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The map label for this gene is zitB [H]

Identifier: 92112528

GI number: 92112528

Start: 441151

End: 442134

Strand: Direct

Name: zitB [H]

Synonym: Csal_0395

Alternate gene names: 92112528

Gene position: 441151-442134 (Clockwise)

Preceding gene: 92112527

Following gene: 92112529

Centisome position: 11.93

GC content: 65.35

Gene sequence:

>984_bases
ATGGGACATTCGTCTTCCGGTCACGATCATGCGCCGCATGATCACGACCACGACCACGGCCACGGCCACGACCATCACCA
CGAGCACGCGCCGACGGTCACCGCCGACAGCGCCAAGCGCGTCAAGCTCGCCATGTACCTGACCGCCGGCTTCATGCTCG
CGGAAGCGATCGGTGGGTGGATCTCGGGCTCGCTGGCGTTGCTGGCCGATGCCGGGCACATGTTCAGCGACAGCTTTTCA
CTGGGGCTGGCGCTGTTCGCCTTCTACATGGGCGACAAGGCGCCGGACAAGCGGCGTACCTTTGGCTACCAGCGTTTTCA
GGTGCTGGCGGCCTTCATCAACGGGCTGACGTTGCTGGGGATCGCGGTGTGGATCCTGATCGCCGCCGTCCAGCGCTTCT
TTCAGCCGGTGGAGGTCATGGCTGCCCCGATGCTGGCCATCGCGGTGCTGGGGCTGCTGGTCAATGTGGTGGTCTTCAGG
ATCCTGCATGGCGGCGACCATGAGAATCTCAATCTGCGCGGAGCGTTGCTGCACGTCATGGGCGACCTGCTGGGCTCGGT
GGCGGCCATCGTGGCCTCGCTGGTCATCATGGCGACCGGATGGATGCCGATCGACCCGTTGCTGTCGATGCTGGCGGCGG
CGTTGATTCTGCGCGGCGCCTGGAAGATCGTTCGGCGTTCGGGCCACACCCTGCTCGAAGGCACCCCCGAGGGGATCGAT
GTCGACGGGATTCGCGCGGCCCTGGAGGACATCGAGGGTGTGGTGAGCGTGCATGACCTTCATGTCTGGGGGCTGACGCC
GCAGGATCCGCTGCTCAGCCTGCATCTGGTGGTGCGCGATGACATGTCGCATGCGGTGATGCTCAAGGCCGCCTATGCAC
GCCTGCACGAGCGTTTCGGGATCAGTCACGCGACCCTGCAGGTCGAGGGCGAGGCGTGCCTGACCGGTGGCGATTGCCAG
GTCACGTCGACCACGCACCCCTGA

Upstream 100 bases:

>100_bases
TGGTTGCGTGCGCCGCGGCGTATCACGGTCTCCGACGATTGACCCTGAAGTCCACTCCAGACATTACACTGGAGAAAAGT
CACCGAGAGGCATGACGCCA

Downstream 100 bases:

>100_bases
GCGGGGCGGTATTCGTGTGCGCTATGATCCGGATTAATGCCAAGCCGAGAAACTTTCATTGGTCAGCGCGGGTGGGGCAC
GGCAGAATGCGCGGCATCCA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MGHSSSGHDHAPHDHDHDHGHGHDHHHEHAPTVTADSAKRVKLAMYLTAGFMLAEAIGGWISGSLALLADAGHMFSDSFS
LGLALFAFYMGDKAPDKRRTFGYQRFQVLAAFINGLTLLGIAVWILIAAVQRFFQPVEVMAAPMLAIAVLGLLVNVVVFR
ILHGGDHENLNLRGALLHVMGDLLGSVAAIVASLVIMATGWMPIDPLLSMLAAALILRGAWKIVRRSGHTLLEGTPEGID
VDGIRAALEDIEGVVSVHDLHVWGLTPQDPLLSLHLVVRDDMSHAVMLKAAYARLHERFGISHATLQVEGEACLTGGDCQ
VTSTTHP

Sequences:

>Translated_327_residues
MGHSSSGHDHAPHDHDHDHGHGHDHHHEHAPTVTADSAKRVKLAMYLTAGFMLAEAIGGWISGSLALLADAGHMFSDSFS
LGLALFAFYMGDKAPDKRRTFGYQRFQVLAAFINGLTLLGIAVWILIAAVQRFFQPVEVMAAPMLAIAVLGLLVNVVVFR
ILHGGDHENLNLRGALLHVMGDLLGSVAAIVASLVIMATGWMPIDPLLSMLAAALILRGAWKIVRRSGHTLLEGTPEGID
VDGIRAALEDIEGVVSVHDLHVWGLTPQDPLLSLHLVVRDDMSHAVMLKAAYARLHERFGISHATLQVEGEACLTGGDCQ
VTSTTHP
>Mature_326_residues
GHSSSGHDHAPHDHDHDHGHGHDHHHEHAPTVTADSAKRVKLAMYLTAGFMLAEAIGGWISGSLALLADAGHMFSDSFSL
GLALFAFYMGDKAPDKRRTFGYQRFQVLAAFINGLTLLGIAVWILIAAVQRFFQPVEVMAAPMLAIAVLGLLVNVVVFRI
LHGGDHENLNLRGALLHVMGDLLGSVAAIVASLVIMATGWMPIDPLLSMLAAALILRGAWKIVRRSGHTLLEGTPEGIDV
DGIRAALEDIEGVVSVHDLHVWGLTPQDPLLSLHLVVRDDMSHAVMLKAAYARLHERFGISHATLQVEGEACLTGGDCQV
TSTTHP

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=315, Percent_Identity=28.5714285714286, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI21359890, Length=319, Percent_Identity=31.3479623824451, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI64762489, Length=321, Percent_Identity=27.4143302180685, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI289803013, Length=270, Percent_Identity=30, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803009, Length=270, Percent_Identity=30, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803007, Length=270, Percent_Identity=30, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI289803003, Length=270, Percent_Identity=30, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI21361112, Length=285, Percent_Identity=28.4210526315789, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI20070323, Length=344, Percent_Identity=26.453488372093, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI14210520, Length=227, Percent_Identity=28.6343612334802, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI52351208, Length=155, Percent_Identity=30.9677419354839, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI52352803, Length=127, Percent_Identity=36.2204724409449, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1786966, Length=290, Percent_Identity=44.1379310344828, Blast_Score=204, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI193210990, Length=340, Percent_Identity=31.4705882352941, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17555794, Length=339, Percent_Identity=31.858407079646, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17555796, Length=314, Percent_Identity=32.8025477707006, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32564488, Length=304, Percent_Identity=29.2763157894737, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17550442, Length=173, Percent_Identity=31.2138728323699, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17550440, Length=173, Percent_Identity=31.2138728323699, Blast_Score=68, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=169, Percent_Identity=34.9112426035503, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=153, Percent_Identity=32.0261437908497, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323899, Length=147, Percent_Identity=35.3741496598639, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24583858, Length=359, Percent_Identity=26.7409470752089, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656728, Length=358, Percent_Identity=29.3296089385475, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656724, Length=358, Percent_Identity=29.3296089385475, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656720, Length=358, Percent_Identity=29.3296089385475, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24656715, Length=358, Percent_Identity=29.3296089385475, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21357035, Length=358, Percent_Identity=29.3296089385475, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24585900, Length=139, Percent_Identity=35.2517985611511, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585898, Length=139, Percent_Identity=35.2517985611511, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24585896, Length=139, Percent_Identity=35.2517985611511, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI19921672, Length=139, Percent_Identity=35.2517985611511, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24584409, Length=164, Percent_Identity=31.0975609756098, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI28574430, Length=164, Percent_Identity=31.0975609756098, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24645863, Length=108, Percent_Identity=38.8888888888889, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 35154; Mature: 35023

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCEEEEEECCCEEEECCCEEECCCCCC
>Mature Secondary Structure 
GHSSSGHDHAPHDHDHDHGHGHDHHHEHAPTVTADSAKRVKLAMYLTAGFMLAEAIGGW
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISGSLALLADAGHMFSDSFSLGLALFAFYMGDKAPDKRRTFGYQRFQVLAAFINGLTLLG
HCCCHHHHECCCHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IAVWILIAAVQRFFQPVEVMAAPMLAIAVLGLLVNVVVFRILHGGDHENLNLRGALLHVM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
GDLLGSVAAIVASLVIMATGWMPIDPLLSMLAAALILRGAWKIVRRSGHTLLEGTPEGID
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCC
VDGIRAALEDIEGVVSVHDLHVWGLTPQDPLLSLHLVVRDDMSHAVMLKAAYARLHERFG
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHHC
ISHATLQVEGEACLTGGDCQVTSTTHP
CCEEEEEECCCEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]