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The map label for this gene is tdh [H]

Identifier: 92112492

GI number: 92112492

Start: 402108

End: 403208

Strand: Direct

Name: tdh [H]

Synonym: Csal_0359

Alternate gene names: 92112492

Gene position: 402108-403208 (Clockwise)

Preceding gene: 92112491

Following gene: 92112493

Centisome position: 10.88

GC content: 63.4

Gene sequence:

>1101_bases
ATGAACGATACGCTCACCCCGTCCCCCGATATCCCGCAGACGATGCGCGCGATCGTCGCGTATGCGCCGGAGGACTATCG
TCTCGAAGAAGTCGCGGTACCCGAGATTGGCGAAAAGGAGATTCTGATCAAGGTCGAGGCCTGCGGGATCTGCGCCGGTG
ATCTCAAGGCGTACGAGGGGGCGCCGAGCTTCTGGGGCGACGAGACGCAGCCGCCGTACATCAAGGCGCCCATGATCCCG
GGCCACGAGTTCGTCGGCCATGTCGTCAAGCTGGGGCCTGGCGTCAAGGGATTCGACATCGGCGACCGCGTGATCTCCGA
GCAGATCGTGCCGTGCTGGGACTGCCGTTTCTGCCATCGCGGCCAGTACTGGATGTGCGAAAAGCATGACGTCTACGGCT
TCCAGAACAACGTCAACGGCGGCATGGCCGAGTACATGAAGTTTCCCCGAGAGGCCATCAACCACAAGCTGCCGGAAAAC
GTTCCGGTGGAGAACATCGTGCTGACCGAGCCGTTCTCCTGCTCGATGCATGCGGTGGAGCGGGCACAGATTCAACTGGG
CGACGTGGTGGTCCTCTCCGGCGCCGGCACCCTGGGGCTGGGAATGATCGGTCCCGCCAAGAAGTCCGGCCCTGCCAAGC
TGGTGGTGCTGGATCTGCACGGCGAGCGCCTGGAGCTGGCCCGCAAGTTCGGGGCCGATGTGGTGCTCAACCCCAGCGAG
GAAGACGTGGTCCAGATCGTCAAGGACATGACCGACGGCTATGGCTGCGACATCTACATCGAGGCCACCGGCGCGCCCAA
GTCCGTGGAGCAGGGGTTGGCGATGCTGCGCAAGCTGGGACGTTTCGTGGAGTTCAGCGTGTTCAAGGATCCGGTCACCG
TGGACTGGAGCATCATCAGCGATCGCAAGGAACTGGACGTGCTCGGTGCGCACCTGGGGCCGTACTGCTATCCGCACGTG
ATCGAGGGCATCGAGAGCGGCGATTTCCCCACCGACGGGGTGGTGACCCACAAGCTGCCGCTGGAGGATTTCCACAAGGG
CATCGAGCTGATGAGGCACGACAGCAGCGCGCTCAAGGTCATCCTCGTGCCCGGCGCCTGA

Upstream 100 bases:

>100_bases
CTCGCCGAGTTCATTGACCTGGCTATACTGAAAAGCGTTAATTCATTTGAGCAACACAAGATCAAATGATACAGAACACG
CAAGCTCAGTGGAGGCCGTC

Downstream 100 bases:

>100_bases
TGTCAGAGCCCGGGCGCCGGGACCTGCATCCCTTTTGACCATTCACCAACGAGACCTCAGGGGCGCGCACCATGAATACA
CGTACCGCCGCCATGTCCGC

Product: alcohol dehydrogenase GroES-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MNDTLTPSPDIPQTMRAIVAYAPEDYRLEEVAVPEIGEKEILIKVEACGICAGDLKAYEGAPSFWGDETQPPYIKAPMIP
GHEFVGHVVKLGPGVKGFDIGDRVISEQIVPCWDCRFCHRGQYWMCEKHDVYGFQNNVNGGMAEYMKFPREAINHKLPEN
VPVENIVLTEPFSCSMHAVERAQIQLGDVVVLSGAGTLGLGMIGPAKKSGPAKLVVLDLHGERLELARKFGADVVLNPSE
EDVVQIVKDMTDGYGCDIYIEATGAPKSVEQGLAMLRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGAHLGPYCYPHV
IEGIESGDFPTDGVVTHKLPLEDFHKGIELMRHDSSALKVILVPGA

Sequences:

>Translated_366_residues
MNDTLTPSPDIPQTMRAIVAYAPEDYRLEEVAVPEIGEKEILIKVEACGICAGDLKAYEGAPSFWGDETQPPYIKAPMIP
GHEFVGHVVKLGPGVKGFDIGDRVISEQIVPCWDCRFCHRGQYWMCEKHDVYGFQNNVNGGMAEYMKFPREAINHKLPEN
VPVENIVLTEPFSCSMHAVERAQIQLGDVVVLSGAGTLGLGMIGPAKKSGPAKLVVLDLHGERLELARKFGADVVLNPSE
EDVVQIVKDMTDGYGCDIYIEATGAPKSVEQGLAMLRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGAHLGPYCYPHV
IEGIESGDFPTDGVVTHKLPLEDFHKGIELMRHDSSALKVILVPGA
>Mature_366_residues
MNDTLTPSPDIPQTMRAIVAYAPEDYRLEEVAVPEIGEKEILIKVEACGICAGDLKAYEGAPSFWGDETQPPYIKAPMIP
GHEFVGHVVKLGPGVKGFDIGDRVISEQIVPCWDCRFCHRGQYWMCEKHDVYGFQNNVNGGMAEYMKFPREAINHKLPEN
VPVENIVLTEPFSCSMHAVERAQIQLGDVVVLSGAGTLGLGMIGPAKKSGPAKLVVLDLHGERLELARKFGADVVLNPSE
EDVVQIVKDMTDGYGCDIYIEATGAPKSVEQGLAMLRKLGRFVEFSVFKDPVTVDWSIISDRKELDVLGAHLGPYCYPHV
IEGIESGDFPTDGVVTHKLPLEDFHKGIELMRHDSSALKVILVPGA

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=348, Percent_Identity=31.8965517241379, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=26.2295081967213, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4501933, Length=364, Percent_Identity=24.4505494505494, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI71565154, Length=379, Percent_Identity=23.4828496042216, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI156523966, Length=381, Percent_Identity=24.6719160104987, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4501939, Length=370, Percent_Identity=25.1351351351351, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI34577061, Length=389, Percent_Identity=23.6503856041131, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71743840, Length=392, Percent_Identity=22.9591836734694, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=23.6074270557029, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788073, Length=340, Percent_Identity=32.0588235294118, Blast_Score=164, Evalue=9e-42,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=31.9767441860465, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788407, Length=361, Percent_Identity=26.0387811634349, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786825, Length=410, Percent_Identity=27.5609756097561, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1787863, Length=350, Percent_Identity=27.7142857142857, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=26.3013698630137, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI226510992, Length=342, Percent_Identity=28.3625730994152, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI87082125, Length=279, Percent_Identity=29.7491039426523, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1790718, Length=326, Percent_Identity=24.2331288343558, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI87081918, Length=220, Percent_Identity=31.3636363636364, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=25.2659574468085, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=31.4868804664723, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562878, Length=339, Percent_Identity=31.5634218289086, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562584, Length=322, Percent_Identity=27.3291925465839, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71988145, Length=292, Percent_Identity=27.7397260273973, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=355, Percent_Identity=26.4788732394366, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=349, Percent_Identity=29.512893982808, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6319258, Length=379, Percent_Identity=28.4960422163588, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319257, Length=390, Percent_Identity=27.4358974358974, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=25.9154929577465, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=25.9154929577465, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320033, Length=378, Percent_Identity=24.3386243386243, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=286, Percent_Identity=32.1678321678322, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=259, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=282, Percent_Identity=28.0141843971631, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=283, Percent_Identity=28.6219081272085, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=220, Percent_Identity=30, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137530, Length=352, Percent_Identity=31.25, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=30.7692307692308, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737895, Length=384, Percent_Identity=25.5208333333333, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221457811, Length=326, Percent_Identity=21.4723926380368, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45550770, Length=326, Percent_Identity=21.4723926380368, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45551930, Length=326, Percent_Identity=21.4723926380368, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 40168; Mature: 40168

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDTLTPSPDIPQTMRAIVAYAPEDYRLEEVAVPEIGEKEILIKVEACGICAGDLKAYEG
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEEECCEECCCHHHCCC
APSFWGDETQPPYIKAPMIPGHEFVGHVVKLGPGVKGFDIGDRVISEQIVPCWDCRFCHR
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCHHHCC
GQYWMCEKHDVYGFQNNVNGGMAEYMKFPREAINHKLPENVPVENIVLTEPFSCSMHAVE
CCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHH
RAQIQLGDVVVLSGAGTLGLGMIGPAKKSGPAKLVVLDLHGERLELARKFGADVVLNPSE
HHEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEECCCH
EDVVQIVKDMTDGYGCDIYIEATGAPKSVEQGLAMLRKLGRFVEFSVFKDPVTVDWSIIS
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEEC
DRKELDVLGAHLGPYCYPHVIEGIESGDFPTDGVVTHKLPLEDFHKGIELMRHDSSALKV
CCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEE
ILVPGA
EEECCC
>Mature Secondary Structure
MNDTLTPSPDIPQTMRAIVAYAPEDYRLEEVAVPEIGEKEILIKVEACGICAGDLKAYEG
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCEECCCCCCCCEEEEEEEECCEECCCHHHCCC
APSFWGDETQPPYIKAPMIPGHEFVGHVVKLGPGVKGFDIGDRVISEQIVPCWDCRFCHR
CCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCHHHCC
GQYWMCEKHDVYGFQNNVNGGMAEYMKFPREAINHKLPENVPVENIVLTEPFSCSMHAVE
CCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCHHHHH
RAQIQLGDVVVLSGAGTLGLGMIGPAKKSGPAKLVVLDLHGERLELARKFGADVVLNPSE
HHEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCEEECCCH
EDVVQIVKDMTDGYGCDIYIEATGAPKSVEQGLAMLRKLGRFVEFSVFKDPVTVDWSIIS
HHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEEEC
DRKELDVLGAHLGPYCYPHVIEGIESGDFPTDGVVTHKLPLEDFHKGIELMRHDSSALKV
CCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEE
ILVPGA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]