Click here to switch to the map view.

The map label for this gene is dxr [H]

Identifier: 92112702

GI number: 92112702

Start: 630408

End: 631580

Strand: Direct

Name: dxr [H]

Synonym: Csal_0569

Alternate gene names: 92112702

Gene position: 630408-631580 (Clockwise)

Preceding gene: 92112701

Following gene: 92112703

Centisome position: 17.05

GC content: 68.03

Gene sequence:

>1173_bases
GTGACCGTGCTCGGGGCCACCGGCTCCATCGGTCGCAGCACCCTCGATGTCATTGGCCGTCACCCCGAACGCTATCGGTT
GCATGCCCTGACCGCCCACCGCTCCCGTGAGACGCTTCGCGATCAGTGTCTTGCGCACCGCCCCGACATCGCGGTCCTCG
GCACGGAAGATGATGCCGCCTGGCTGCGTGCCGCACTGAGCGACGCCGGCCTCGACACCGAGGTGCGCGCCGGCGAGGCG
GCGCTCGCCGAGGTCGCGGGAAGTCGCGACAGCGACGTGGTCATGGCCGCGATCATGGGGGCCGCCGGCTTGATGCCGAC
GCTTGCGGCGGTACGCGCCGGCAAGCGCGTCCTGCTGGCCAACAAGGAAGCCCTGGTGATGTCCGGCGCGTTGTTCATGG
ACGCCGTCGACCGGCATGGCGCGGTACTTTTGCCCATCGATTCTGAACATAATGCCATCTACCAGTGTCTACCCACGGAG
CATCGTGGCGGACTGACGCGCCATGGCGTGACCCAGTTGTTGCTGACGGCGTCGGGCGGGCCGTTCCGAGGCTGGTCGCA
AGCCCAGCTGGACGAGGTGACGCCCGAACAGGCTTGTGCGCACCCCAACTGGTCGATGGGCCGCAAGATCTCGGTGGACA
GCGCGACCTTGATGAACAAGGGGCTCGAGTTGATCGAGGCCTGCTGGTTGTTCGATGCGCGTCCCGAACAGATCCAGGTG
GTGGTGCATCCGCAGAGCGTGATTCACTCGATGGCGGCGTACAGCGATGGGTCGGTGATCGCCCAGATGGGCAATCCCGA
CATGCGCACTCCGATCGCCCACGGACTGGCGTGGCCCGAGCGCATCGACGCCGGCGTCGCGCCGCTGGACCTGTTCGCCG
TGGCGAGGCTCGATTTCGAGGCCCCCGACGAGTCGCGTTTCCCGTGCCTGCGTCTCGCCCGCGAGGCGATGGCGGCGGGC
GGTACGGCGCCGGCCACCTTGAACGCCGCCAACGAAGTGGCCGTGGCGGCGTTTCTCGAGGGGCGGTTGAAGTTTGCGCA
GATCCCCGCGCTGGTGGCGGTGGTATGCGAGGCATGCGAGGTGCAGTCGGCTCACACGCTGGAGGCGGTGCTGGCGGCTG
ACGCCACCGCGCGGCGTGTCGCCGAGCGCGAATTGAGCCGGTTCACGTCATGA

Upstream 100 bases:

>100_bases
TCGACAGTCTGACCGCCGCGATTCCTCTCTTTGTCTTGTTGCGCCCATGGTTGGGCTGAGGTGACGAATGGATTATGCCG
ACTCCGCTGGGAGACAATGT

Downstream 100 bases:

>100_bases
TGTCAGGGCGGTGGCCCGCGCGAGGAAGGAGGACGGTCCCATGGGCGTGATTGAGAACCTGCTGGCGGTCATCGTGGTTC
TGGGATTGTTGATCACCTTC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTVLGATGSIGRSTLDVIGRHPERYRLHALTAHRSRETLRDQCLAHRPDIAVLGTEDDAAWLRAALSDAGLDTEVRAGEA
ALAEVAGSRDSDVVMAAIMGAAGLMPTLAAVRAGKRVLLANKEALVMSGALFMDAVDRHGAVLLPIDSEHNAIYQCLPTE
HRGGLTRHGVTQLLLTASGGPFRGWSQAQLDEVTPEQACAHPNWSMGRKISVDSATLMNKGLELIEACWLFDARPEQIQV
VVHPQSVIHSMAAYSDGSVIAQMGNPDMRTPIAHGLAWPERIDAGVAPLDLFAVARLDFEAPDESRFPCLRLAREAMAAG
GTAPATLNAANEVAVAAFLEGRLKFAQIPALVAVVCEACEVQSAHTLEAVLAADATARRVAERELSRFTS

Sequences:

>Translated_390_residues
MTVLGATGSIGRSTLDVIGRHPERYRLHALTAHRSRETLRDQCLAHRPDIAVLGTEDDAAWLRAALSDAGLDTEVRAGEA
ALAEVAGSRDSDVVMAAIMGAAGLMPTLAAVRAGKRVLLANKEALVMSGALFMDAVDRHGAVLLPIDSEHNAIYQCLPTE
HRGGLTRHGVTQLLLTASGGPFRGWSQAQLDEVTPEQACAHPNWSMGRKISVDSATLMNKGLELIEACWLFDARPEQIQV
VVHPQSVIHSMAAYSDGSVIAQMGNPDMRTPIAHGLAWPERIDAGVAPLDLFAVARLDFEAPDESRFPCLRLAREAMAAG
GTAPATLNAANEVAVAAFLEGRLKFAQIPALVAVVCEACEVQSAHTLEAVLAADATARRVAERELSRFTS
>Mature_389_residues
TVLGATGSIGRSTLDVIGRHPERYRLHALTAHRSRETLRDQCLAHRPDIAVLGTEDDAAWLRAALSDAGLDTEVRAGEAA
LAEVAGSRDSDVVMAAIMGAAGLMPTLAAVRAGKRVLLANKEALVMSGALFMDAVDRHGAVLLPIDSEHNAIYQCLPTEH
RGGLTRHGVTQLLLTASGGPFRGWSQAQLDEVTPEQACAHPNWSMGRKISVDSATLMNKGLELIEACWLFDARPEQIQVV
VHPQSVIHSMAAYSDGSVIAQMGNPDMRTPIAHGLAWPERIDAGVAPLDLFAVARLDFEAPDESRFPCLRLAREAMAAGG
TAPATLNAANEVAVAAFLEGRLKFAQIPALVAVVCEACEVQSAHTLEAVLAADATARRVAERELSRFTS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=54.4303797468354, Blast_Score=411, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41535; Mature: 41404

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLGATGSIGRSTLDVIGRHPERYRLHALTAHRSRETLRDQCLAHRPDIAVLGTEDDAA
CEEECCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
WLRAALSDAGLDTEVRAGEAALAEVAGSRDSDVVMAAIMGAAGLMPTLAAVRAGKRVLLA
HHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NKEALVMSGALFMDAVDRHGAVLLPIDSEHNAIYQCLPTEHRGGLTRHGVTQLLLTASGG
CCCHHHHCCHHHHHHHCCCCEEEEEECCCCCEEEEECCCHHCCCCCHHHHHHEEEECCCC
PFRGWSQAQLDEVTPEQACAHPNWSMGRKISVDSATLMNKGLELIEACWLFDARPEQIQV
CCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VVHPQSVIHSMAAYSDGSVIAQMGNPDMRTPIAHGLAWPERIDAGVAPLDLFAVARLDFE
EECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHCCCCHHHHCCCCCHHHHHHHHHCCCC
APDESRFPCLRLAREAMAAGGTAPATLNAANEVAVAAFLEGRLKFAQIPALVAVVCEACE
CCCCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
VQSAHTLEAVLAADATARRVAERELSRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVLGATGSIGRSTLDVIGRHPERYRLHALTAHRSRETLRDQCLAHRPDIAVLGTEDDAA
EEECCCCCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
WLRAALSDAGLDTEVRAGEAALAEVAGSRDSDVVMAAIMGAAGLMPTLAAVRAGKRVLLA
HHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
NKEALVMSGALFMDAVDRHGAVLLPIDSEHNAIYQCLPTEHRGGLTRHGVTQLLLTASGG
CCCHHHHCCHHHHHHHCCCCEEEEEECCCCCEEEEECCCHHCCCCCHHHHHHEEEECCCC
PFRGWSQAQLDEVTPEQACAHPNWSMGRKISVDSATLMNKGLELIEACWLFDARPEQIQV
CCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEE
VVHPQSVIHSMAAYSDGSVIAQMGNPDMRTPIAHGLAWPERIDAGVAPLDLFAVARLDFE
EECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHCCCCHHHHCCCCCHHHHHHHHHCCCC
APDESRFPCLRLAREAMAAGGTAPATLNAANEVAVAAFLEGRLKFAQIPALVAVVCEACE
CCCCCCCHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
VQSAHTLEAVLAADATARRVAERELSRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA