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The map label for this gene is phoQ [H]

Identifier: 92112764

GI number: 92112764

Start: 708015

End: 709394

Strand: Direct

Name: phoQ [H]

Synonym: Csal_0631

Alternate gene names: 92112764

Gene position: 708015-709394 (Clockwise)

Preceding gene: 92112763

Following gene: 92112765

Centisome position: 19.15

GC content: 68.19

Gene sequence:

>1380_bases
ATGAGGCGACGCGCCTGGCAACAGCGCATCGCGCGTACCTCGATCCGGGCTCGGTTGCTGATCGCCTCGCTGTTGCTGGT
CATGGTCGCGTTGCCACTGGCCGGCACCGGCCTGGCCTATAACTTCCGCGATGCCGTCACCACTGCCTTCGACGATCGCC
TCGAGTCATTGCTCAACGTGCTGCTGGCCGGGGCGCAGCTCGATCCCCAGAGCAATGAACTGCGCATGACGCGTTCCTTG
GGCGATCCACGCTTCGAGCGCGTCTACTCGGGCTGGTACTGGCAGGTGGCGGGCGAGGAGCAGGCACTGACGTCGCGCTC
GCTATGGGATCAGCGCCTGCCGACCGACGACATCCAGGGCCTGGCGGTCTCCGAAGTCGATGGGCCGCGCGGCAATCGCT
TGCGAGTCATGGAACGCGACATCCGCTTGCCGGGGCATGCCGGGACGCTGCATGTCAGCGTCGCCGCTTCTCGCGAGGAG
CTGGATCGCGAAGTGGCGCGTTTCGAGTGGTTGTTGGGCCTGTCGCTGCTGGCACTGGGGGCCTTGCTGCTGGTCGGCCT
GGCGGTGCAGATCCGCTGGGGACTGGCGCCGCTGCGGCGCATGCACGCCAACTTGCGGGCCGTGGAGTCCGGAGACGCCG
AGAGTCTGGAGACGCGTTTTCTGCCCGACGAACTGGCACGTCTGGCAGGTGCCATGAACGGTGTGCTGGAACGCGATCGG
CGGCTGATCGAACGTGGCCGCCATGCCGCCGGTAATCTGGCGCATGCCCTCAAGACTCCGGTCAGCGTGCTGACGACGCT
GGCGGAGCGTTTTCCAGACGAGACGCGTGACCGTGTGCAGGGCGAGCTCGGACGCATCGACGATGCCGTGCGTCACCATC
TGGCACGTGCCTCGGCGACGGGGGGCGGCGTGCTGGCCGGCAAGATCGATGTCGGGAAAACCCTCGCCCCGGTGCTCGAT
GGCCTGACCCGGATGGGGGAGCGGCGCGGGGTTCGGCTGGACGCCGAGCTGGCGGCCGACCTCAGTGTGCGCATGGATGC
CCAGGATCTTCAGGAACTGGTCGGCAACCTGCTCGAGAATGCCCTGCGCTGGGCGTCGTCGCAGGTCTCGCTGCGTTTCT
ATCCGCAGGGCGCGGGCGTCGCGCTGGTGATCGAAGACGACGGGCCGGGGATGAGCGAGGACCAGCGTGAGGCCGCCCTG
GCACGCGGCGCGCGTCTCGACGAACGGCGCTCCGGCTCCGGCCTGGGGCTGGCGATCGTCGAGGATTTGATGACTCTCTA
CGGCGGTCGTCTGCAGCTCGCCGAGTCTACGCTGGGCGGACTGGCGGCGCGTGCCTGGTTACCGTCATCGCCGGTGGCGC
CGAGTGTCGCCGAGTCGTGA

Upstream 100 bases:

>100_bases
TCGATGTCCAGATCAGCCGCCTGCGTCGCAAGCTGGGCAACCAGCGCATCGAGACCCTGCGCGGCCAGGGCTATCGTCTG
GTGGCGCTCGAGGAGACGCC

Downstream 100 bases:

>100_bases
TCGCGGTGCCACTGTGCCATCGTCTCAGTTGTACGGTGCGTGCGCGGTTGCGATGATGCCTGGCATTGGCGTTCGACAGA
CGTGATGTTCAAGTACGTGG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MRRRAWQQRIARTSIRARLLIASLLLVMVALPLAGTGLAYNFRDAVTTAFDDRLESLLNVLLAGAQLDPQSNELRMTRSL
GDPRFERVYSGWYWQVAGEEQALTSRSLWDQRLPTDDIQGLAVSEVDGPRGNRLRVMERDIRLPGHAGTLHVSVAASREE
LDREVARFEWLLGLSLLALGALLLVGLAVQIRWGLAPLRRMHANLRAVESGDAESLETRFLPDELARLAGAMNGVLERDR
RLIERGRHAAGNLAHALKTPVSVLTTLAERFPDETRDRVQGELGRIDDAVRHHLARASATGGGVLAGKIDVGKTLAPVLD
GLTRMGERRGVRLDAELAADLSVRMDAQDLQELVGNLLENALRWASSQVSLRFYPQGAGVALVIEDDGPGMSEDQREAAL
ARGARLDERRSGSGLGLAIVEDLMTLYGGRLQLAESTLGGLAARAWLPSSPVAPSVAES

Sequences:

>Translated_459_residues
MRRRAWQQRIARTSIRARLLIASLLLVMVALPLAGTGLAYNFRDAVTTAFDDRLESLLNVLLAGAQLDPQSNELRMTRSL
GDPRFERVYSGWYWQVAGEEQALTSRSLWDQRLPTDDIQGLAVSEVDGPRGNRLRVMERDIRLPGHAGTLHVSVAASREE
LDREVARFEWLLGLSLLALGALLLVGLAVQIRWGLAPLRRMHANLRAVESGDAESLETRFLPDELARLAGAMNGVLERDR
RLIERGRHAAGNLAHALKTPVSVLTTLAERFPDETRDRVQGELGRIDDAVRHHLARASATGGGVLAGKIDVGKTLAPVLD
GLTRMGERRGVRLDAELAADLSVRMDAQDLQELVGNLLENALRWASSQVSLRFYPQGAGVALVIEDDGPGMSEDQREAAL
ARGARLDERRSGSGLGLAIVEDLMTLYGGRLQLAESTLGGLAARAWLPSSPVAPSVAES
>Mature_459_residues
MRRRAWQQRIARTSIRARLLIASLLLVMVALPLAGTGLAYNFRDAVTTAFDDRLESLLNVLLAGAQLDPQSNELRMTRSL
GDPRFERVYSGWYWQVAGEEQALTSRSLWDQRLPTDDIQGLAVSEVDGPRGNRLRVMERDIRLPGHAGTLHVSVAASREE
LDREVARFEWLLGLSLLALGALLLVGLAVQIRWGLAPLRRMHANLRAVESGDAESLETRFLPDELARLAGAMNGVLERDR
RLIERGRHAAGNLAHALKTPVSVLTTLAERFPDETRDRVQGELGRIDDAVRHHLARASATGGGVLAGKIDVGKTLAPVLD
GLTRMGERRGVRLDAELAADLSVRMDAQDLQELVGNLLENALRWASSQVSLRFYPQGAGVALVIEDDGPGMSEDQREAAL
ARGARLDERRSGSGLGLAIVEDLMTLYGGRLQLAESTLGGLAARAWLPSSPVAPSVAES

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=285, Percent_Identity=29.8245614035088, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=29.0441176470588, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=26.4705882352941, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=24.5674740484429, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=263, Percent_Identity=27.7566539923954, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=279, Percent_Identity=25.089605734767, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789808, Length=111, Percent_Identity=35.1351351351351, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=283, Percent_Identity=26.5017667844523, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=25.7777777777778, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50041; Mature: 50041

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRRAWQQRIARTSIRARLLIASLLLVMVALPLAGTGLAYNFRDAVTTAFDDRLESLLNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LLAGAQLDPQSNELRMTRSLGDPRFERVYSGWYWQVAGEEQALTSRSLWDQRLPTDDIQG
HHHCCCCCCCCCHHHHHHHCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCHHCC
LAVSEVDGPRGNRLRVMERDIRLPGHAGTLHVSVAASREELDREVARFEWLLGLSLLALG
CEEECCCCCCCCEEEEEHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ALLLVGLAVQIRWGLAPLRRMHANLRAVESGDAESLETRFLPDELARLAGAMNGVLERDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLIERGRHAAGNLAHALKTPVSVLTTLAERFPDETRDRVQGELGRIDDAVRHHLARASAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGVLAGKIDVGKTLAPVLDGLTRMGERRGVRLDAELAADLSVRMDAQDLQELVGNLLEN
CCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECHHHHCCCCEECCHHHHHHHHHHHHHH
ALRWASSQVSLRFYPQGAGVALVIEDDGPGMSEDQREAALARGARLDERRSGSGLGLAIV
HHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCCHHHHH
EDLMTLYGGRLQLAESTLGGLAARAWLPSSPVAPSVAES
HHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRRRAWQQRIARTSIRARLLIASLLLVMVALPLAGTGLAYNFRDAVTTAFDDRLESLLNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LLAGAQLDPQSNELRMTRSLGDPRFERVYSGWYWQVAGEEQALTSRSLWDQRLPTDDIQG
HHHCCCCCCCCCHHHHHHHCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCHHCC
LAVSEVDGPRGNRLRVMERDIRLPGHAGTLHVSVAASREELDREVARFEWLLGLSLLALG
CEEECCCCCCCCEEEEEHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ALLLVGLAVQIRWGLAPLRRMHANLRAVESGDAESLETRFLPDELARLAGAMNGVLERDR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RLIERGRHAAGNLAHALKTPVSVLTTLAERFPDETRDRVQGELGRIDDAVRHHLARASAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
GGGVLAGKIDVGKTLAPVLDGLTRMGERRGVRLDAELAADLSVRMDAQDLQELVGNLLEN
CCCEEEECCCCCHHHHHHHHHHHHHHHHCCCEECHHHHCCCCEECCHHHHHHHHHHHHHH
ALRWASSQVSLRFYPQGAGVALVIEDDGPGMSEDQREAALARGARLDERRSGSGLGLAIV
HHHHHCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCHHCCCCCCHHHHH
EDLMTLYGGRLQLAESTLGGLAARAWLPSSPVAPSVAES
HHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]