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The map label for this gene is mlaE [H]

Identifier: 91785391

GI number: 91785391

Start: 4446864

End: 4447631

Strand: Reverse

Name: mlaE [H]

Synonym: Bxe_A0388

Alternate gene names: 91785391

Gene position: 4447631-4446864 (Counterclockwise)

Preceding gene: 91785392

Following gene: 91785390

Centisome position: 90.85

GC content: 64.32

Gene sequence:

>768_bases
ATGATCAGTGCGATCGGCCGCTCCGTGCTCGACGGGCTGGGCACGGCCGGCTATGCCACGCGTTTCTTCTTCCGGCTGCT
GCTCGAGTTTTTCCCGTTGTTGCGCCGTCCACGTCTTGTCACGAAGCAGATCCACTTCGTCGGTAATTATTCGCTGGTGA
TCATCGCCGTGTCGGGCCTGTTCGTCGGCTTCGTGCTCGGTCTTCAGGGCTATTACACGCTGACCCGGTACGGCTCCGAG
GAGGCGCTCGGACTGCTGGTCGCGCTCTCGCTCGTGCGCGAGCTCGGGCCGGTGGTCACGGCGCTGCTGTTCGCCGGGCG
CGCCGGTACGTCGCTCACGGCCGAGATCGGCCTGATGAAGGCGGGCGAGCAACTGACCGCAATGGAAATGATGGCGGTGG
ACCCGGTGAAGATCGTGATCGCGCCGCGCCTGTGGGCCGGCATTATTTCAATGCCGATCCTCGCCGCGATTTTCAGCGCG
GTCGGCGTATTCGGCGGCTATGTGGTGGGCGTGCTGCTGATCGGTGTCGATGCCGGTGCGTTCTGGTCGCAGATGCAAGG
CGGCGTCGATGTCTGGCACGACGTGGGCGCCGGCGTCGTCAAGAGCGTGGTGTTCGGCCTCGCGGTGACGTTCGTTGCGC
TGTTTCAGGGCTATGAAGCCAAGCCGACGCCGGAAGGCGTGTCGCGCGCCACGACCAAGACAGTCGTGTACGCGTCGCTT
GCGGTGCTCGGCCTCGATTTTCTGCTGACCGCGCTGATGTTCAGCTAA

Upstream 100 bases:

>100_bases
TGCGCCAGTTCATCGACGGCGCGCCGGACGGCCCCTTCAAATTTCACTATCCCAGCAAGACGCCGCTCGCGGCGGACTTC
GGCATTGGCGGAGGTCAGTC

Downstream 100 bases:

>100_bases
GACTGCGCCACACTGTTTCGCCAGCGGTGCGTCTACCGGACGCGCGCGGCGGGAGTGTCGACGGCGCGGCGGATTCACTT
TGGGATGACGATGAAAAAGA

Product: ABC transporter inner membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MISAIGRSVLDGLGTAGYATRFFFRLLLEFFPLLRRPRLVTKQIHFVGNYSLVIIAVSGLFVGFVLGLQGYYTLTRYGSE
EALGLLVALSLVRELGPVVTALLFAGRAGTSLTAEIGLMKAGEQLTAMEMMAVDPVKIVIAPRLWAGIISMPILAAIFSA
VGVFGGYVVGVLLIGVDAGAFWSQMQGGVDVWHDVGAGVVKSVVFGLAVTFVALFQGYEAKPTPEGVSRATTKTVVYASL
AVLGLDFLLTALMFS

Sequences:

>Translated_255_residues
MISAIGRSVLDGLGTAGYATRFFFRLLLEFFPLLRRPRLVTKQIHFVGNYSLVIIAVSGLFVGFVLGLQGYYTLTRYGSE
EALGLLVALSLVRELGPVVTALLFAGRAGTSLTAEIGLMKAGEQLTAMEMMAVDPVKIVIAPRLWAGIISMPILAAIFSA
VGVFGGYVVGVLLIGVDAGAFWSQMQGGVDVWHDVGAGVVKSVVFGLAVTFVALFQGYEAKPTPEGVSRATTKTVVYASL
AVLGLDFLLTALMFS
>Mature_255_residues
MISAIGRSVLDGLGTAGYATRFFFRLLLEFFPLLRRPRLVTKQIHFVGNYSLVIIAVSGLFVGFVLGLQGYYTLTRYGSE
EALGLLVALSLVRELGPVVTALLFAGRAGTSLTAEIGLMKAGEQLTAMEMMAVDPVKIVIAPRLWAGIISMPILAAIFSA
VGVFGGYVVGVLLIGVDAGAFWSQMQGGVDVWHDVGAGVVKSVVFGLAVTFVALFQGYEAKPTPEGVSRATTKTVVYASL
AVLGLDFLLTALMFS

Specific function: Part of the ABC transporter complex mlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner memb

COG id: COG0767

COG function: function code Q; ABC-type transport system involved in resistance to organic solvents, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaE permease family [H]

Homologues:

Organism=Escherichia coli, GI1789585, Length=253, Percent_Identity=56.9169960474308, Blast_Score=278, Evalue=3e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003453 [H]

Pfam domain/function: PF02405 DUF140 [H]

EC number: NA

Molecular weight: Translated: 27018; Mature: 27018

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISAIGRSVLDGLGTAGYATRFFFRLLLEFFPLLRRPRLVTKQIHFVGNYSLVIIAVSGL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHH
FVGFVLGLQGYYTLTRYGSEEALGLLVALSLVRELGPVVTALLFAGRAGTSLTAEIGLMK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AGEQLTAMEMMAVDPVKIVIAPRLWAGIISMPILAAIFSAVGVFGGYVVGVLLIGVDAGA
CCCHHHHHHHHHCCCHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FWSQMQGGVDVWHDVGAGVVKSVVFGLAVTFVALFQGYEAKPTPEGVSRATTKTVVYASL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
AVLGLDFLLTALMFS
HHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]