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The map label for this gene is pyrG

Identifier: 92112750

GI number: 92112750

Start: 690739

End: 692385

Strand: Direct

Name: pyrG

Synonym: Csal_0617

Alternate gene names: 92112750

Gene position: 690739-692385 (Clockwise)

Preceding gene: 92112749

Following gene: 92112751

Centisome position: 18.69

GC content: 63.02

Gene sequence:

>1647_bases
ATGACGCGATATATCTTCGTGACCGGCGGCGTTGTGTCCTCTCTCGGCAAGGGCATCGCCTCCGCTTCCCTCGCGGCGAT
CCTCGAGGCGCGCGGCCTCAAGGTCACCATCCTCAAGCTGGACCCCTACATCAATGTCGATCCGGGCACGATGAGCCCGT
TCCAGCACGGCGAGGTATTCGTCACCGAAGATGGCGCCGAAACCGACCTCGACCTGGGGCATTACGAGCGCTTCATCCGC
ACCAAGATGACCCAGGGCAACAACTTCACCACCGGGCGCGTCTACGAGCACGTGCTACGCAAGGAGCGCCGCGGTGATTA
TCTCGGCGGCACCGTGCAGGTGATTCCGCACATTACCGACGAAATCAAGCGCCGGGTCTACGAAGGCGGCGACGGCTTCG
ACGTCGCGCTGGTGGAAATCGGTGGCACGGTGGGCGACATCGAATCGCTGCCGTTTCTCGAGGCGACGCGTCAGATCCGC
AGCGAGAAGGGCGCCAACCAGGCGATCTTCATGCATCTCACGCTGGTGCCCTACATCAAGACCGCCGGCGAGACCAAGAC
CAAGCCGACCCAGCATAGCGTCAAGGAACTGCGCTCGATCGGCATCCAGCCGGACATCCTGATCTGCCGCAGCGAGGTCG
AGCTCGAGGAGAGCGAGCGGCGCAAGATCGCGCTGTTCACCAATGTCGAGGAGCGCGCCGTGGTCCCGCTGCAGGATGCC
GATACCATCTATCGCATTCCGCTGATGCTGCACGAGCACGGACTGGACGACATCATCTGCGACAAGCTGCGTATCGAGGC
CGACGAGGTCGACCTCGCCGAGTGGGTGCGGGTGCTGGATGCCAAGCTGAATCCGCTGAAGTCGGTCAACATCGCCATGG
TCGGCAAGTACATGGAGCTGCTCGACGCCTACAAGTCGCTCAACGAGGCGTTGATCCATGCCGGTATCCAGGGACGGGTC
AAGGTCAACATCGACTACATCGACTCCGAGGACATCGAGCATCACGGCACCGAACGCCTGGCCGGCAAGGATGCCATCCT
GGTACCCGGCGGCTTCGGTGAGCGTGGTGTGGAAGGCAAGATCGCCACCGCGCGTTATGCCCGCGAGAACGGCGTGCCCT
ATCTGGGCATCTGCCTGGGCATGCAGGTGGCGGTCATCGAATATGCCCGTCATGTCGCGGGCTGGGCGGATGCCAATTCC
ACCGAGTTCACTCATGATACCCAGCATCCGGTGGTGGGCCTGATCACCGAGTGGGTCAACGCCGAAGGCAAGATCGAGCT
GCGCGATGCCGCCTCGGATCTGGGGGGCACCATGCGTCTCGGTGGCCAGGTGTGCCATCTCAAGCCGGGCACGCGGGCAC
ACGAGGCTTATGGCCTGGACGAGATCACCGAGCGCCACCGGCATCGCTTCGAGGTCAACAATCAGTTCGTCGAGGCGCTC
GAATCCGCCGGACTGGTGATCTCGGGCAAGAGCGCCGATCATTCGCTGGTCGAGATGATCGAGTTGCCGGAGCATCCCTG
GTACGTGGCCTGTCAGTTCCACCCGGAATTCACGTCCACGCCGCGTGATGGACACCCGCTGTTTTCCGGCTTCGTCAATG
CCGCGCTGGCGTACAAGGCCGCGCGTGCCCGTGCACAGCAGAGCTGA

Upstream 100 bases:

>100_bases
GCAGCTGAAATTGAGCGCCCCGCGGTATTCTGCTATTCTGGCGTCCCATCCAGGCCCGGTTCTCTCCACGGCCTTCAGAT
CACGTTTCGACAGGTTTTCC

Downstream 100 bases:

>100_bases
GGACCCAGACATGGCCGAGACATCCAAACAGATCGAATTCGCCGGCCTGAGGGCCGGCAATTCGTTGCCGCTGGCGCTGT
TCGGCGGCATGAACGTGCTC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTILKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIR
TKMTQGNNFTTGRVYEHVLRKERRGDYLGGTVQVIPHITDEIKRRVYEGGDGFDVALVEIGGTVGDIESLPFLEATRQIR
SEKGANQAIFMHLTLVPYIKTAGETKTKPTQHSVKELRSIGIQPDILICRSEVELEESERRKIALFTNVEERAVVPLQDA
DTIYRIPLMLHEHGLDDIICDKLRIEADEVDLAEWVRVLDAKLNPLKSVNIAMVGKYMELLDAYKSLNEALIHAGIQGRV
KVNIDYIDSEDIEHHGTERLAGKDAILVPGGFGERGVEGKIATARYARENGVPYLGICLGMQVAVIEYARHVAGWADANS
TEFTHDTQHPVVGLITEWVNAEGKIELRDAASDLGGTMRLGGQVCHLKPGTRAHEAYGLDEITERHRHRFEVNNQFVEAL
ESAGLVISGKSADHSLVEMIELPEHPWYVACQFHPEFTSTPRDGHPLFSGFVNAALAYKAARARAQQS

Sequences:

>Translated_548_residues
MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTILKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIR
TKMTQGNNFTTGRVYEHVLRKERRGDYLGGTVQVIPHITDEIKRRVYEGGDGFDVALVEIGGTVGDIESLPFLEATRQIR
SEKGANQAIFMHLTLVPYIKTAGETKTKPTQHSVKELRSIGIQPDILICRSEVELEESERRKIALFTNVEERAVVPLQDA
DTIYRIPLMLHEHGLDDIICDKLRIEADEVDLAEWVRVLDAKLNPLKSVNIAMVGKYMELLDAYKSLNEALIHAGIQGRV
KVNIDYIDSEDIEHHGTERLAGKDAILVPGGFGERGVEGKIATARYARENGVPYLGICLGMQVAVIEYARHVAGWADANS
TEFTHDTQHPVVGLITEWVNAEGKIELRDAASDLGGTMRLGGQVCHLKPGTRAHEAYGLDEITERHRHRFEVNNQFVEAL
ESAGLVISGKSADHSLVEMIELPEHPWYVACQFHPEFTSTPRDGHPLFSGFVNAALAYKAARARAQQS
>Mature_547_residues
TRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTILKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFIRT
KMTQGNNFTTGRVYEHVLRKERRGDYLGGTVQVIPHITDEIKRRVYEGGDGFDVALVEIGGTVGDIESLPFLEATRQIRS
EKGANQAIFMHLTLVPYIKTAGETKTKPTQHSVKELRSIGIQPDILICRSEVELEESERRKIALFTNVEERAVVPLQDAD
TIYRIPLMLHEHGLDDIICDKLRIEADEVDLAEWVRVLDAKLNPLKSVNIAMVGKYMELLDAYKSLNEALIHAGIQGRVK
VNIDYIDSEDIEHHGTERLAGKDAILVPGGFGERGVEGKIATARYARENGVPYLGICLGMQVAVIEYARHVAGWADANST
EFTHDTQHPVVGLITEWVNAEGKIELRDAASDLGGTMRLGGQVCHLKPGTRAHEAYGLDEITERHRHRFEVNNQFVEALE
SAGLVISGKSADHSLVEMIELPEHPWYVACQFHPEFTSTPRDGHPLFSGFVNAALAYKAARARAQQS

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=43.8282647584973, Blast_Score=475, Evalue=1e-134,
Organism=Homo sapiens, GI28559085, Length=557, Percent_Identity=42.3698384201077, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=557, Percent_Identity=42.3698384201077, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=557, Percent_Identity=42.3698384201077, Blast_Score=453, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=543, Percent_Identity=67.7716390423573, Blast_Score=746, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=39.672131147541, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=572, Percent_Identity=41.2587412587413, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6319432, Length=570, Percent_Identity=41.0526315789474, Blast_Score=436, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=41.7562724014337, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=40.3578528827038, Blast_Score=369, Evalue=1e-102,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHRSD (Q1QZX9)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572678.1
- ProteinModelPortal:   Q1QZX9
- SMR:   Q1QZX9
- STRING:   Q1QZX9
- GeneID:   4029086
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0617
- NMPDR:   fig|290398.4.peg.420
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   CSAL290398:CSAL_0617-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60664; Mature: 60532

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 378-378 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTILKLDPYINVDPGTMSPFQHGEVF
CCEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIRTKMTQGNNFTTGRVYEHVLRKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKRRVYEGGDGFDVALVEIGGTVGDIESLPFLEATRQIRSEKGANQAIFMHLTLVPYIK
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
TAGETKTKPTQHSVKELRSIGIQPDILICRSEVELEESERRKIALFTNVEERAVVPLQDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCC
DTIYRIPLMLHEHGLDDIICDKLRIEADEVDLAEWVRVLDAKLNPLKSVNIAMVGKYMEL
CCEEEEHHHHHHCCCHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LDAYKSLNEALIHAGIQGRVKVNIDYIDSEDIEHHGTERLAGKDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHCCCHHHCCCCEEEECCCCCCCCCCCC
IATARYARENGVPYLGICLGMQVAVIEYARHVAGWADANSTEFTHDTQHPVVGLITEWVN
CHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHC
AEGKIELRDAASDLGGTMRLGGQVCHLKPGTRAHEAYGLDEITERHRHRFEVNNQFVEAL
CCCCEEEHHHHHHCCCEEECCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHH
ESAGLVISGKSADHSLVEMIELPEHPWYVACQFHPEFTSTPRDGHPLFSGFVNAALAYKA
HHCCEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ARARAQQS
HHHHHCCC
>Mature Secondary Structure 
TRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTILKLDPYINVDPGTMSPFQHGEVF
CEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIRTKMTQGNNFTTGRVYEHVLRKERRGDYLGGTVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECHHHH
EIKRRVYEGGDGFDVALVEIGGTVGDIESLPFLEATRQIRSEKGANQAIFMHLTLVPYIK
HHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
TAGETKTKPTQHSVKELRSIGIQPDILICRSEVELEESERRKIALFTNVEERAVVPLQDA
CCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEECCC
DTIYRIPLMLHEHGLDDIICDKLRIEADEVDLAEWVRVLDAKLNPLKSVNIAMVGKYMEL
CCEEEEHHHHHHCCCHHHHHHHHEECCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
LDAYKSLNEALIHAGIQGRVKVNIDYIDSEDIEHHGTERLAGKDAILVPGGFGERGVEGK
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHCCCHHHCCCCEEEECCCCCCCCCCCC
IATARYARENGVPYLGICLGMQVAVIEYARHVAGWADANSTEFTHDTQHPVVGLITEWVN
CHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHC
AEGKIELRDAASDLGGTMRLGGQVCHLKPGTRAHEAYGLDEITERHRHRFEVNNQFVEAL
CCCCEEEHHHHHHCCCEEECCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHH
ESAGLVISGKSADHSLVEMIELPEHPWYVACQFHPEFTSTPRDGHPLFSGFVNAALAYKA
HHCCEEEECCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
ARARAQQS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA