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The map label for this gene is ilvC

Identifier: 92112637

GI number: 92112637

Start: 554760

End: 555776

Strand: Direct

Name: ilvC

Synonym: Csal_0504

Alternate gene names: 92112637

Gene position: 554760-555776 (Clockwise)

Preceding gene: 92112635

Following gene: 92112638

Centisome position: 15.01

GC content: 62.14

Gene sequence:

>1017_bases
ATGCGCGTTTATTACGACAAAGATTGCGACCTCTCGCTGATCCAGGCGAAGAACGTCACCATCGTGGGCTATGGCTCCCA
GGGGCATGCTCATGCGCATAACCTCAAGGAGTCCGGCGTCGACGTCACCGTGGCACTGCGTCCGGGGTCTTCGTCGGTGG
CCAAGGCCGAAGCGGCCGGCTTCAAGGTCGCTTCCGTTCCTGACGCCTGCAAGACCGCCGACGTGCTGATGCTGCTGGCG
CCGGACGAGAACCAGAAAGCCATCTACGAGCAGGACATCGCGCCCAACCTTAAGCAAGGCGCGACGCTGGCTTTCGCGCA
TGGCTTCAACATCCACTACAACCAGGTGACGCCGCGCGCGGATCTGGACGTGATCATGATCGCGCCCAAGGCGCCGGGTC
ACACGGTTCGCTCCGAGTTCGTGCGGGGCGCAGGCGTTCCGGACCTGATCGCCGTGCAGCAGGATGCCACGGGGCAGGCC
AAGGAACTGGCACTGTCGTACGCCGCCGGCGTGGGTGGCGGTCGTAGCGGCATCATCGAAACGACCTTCAAGGATGAAAC
GGAAACCGATCTGTTCGGCGAGCAGGCGGTGCTGTGCGGTGGCGCGGTCGAGCTGGTCAAGGCCGGTTTCGAGACACTGA
CCGAGGCCGGGTACGAGCCCGAGATGGCCTACTTCGAGTGTCTGCACGAGCTCAAGTTGATCGTCGACCTGATGTACGAA
GGCGGCATCGCCAACATGAACTACTCCATCTCCAACAATGCGGAGTACGGCGAGTACGTGACGGGCCCGGAAGTCATCAA
CGAGCAGTCGCGGGAAGCCATGCGCAATGCCCTGAAGCGCATCCAGAACGGTGAATACGCCAAGATGTTCATCAGCGAAG
GCAACAGCAACTATCCGTCGATGCACGCGCGTCGTCGCCTGAACGCCGAGCATCCCGTCGAGCAGGTCGGCGAGAAGCTG
CGCGGCATGATGCCCTGGATCGCGGCGAATCAGCTGGTCGACAAGAGCAAGAACTGA

Upstream 100 bases:

>100_bases
GCGTAAGGTGGCATCAAAGCGTCGCGATAGACGACGCTACGGCGGAAAGCCATCAACGCTGACACTTCACACGTTTCTTC
TTCGATATCTGGAGTACGAC

Downstream 100 bases:

>100_bases
GCGTCCTGAAACGGACGGCATGAAACGGGCGCGACCACTGGTCGCGCCCGTTTGCGTTTTCGGTCGTCAATGGTCCCGAC
TGTCGACTAGGCTGGCAGTA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MRVYYDKDCDLSLIQAKNVTIVGYGSQGHAHAHNLKESGVDVTVALRPGSSSVAKAEAAGFKVASVPDACKTADVLMLLA
PDENQKAIYEQDIAPNLKQGATLAFAHGFNIHYNQVTPRADLDVIMIAPKAPGHTVRSEFVRGAGVPDLIAVQQDATGQA
KELALSYAAGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYEPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQNGEYAKMFISEGNSNYPSMHARRRLNAEHPVEQVGEKL
RGMMPWIAANQLVDKSKN

Sequences:

>Translated_338_residues
MRVYYDKDCDLSLIQAKNVTIVGYGSQGHAHAHNLKESGVDVTVALRPGSSSVAKAEAAGFKVASVPDACKTADVLMLLA
PDENQKAIYEQDIAPNLKQGATLAFAHGFNIHYNQVTPRADLDVIMIAPKAPGHTVRSEFVRGAGVPDLIAVQQDATGQA
KELALSYAAGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYEPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQNGEYAKMFISEGNSNYPSMHARRRLNAEHPVEQVGEKL
RGMMPWIAANQLVDKSKN
>Mature_338_residues
MRVYYDKDCDLSLIQAKNVTIVGYGSQGHAHAHNLKESGVDVTVALRPGSSSVAKAEAAGFKVASVPDACKTADVLMLLA
PDENQKAIYEQDIAPNLKQGATLAFAHGFNIHYNQVTPRADLDVIMIAPKAPGHTVRSEFVRGAGVPDLIAVQQDATGQA
KELALSYAAGVGGGRSGIIETTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYEPEMAYFECLHELKLIVDLMYE
GGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQNGEYAKMFISEGNSNYPSMHARRRLNAEHPVEQVGEKL
RGMMPWIAANQLVDKSKN

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=36.518771331058, Blast_Score=158, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323387, Length=301, Percent_Identity=30.5647840531561, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_CHRSD (Q1R092)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572565.1
- ProteinModelPortal:   Q1R092
- SMR:   Q1R092
- STRING:   Q1R092
- GeneID:   4026874
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0504
- NMPDR:   fig|290398.4.peg.79
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   CSAL290398:CSAL_0504-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36660; Mature: 36660

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVYYDKDCDLSLIQAKNVTIVGYGSQGHAHAHNLKESGVDVTVALRPGSSSVAKAEAAG
CCEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHCC
FKVASVPDACKTADVLMLLAPDENQKAIYEQDIAPNLKQGATLAFAHGFNIHYNQVTPRA
EEEECCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVRGAGVPDLIAVQQDATGQAKELALSYAAGVGGGRSGIIE
CCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYEPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQNGEYAKMFISEGNSNYPS
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
MHARRRLNAEHPVEQVGEKLRGMMPWIAANQLVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCC
>Mature Secondary Structure
MRVYYDKDCDLSLIQAKNVTIVGYGSQGHAHAHNLKESGVDVTVALRPGSSSVAKAEAAG
CCEEECCCCCEEEEEECCEEEEEECCCCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHCC
FKVASVPDACKTADVLMLLAPDENQKAIYEQDIAPNLKQGATLAFAHGFNIHYNQVTPRA
EEEECCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCCEEEEEECCEEEECCCCCCC
DLDVIMIAPKAPGHTVRSEFVRGAGVPDLIAVQQDATGQAKELALSYAAGVGGGRSGIIE
CCCEEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEE
TTFKDETETDLFGEQAVLCGGAVELVKAGFETLTEAGYEPEMAYFECLHELKLIVDLMYE
ECCCCCCCHHHCCCCEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGIANMNYSISNNAEYGEYVTGPEVINEQSREAMRNALKRIQNGEYAKMFISEGNSNYPS
CCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCC
MHARRRLNAEHPVEQVGEKLRGMMPWIAANQLVDKSKN
HHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA