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The map label for this gene is gltP [H]

Identifier: 92112923

GI number: 92112923

Start: 889936

End: 891225

Strand: Direct

Name: gltP [H]

Synonym: Csal_0795

Alternate gene names: 92112923

Gene position: 889936-891225 (Clockwise)

Preceding gene: 92112921

Following gene: 92112924

Centisome position: 24.07

GC content: 64.96

Gene sequence:

>1290_bases
ATGGAGCGACACCATCATGGCCAAACACAGGGAGAAGGAGCGGTGAAAGCACTGCTGCATGCTTATTTGAATGCCTCGTT
GATTCTGCGCGTCACGCTGGCGCTGATACTGGGTGTCGTGGTGGGCCTGGCAGGTGGCCAGAGCGTGGCCGACTGGCTGG
CACCGTTCGGCGATCTATTGCTGCGCCTGCTGAAGTTCCTGATCGTGCCGATCGTGCTGTTCACCCTGCTGGTGGGCATC
AACCAGGCCAGTGCCGGGAGCATGGGGCGCATCGGGCGCAAGGTGTTTTTCTATTACGTCGGGACCTCGGCGCTGGCGAT
CGTCGTGGGGCTCACGGTGGCCACGTTGCTGTCGCCCGGCAGCGGCATTACGCTGGACGACAGCGCCGAGGTATCGGTGC
CCGAGAATCCCGGTATCGCGCAGGTAGTGCTGGGCGTGGTGCCGGACAATATCATCGGTGCCTTTGCCGAGCTGAACCTG
CTGGGCATCATCTTTACCGCCATCGTCTTCGGCATTGCCTTGTTGAAGCTGCGCGCGTCCGAGTCCCACGGCGCGCTGGC
CGAGCAGCTGTTCCGGGTCATCGAGGCGCTCAACGAGGTCACGCTCAAGGTGATGTCGGGGGTGCTGCATTACGTGCCGA
TCGGGGTGTTCGCCATCGTGGCCGGCACCGTGGCCGAGCAGGGAATGGCTACGCTGCTGTCGCTGGGCGACATGGTGCTG
GTGCTGTACCTCGCGCTGGGCGTGCATGTCCTGCTGTATTGCGTCTTGATGGGCGTCTTCGGCGTCAAGTTGCGGGATTT
CTTTCGCGAAGCGCGCACGCCGATGGCGACCGCCTTCGCCACCCAGAGCAGCTCCGGCACGCTGCCGCTGACGCTGGACG
CGGCCCGGCGCATGGGGCTGTCGCGTGGGGTCTACGGCTTCAGCCTGCCGCTGGGGGCGACCATCAACATGGATGGCGCC
GCCATTCGCATCGCCATTTCCGCCGTGTTTGCGGCCAACGTGATCGGCGCGCCGCTGGATTTTGCCAGCATGCTGGAAAT
CGTGCTGATCGGCACCCTGGTCTCCATCGGGACCGCCGGCGTGCCGGGCGCGGGCATCATCATGATCGCCACGGTGTTCT
CCCAGGTGGGCCTGCCCATCGAGACGGTAGCGTTGCTGACCGCCATCGATGCCCTGGTGGGCATGGGCTGCACGGCGCTC
AACGTCACCGGCGACATGGTAGGGGCGTCGATCATCGGGCGCAGCGAGCGGACACGGAATGCCGAGTGCGTCGATGCGCC
GCAAGCGTAG

Upstream 100 bases:

>100_bases
GCGTTCGCTCATTGCCTCGTATCCCGTGTCCGAATCCATGCGCCCAGCATAATGGTAATATGACGCCGCCGCAGCCTTCG
TGTCAGGCGTTGTGGCCGAC

Downstream 100 bases:

>100_bases
TGCCCCGCGAGCCGGCGGTGTCCGCTATGCTCGTCGTCTGAATGTCAGGTGCGCCCAGGGGAGACGTCATGCAGCATGAA
GAACAGCTCGATGCGACCGA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MERHHHGQTQGEGAVKALLHAYLNASLILRVTLALILGVVVGLAGGQSVADWLAPFGDLLLRLLKFLIVPIVLFTLLVGI
NQASAGSMGRIGRKVFFYYVGTSALAIVVGLTVATLLSPGSGITLDDSAEVSVPENPGIAQVVLGVVPDNIIGAFAELNL
LGIIFTAIVFGIALLKLRASESHGALAEQLFRVIEALNEVTLKVMSGVLHYVPIGVFAIVAGTVAEQGMATLLSLGDMVL
VLYLALGVHVLLYCVLMGVFGVKLRDFFREARTPMATAFATQSSSGTLPLTLDAARRMGLSRGVYGFSLPLGATINMDGA
AIRIAISAVFAANVIGAPLDFASMLEIVLIGTLVSIGTAGVPGAGIIMIATVFSQVGLPIETVALLTAIDALVGMGCTAL
NVTGDMVGASIIGRSERTRNAECVDAPQA

Sequences:

>Translated_429_residues
MERHHHGQTQGEGAVKALLHAYLNASLILRVTLALILGVVVGLAGGQSVADWLAPFGDLLLRLLKFLIVPIVLFTLLVGI
NQASAGSMGRIGRKVFFYYVGTSALAIVVGLTVATLLSPGSGITLDDSAEVSVPENPGIAQVVLGVVPDNIIGAFAELNL
LGIIFTAIVFGIALLKLRASESHGALAEQLFRVIEALNEVTLKVMSGVLHYVPIGVFAIVAGTVAEQGMATLLSLGDMVL
VLYLALGVHVLLYCVLMGVFGVKLRDFFREARTPMATAFATQSSSGTLPLTLDAARRMGLSRGVYGFSLPLGATINMDGA
AIRIAISAVFAANVIGAPLDFASMLEIVLIGTLVSIGTAGVPGAGIIMIATVFSQVGLPIETVALLTAIDALVGMGCTAL
NVTGDMVGASIIGRSERTRNAECVDAPQA
>Mature_429_residues
MERHHHGQTQGEGAVKALLHAYLNASLILRVTLALILGVVVGLAGGQSVADWLAPFGDLLLRLLKFLIVPIVLFTLLVGI
NQASAGSMGRIGRKVFFYYVGTSALAIVVGLTVATLLSPGSGITLDDSAEVSVPENPGIAQVVLGVVPDNIIGAFAELNL
LGIIFTAIVFGIALLKLRASESHGALAEQLFRVIEALNEVTLKVMSGVLHYVPIGVFAIVAGTVAEQGMATLLSLGDMVL
VLYLALGVHVLLYCVLMGVFGVKLRDFFREARTPMATAFATQSSSGTLPLTLDAARRMGLSRGVYGFSLPLGATINMDGA
AIRIAISAVFAANVIGAPLDFASMLEIVLIGTLVSIGTAGVPGAGIIMIATVFSQVGLPIETVALLTAIDALVGMGCTAL
NVTGDMVGASIIGRSERTRNAECVDAPQA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI223468564, Length=274, Percent_Identity=37.2262773722628, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI223468566, Length=275, Percent_Identity=37.4545454545455, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI21314632, Length=410, Percent_Identity=30.7317073170732, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI40254478, Length=418, Percent_Identity=28.2296650717703, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI169790839, Length=508, Percent_Identity=25.9842519685039, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI66773030, Length=466, Percent_Identity=27.8969957081545, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI194239697, Length=277, Percent_Identity=33.5740072202166, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4827012, Length=261, Percent_Identity=32.183908045977, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI5032093, Length=312, Percent_Identity=29.4871794871795, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI262359914, Length=429, Percent_Identity=24.009324009324, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI301601644, Length=157, Percent_Identity=34.3949044585987, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1790514, Length=422, Percent_Identity=31.042654028436, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI1789947, Length=418, Percent_Identity=28.2296650717703, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1788024, Length=407, Percent_Identity=26.2899262899263, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789473, Length=381, Percent_Identity=27.8215223097113, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983099, Length=459, Percent_Identity=30.0653594771242, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71983106, Length=414, Percent_Identity=31.1594202898551, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17537407, Length=456, Percent_Identity=25.8771929824561, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI193206505, Length=447, Percent_Identity=27.5167785234899, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71996953, Length=445, Percent_Identity=26.7415730337079, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=403, Percent_Identity=25.3101736972705, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17541374, Length=410, Percent_Identity=27.0731707317073, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583025, Length=459, Percent_Identity=27.0152505446623, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137668, Length=459, Percent_Identity=27.0152505446623, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24583023, Length=459, Percent_Identity=27.0152505446623, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281360481, Length=466, Percent_Identity=26.6094420600858, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281360483, Length=466, Percent_Identity=26.6094420600858, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI17137666, Length=466, Percent_Identity=26.6094420600858, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44412; Mature: 44412

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERHHHGQTQGEGAVKALLHAYLNASLILRVTLALILGVVVGLAGGQSVADWLAPFGDLL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LRLLKFLIVPIVLFTLLVGINQASAGSMGRIGRKVFFYYVGTSALAIVVGLTVATLLSPG
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEEHHHHHHHHHHHHHHHHHHCCC
SGITLDDSAEVSVPENPGIAQVVLGVVPDNIIGAFAELNLLGIIFTAIVFGIALLKLRAS
CCCEECCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ESHGALAEQLFRVIEALNEVTLKVMSGVLHYVPIGVFAIVAGTVAEQGMATLLSLGDMVL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLYLALGVHVLLYCVLMGVFGVKLRDFFREARTPMATAFATQSSSGTLPLTLDAARRMGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCCEEEEHHHHHHCCH
SRGVYGFSLPLGATINMDGAAIRIAISAVFAANVIGAPLDFASMLEIVLIGTLVSIGTAG
HCCCCEEECCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
VPGAGIIMIATVFSQVGLPIETVALLTAIDALVGMGCTALNVTGDMVGASIIGRSERTRN
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHCCCCCCCC
AECVDAPQA
CCCCCCCCC
>Mature Secondary Structure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CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]