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The map label for this gene is emrA [H]

Identifier: 92112685

GI number: 92112685

Start: 613630

End: 614682

Strand: Direct

Name: emrA [H]

Synonym: Csal_0552

Alternate gene names: 92112685

Gene position: 613630-614682 (Clockwise)

Preceding gene: 92112683

Following gene: 92112686

Centisome position: 16.6

GC content: 66.67

Gene sequence:

>1053_bases
ATGAAAATCAAGAAGCGACTTTATACGGCGCTGGCACTGGTCGTGTTGGTGGTGCTGGCATTGGTGTGGGGCGTGCACTG
GTGGCAGACGGGCCGTTTCTTCGAAGAGACCGACAACGCCTACGTGCACGCCGACAGCGTGGCGGTGCGCGCCGAAGTCA
CGGGGCGCGTGGCCGAGGTGGCGGTCGCCGACAACCAGCGGGTCGCAGCCGGCGATATCCTGGTGAAGCTCGATCCCAGC
GATGCCAAGTCACAGCTGGCCCAGGCGCAGGCGTCACTGGCCGTGGCCCAGGCCAATGCCGTGAGTGCCGCGCGTCAGGT
CGAGCAGCAGCAGGCGGCGATCGAGGAGGCCCAGGCCCGGGTGACGTCGGCACAGGCCGATGTCGAGCAGGCACGTCTTC
ATCTCGAGCGCTCGCAACGCTTGGCGGAAAAGAACTACGCCTCACAGCAGGAATATCAGGACGACCAGGCGGCGTTGCAG
GTCGCGGAGGCGACGCTGGCGGCGCGACGCGCCACGCTGGCATCGTCGCGCAAGCAGCTCGATGTGCTGAACGCCGAGCG
CGACAGTGCCGAGGCCAACATCGAAGCCGCCCGTGCGGACCTGGACAACGCGCGCCACCAGCTCGACAAGACGCGTCTGA
GGGCACCGGTGGCGGGCGTGATCGGCAACAAGACGGTCGAGGTGGGAACACTGGCGCAGCCGTCGCTGACGCTGATGCAC
CTGGTTCCCATCCGCTCGGCGTATGTCGTCGCCAACTACAAGGAAACCCAGACGGCGCGGATGCGGTCGGGACAGCCGGT
CTCGCTGCATGTCGATGCATATCCCGATATCGCCTTCGAGGGCGTCGTCGACAGCCTGGCGCCGGCCACGGGCTCGCGTT
TCAGTCTGCTGCCGAATGACAACGCCACCGGCAACTTCAACAAGATCGTGCAGCGGGTGCCGGTGCGCATCCGTGTGACG
GGACCGGAAGAAGCCCTGGGACGCCTGCGCGACGGCCTCTCGGTGGTGCCAACGGTGGATACGCGCGATCTCGACCCCGA
GGACGACGCCTGA

Upstream 100 bases:

>100_bases
CGGGTGCGGAGGTGTCGTTTCGTCGGCGTGTCCTCAAGCGTCGTCGGGGCAAATTAGTGTATCCTACTCGCCCCTGTAGT
CCGCCCGGTGAACGCGAGTT

Downstream 100 bases:

>100_bases
CATGGCGGAGGCGGTGACCGATACGGCGTCAGGGCCCCGGGAGGCTCCTTCGCGGCGCACGCAACTGGGCTTCGTGGCCG
CCGTGTTCGGCATGTTCATG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKIKKRLYTALALVVLVVLALVWGVHWWQTGRFFEETDNAYVHADSVAVRAEVTGRVAEVAVADNQRVAAGDILVKLDPS
DAKSQLAQAQASLAVAQANAVSAARQVEQQQAAIEEAQARVTSAQADVEQARLHLERSQRLAEKNYASQQEYQDDQAALQ
VAEATLAARRATLASSRKQLDVLNAERDSAEANIEAARADLDNARHQLDKTRLRAPVAGVIGNKTVEVGTLAQPSLTLMH
LVPIRSAYVVANYKETQTARMRSGQPVSLHVDAYPDIAFEGVVDSLAPATGSRFSLLPNDNATGNFNKIVQRVPVRIRVT
GPEEALGRLRDGLSVVPTVDTRDLDPEDDA

Sequences:

>Translated_350_residues
MKIKKRLYTALALVVLVVLALVWGVHWWQTGRFFEETDNAYVHADSVAVRAEVTGRVAEVAVADNQRVAAGDILVKLDPS
DAKSQLAQAQASLAVAQANAVSAARQVEQQQAAIEEAQARVTSAQADVEQARLHLERSQRLAEKNYASQQEYQDDQAALQ
VAEATLAARRATLASSRKQLDVLNAERDSAEANIEAARADLDNARHQLDKTRLRAPVAGVIGNKTVEVGTLAQPSLTLMH
LVPIRSAYVVANYKETQTARMRSGQPVSLHVDAYPDIAFEGVVDSLAPATGSRFSLLPNDNATGNFNKIVQRVPVRIRVT
GPEEALGRLRDGLSVVPTVDTRDLDPEDDA
>Mature_350_residues
MKIKKRLYTALALVVLVVLALVWGVHWWQTGRFFEETDNAYVHADSVAVRAEVTGRVAEVAVADNQRVAAGDILVKLDPS
DAKSQLAQAQASLAVAQANAVSAARQVEQQQAAIEEAQARVTSAQADVEQARLHLERSQRLAEKNYASQQEYQDDQAALQ
VAEATLAARRATLASSRKQLDVLNAERDSAEANIEAARADLDNARHQLDKTRLRAPVAGVIGNKTVEVGTLAQPSLTLMH
LVPIRSAYVVANYKETQTARMRSGQPVSLHVDAYPDIAFEGVVDSLAPATGSRFSLLPNDNATGNFNKIVQRVPVRIRVT
GPEEALGRLRDGLSVVPTVDTRDLDPEDDA

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=331, Percent_Identity=34.1389728096677, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788711, Length=343, Percent_Identity=33.2361516034985, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790519, Length=307, Percent_Identity=31.5960912052117, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI87081951, Length=326, Percent_Identity=26.6871165644172, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790024, Length=317, Percent_Identity=27.7602523659306, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789900, Length=345, Percent_Identity=24.9275362318841, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789637, Length=335, Percent_Identity=25.9701492537313, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI87081796, Length=298, Percent_Identity=25.503355704698, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790012, Length=254, Percent_Identity=24.4094488188976, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37965; Mature: 37965

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKKRLYTALALVVLVVLALVWGVHWWQTGRFFEETDNAYVHADSVAVRAEVTGRVAEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCEEEEEECCCCEEEE
AVADNQRVAAGDILVKLDPSDAKSQLAQAQASLAVAQANAVSAARQVEQQQAAIEEAQAR
EECCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSAQADVEQARLHLERSQRLAEKNYASQQEYQDDQAALQVAEATLAARRATLASSRKQL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLNAERDSAEANIEAARADLDNARHQLDKTRLRAPVAGVIGNKTVEVGTLAQPSLTLMH
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCHHHHH
LVPIRSAYVVANYKETQTARMRSGQPVSLHVDAYPDIAFEGVVDSLAPATGSRFSLLPND
HHHCCCEEEEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCC
NATGNFNKIVQRVPVRIRVTGPEEALGRLRDGLSVVPTVDTRDLDPEDDA
CCCCCHHHHHHHCCEEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIKKRLYTALALVVLVVLALVWGVHWWQTGRFFEETDNAYVHADSVAVRAEVTGRVAEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCEEEEEECCCCEEEE
AVADNQRVAAGDILVKLDPSDAKSQLAQAQASLAVAQANAVSAARQVEQQQAAIEEAQAR
EECCCCEEEECEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSAQADVEQARLHLERSQRLAEKNYASQQEYQDDQAALQVAEATLAARRATLASSRKQL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DVLNAERDSAEANIEAARADLDNARHQLDKTRLRAPVAGVIGNKTVEVGTLAQPSLTLMH
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCEEEECCCCCCCHHHHH
LVPIRSAYVVANYKETQTARMRSGQPVSLHVDAYPDIAFEGVVDSLAPATGSRFSLLPND
HHHCCCEEEEECCCHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCC
NATGNFNKIVQRVPVRIRVTGPEEALGRLRDGLSVVPTVDTRDLDPEDDA
CCCCCHHHHHHHCCEEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]