCGTCGAAGCGCCGGACAGTGGCCGCGTCCTG
GAGATCGCCACGTCGGAGCCCGGTGTGCAGTTCTACTCGGGCAACTTTCTCGATGGCACGCTGATCGGCAAGCAGGGCAA
GGCATACGAAAAGCGCAGCGGGTTCGCGCTGGAAACCCAGCATTTTCCGGATTCACCCAACCAGGCGGCCTTTCCCTCGA
CGATTCTCGAGCCCGGCGAGACCTATCAATCGCGCACGGTGTGGCGTTTCTCCACGCAGACACCGACGCCCTGA

Upstream 100 bases:

>100_bases
CGTGACTCGGTTATTGGTGGGACTGGTGGGCGCCGTCTAGCGTGAAGGGGCGTGGCGATGCATGTCGCGTCGCCATGACG
AGGCCCAGGAGGCGCGCACC

Downstream 100 bases:

>100_bases
ACCGTCGGTCACGGGCGGGCGTAATGTGCCGCCCAGTCCAGCGCGTCGGCCAGCGGCAGGGCCGGGCTGTAAAGGAAGCC
CTGGCCCATGTCGCATCCCA

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSRFSGISRLAMGVGMTCLALSAAQANTMQTQSPSVEKESFGQLPDGRKVEAYHLRNGHGIDMKVTTYGGIITSLRTPDA
EGEWADVVLGFDNLADYRSEAYRQSNPYFGALIGRYGNRIAEGRFTLDGTTHELATNDGANHLHGGERGFDKRLWTAAPF
ENDSEVGVELTYVSEDGEEGYPGRLETHVTYTLTADDEVIIDYHATTDKATPVNLTQHSYFNLEGEGSGSIVDHRLMLNA
DAFTPVDDTLIPTGELRDVADTPFDFREATPIGARIGADNTQLAYGQGYDHNFVLMRDATAEDELVLAARVEAPDSGRVL
EIATSEPGVQFYSGNFLDGTLIGKQGKAYEKRSGFALETQHFPDSPNQAAFPSTILEPGETYQSRTVWRFSTQTPTP

Sequences:

>Translated_397_residues
MSRFSGISRLAMGVGMTCLALSAAQANTMQTQSPSVEKESFGQLPDGRKVEAYHLRNGHGIDMKVTTYGGIITSLRTPDA
EGEWADVVLGFDNLADYRSEAYRQSNPYFGALIGRYGNRIAEGRFTLDGTTHELATNDGANHLHGGERGFDKRLWTAAPF
ENDSEVGVELTYVSEDGEEGYPGRLETHVTYTLTADDEVIIDYHATTDKATPVNLTQHSYFNLEGEGSGSIVDHRLMLNA
DAFTPVDDTLIPTGELRDVADTPFDFREATPIGARIGADNTQLAYGQGYDHNFVLMRDATAEDELVLAARVEAPDSGRVL
EIATSEPGVQFYSGNFLDGTLIGKQGKAYEKRSGFALETQHFPDSPNQAAFPSTILEPGETYQSRTVWRFSTQTPTP
>Mature_396_residues
SRFSGISRLAMGVGMTCLALSAAQANTMQTQSPSVEKESFGQLPDGRKVEAYHLRNGHGIDMKVTTYGGIITSLRTPDAE
GEWADVVLGFDNLADYRSEAYRQSNPYFGALIGRYGNRIAEGRFTLDGTTHELATNDGANHLHGGERGFDKRLWTAAPFE
NDSEVGVELTYVSEDGEEGYPGRLETHVTYTLTADDEVIIDYHATTDKATPVNLTQHSYFNLEGEGSGSIVDHRLMLNAD
AFTPVDDTLIPTGELRDVADTPFDFREATPIGARIGADNTQLAYGQGYDHNFVLMRDATAEDELVLAARVEAPDSGRVLE
IATSEPGVQFYSGNFLDGTLIGKQGKAYEKRSGFALETQHFPDSPNQAAFPSTILEPGETYQSRTVWRFSTQTPTP

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=359, Percent_Identity=48.4679665738162, Blast_Score=318, Evalue=5e-87,
Organism=Escherichia coli, GI1786971, Length=348, Percent_Identity=41.0919540229885, Blast_Score=241, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI17557428, Length=337, Percent_Identity=32.6409495548961, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI115533334, Length=337, Percent_Identity=32.6409495548961, Blast_Score=176, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319493, Length=311, Percent_Identity=32.7974276527331, Blast_Score=152, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6322004, Length=323, Percent_Identity=31.2693498452012, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324399, Length=328, Percent_Identity=29.2682926829268, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24659048, Length=350, Percent_Identity=44, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI24668282, Length=353, Percent_Identity=37.9603399433428, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24668278, Length=370, Percent_Identity=37.027027027027, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI24583720, Length=375, Percent_Identity=37.0666666666667, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24641876, Length=354, Percent_Identity=33.0508474576271, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 43418; Mature: 43287

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFSGISRLAMGVGMTCLALSAAQANTMQTQSPSVEKESFGQLPDGRKVEAYHLRNGHG
CCCHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCHHHHCCCCCCCEEEEEEECCCCC
IDMKVTTYGGIITSLRTPDAEGEWADVVLGFDNLADYRSEAYRQSNPYFGALIGRYGNRI
CEEEEEECCCEEEEECCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHCCEE
AEGRFTLDGTTHELATNDGANHLHGGERGFDKRLWTAAPFENDSEVGVELTYVSEDGEEG
ECCEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCC
YPGRLETHVTYTLTADDEVIIDYHATTDKATPVNLTQHSYFNLEGEGSGSIVDHRLMLNA
CCCEEEEEEEEEEECCCEEEEEEECCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEEEC
DAFTPVDDTLIPTGELRDVADTPFDFREATPIGARIGADNTQLAYGQGYDHNFVLMRDAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEECCC
AEDELVLAARVEAPDSGRVLEIATSEPGVQFYSGNFLDGTLIGKQGKAYEKRSGFALETQ
CCCCEEEEEEECCCCCCCEEEEECCCCCEEEEECCEECEEEECCCCCCHHHCCCCEEEEC
HFPDSPNQAAFPSTILEPGETYQSRTVWRFSTQTPTP
CCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCC
>Mature Secondary Structure 
SRFSGISRLAMGVGMTCLALSAAQANTMQTQSPSVEKESFGQLPDGRKVEAYHLRNGHG
CCHHHHHHHHHHCCCHHHHHHHHHCCCEECCCCCCCHHHHCCCCCCCEEEEEEECCCCC
IDMKVTTYGGIITSLRTPDAEGEWADVVLGFDNLADYRSEAYRQSNPYFGALIGRYGNRI
CEEEEEECCCEEEEECCCCCCCCEEEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHCCEE
AEGRFTLDGTTHELATNDGANHLHGGERGFDKRLWTAAPFENDSEVGVELTYVSEDGEEG
ECCEEEECCCCEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCC
YPGRLETHVTYTLTADDEVIIDYHATTDKATPVNLTQHSYFNLEGEGSGSIVDHRLMLNA
CCCEEEEEEEEEEECCCEEEEEEECCCCCCCCEEEECCEEEEEECCCCCCEEEEEEEEEC
DAFTPVDDTLIPTGELRDVADTPFDFREATPIGARIGADNTQLAYGQGYDHNFVLMRDAT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCCCEEEEECCC
AEDELVLAARVEAPDSGRVLEIATSEPGVQFYSGNFLDGTLIGKQGKAYEKRSGFALETQ
CCCCEEEEEEECCCCCCCEEEEECCCCCEEEEECCEECEEEECCCCCCHHHCCCCEEEEC
HFPDSPNQAAFPSTILEPGETYQSRTVWRFSTQTPTP
CCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3012466; 3531172 [H]