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The map label for this gene is oprM [H]

Identifier: 91785789

GI number: 91785789

Start: 4865900

End: 4867471

Strand: Reverse

Name: oprM [H]

Synonym: Bxe_A4489

Alternate gene names: 91785789

Gene position: 4867471-4865900 (Counterclockwise)

Preceding gene: 91785790

Following gene: 91785780

Centisome position: 99.42

GC content: 67.49

Gene sequence:

>1572_bases
ATGCAGTCTGATCGAATCTCGCGCGCGCGGACGCTTGCGCCACGCGCCCTGACTATTGCTGTCGCAGCGGCTCTCGCCGG
CCTGCTGTCCGCCTGCGTGGTCGGCCCCGACTACAAGCGGCCCGCGGCCACGATCCCGGCGTCATACAAGGAAGCTGCCC
CCGGCTGGAAAGTCGCCGAGCCGGCCGATCAGCACGATCGAGGCGACTGGTGGACCATTTACGAAGATCCGCAACTCAAC
GCGCTGGAAGACCGGCTGAACACCGCGAACCAGACCGTCGCCCAGTTCGCCGCCGCGTACCGTCAGGCGCGCGCGCTGGT
TGGCGAAGCGCGTGCAGCGTATTTCCCCACCATCGGCGCATCGGCGGGCGCCACGCGTTCCGGCAACGGCTCGTCGTCGA
GTCGCAGCTCGACTGCCACGACGAGCCGCTCCGGCATCAGCAATAGTTTCAACGTACAACTCGACGCAAGCTGGGAGCCG
GACCTGTGGGGTTCGGTCACCCGCTCGGTCAACTCGCAGAAGGCCGGCCAGCAAAGCGCCGCGGCGGACCTCGCGAACGC
GCGGCTGTCGGCGCAAGCCACGCTTGCCCAGACCTATTTCTCGCTGCGCGCGCTCGATTCGACTCAGAAATTACTCGACG
ACACCGTCGCGGCTTACCAACGCTCGCTGCAACTCACGCAGAACCAGTACGCGGCCGGCGTCGCCGCGCGCTCCGACGTG
ATCCAGGCGCAAACGCAATTGCAGTCGGCCCAGGCAGCCGCGATCGACAACGGCGTCCAGCGCGCCCAGGACGAGCACGC
GATCGCCGTACTGGTCGGCGAACCCGCCTCCACCTTCTCGATTCCGCCGATGCCGCTAACGGCCACGCCGCCCGCCGTGC
CGGCGCAAATGCCGTCGGCGCTGCTCGAACGGCGGCCGGACATCGCGTCGGCGGAACGCAAGGCCGCCGCGGCTAACGAA
CAGATCGGCGTAGCCATCGCCGCTTTTTTCCCGTCGCTGACCCTGTCCGCTTCCGGCGGCTTCGAAAATTCAGTGTTCTC
GCAATTGCTGACCGCGCCGTCGCGCTTCTGGACGCTCGGCCCGCAACTCGCCGCAACGCTCTTCGACGCCGGTCTGCGCC
AGGCCCAGACCGACGCCGCCCGAGCCGCCTACGACGGCGACGTCGCGAGCTACCGTCAAACGGTGCTGGCCGCATTCCAG
GACGTCGAGGACAATCTCGCATCACAGCGCATCCTCGAGCAGGAAATCGTCGTGCAGCGGCAAGCGGTGGATTCGGCGCG
TCAGGCGCTGGCCATCGTCACGAACGAGTACAAGGCGGGCACGGTCGGCTACGTCAACGTGCTAACCGCGCAAACCACCG
CCTTCACGGCTGAGCAGAAACTGGAGAACATCGCCGGGCAGCGGATGGTGTCGTCGGTAGGTCTGGTGAAGGCGCTGGGC
GGCGGCTGGGACGCGTCGCAGATGAATCGCGAAACGGGCGATGTGGCCGCGCCAGCGCCGCTGCCGGCATCAGCGGCTGC
GCCGGTCGCGCAAAACGGGGCGACGCCGCCTTCGCAGATGCACAACGAATAG

Upstream 100 bases:

>100_bases
CCCGCGCCCAGCGGGCTCATACGCTAACATTCCCGCAGACCAGGATCTCGTCCGGCGTGCCGCCATCGGCTGCGCCGCGG
CGTCAGAAGGAATTCATTGC

Downstream 100 bases:

>100_bases
AAGCGCCGGCCGTCGGCGTAACGCAAAAGAGGCACGACCGCTTTCTCCACGGTCATGCCTCTTTTTTGCATCGACGCCTC
AAGGCTCTAGCAGTTTGAGC

Product: RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MQSDRISRARTLAPRALTIAVAAALAGLLSACVVGPDYKRPAATIPASYKEAAPGWKVAEPADQHDRGDWWTIYEDPQLN
ALEDRLNTANQTVAQFAAAYRQARALVGEARAAYFPTIGASAGATRSGNGSSSSRSSTATTSRSGISNSFNVQLDASWEP
DLWGSVTRSVNSQKAGQQSAAADLANARLSAQATLAQTYFSLRALDSTQKLLDDTVAAYQRSLQLTQNQYAAGVAARSDV
IQAQTQLQSAQAAAIDNGVQRAQDEHAIAVLVGEPASTFSIPPMPLTATPPAVPAQMPSALLERRPDIASAERKAAAANE
QIGVAIAAFFPSLTLSASGGFENSVFSQLLTAPSRFWTLGPQLAATLFDAGLRQAQTDAARAAYDGDVASYRQTVLAAFQ
DVEDNLASQRILEQEIVVQRQAVDSARQALAIVTNEYKAGTVGYVNVLTAQTTAFTAEQKLENIAGQRMVSSVGLVKALG
GGWDASQMNRETGDVAAPAPLPASAAAPVAQNGATPPSQMHNE

Sequences:

>Translated_523_residues
MQSDRISRARTLAPRALTIAVAAALAGLLSACVVGPDYKRPAATIPASYKEAAPGWKVAEPADQHDRGDWWTIYEDPQLN
ALEDRLNTANQTVAQFAAAYRQARALVGEARAAYFPTIGASAGATRSGNGSSSSRSSTATTSRSGISNSFNVQLDASWEP
DLWGSVTRSVNSQKAGQQSAAADLANARLSAQATLAQTYFSLRALDSTQKLLDDTVAAYQRSLQLTQNQYAAGVAARSDV
IQAQTQLQSAQAAAIDNGVQRAQDEHAIAVLVGEPASTFSIPPMPLTATPPAVPAQMPSALLERRPDIASAERKAAAANE
QIGVAIAAFFPSLTLSASGGFENSVFSQLLTAPSRFWTLGPQLAATLFDAGLRQAQTDAARAAYDGDVASYRQTVLAAFQ
DVEDNLASQRILEQEIVVQRQAVDSARQALAIVTNEYKAGTVGYVNVLTAQTTAFTAEQKLENIAGQRMVSSVGLVKALG
GGWDASQMNRETGDVAAPAPLPASAAAPVAQNGATPPSQMHNE
>Mature_523_residues
MQSDRISRARTLAPRALTIAVAAALAGLLSACVVGPDYKRPAATIPASYKEAAPGWKVAEPADQHDRGDWWTIYEDPQLN
ALEDRLNTANQTVAQFAAAYRQARALVGEARAAYFPTIGASAGATRSGNGSSSSRSSTATTSRSGISNSFNVQLDASWEP
DLWGSVTRSVNSQKAGQQSAAADLANARLSAQATLAQTYFSLRALDSTQKLLDDTVAAYQRSLQLTQNQYAAGVAARSDV
IQAQTQLQSAQAAAIDNGVQRAQDEHAIAVLVGEPASTFSIPPMPLTATPPAVPAQMPSALLERRPDIASAERKAAAANE
QIGVAIAAFFPSLTLSASGGFENSVFSQLLTAPSRFWTLGPQLAATLFDAGLRQAQTDAARAAYDGDVASYRQTVLAAFQ
DVEDNLASQRILEQEIVVQRQAVDSARQALAIVTNEYKAGTVGYVNVLTAQTTAFTAEQKLENIAGQRMVSSVGLVKALG
GGWDASQMNRETGDVAAPAPLPASAAAPVAQNGATPPSQMHNE

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=483, Percent_Identity=28.9855072463768, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI2367348, Length=444, Percent_Identity=26.8018018018018, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54873; Mature: 54873

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00037 MYB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSDRISRARTLAPRALTIAVAAALAGLLSACVVGPDYKRPAATIPASYKEAAPGWKVAE
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCC
PADQHDRGDWWTIYEDPQLNALEDRLNTANQTVAQFAAAYRQARALVGEARAAYFPTIGA
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SAGATRSGNGSSSSRSSTATTSRSGISNSFNVQLDASWEPDLWGSVTRSVNSQKAGQQSA
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHH
AADLANARLSAQATLAQTYFSLRALDSTQKLLDDTVAAYQRSLQLTQNQYAAGVAARSDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAQTQLQSAQAAAIDNGVQRAQDEHAIAVLVGEPASTFSIPPMPLTATPPAVPAQMPSA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
LLERRPDIASAERKAAAANEQIGVAIAAFFPSLTLSASGGFENSVFSQLLTAPSRFWTLG
HHHCCCCHHHHHHHHHHCCCHHCCHHHHHHCCCEEECCCCCCHHHHHHHHHCCHHHHCCC
PQLAATLFDAGLRQAQTDAARAAYDGDVASYRQTVLAAFQDVEDNLASQRILEQEIVVQR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVDSARQALAIVTNEYKAGTVGYVNVLTAQTTAFTAEQKLENIAGQRMVSSVGLVKALG
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGWDASQMNRETGDVAAPAPLPASAAAPVAQNGATPPSQMHNE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHCCC
>Mature Secondary Structure
MQSDRISRARTLAPRALTIAVAAALAGLLSACVVGPDYKRPAATIPASYKEAAPGWKVAE
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCC
PADQHDRGDWWTIYEDPQLNALEDRLNTANQTVAQFAAAYRQARALVGEARAAYFPTIGA
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SAGATRSGNGSSSSRSSTATTSRSGISNSFNVQLDASWEPDLWGSVTRSVNSQKAGQQSA
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHH
AADLANARLSAQATLAQTYFSLRALDSTQKLLDDTVAAYQRSLQLTQNQYAAGVAARSDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IQAQTQLQSAQAAAIDNGVQRAQDEHAIAVLVGEPASTFSIPPMPLTATPPAVPAQMPSA
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHH
LLERRPDIASAERKAAAANEQIGVAIAAFFPSLTLSASGGFENSVFSQLLTAPSRFWTLG
HHHCCCCHHHHHHHHHHCCCHHCCHHHHHHCCCEEECCCCCCHHHHHHHHHCCHHHHCCC
PQLAATLFDAGLRQAQTDAARAAYDGDVASYRQTVLAAFQDVEDNLASQRILEQEIVVQR
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVDSARQALAIVTNEYKAGTVGYVNVLTAQTTAFTAEQKLENIAGQRMVSSVGLVKALG
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GGWDASQMNRETGDVAAPAPLPASAAAPVAQNGATPPSQMHNE
CCCCHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]