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The map label for this gene is lpxA [H]

Identifier: 92112708

GI number: 92112708

Start: 637749

End: 638516

Strand: Direct

Name: lpxA [H]

Synonym: Csal_0575

Alternate gene names: 92112708

Gene position: 637749-638516 (Clockwise)

Preceding gene: 92112707

Following gene: 92112709

Centisome position: 17.25

GC content: 64.06

Gene sequence:

>768_bases
TTGATTCATCCCACCGCCCTCGTCGACCCCAGTGCGCGTGTGTCCGATGACGTCGACATCGGCCCGTTCTGCGTGATCGG
CCCCGAGGTGGAAATCGGGGACGGCACGGTCATCGGTCCGCATGTGGTCATCAAGGGCCCCACGCGGCTGGGCAAGCGCA
ATCGTATCTTTCAGTTCGCCTCCGTGGGCGAGGACTGTCAGGACAAGAAGTACGCCGGAGAAGCCACCCGCCTGGAGATG
GGCGACGACAACGTCGTGCGTGAAGGCGTGACGCTGCATCGCGGCACGGTGCAGGACAAGGCCGTGACCACCATCGGCTC
GCGCAATCTCTTCATGGCGTACTCCCACGTCGGCCATGACTGCGTGATCGGCGACGACTGCATCCTGGCCAATCAGGCTA
CCCTGGCGGGGCATGTCACGCTCGGCAACTTCGCGATCCTCGGCGGACTGTCGGCGATTCACCAGTTCTGCCACATGGGA
GAGCACGCCATGGCCGGCGGCGGCTCGATCATCACCAAGGACGTTCCGGCTTACGTCATCGTCAACGGCAACCCGGCGCA
GACCCATGGGCTCAACCTGGTGGGGCTCAAGCGGCGCGGCTTCGAACGCGATGCGCTGCGCGCACTGGGCGACGCCTATC
GCATCGTCTATCGTCAGGGCCTGACCATGGAACAGGCGATCGAACGTCTCGAAAACGATTTCGCCGTTCCCGAGGTGGAG
ACCTTCCTCGCGTCACTCAAGACGTCCCAGCGCGGGATCACGCGCTAA

Upstream 100 bases:

>100_bases
TCAGGGGCAAGCGCGGTATCTGGAAATTCGCCTGCCGTGCTACGGTCGATGGCGAGCTGGCCTGTGAAGCCGAGATCATC
TGTGCCGAGAGGAAAGTCGC

Downstream 100 bases:

>100_bases
ACGGAATCTGCCATGCGTATTTACCTGGTCGCGGGAGAGCTGTCGGGCGACATCCTGGGCGCCGGGCTGATGCAAGCGTT
GAAACGCCGCCACCCCGATG

Product: acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIHPTALVDPSARVSDDVDIGPFCVIGPEVEIGDGTVIGPHVVIKGPTRLGKRNRIFQFASVGEDCQDKKYAGEATRLEM
GDDNVVREGVTLHRGTVQDKAVTTIGSRNLFMAYSHVGHDCVIGDDCILANQATLAGHVTLGNFAILGGLSAIHQFCHMG
EHAMAGGGSIITKDVPAYVIVNGNPAQTHGLNLVGLKRRGFERDALRALGDAYRIVYRQGLTMEQAIERLENDFAVPEVE
TFLASLKTSQRGITR

Sequences:

>Translated_255_residues
MIHPTALVDPSARVSDDVDIGPFCVIGPEVEIGDGTVIGPHVVIKGPTRLGKRNRIFQFASVGEDCQDKKYAGEATRLEM
GDDNVVREGVTLHRGTVQDKAVTTIGSRNLFMAYSHVGHDCVIGDDCILANQATLAGHVTLGNFAILGGLSAIHQFCHMG
EHAMAGGGSIITKDVPAYVIVNGNPAQTHGLNLVGLKRRGFERDALRALGDAYRIVYRQGLTMEQAIERLENDFAVPEVE
TFLASLKTSQRGITR
>Mature_255_residues
MIHPTALVDPSARVSDDVDIGPFCVIGPEVEIGDGTVIGPHVVIKGPTRLGKRNRIFQFASVGEDCQDKKYAGEATRLEM
GDDNVVREGVTLHRGTVQDKAVTTIGSRNLFMAYSHVGHDCVIGDDCILANQATLAGHVTLGNFAILGGLSAIHQFCHMG
EHAMAGGGSIITKDVPAYVIVNGNPAQTHGLNLVGLKRRGFERDALRALGDAYRIVYRQGLTMEQAIERLENDFAVPEVE
TFLASLKTSQRGITR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=258, Percent_Identity=51.5503875968992, Blast_Score=281, Evalue=2e-77,
Organism=Escherichia coli, GI1786376, Length=178, Percent_Identity=25.8426966292135, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27446; Mature: 27446

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPTALVDPSARVSDDVDIGPFCVIGPEVEIGDGTVIGPHVVIKGPTRLGKRNRIFQFA
CCCCCCEECCCCCCCCCCCCCCEEEECCEEEECCCEEECCEEEEECCHHCCCCCCEEEEH
SVGEDCQDKKYAGEATRLEMGDDNVVREGVTLHRGTVQDKAVTTIGSRNLFMAYSHVGHD
HCCCCCCCHHHCCCCEEEECCCCHHHHCCCEEECCCCCCHHEEEECCCCEEEEEECCCCE
CVIGDDCILANQATLAGHVTLGNFAILGGLSAIHQFCHMGEHAMAGGGSIITKDVPAYVI
EEECCCEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCCEEEEECCCEEEE
VNGNPAQTHGLNLVGLKRRGFERDALRALGDAYRIVYRQGLTMEQAIERLENDFAVPEVE
ECCCCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
TFLASLKTSQRGITR
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MIHPTALVDPSARVSDDVDIGPFCVIGPEVEIGDGTVIGPHVVIKGPTRLGKRNRIFQFA
CCCCCCEECCCCCCCCCCCCCCEEEECCEEEECCCEEECCEEEEECCHHCCCCCCEEEEH
SVGEDCQDKKYAGEATRLEMGDDNVVREGVTLHRGTVQDKAVTTIGSRNLFMAYSHVGHD
HCCCCCCCHHHCCCCEEEECCCCHHHHCCCEEECCCCCCHHEEEECCCCEEEEEECCCCE
CVIGDDCILANQATLAGHVTLGNFAILGGLSAIHQFCHMGEHAMAGGGSIITKDVPAYVI
EEECCCEEEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCHHCCCCCEEEEECCCEEEE
VNGNPAQTHGLNLVGLKRRGFERDALRALGDAYRIVYRQGLTMEQAIERLENDFAVPEVE
ECCCCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHH
TFLASLKTSQRGITR
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA